fluorouracil has been researched along with Magnesium Deficiency in 3 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Magnesium Deficiency: A nutritional condition produced by a deficiency of magnesium in the diet, characterized by anorexia, nausea, vomiting, lethargy, and weakness. Symptoms are paresthesias, muscle cramps, irritability, decreased attention span, and mental confusion, possibly requiring months to appear. Deficiency of body magnesium can exist even when serum values are normal. In addition, magnesium deficiency may be organ-selective, since certain tissues become deficient before others. (Harrison's Principles of Internal Medicine, 12th ed, p1936)
| Excerpt | Relevance | Reference |
|---|---|---|
| "5-fluorouracil was given as a continuous infusion." | 2.68 | A randomised study to determine whether routine intravenous magnesium supplements are necessary in patients receiving cisplatin chemotherapy with continuous infusion 5-fluorouracil. ( Beveridge, IG; Evans, TR; Harper, CL; Mansi, JL; Wastnage, R, 1995) |
| " There was no difference in adverse effects or response rate between the two groups." | 1.46 | Premedication with intravenous magnesium has a protective effect against cisplatin-induced nephrotoxicity. ( Dosaka-Akita, H; Honma, R; Iseki, K; Kasashi, K; Kinoshita, I; Kobayashi, M; Saito, Y; Shimizu, Y; Takeuchi, S; Yamada, T, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (66.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Saito, Y | 1 |
| Kobayashi, M | 1 |
| Yamada, T | 1 |
| Kasashi, K | 1 |
| Honma, R | 1 |
| Takeuchi, S | 1 |
| Shimizu, Y | 1 |
| Kinoshita, I | 1 |
| Dosaka-Akita, H | 1 |
| Iseki, K | 1 |
| Evans, TR | 1 |
| Harper, CL | 1 |
| Beveridge, IG | 1 |
| Wastnage, R | 1 |
| Mansi, JL | 1 |
| Cappelaere, P | 1 |
| Vincent, A | 1 |
| Staumont, M | 1 |
| Dupuis, B | 1 |
| Gautier, P | 1 |
| Adenis, L | 1 |
1 trial available for fluorouracil and Magnesium Deficiency
| Article | Year |
|---|---|
A randomised study to determine whether routine intravenous magnesium supplements are necessary in patients receiving cisplatin chemotherapy with continuous infusion 5-fluorouracil.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Fluorouracil; Gastrointestin | 1995 |
2 other studies available for fluorouracil and Magnesium Deficiency
| Article | Year |
|---|---|
Premedication with intravenous magnesium has a protective effect against cisplatin-induced nephrotoxicity.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Dietary Supplements; Docetaxel; Fem | 2017 |
[Continuous Holter cardiac monitoring and chemotherapy by combination with platinum and fluoro-uracil].
Topics: Adult; Aged; Carcinoma, Squamous Cell; Cisplatin; Drug Therapy, Combination; Electrocardiography, Am | 1991 |