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fluorouracil and Macular Degeneration

fluorouracil has been researched along with Macular Degeneration in 3 studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Macular Degeneration: Degenerative changes in the RETINA usually of older adults which results in a loss of vision in the center of the visual field (the MACULA LUTEA) because of damage to the retina. It occurs in dry and wet forms.

Research Excerpts

ExcerptRelevanceReference
" Macular relocation surgery involved phacoemulsification, vitrectomy, 360 degrees retinotomy, excision of choroidal neovascular membrane, and macular relocation using an infusion of 5-fluorouracil and low molecular weight heparin as adjuvant to prevent proliferative vitreoretinopathy."3.72Case selection in macular relocation surgery for age related macular degeneration. ( Briggs, M; Groenewald, C; Lancaster, E; Lenfestey, P; Li, KK; Lim, KS; Stanga, P; Wong, D, 2004)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (33.33)18.2507
2000's1 (33.33)29.6817
2010's1 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Buyse, M1
Wong, D1
Stanga, P1
Briggs, M1
Lenfestey, P1
Lancaster, E1
Li, KK1
Lim, KS1
Groenewald, C1
Singh, K1
Byrd, S1
Egbert, PR1
Budenz, D1

Trials

1 trial available for fluorouracil and Macular Degeneration

ArticleYear
Risk of hypotony after primary trabeculectomy with antifibrotic agents in a black west African population.
    Journal of glaucoma, 1998, Volume: 7, Issue:2

    Topics: Fluorouracil; Follow-Up Studies; Ghana; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Intraope

1998

Other Studies

2 other studies available for fluorouracil and Macular Degeneration

ArticleYear
Generalized pairwise comparisons of prioritized outcomes in the two-sample problem.
    Statistics in medicine, 2010, Dec-30, Volume: 29, Issue:30

    Topics: Antineoplastic Combined Chemotherapy Protocols; Aptamers, Nucleotide; Colorectal Neoplasms; Disease-

2010
Case selection in macular relocation surgery for age related macular degeneration.
    The British journal of ophthalmology, 2004, Volume: 88, Issue:2

    Topics: Aged; Aged, 80 and over; Chemotherapy, Adjuvant; Choroidal Neovascularization; Fluorouracil; Follow-

2004