fluorouracil has been researched along with Macular Degeneration in 3 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Macular Degeneration: Degenerative changes in the RETINA usually of older adults which results in a loss of vision in the center of the visual field (the MACULA LUTEA) because of damage to the retina. It occurs in dry and wet forms.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Macular relocation surgery involved phacoemulsification, vitrectomy, 360 degrees retinotomy, excision of choroidal neovascular membrane, and macular relocation using an infusion of 5-fluorouracil and low molecular weight heparin as adjuvant to prevent proliferative vitreoretinopathy." | 3.72 | Case selection in macular relocation surgery for age related macular degeneration. ( Briggs, M; Groenewald, C; Lancaster, E; Lenfestey, P; Li, KK; Lim, KS; Stanga, P; Wong, D, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Buyse, M | 1 |
| Wong, D | 1 |
| Stanga, P | 1 |
| Briggs, M | 1 |
| Lenfestey, P | 1 |
| Lancaster, E | 1 |
| Li, KK | 1 |
| Lim, KS | 1 |
| Groenewald, C | 1 |
| Singh, K | 1 |
| Byrd, S | 1 |
| Egbert, PR | 1 |
| Budenz, D | 1 |
1 trial available for fluorouracil and Macular Degeneration
| Article | Year |
|---|---|
Risk of hypotony after primary trabeculectomy with antifibrotic agents in a black west African population.
Topics: Fluorouracil; Follow-Up Studies; Ghana; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Intraope | 1998 |
2 other studies available for fluorouracil and Macular Degeneration
| Article | Year |
|---|---|
Generalized pairwise comparisons of prioritized outcomes in the two-sample problem.
Topics: Antineoplastic Combined Chemotherapy Protocols; Aptamers, Nucleotide; Colorectal Neoplasms; Disease- | 2010 |
Case selection in macular relocation surgery for age related macular degeneration.
Topics: Aged; Aged, 80 and over; Chemotherapy, Adjuvant; Choroidal Neovascularization; Fluorouracil; Follow- | 2004 |