fluorouracil has been researched along with Lymphocytopenia in 11 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This phase II study evaluated a modified Japanese capecitabine regimen as first-line treatment for advanced/metastatic colorectal cancer." | 9.11 | A phase II Japanese study of a modified capecitabine regimen for advanced or metastatic colorectal cancer. ( Kondo, Y; Nishisho, I; Sakamoto, J; Sakamoto, N; Takemiya, S, 2004) |
| "This phase II study evaluated a modified Japanese capecitabine regimen as first-line treatment for advanced/metastatic colorectal cancer." | 5.11 | A phase II Japanese study of a modified capecitabine regimen for advanced or metastatic colorectal cancer. ( Kondo, Y; Nishisho, I; Sakamoto, J; Sakamoto, N; Takemiya, S, 2004) |
| " The aim of this study is to determine if SBRT with either chemotherapy (CMT) (Fluorouracil (5FU) or capecitabine) or Nelfinavir (NFV) to pancreatic adenocarcinoma induces lymphopenia to the same degree as CFRT with 5FU or capecitabine and how any associated difference affects patient survival outcomes." | 3.91 | Lymphocyte-sparing effect of stereotactic body radiation therapy compared to conventional fractionated radiation therapy in patients with locally advanced pancreatic cancer. ( Baine, MJ; Li, S; Li, X; Lin, C; Wu, G; Zhao, N, 2019) |
| "Pancreatic cancer is one of the leading causes of cancer-related deaths worldwide." | 2.79 | Phase I dose escalation study of capecitabine and erlotinib concurrent with radiation in locally advanced pancreatic cancer. ( Belani, CP; Gusani, N; Jiang, Y; Kaifi, J; Kimchi, ET; Mackley, HB; Staveley-O'Carroll, KF; Zhu, J, 2014) |
| "To investigate the relationship between treatment-related lymphopenia and pathologic response to neoadjuvant chemoradiotherapy (CRT) in patients with esophageal squamous cell carcinoma (ESCC)." | 1.51 | Treatment-Related Lymphopenia Predicts Pathologic Complete Response and Recurrence in Esophageal Squamous Cell Carcinoma Undergoing Neoadjuvant Chemoradiotherapy. ( Hu, Y; Li, Q; Liu, M; Liu, S; Xi, M; Yang, H; Zhao, L; Zhou, S, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (18.18) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (18.18) | 29.6817 |
| 2010's | 6 (54.55) | 24.3611 |
| 2020's | 1 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Xiao, H | 1 |
| Wang, Y | 1 |
| Wang, Z | 1 |
| Wang, B | 1 |
| Hu, L | 1 |
| Hou, J | 1 |
| Du, K | 1 |
| Sun, N | 1 |
| Wang, L | 1 |
| Wu, G | 1 |
| Baine, MJ | 1 |
| Zhao, N | 1 |
| Li, S | 1 |
| Li, X | 1 |
| Lin, C | 1 |
| Davuluri, R | 1 |
| Jiang, W | 1 |
| Fang, P | 1 |
| Xu, C | 1 |
| Komaki, R | 1 |
| Gomez, DR | 1 |
| Welsh, J | 1 |
| Cox, JD | 1 |
| Crane, CH | 1 |
| Hsu, CC | 1 |
| Lin, SH | 1 |
| Li, Q | 1 |
| Zhou, S | 1 |
| Liu, S | 2 |
| Yang, H | 1 |
| Zhao, L | 1 |
| Liu, M | 1 |
| Hu, Y | 1 |
| Xi, M | 1 |
| Jiang, Y | 1 |
| Mackley, HB | 1 |
| Kimchi, ET | 1 |
| Zhu, J | 1 |
| Gusani, N | 1 |
| Kaifi, J | 1 |
| Staveley-O'Carroll, KF | 1 |
| Belani, CP | 1 |
| Wild, AT | 1 |
| Herman, JM | 1 |
| Dholakia, AS | 1 |
| Moningi, S | 1 |
| Lu, Y | 1 |
| Rosati, LM | 1 |
| Hacker-Prietz, A | 1 |
| Assadi, RK | 1 |
| Saeed, AM | 1 |
| Pawlik, TM | 1 |
| Jaffee, EM | 1 |
| Laheru, DA | 1 |
| Tran, PT | 1 |
| Weiss, MJ | 1 |
| Wolfgang, CL | 1 |
| Ford, E | 1 |
| Grossman, SA | 1 |
| Ye, X | 1 |
| Ellsworth, SG | 1 |
| Zhang, J | 1 |
| Lee, J | 1 |
| Urba, S | 1 |
| Foster, J | 1 |
| Worden, F | 1 |
| Sakamoto, J | 1 |
| Kondo, Y | 1 |
| Takemiya, S | 1 |
| Sakamoto, N | 1 |
| Nishisho, I | 1 |
| Hennequin, C | 1 |
| Salemkour, A | 1 |
| Mal, F | 1 |
| Lecomte, T | 1 |
| Boudet, MJ | 1 |
| Perniceni, T | 1 |
| Gayet, B | 1 |
| Maylin, C | 1 |
| Raymond, E | 1 |
| Kulish, OP | 1 |
| Korol'chuk, VP | 1 |
| Iushkov, SF | 1 |
4 trials available for fluorouracil and Lymphocytopenia
| Article | Year |
|---|---|
Phase I dose escalation study of capecitabine and erlotinib concurrent with radiation in locally advanced pancreatic cancer.
Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Chemoradiotherap | 2014 |
Lymphocyte-Sparing Effect of Stereotactic Body Radiation Therapy in Patients With Unresectable Pancreatic Cancer.
Topics: Adenocarcinoma; Aged; Antimetabolites, Antineoplastic; Chemoradiotherapy; Deoxycytidine; Dose Fracti | 2016 |
A phase II trial evaluating weekly docetaxel and capecitabine in patients with metastatic or advanced, locally recurrent head and neck cancers.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Case-Control Studies; Deo | 2010 |
A phase II Japanese study of a modified capecitabine regimen for advanced or metastatic colorectal cancer.
Topics: Administration, Oral; Adult; Aged; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Disease Progre | 2004 |
7 other studies available for fluorouracil and Lymphocytopenia
| Article | Year |
|---|---|
Angelica sinensis polysaccharides ameliorated 5-Fluorouracil-induced damage of early B cell progenitors by alleviating oxidative stress of IL-7 producing mesenchymal stem and progenitor cells.
Topics: Angelica sinensis; Animals; Fluorouracil; Interleukin-7; Lymphopenia; Mice; NF-E2-Related Factor 2; | 2023 |
Lymphocyte-sparing effect of stereotactic body radiation therapy compared to conventional fractionated radiation therapy in patients with locally advanced pancreatic cancer.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Capecitabine; Chemo | 2019 |
Lymphocyte Nadir and Esophageal Cancer Survival Outcomes After Chemoradiation Therapy.
Topics: Adenocarcinoma; Carcinoma, Squamous Cell; Chemoradiotherapy; Esophageal Neoplasms; Fluorouracil; Hum | 2017 |
Treatment-Related Lymphopenia Predicts Pathologic Complete Response and Recurrence in Esophageal Squamous Cell Carcinoma Undergoing Neoadjuvant Chemoradiotherapy.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; China; Cisplatin; Esophageal Neoplasms; | 2019 |
[Chemotherapy with cisplatinum, carboplatin and 5FU-folinic acid, followed by concomitant chemo-radiotherapy in unresectable esophageal carcinomas].
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Cisplatin; Combined Modali | 2001 |
[Effect high-altitude conditions on the antitumor activity of cyclophosphane and its action on lymphoid tissue cells].
Topics: Altitude; Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carcinoma 256, | 1985 |
[Correlation between lymphocytes and polyblast-macrophages and their cytologic characteristic during the use of antineoplastic agents].
Topics: Animals; Blood Cell Count; Cell Differentiation; Culture Techniques; Cyclophosphamide; Depression, C | 1971 |