fluorouracil has been researched along with Lupus Erythematosus, Discoid in 6 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Lupus Erythematosus, Discoid: A chronic form of cutaneous lupus erythematosus (LUPUS ERYTHEMATOSUS, CUTANEOUS) in which the skin lesions mimic those of the systemic form but in which systemic signs are rare. It is characterized by the presence of discoid skin plaques showing varying degrees of edema, erythema, scaliness, follicular plugging, and skin atrophy. Lesions are surrounded by an elevated erythematous border. The condition typically involves the face and scalp, but widespread dissemination may occur.
| Excerpt | Relevance | Reference |
|---|---|---|
| "It is well known that fluorouracil (FU) agents frequently induce discoid-lupus-erythematosus (DLE)-like eruptions and acral erythema in Japan." | 7.74 | Anti-SSA/Ro antibody as a risk factor for fluorouracil-induced drug eruptions showing acral erythema and discoid-lupus-erythematosus-like lesions. ( Adachi, A; Horikawa, T; Nagai, H, 2007) |
| "It is well known that fluorouracil (FU) agents frequently induce discoid-lupus-erythematosus (DLE)-like eruptions and acral erythema in Japan." | 3.74 | Anti-SSA/Ro antibody as a risk factor for fluorouracil-induced drug eruptions showing acral erythema and discoid-lupus-erythematosus-like lesions. ( Adachi, A; Horikawa, T; Nagai, H, 2007) |
| "5-Fluorouracil is an antineoplastic antimetabolite responsible for a variety of cutaneous reactions." | 1.33 | Chronic cutaneous lupus flare induced by systemic 5-fluorouracil. ( Bessis, D; Guillot, B; Kluger, N, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 3 (50.00) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Borucki, R | 1 |
| Werth, VP | 1 |
| Saade Lemus, P | 1 |
| Anderson, K | 1 |
| Smith, M | 1 |
| Bullock, A | 1 |
| Kluger, N | 1 |
| Bessis, D | 1 |
| Guillot, B | 1 |
| Adachi, A | 1 |
| Nagai, H | 1 |
| Horikawa, T | 1 |
| Merlin, F | 1 |
| Prochilo, T | 1 |
| Kildani, B | 1 |
| Lombardi, C | 1 |
| Pasolini, G | 1 |
| Bonetti, F | 1 |
| Beretta, GD | 1 |
| de Castelbajac, D | 1 |
| Guillaume, JC | 1 |
| Prost, C | 1 |
| Revuz, J | 1 |
1 review available for fluorouracil and Lupus Erythematosus, Discoid
| Article | Year |
|---|---|
[Chronic lupus erythematosus and epidermoid carcinoma].
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Carcinoma, Squamous Cell; Cisplati | 1990 |
5 other studies available for fluorouracil and Lupus Erythematosus, Discoid
| Article | Year |
|---|---|
Response letter to 'chronic cutaneous lupus erythematosus induced by 5-fluorouracil'.
Topics: Fluorouracil; Humans; Lupus Erythematosus, Cutaneous; Lupus Erythematosus, Discoid | 2020 |
Spontaneous regression of pancreatic cancer with liver metastases.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Pancreatic Ductal; Female; Fluorouracil; | 2019 |
Chronic cutaneous lupus flare induced by systemic 5-fluorouracil.
Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Breast Neoplasms; Female; Fluorouracil; Humans; Lup | 2006 |
Anti-SSA/Ro antibody as a risk factor for fluorouracil-induced drug eruptions showing acral erythema and discoid-lupus-erythematosus-like lesions.
Topics: Aged; Antimetabolites, Antineoplastic; Autoantibodies; Biopsy; Diagnosis, Differential; Drug Eruptio | 2007 |
Discoid lupus erythematosus (DLE)-like lesions induced by capecitabine.
Topics: Animals; Antibodies, Antinuclear; Antimetabolites, Antineoplastic; Capecitabine; Deoxycytidine; Fema | 2008 |