fluorouracil has been researched along with Liver Failure in 12 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Liver Failure: Severe inability of the LIVER to perform its normal metabolic functions, as evidenced by severe JAUNDICE and abnormal serum levels of AMMONIA; BILIRUBIN; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; LACTATE DEHYDROGENASES; and albumin/globulin ratio. (Blakiston's Gould Medical Dictionary, 4th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "We report on a 45-year-old breast cancer patient with disseminated hepatic metastases." | 5.36 | Successful remission of extensive liver metastases in a breast cancer patient with acute liver failure using a combined chemotherapy regimen with mitomycin, folinate, and 5-fluorouracil (Mi/Fo/FU). ( Eichbaum, MH; Hauser, N; Hohl, MK; Sohn, C; Stoiber, B; Stoiber, N, 2010) |
| "We report on a 45-year-old breast cancer patient with disseminated hepatic metastases." | 1.36 | Successful remission of extensive liver metastases in a breast cancer patient with acute liver failure using a combined chemotherapy regimen with mitomycin, folinate, and 5-fluorouracil (Mi/Fo/FU). ( Eichbaum, MH; Hauser, N; Hohl, MK; Sohn, C; Stoiber, B; Stoiber, N, 2010) |
| "There were upper gastrointestinal hemorrhage in 3 cases, hepatic failure in 4, pulmonary embolism in 1, cholecystitis in 4, hepatic encephalopathy in 2, gastric perforation in 1, and intrahepatic biloma in 2 cases." | 1.35 | [Analysis of severe complications after transcatheter arterial chemoembolization for primary hepatocellular carcinoma]. ( Feng, B; Liang, SN; Liu, LL; Su, HY; Xu, K; Zhao, GS, 2008) |
| "A case of colorectal cancer in a 60-year-old man became resectable after downstaging was achieved with mFOLFOX 6 for multiple liver metastases from colorectal cancer." | 1.34 | [A case of liver failure associated with liver damage due to mFOLFOX 6 after resection for multiple liver metastases from colorectal cancer]. ( Abe, T; Aoki, T; Ishizaki, T; Katsumata, K; Koyanagi, Y; Tsuchida, A; Wada, T, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (8.33) | 18.2507 |
| 2000's | 8 (66.67) | 29.6817 |
| 2010's | 3 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sawai, K | 1 |
| Goi, T | 1 |
| Koneri, K | 1 |
| Katayama, K | 1 |
| Yamaguchi, A | 1 |
| Liang, SN | 1 |
| Liu, LL | 1 |
| Su, HY | 1 |
| Feng, B | 1 |
| Zhao, GS | 1 |
| Xu, K | 1 |
| Shimura, T | 1 |
| Kataoka, H | 1 |
| Hirata, Y | 1 |
| Mizushima, T | 1 |
| Murakami, K | 1 |
| Mabuchi, M | 1 |
| Mizoshita, T | 1 |
| Kubota, E | 1 |
| Tanida, S | 1 |
| Kamiya, T | 1 |
| Joh, T | 1 |
| Stoiber, N | 1 |
| Hauser, N | 1 |
| Stoiber, B | 1 |
| Hohl, MK | 1 |
| Sohn, C | 1 |
| Eichbaum, MH | 1 |
| Seong, J | 1 |
| Han, KH | 1 |
| Park, YN | 1 |
| Nam, SH | 2 |
| Kim, SH | 1 |
| Keum, WS | 1 |
| Kim, KS | 1 |
| Stippel, DL | 1 |
| Töx, U | 1 |
| Gossmann, A | 1 |
| Beckurts, KT | 1 |
| Hölscher, AH | 1 |
| Henry, S | 1 |
| Machiels, JP | 1 |
| Baurain, JF | 1 |
| Duck, L | 1 |
| Mori, T | 1 |
| Munakata, M | 1 |
| Kasai, M | 1 |
| Nozaki, T | 1 |
| Kawamura, S | 1 |
| Sawamura, N | 1 |
| Hiraga, H | 1 |
| Sakata, Y | 1 |
| Fakih, MG | 1 |
| Hwang, SJ | 1 |
| Park, JW | 1 |
| Lee, SD | 1 |
| Kim, GJ | 1 |
| Sin, CH | 1 |
| Kim, BS | 1 |
| Ishizaki, T | 1 |
| Abe, T | 1 |
| Koyanagi, Y | 1 |
| Katsumata, K | 1 |
| Wada, T | 1 |
| Tsuchida, A | 1 |
| Aoki, T | 1 |
| Patiutko, IuI | 1 |
| Sagaĭdak, IV | 1 |
| Kotel'nikov, AG | 1 |
| Badalian, KhV | 1 |
| Tumanian, AO | 1 |
1 review available for fluorouracil and Liver Failure
| Article | Year |
|---|---|
Successful treatment of radiofrequency-induced biliary lesions by interventional endoscopic retrograde cholangiography (ERC).
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Biliary Tract; Carcinoma, Hepatocellula | 2003 |
11 other studies available for fluorouracil and Liver Failure
| Article | Year |
|---|---|
Partial response after transcatheter arterial infusion chemotherapy in a patient with systemic chemotherapy-resistant unresectable colon cancer and hepatic metastasis: (case report).
Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camp | 2013 |
[Analysis of severe complications after transcatheter arterial chemoembolization for primary hepatocellular carcinoma].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinom | 2008 |
Metastatic colorectal cancer with severe liver dysfunction successfully treated using FOLFOX therapy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Disease Progression; Fluoroura | 2011 |
Successful remission of extensive liver metastases in a breast cancer patient with acute liver failure using a combined chemotherapy regimen with mitomycin, folinate, and 5-fluorouracil (Mi/Fo/FU).
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carcinoma; Female; Fluorouracil; H | 2010 |
Lethal hepatic injury by combined treatment of radiation plus chemotherapy in rats with thioacetamide-induced liver cirrhosis.
Topics: Animals; Combined Modality Therapy; Fluorouracil; Liver; Liver Cirrhosis, Experimental; Liver Failur | 2003 |
Liver insufficiency due to breast cancer metastases--fast biological response with capecitabine.
Topics: Aged; Breast Neoplasms; Capecitabine; Deoxycytidine; Female; Fluorouracil; Humans; Liver Failure; Li | 2004 |
[Successful treatment of 5-FU intraarterial infusion on the third postoperative day for a patient with multiple liver metastases from colon cancer and high risk of liver failure].
Topics: Adenocarcinoma; Aged; Antimetabolites, Antineoplastic; Benzimidazoles; Colectomy; Colonic Neoplasms; | 2004 |
5-fluorouracil leucovorin and oxaliplatin (FOLFOX) in the treatment of metastatic colon cancer with severe liver dysfunction.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Female; Fluorouracil; Huma | 2004 |
Capecitabine and oxaliplatin (XELOX) for the treatment of patients with metastatic gastric cancer and severe liver dysfunction.
Topics: Adenocarcinoma; Antineoplastic Agents; Capecitabine; Deoxycytidine; Drug Therapy, Combination; Fluor | 2006 |
[A case of liver failure associated with liver damage due to mFOLFOX 6 after resection for multiple liver metastases from colorectal cancer].
Topics: Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colorectal Neoplasms; Combin | 2007 |
[Current approaches to surgical treatment of liver tumors].
Topics: Adjuvants, Immunologic; Antimetabolites, Antineoplastic; Antineoplastic Agents; Chemotherapy, Adjuva | 1998 |