fluorouracil has been researched along with Liver Failure, Acute in 2 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Liver Failure, Acute: A form of rapid-onset LIVER FAILURE, also known as fulminant hepatic failure, caused by severe liver injury or massive loss of HEPATOCYTES. It is characterized by sudden development of liver dysfunction and JAUNDICE. Acute liver failure may progress to exhibit cerebral dysfunction even HEPATIC COMA depending on the etiology that includes hepatic ISCHEMIA, drug toxicity, malignant infiltration, and viral hepatitis such as post-transfusion HEPATITIS B and HEPATITIS C.
| Excerpt | Relevance | Reference |
|---|---|---|
| "5-Fluorouracil was infused for 15 min into the hepatic artery or the saphenous vein of rats at a dose of 1." | 5.36 | Effect of acute hepatic failure on the hepatic first-pass effect of 5-fluorouracil in rats. ( Arimori, K; Hidaka, M; Hidaka, Y; Iwakiri, T; Kawano, Y; Nagata, M; Okumura, M, 2010) |
| "5-Fluorouracil was infused for 15 min into the hepatic artery or the saphenous vein of rats at a dose of 1." | 1.36 | Effect of acute hepatic failure on the hepatic first-pass effect of 5-fluorouracil in rats. ( Arimori, K; Hidaka, M; Hidaka, Y; Iwakiri, T; Kawano, Y; Nagata, M; Okumura, M, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hajj, A | 1 |
| Ghosn, M | 1 |
| Mourad, D | 1 |
| Hojaiban, K | 1 |
| Mousallem, P | 1 |
| Khabbaz, LR | 1 |
| Nagata, M | 1 |
| Hidaka, Y | 1 |
| Hidaka, M | 1 |
| Kawano, Y | 1 |
| Iwakiri, T | 1 |
| Okumura, M | 1 |
| Arimori, K | 1 |
2 other studies available for fluorouracil and Liver Failure, Acute
| Article | Year |
|---|---|
Lethal hepatotoxicity following 5-fluorouracil/cisplatin chemotherapy: a relevant case report.
Topics: Aged; Chemical and Drug Induced Liver Injury; Cisplatin; Drug-Related Side Effects and Adverse React | 2017 |
Effect of acute hepatic failure on the hepatic first-pass effect of 5-fluorouracil in rats.
Topics: Animals; Antineoplastic Agents; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Inju | 2010 |