fluorouracil has been researched along with Lichen Planus in 4 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Lichen Planus: An inflammatory, pruritic disease of the skin and mucous membranes, which can be either generalized or localized. It is characterized by distinctive purplish, flat-topped papules having a predilection for the trunk and flexor surfaces. The lesions may be discrete or coalesce to form plaques. Histologically, there is a saw-tooth pattern of epidermal hyperplasia and vacuolar alteration of the basal layer of the epidermis along with an intense upper dermal inflammatory infiltrate composed predominantly of T-cells. Etiology is unknown.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A photosensitive lichen planus-like eruption developed in a 63-year-old man during postoperative chemotherapy with 1-(2-tetrahydrofuryl)-5-fluorouracil." | 3.66 | Photosensitivity due to a fluorouracil derivative. ( Horio, T; Ikai, K; Murai, T, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Horio, T | 1 |
| Murai, T | 1 |
| Ikai, K | 1 |
| Weed, JC | 1 |
| Spencer, SK | 1 |
| Kierland, RR | 1 |
| Weitgasser, H | 1 |
4 other studies available for fluorouracil and Lichen Planus
| Article | Year |
|---|---|
Photosensitivity due to a fluorouracil derivative.
Topics: Fluorouracil; Humans; Lichen Planus; Male; Middle Aged; Photosensitivity Disorders; Tegafur; Ultravi | 1978 |
Office gynecology.
Topics: Adult; Alcohols; Behcet Syndrome; Candidiasis, Vulvovaginal; Colposcopy; Condylomata Acuminata; Cryo | 1972 |
The aging skin: problems and their causes.
Topics: Aged; Aging; Arsenicals; Balanitis; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Female; Fluorou | 1970 |
[Experiences with a cytostaticly active ointment in the dermatologic practice. (5 per cent--5-fluorouracil ointment)].
Topics: Adult; Aged; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Female; Fluorouracil; Humans; Lichen P | 1969 |