fluorouracil has been researched along with Leukoplakia in 7 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Leukoplakia: A white patch lesion found on a MUCOUS MEMBRANE that cannot be scraped off. Leukoplakia is generally considered a precancerous condition, however its appearance may also result from a variety of HEREDITARY DISEASES.
| Excerpt | Relevance | Reference |
|---|---|---|
| "15 patients with superficial basaliomas or premalignant epithelial neoplastic disorders (actinic keratosis, leukoplakia, Bowen's disease) were treated locally over three weeks with retinoic acid (RA) alone or in combination with 5-fluorouracil (5-FU)." | 3.66 | [Vitamin A acid for the topical management of epithelial neoplasms. Combination with 5-fluorouracil]. ( Kurka, M; Orfanos, CE; Pullmann, H, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chiaffitelli, C | 1 |
| Suarez Halty, L | 1 |
| Katz, H | 1 |
| Redding, KG | 1 |
| Kurka, M | 1 |
| Orfanos, CE | 1 |
| Pullmann, H | 1 |
| Cavins, JA | 1 |
| Williams, AC | 1 |
| Klein, E | 1 |
| Spencer, SK | 1 |
| Kierland, RR | 1 |
| Midana, A | 1 |
| Leigheb, G | 1 |
7 other studies available for fluorouracil and Leukoplakia
| Article | Year |
|---|---|
[Experience on topical 5-fluoruracil- (5-FU) in cutaneous carcinomatosis. I. Test on the efficiency of topical 5-FU].
Topics: Carcinoma, Basal Cell; Cheilitis; Facial Dermatoses; Female; Fluorouracil; Hand Dermatoses; Humans; | 1966 |
Therapeutic challenge of premalignant and malignant skin lesions.
Topics: Acetates; Adrenal Cortex Hormones; Adult; Aged; Balanitis; Bowen's Disease; Clioquinol; Cryosurgery; | 1975 |
[Vitamin A acid for the topical management of epithelial neoplasms. Combination with 5-fluorouracil].
Topics: Aged; Carcinoma, Basal Cell; Drug Therapy, Combination; Female; Fluorouracil; Humans; Keratosis; Leu | 1978 |
Topical chemotherapy of cutaneous neoplasms.
Topics: Antineoplastic Agents; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Fluorouracil; Humans; Leukop | 1972 |
Experiences with local chemotherapy and immunotherapy in premalignant and malignant skin lesions.
Topics: Antigen-Antibody Reactions; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Dermatitis; Dermatitis, | 1970 |
The aging skin: problems and their causes.
Topics: Aged; Aging; Arsenicals; Balanitis; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Female; Fluorou | 1970 |
5-fluorouracil (5-FU) ointment in the treatment of benign and malignant skin lesions.
Topics: Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Fluorouracil; Humans; Keratoacanthoma; Keratosis; L | 1970 |