fluorouracil has been researched along with Leukoencephalopathy, Progressive Multifocal in 19 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Leukoencephalopathy, Progressive Multifocal: An opportunistic viral infection of the central nervous system associated with conditions that impair cell-mediated immunity (e.g., ACQUIRED IMMUNODEFICIENCY SYNDROME and other IMMUNOLOGIC DEFICIENCY SYNDROMES; HEMATOLOGIC NEOPLASMS; IMMUNOSUPPRESSION; and COLLAGEN DISEASES). The causative organism is JC Polyomavirus (JC VIRUS) which primarily affects oligodendrocytes, resulting in multiple areas of demyelination. Clinical manifestations include DEMENTIA; ATAXIA; visual disturbances; and other focal neurologic deficits, generally progressing to a vegetative state within 6 months. (From Joynt, Clinical Neurology, 1996, Ch26, pp36-7)
| Excerpt | Relevance | Reference |
|---|---|---|
| "We report a 37-year-old patient with gastric cancer who suffered two distinct episodes of generalized tonic-clonic seizures during ongoing chemotherapy with cisplatin and 5-fluorouracil." | 3.73 | [Relapsing reversible posterior leukoencephalopathy after chemotherapy with cisplatin and 5-fluorouracil]. ( Aktas, O; Dieste, FJ; Kreitsch, P; Paul, F; Vogel, HP; Zipp, F, 2006) |
| "We report the fourth case of cerebral demyelinating disease associated with 5-fluorouracil and levamisole hydrochloride therapy for adenocarcinoma of the colon." | 3.68 | Multifocal leukoencephalopathy: occurrence during 5-fluorouracil and levamisole therapy and resolution after discontinuation of chemotherapy. ( Kimmel, DW; Schutt, AJ, 1993) |
| "Levamisole and 5-FU were discontinued, and she received intravenously 1 g of methylprednisolone daily for 5 d." | 1.40 | The diagnostic role of diffusion tensor imaging in multifocal inflammatory leukoencephalopathy. ( Hwang, YH; Kang, DH; Kim, JH; Kim, YS; Kim, YW; Park, SP; Song, HS, 2014) |
| "5-Fluorouracil (5-FU) is a commonly used chemotherapeutic agent." | 1.31 | A case of neurotoxicity following 5-fluorouracil-based chemotherapy. ( Han, CJ; Hong, YJ; Jeong, JM; Jeong, SH; Ki, SS; Kim, SH; Kim, YC; Lee, JH; Lee, JO, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (21.05) | 18.7374 |
| 1990's | 8 (42.11) | 18.2507 |
| 2000's | 5 (26.32) | 29.6817 |
| 2010's | 2 (10.53) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Heine, A | 1 |
| Schmiedel, A | 1 |
| Menschik, T | 1 |
| Held, SA | 1 |
| Erdmann, C | 1 |
| Brossart, P | 1 |
| Kim, YW | 1 |
| Hwang, YH | 2 |
| Kang, DH | 1 |
| Park, SP | 2 |
| Song, HS | 1 |
| Kim, JH | 1 |
| Kim, YS | 1 |
| Sucker, C | 1 |
| Lambers, C | 1 |
| Stockschläder, M | 1 |
| Dölken, G | 1 |
| Suh, CK | 1 |
| Paul, F | 1 |
| Aktas, O | 1 |
| Dieste, FJ | 1 |
| Kreitsch, P | 1 |
| Vogel, HP | 1 |
| Zipp, F | 1 |
| Chen, TC | 1 |
| Hinton, DR | 1 |
| Leichman, L | 1 |
| Atkinson, RD | 1 |
| Apuzzo, ML | 1 |
| Couldwell, WT | 1 |
| de'Clari, F | 1 |
| Kimmel, DW | 1 |
| Schutt, AJ | 1 |
| Luppi, G | 1 |
| Zoboli, A | 1 |
| Barbieri, F | 1 |
| Crisi, G | 1 |
| Piccinini, L | 1 |
| Silingardi, V | 1 |
| Galassi, G | 1 |
| Tassone, G | 1 |
| Sintini, M | 1 |
| Spagnoli, M | 1 |
| Bertolani, L | 1 |
| Mavilla, L | 1 |
| Murray, CL | 1 |
| Ford, WJ | 1 |
| Swenson, KK | 1 |
| Heros, D | 1 |
| Sperduto, PW | 1 |
| Franco, DA | 1 |
| Greenberg, HS | 1 |
| Ki, SS | 1 |
| Jeong, JM | 1 |
| Kim, SH | 1 |
| Jeong, SH | 1 |
| Lee, JH | 1 |
| Han, CJ | 1 |
| Kim, YC | 1 |
| Lee, JO | 1 |
| Hong, YJ | 1 |
| Neu, IS | 1 |
| Ober, H | 1 |
| Suzuki, T | 1 |
| Koizumi, J | 1 |
| Uchida, K | 1 |
| Shiraishi, H | 1 |
| Hori, M | 1 |
| Saitoh, H | 1 |
| Shinohara, Y | 1 |
| Fujita, H | 1 |
| Aoki, Y | 1 |
| Takagi, S | 1 |
| Aoki, N | 1 |
| Kuzuhara, S | 1 |
| Ohkoshi, N | 1 |
| Kanemaru, K | 1 |
| Hashimoto, H | 1 |
| Nakanishi, T | 1 |
| Toyokura, Y | 1 |
| Furuya, A | 1 |
| Shiroyama, H | 1 |
| Yano, Y | 1 |
| Kishida, S | 1 |
| Okeda, R | 1 |
4 reviews available for fluorouracil and Leukoencephalopathy, Progressive Multifocal
| Article | Year |
|---|---|
[Neurotoxicity of 5-fluorouracil].
Topics: Antimetabolites, Antineoplastic; Cerebellar Ataxia; Fluorouracil; Humans; Leukoencephalopathy, Progr | 2002 |
Multifocal leukoencephalopathy associated with 5-fluorouracil and levamisole adjuvant therapy for colon cancer. A report of two cases and review of the literature. The INTACC. Intergruppo Nazionale Terpia Adiuvante Colon Carcinoma.
Topics: Chemotherapy, Adjuvant; Colonic Neoplasms; Female; Fluorouracil; Humans; Leukoencephalopathy, Progre | 1996 |
Subacute leucoencephalopathy induced by carmofur, a 5-fluorouracil derivative.
Topics: Aged; Antineoplastic Agents; Electroencephalography; Female; Fluorouracil; Humans; Leukoencephalopat | 1987 |
[Report on an autopsy of a cancer patient with Carmofur (HCFU) leukoencephalopathy].
Topics: Antineoplastic Agents; Brain; Female; Fluorouracil; Humans; Leukoencephalopathy, Progressive Multifo | 1987 |
15 other studies available for fluorouracil and Leukoencephalopathy, Progressive Multifocal
| Article | Year |
|---|---|
Regression of liver metastases after treatment with oxaliplatin/capecitabine and development of a progressive multifocal leukoencephalopathy in a patient with advanced thymoma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Deoxycytidine; Fluorouracil; Humans; L | 2013 |
The diagnostic role of diffusion tensor imaging in multifocal inflammatory leukoencephalopathy.
Topics: Antimetabolites; Antineoplastic Agents; Biopsy; Brain; Diffusion Tensor Imaging; Female; Fluorouraci | 2014 |
Multifocal inflammatory leukoencephalopathy: use of thallium-201 SPECT and proton MRS.
Topics: Adjuvants, Immunologic; Antimetabolites, Antineoplastic; Aspartic Acid; Axons; Biopsy; Brain; Brain | 2003 |
[Relapsing reversible posterior leukoencephalopathy after chemotherapy with cisplatin and 5-fluorouracil].
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Drug-Related Side Effects and Adve | 2006 |
Multifocal inflammatory leukoencephalopathy associated with levamisole and 5-fluorouracil: case report.
Topics: Aged; Cerebral Cortex; Chemotherapy, Adjuvant; Colonic Neoplasms; Cytokines; Female; Fluorouracil; H | 1994 |
[An accelerated appearance of a multifocal leukoencephalopathy caused by fluorouracil and ranitidine].
Topics: Adjuvants, Pharmaceutic; Colonic Neoplasms; Female; Fluorouracil; Humans; Leukoencephalopathy, Progr | 1993 |
Multifocal leukoencephalopathy: occurrence during 5-fluorouracil and levamisole therapy and resolution after discontinuation of chemotherapy.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Fluorouracil; Hum | 1993 |
5-Fluorouracil- and levamisole-associated multifocal leukoencephalopathy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colonic Neoplasms; Female; F | 1996 |
Multifocal inflammatory leukoencephalopathy after fluorouracil and levamisole therapy for colon cancer.
Topics: Adenocarcinoma; Adjuvants, Immunologic; Antimetabolites, Antineoplastic; Brain; Chemotherapy, Adjuva | 1997 |
5-FU multifocal inflammatory leukoencephalopathy and dihydropyrimidine dehydrogenase deficiency.
Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents; Carboplatin; Dihydrouracil Dehydrogena | 2001 |
A case of neurotoxicity following 5-fluorouracil-based chemotherapy.
Topics: Adult; Brain; Electroencephalography; Fluorouracil; Gastrointestinal Neoplasms; Humans; Leukoencepha | 2002 |
[Multifocal leukoencephalopathy following adjuvant therapy with fluorouracil and levamisole].
Topics: Adenocarcinoma; Chemotherapy, Adjuvant; Combined Modality Therapy; Fluorouracil; Humans; Leukoenceph | 1992 |
Carmofur-induced organic mental disorders.
Topics: Adenocarcinoma; Adult; Antineoplastic Agents; Electroencephalography; Female; Fluorouracil; Follow-U | 1990 |
A case of carmofur-induced leukoencephalopathy--MR images and CT findings.
Topics: Aged; Antineoplastic Agents; Colonic Neoplasms; Female; Fluorouracil; Humans; Leukoencephalopathy, P | 1989 |
Reversible leukoencephalopathy caused by 5-fluorouracil derivatives, presenting as akinetic mutism.
Topics: Anal Gland Neoplasms; Animals; Breast Neoplasms; Carcinoma; Female; Fluorouracil; Humans; Leukoencep | 1986 |