fluorouracil has been researched along with Leukocytosis in 5 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Leukocytosis: A transient increase in the number of leukocytes in a body fluid.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Peripheral blood leukocytosis and neutrophilia reflect cancer inflammation and have been proposed as prognostic immunological biomarkers in various malignancies." | 2.90 | Leukocytosis and neutrophilia as independent prognostic immunological biomarkers for clinical outcome in the CAO/ARO/AIO-04 randomized phase 3 rectal cancer trial. ( Arnold, D; Beißbarth, T; Diefenhardt, M; Fietkau, R; Fokas, E; Folprecht, G; Ghadimi, M; Grabenbauer, GG; Graeven, U; Grützmann, R; Hartmann, A; Hofheinz, RD; Liersch, T; Martin, D; Rieger, M; Rödel, C; Rödel, F; Ströbel, P; von der Grün, J; Weitz, J, 2019) |
| "The formation of adhesions and the leukocytosis on the anastomoses were significantly higher in the 2nd, 3rd and 4th group than in the 1st group (P < 0." | 1.37 | The effects of the intraperitoneal administration of oxaliplatin and 5-FU on the healing of colonic anastomoses: an experimental study. ( Despoudi, K; Kanellos, D; Koliakos, G; Lazaridis, H; Mantzoros, I; Pramateftakis, MG; Raptis, D; Zacharakis, E; Zaraboukas, T, 2011) |
| "Local postoperative complications affected 25 of 61 patients, who had lower perioperative neutrophil increases than their counterparts (P = 0." | 1.36 | Suppression of the postoperative neutrophil leucocytosis following neoadjuvant chemoradiotherapy for rectal cancer and implications for surgical morbidity. ( Glynne-Jones, R; Kerr, SF; Klonizakis, M, 2010) |
| "This is a retrospective analysis of breast cancer patients given adjuvant 'CMF' cytotoxic chemotherapy." | 1.29 | Does dexamethasone leucocytosis facilitate full dosage adjuvant chemotherapy for breast cancer? ( Rees, GJ, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Diefenhardt, M | 1 |
| Hofheinz, RD | 1 |
| Martin, D | 1 |
| Beißbarth, T | 1 |
| Arnold, D | 1 |
| Hartmann, A | 1 |
| von der Grün, J | 1 |
| Grützmann, R | 1 |
| Liersch, T | 1 |
| Ströbel, P | 1 |
| Grabenbauer, GG | 1 |
| Rieger, M | 1 |
| Fietkau, R | 1 |
| Graeven, U | 1 |
| Weitz, J | 1 |
| Folprecht, G | 1 |
| Ghadimi, M | 1 |
| Rödel, F | 1 |
| Rödel, C | 1 |
| Fokas, E | 1 |
| Kerr, SF | 1 |
| Klonizakis, M | 1 |
| Glynne-Jones, R | 1 |
| Kanellos, D | 1 |
| Pramateftakis, MG | 1 |
| Mantzoros, I | 1 |
| Zacharakis, E | 1 |
| Raptis, D | 1 |
| Despoudi, K | 1 |
| Zaraboukas, T | 1 |
| Koliakos, G | 1 |
| Lazaridis, H | 1 |
| Rees, GJ | 1 |
| Glumenson, LE | 1 |
1 trial available for fluorouracil and Leukocytosis
| Article | Year |
|---|---|
Leukocytosis and neutrophilia as independent prognostic immunological biomarkers for clinical outcome in the CAO/ARO/AIO-04 randomized phase 3 rectal cancer trial.
Topics: Aged; Antineoplastic Agents; Biomarkers, Tumor; Chemoradiotherapy, Adjuvant; Chemotherapy, Adjuvant; | 2019 |
4 other studies available for fluorouracil and Leukocytosis
| Article | Year |
|---|---|
Suppression of the postoperative neutrophil leucocytosis following neoadjuvant chemoradiotherapy for rectal cancer and implications for surgical morbidity.
Topics: Aged; Antimetabolites, Antineoplastic; Chemotherapy, Adjuvant; Combined Modality Therapy; Female; Fl | 2010 |
The effects of the intraperitoneal administration of oxaliplatin and 5-FU on the healing of colonic anastomoses: an experimental study.
Topics: Anastomosis, Surgical; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Colon; Fluor | 2011 |
Does dexamethasone leucocytosis facilitate full dosage adjuvant chemotherapy for breast cancer?
Topics: Adult; Antiemetics; Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylating; Antineoplast | 1995 |
A comprehensive modeling procedure for the human granulopoietic system: over-all view and summary of data.
Topics: Aged; Animals; Blood Platelets; Bone Marrow Cells; Erythropoiesis; Feedback; Female; Fluorouracil; H | 1973 |