fluorouracil has been researched along with Leukemia L5178 in 9 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Leukemia L5178: An experimental lymphocytic leukemia of mice.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The mechanism of antitumor activity of 5-fluorouracil (FU) was studied in mouse leukemia L5178Y cells in vitro." | 3.66 | The difference in mechanism of action of 5-fluorouracil and its nucleosides in L5178y cells. ( Hoshi, A; Kuretani, K; Yoshida, M, 1980) |
| "Mannitol was the only exception, being tested in only one laboratory." | 1.33 | SFTG international collaborative study on in vitro micronucleus test V. Using L5178Y cells. ( Awogi, T; Bichet, N; Elhajouji, A; Lorenzon, G; Lorge, E; Marzin, D; Meunier, JR; Oliver, J; Ouldelhkim, MC; Thybaud, V, 2006) |
| "Mitomycin C was used as a positive control for all cell types." | 1.33 | SFTG international collaborative study on in vitro micronucleus test I. General conditions and overall conclusions of the study. ( Aardema, MJ; Lorenzon, G; Lorge, E; Marzin, D; Oliver, J; Thybaud, V; Wakata, A, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (66.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 1 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cariou, O | 1 |
| Laroche-Prigent, N | 1 |
| Ledieu, S | 1 |
| Guizon, I | 1 |
| Paillard, F | 1 |
| Thybaud, V | 3 |
| Oliver, J | 2 |
| Meunier, JR | 1 |
| Awogi, T | 1 |
| Elhajouji, A | 1 |
| Ouldelhkim, MC | 1 |
| Bichet, N | 1 |
| Lorenzon, G | 2 |
| Marzin, D | 2 |
| Lorge, E | 2 |
| Aardema, MJ | 1 |
| Wakata, A | 1 |
| Yoshida, M | 3 |
| Hoshi, A | 4 |
| Kuretani, K | 4 |
| Kanzawa, F | 1 |
| Hill, BT | 2 |
| Bellamy, AS | 1 |
| Inomata, M | 1 |
| Iigo, M | 1 |
| Ando, N | 1 |
9 other studies available for fluorouracil and Leukemia L5178
| Article | Year |
|---|---|
Cytosine arabinoside, vinblastine, 5-fluorouracil and 2-aminoanthracene testing in the in vitro micronucleus assay with L5178Y mouse lymphoma cells at Sanofi Aventis, with different cytotoxicity measurements, in support of the draft OECD Test Guideline on
Topics: Animals; Anthracenes; Cell Count; Cell Line, Tumor; Cytarabine; Fluorouracil; France; Guidelines as | 2010 |
SFTG international collaborative study on in vitro micronucleus test V. Using L5178Y cells.
Topics: Aneugens; Animals; Bleomycin; Colchicine; Fluorouracil; Griseofulvin; In Vitro Techniques; Internati | 2006 |
SFTG international collaborative study on in vitro micronucleus test I. General conditions and overall conclusions of the study.
Topics: Aneugens; Animals; Bleomycin; Cell Line; CHO Cells; Clofibrate; Colchicine; Cricetinae; Cytarabine; | 2006 |
The difference in mechanism of action of 5-fluorouracil and its nucleosides in L5178y cells.
Topics: Animals; Cell Division; Cell Line; DNA, Neoplasm; Floxuridine; Fluorouracil; Leukemia L5178; Leukemi | 1980 |
Isolation and characterization of the murine lymphoma L5178Y cell line highly resistant to 5-fluorouracil.
Topics: Animals; Cell Division; Cell Line; Drug Resistance; Floxuridine; Fluorouracil; Leukemia L5178; Leuke | 1980 |
Preclinical screening for drugs effective against 5-fluorouracil-resistant cells with a murine L5178Y cell line in vitro.
Topics: Animals; Antineoplastic Agents; Cell Survival; Drug Resistance; Fluorouracil; Leukemia L5178; Leukem | 1983 |
Murine L5178Y cells resulting in altered drug sensitivities from fractionated radiation exposure in vitro.
Topics: Animals; Antineoplastic Agents; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance; Etop | 1984 |
Inhibition of phosphoribosylation of 5-fluorouracil by purines.
Topics: Adenine; Animals; Fluorouracil; Inosine; Kinetics; Leukemia L5178; Leukemia, Experimental; Mice; Pen | 1980 |
Antitumor activity of metabolites of 1-hexylcarbamoyl-5-fluorouracil and related compounds against L1210 leukemia in vivo and L5178Y lymphoma cells in vitro.
Topics: Animals; Antineoplastic Agents; Cells, Cultured; Fluorouracil; Leukemia L1210; Leukemia L5178; Male; | 1980 |