fluorouracil has been researched along with Leukemia L 1210 in 220 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Different methods were compared for the in vitro evaluation of the therapeutic effects of the antineoplastic agents doxorubicin, cisplatin, fluorouracil, and vinblastine sulfate in a model system of murine tumor cell lines consisting of L1210 leukemia, P815 mast cell leukemia, and B16 melanoma." | 3.67 | In vitro assessment of cytotoxic agents in murine cancers: comparison between antiproliferative and antimetabolic assays. ( Atassi, G; Bernheim, JL; Roobol, C; Sips, HC; Theunissen, J, 1984) |
| "Mice BDF1 with L 1210 or mice BALB/c with plasmacytoma MOPS-406 after pretreatment with ineffective doses of 1-beta-D-ribofuranosyl-4-methylmercaptopyrazolo(3,4-d)pyramidin e (25 to 100 mg/kg per 5 days) were treated with 5-fluorouracil at the optimal dose 100 mg per day." | 3.67 | [Enhanced antitumor action of 5-fluorouracil when used in combination with 4-methylmercaptopyrazolo[3,4-d]pyrimidine 1-nucleoside]. ( Garin, AM; Korbukh, IA; Lobova, TG; Preobrazhenskaia, MN, 1988) |
| "A comparison has been made between the cloning capacity and changes in tritiated deoxyuridine (6-[3H]-UdR) incorporation of L1210 (murine leukaemia) and PMC-22 (human melanoma) cells treated with methotrexate (MTX), 5-fluorouracil (5-FU) and cytosine arabinoside (ARA-C)." | 3.66 | Assessment of antimetabolite cytotoxicity: a comparison of clonogenic assays and tritiated deoxyuridine incorporation. ( Perez, DJ; Tattersall, MH, 1983) |
| "We examined the ability of uridine to increase the therapeutic index of 5-fluorouracil (FUra) against C57BL/6 X DBA/2 F1 mice bearing a Day 1 B16 melanoma or L1210 leukemia." | 3.66 | Use of uridine rescue to enhance the antitumor selectivity of 5-fluorouracil. ( Cerna, I; Klubes, P, 1983) |
| "Antitumor activity of seven 5-fluorouracil derivatives having carbamoyl linkage with amino acid was examined against L-1210 leukemia, adenocarcinoma 755, ascites sarcoma 180, Ehrlich ascites carcinoma and Lewis lung carcinoma by oral administration." | 3.66 | Antitumor activity of 1-alkoxycarbonylalkylcarbamoyl-5-fluorouracil derivatives by oral administration. ( Ando, N; Hoshi, A; Iigo, M; Inomata, M; Kuretani, K, 1981) |
| " In combination therapy with mitomycin C, bleomycin, cyclophosphamide, and 5-fluorouracil, palmitoyldextran phosphate manifested strong synergistic effects against both Sarcoma 180 ascites and L1210 leukemic tumors." | 3.65 | Dextran derivatives in single and combination chemotherapy against transplantable mouse ascites and solid tumors. ( Kadowaki, M; Matsumoto, T; Mikami, T; Suzuki, M; Suzuki, S, 1977) |
| "Thymidine has been demonstrated to alter the pharmacokinetic parameters of 5-FU in man and in mice, but a selective modification of the antitumor activity of 5-FU has not yet been unequivocally demonstrated." | 2.36 | Determinants of response to antimetabolites and their modulation by normal purine and pyrimidine metabolites. ( Au, JL; Danhauser, L; Luccioni, C; Rustum, YM, 1981) |
| " However, it was repeatedly shown that the sequence of 5-FU followed by CDDP is more active and less toxic in tumor-bearing animals." | 1.33 | Schedule-dependent antitumor activity and toxicity of combinations of 5-fluorouracil and cisplatin/carboplatin against L1210 leukemia-bearing mice. ( Fujimoto, S, 2006) |
| " Thus, by using a dosing schedule of cyclophosphamide that provided more sustained apoptosis of endothelial cells within the vascular bed of a tumor, we show that a chemotherapeutic agent can more effectively control tumor growth in mice, regardless of whether the tumor cells are drug resistant." | 1.31 | Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer. ( Browder, T; Butterfield, CE; Folkman, J; Kräling, BM; Marshall, B; O'Reilly, MS; Shi, B, 2000) |
| " The dosage of the oral clinical use for human cancer of 5-FU, HCFU, 5'-DFUR and UFT as tegafur (FT) is 200-300mg/d, 600mg/d, 800-1,200mg/d and 300-600mg/d respectively." | 1.31 | Plasma, intestine and tumor levels of 5-fluorouracil in mice bearing L1210 ascites tumor following oral administration of 5-fluorouracil, UFT (mixed compound of tegafur and uracil), carmofur and 5'-deoxy-5-fluorouridine. ( Higashigawa, M; Kagawa, Y; Kakito, H; Kawasaki, H; Kojima, M; Ohkubo, T; Ooi, A; Sakurai, M, 2001) |
| " The antileukemic action of AS 15557, alone or in combination with 5-FU, against L1210 leukemia was superior to that of a streptococcal preparation (OK-432) and was almost the same as of bacillus Calmette-Guérin with or without 5-FU." | 1.30 | Synergistic effects of Actinobacillus suis cells in combination with 5-fluorouracil on mice bearing murine L1210 leukemia cells. ( Itoh, S; Watanabe, T, 1997) |
| " None of the four compounds caused a significant inhibition of cell growth, even at the maximum dosage of 10(-4) M." | 1.29 | In the search for new anticancer drugs. XXV: Role of N-nitrosated amadori compounds derived from glucose-amino acid conjugates in cancer promotion or inhibition. ( Gnewuch, CT; Ryoo, ES; Sosnovsky, G, 1993) |
| "Goralatide treatment (10(-8), 10(-9), and 10(-10) M) up to 24 hours had no effect on the growth kinetics and cell cycle distribution and consequently on the hyperthermic sensitivity of L1210 cells." | 1.29 | Goralatide (AcSDKP) selectively protects murine hematopoietic progenitors and stem cells against hyperthermic damage. ( Konings, AW; Wierenga, PK, 1996) |
| " The bioavailability of UK-21 given p." | 1.28 | Antitumor activity of two novel low immunosuppressive fluoropyrimidines UK-21 and UK-25. ( Kato, T; Kitaichi, K; Koda, A; Mori, H; Sakamoto, O, 1992) |
| "This study attempted to develop sustained release implantable dosage forms based on PHYCON 6600, a new silicone gel." | 1.28 | Application of PHYCON 6600 to achieve sustained release of an antitumor drug (carmofur). ( Azuma, T; Imasaka, K; Nagai, T; Ueda, H, 1989) |
| "Augmentation of antitumor activity of Lactobacillus casei YIT 9018 (LC 9018), which strongly inhibits the growth of transplantable allogeneic and syngeneic mouse tumors, in combination with antitumor drugs was investigated." | 1.27 | [Augmentation of antitumor activity of Lactobacillus casei YIT 8018 (LC 9018) in combination with various antitumor drugs]. ( Kato, I; Matsuzaki, T; Mutai, M; Yokokura, T, 1984) |
| " In this study leucovorin (folinic acid, LCV) was added to the MTX/FUra combination with the intention of generating elevated levels of methylenetetrahydrofolate to promote the formation of a stable fluorodeoxyuridylate-thymidylate synthetase ternary complex, thereby augmenting the cytotoxicity of the MTX-FUra sequence." | 1.27 | Lack of enhanced cytotoxicity of cultured L1210 cells using folinic acid in combination with sequential methotrexate and fluorouracil. ( Cadman, E; Danhauser, LL; Heimer, R, 1985) |
| "Studies have been conducted on liver microsomal enzymes of B6D2F(1) mice bearing a Day 4 L1210 ascites tumor after treatment with a single intraperitoneal injection of 5-fluorouracil (FUra) alone, and in combination with either cyclophosphamide (CP), methotrexate (MTX), or methyl-CCNU (MeCCNU)." | 1.26 | Studies of the effects of treatment with 5-flourouracil alone and in combination with either cyclophosphamide, methotrexate, or methyl-CCNU on hepatic drug-metabolizing enzymes in murine L1210 leukemia. ( Klubes, P; Miller, HG; Trevithick, J, 1980) |
| "This paper represents a method for determining optimal dose levels in a drug combination by analyzing the dose-response surfaces estimated from experimental data." | 1.26 | Combination chemotherapy: arriving at optimal treatment levels by incorporating side effect constraints. ( Carter, WH; Wampler, GL; Williams, VR, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 188 (85.45) | 18.7374 |
| 1990's | 23 (10.45) | 18.2507 |
| 2000's | 9 (4.09) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lin, AJ | 1 |
| Benjamin, RS | 1 |
| Rao, PN | 1 |
| Loo, TL | 2 |
| Matsuda, A | 5 |
| Takenuki, K | 2 |
| Sasaki, T | 5 |
| Ueda, T | 3 |
| Giorgi-Renault, S | 1 |
| Renault, J | 1 |
| Gebel-Servolles, P | 1 |
| Baron, M | 1 |
| Paoletti, C | 2 |
| Cros, S | 1 |
| Bissery, MC | 1 |
| Lavelle, F | 1 |
| Atassi, G | 2 |
| Minakawa, N | 3 |
| Takeda, T | 1 |
| Tanaka, M | 2 |
| Kumar, R | 1 |
| Xu, LH | 1 |
| Knaus, EE | 1 |
| Wiebe, LI | 1 |
| Tovell, DR | 1 |
| Tyrrell, DL | 1 |
| Allen, TM | 2 |
| Selassie, CD | 1 |
| Hansch, C | 1 |
| Khwaja, TA | 1 |
| Bobek, M | 2 |
| An, SH | 1 |
| Skrincosky, D | 1 |
| De Clercq, E | 3 |
| Bernacki, RJ | 1 |
| Jurd, L | 1 |
| Narayanan, VL | 1 |
| Paull, KD | 1 |
| Béres, J | 1 |
| Bentrude, WG | 1 |
| Kálmán, A | 1 |
| Párkányi, L | 1 |
| Balzarini, J | 4 |
| Nguyen, CH | 1 |
| Bisagni, E | 1 |
| Pepin, O | 1 |
| Pierré, A | 1 |
| de Cointet, P | 1 |
| Cristalli, G | 1 |
| Franchetti, P | 1 |
| Grifantini, M | 1 |
| Vittori, S | 1 |
| Bordoni, T | 1 |
| Geroni, C | 1 |
| Holshouser, MH | 2 |
| Shipp, AM | 2 |
| Ferguson, PW | 2 |
| Ajmera, S | 1 |
| Danenberg, PV | 4 |
| Rosowsky, A | 1 |
| Kim, SH | 1 |
| Trites, D | 1 |
| Wick, M | 1 |
| Fries, KM | 1 |
| Joswig, C | 2 |
| Borch, RF | 2 |
| Bussolari, JC | 1 |
| Ramesh, K | 1 |
| Stoeckler, JD | 1 |
| Chen, SF | 1 |
| Panzica, RP | 1 |
| Azuma, A | 1 |
| Nakajima, Y | 2 |
| Nishizono, N | 1 |
| Suzuki, M | 2 |
| Hanaoka, K | 1 |
| Kobayashi, T | 1 |
| Freel Meyers, CL | 1 |
| Hong, L | 1 |
| Kim, KH | 1 |
| Kim, JY | 1 |
| Lee, KH | 1 |
| Noh, MJ | 1 |
| Kim, YC | 1 |
| Park, HJ | 1 |
| El Akri, K | 1 |
| Bougrin, K | 1 |
| Faraj, A | 1 |
| Benhida, R | 1 |
| Gazivoda, T | 1 |
| Raić-Malić, S | 1 |
| Kristafor, V | 1 |
| Makuc, D | 1 |
| Plavec, J | 1 |
| Bratulić, S | 1 |
| Kraljević-Pavelić, S | 1 |
| Pavelić, K | 1 |
| Naesens, L | 1 |
| Andrei, G | 1 |
| Snoeck, R | 1 |
| Mintas, M | 1 |
| Dimmock, JR | 1 |
| Padmanilayam, MP | 1 |
| Zello, GA | 1 |
| Nienaber, KH | 1 |
| Santos, CL | 1 |
| Manavathu, EK | 1 |
| Stables, JP | 1 |
| SCHRECKER, AW | 2 |
| VENDITTI, JM | 7 |
| GREENBERG, NH | 1 |
| BIEDLER, JL | 2 |
| ROBINSON, DL | 2 |
| HUTCHISON, DJ | 6 |
| BROCKMAN, RW | 3 |
| ANDERSON, EP | 1 |
| GELLHORN, A | 1 |
| WAGNER, M | 1 |
| RECHLER, M | 1 |
| KOREN, Z | 1 |
| BENJAMIN, W | 1 |
| RUTMAN, RJ | 1 |
| Fujimoto, S | 2 |
| Abraham, D | 1 |
| Carbone, PP | 1 |
| Kline, I | 6 |
| Goldin, A | 8 |
| Burchenal, JH | 3 |
| Dollinger, M | 1 |
| Butterbaugh, J | 1 |
| Stoll, D | 1 |
| Giner-Sorolla, A | 1 |
| Wilkoff, LJ | 2 |
| Wilcox, WS | 1 |
| Burdeshaw, JA | 1 |
| Dixon, GJ | 1 |
| Dulmadge, EA | 1 |
| Fernandes, DJ | 4 |
| Bertino, JR | 3 |
| Cadman, E | 4 |
| Heimer, R | 3 |
| Benz, C | 1 |
| Moroson, BA | 1 |
| Chou, TC | 1 |
| Schmid, FA | 2 |
| Feinberg, A | 1 |
| Philips, FS | 1 |
| Han, J | 1 |
| Matsuzaki, T | 1 |
| Kato, I | 1 |
| Yokokura, T | 1 |
| Mutai, M | 1 |
| Grant, S | 1 |
| Moran, RG | 4 |
| Heidelberger, C | 5 |
| Au, JL | 2 |
| Rustum, YM | 6 |
| Minowada, J | 1 |
| Srivastava, BI | 1 |
| Canti, G | 1 |
| Franco, P | 1 |
| Marelli, O | 1 |
| Ricci, L | 1 |
| Nicolin, A | 1 |
| Roobol, C | 3 |
| De Dobbeleer, GB | 2 |
| Bernheim, JL | 3 |
| Iigo, M | 16 |
| Kuretani, K | 11 |
| Hoshi, A | 18 |
| Danysz, A | 1 |
| Wierzba, K | 1 |
| Wutkiewicz, M | 1 |
| Pniewska, A | 1 |
| Pragłowski, T | 1 |
| Burba-Anczewska, I | 1 |
| Tamemasa, O | 2 |
| Tezuka, M | 2 |
| Ninomiya, K | 1 |
| Sekido, S | 1 |
| Araki, T | 1 |
| Ishitsuka, H | 3 |
| Miwa, M | 2 |
| Takemoto, K | 1 |
| Fukuoka, K | 1 |
| Itoga, A | 1 |
| Maruyama, HB | 1 |
| Pogolotti, AL | 1 |
| Nolan, PA | 1 |
| Santi, DV | 2 |
| Mulkins, MA | 2 |
| Suga, S | 2 |
| Kimura, K | 1 |
| Kubo, K | 1 |
| Aoyama, H | 1 |
| Inukai, N | 1 |
| Kato, K | 1 |
| Horiuchi, T | 1 |
| Sawada, H | 1 |
| Yokoyama, Y | 1 |
| Ueno, H | 1 |
| Dionet, C | 1 |
| Verrelle, P | 1 |
| Block, JB | 1 |
| Chlebowski, RT | 1 |
| Dietrich, MF | 1 |
| Isacoff, WH | 1 |
| Umeda, Y | 1 |
| Sakamoto, A | 1 |
| Nakamura, J | 1 |
| Yagi, Y | 1 |
| Sips, HC | 1 |
| Theunissen, J | 1 |
| Piper, AA | 1 |
| Nott, SE | 1 |
| Mackinnon, WB | 1 |
| Tattersall, MH | 4 |
| Perez, DJ | 1 |
| Warrington, RC | 2 |
| Muzyka, TG | 1 |
| Fang, WD | 2 |
| Shani, J | 3 |
| Schultze, B | 2 |
| Jellinghaus, W | 1 |
| Weis, G | 1 |
| Müller, V | 1 |
| Maurer, W | 2 |
| Grossie, VB | 1 |
| Rosenblum, MG | 1 |
| Klubes, P | 6 |
| Cerna, I | 3 |
| Mulder, JH | 2 |
| Smink, T | 2 |
| Ossewaarde, T | 1 |
| van Putten, LM | 4 |
| Schabel, FM | 3 |
| Skipper, HE | 2 |
| Trader, MW | 1 |
| Laster, WR | 1 |
| Corbett, TH | 1 |
| Griswold, DP | 1 |
| Ogawa, M | 1 |
| Sakurai, Y | 1 |
| Meldon, MA | 1 |
| Danhauser, L | 2 |
| Luccioni, C | 1 |
| Citarella, RV | 1 |
| Wallace, RE | 1 |
| Murdock, KC | 1 |
| Angier, RB | 1 |
| Durr, FE | 1 |
| Forbes, M | 1 |
| Inomata, M | 4 |
| Kanzawa, F | 2 |
| Kundu, NG | 1 |
| Schmitz, SA | 1 |
| Bernal, SD | 1 |
| Shapiro, HM | 1 |
| Chen, LB | 1 |
| Ando, N | 3 |
| Belousova, AK | 2 |
| Gerasimova, GK | 3 |
| Kim, K | 1 |
| Blechman, WJ | 1 |
| Riddle, VG | 1 |
| Pardee, AB | 2 |
| Koza, I | 1 |
| Balázová, E | 1 |
| Ujházy, V | 1 |
| Shealy, YF | 1 |
| Frye, JL | 1 |
| DuBois, NF | 1 |
| Shaddix, SC | 1 |
| Santelli, G | 3 |
| Valeriote, F | 3 |
| Vietti, T | 1 |
| Coulter, D | 1 |
| Kessel, D | 3 |
| Glazer, RI | 3 |
| Hartman, KD | 1 |
| Trevithick, J | 1 |
| Miller, HG | 1 |
| Yoshida, M | 4 |
| Sosnovsky, G | 1 |
| Gnewuch, CT | 1 |
| Ryoo, ES | 1 |
| Kakito, H | 2 |
| Ohkubo, T | 2 |
| Kagawa, Y | 2 |
| Inagaki, S | 1 |
| Sumida, K | 1 |
| Ooi, K | 1 |
| Higashigawa, M | 3 |
| Sakurai, M | 4 |
| Wierenga, PK | 1 |
| Konings, AW | 1 |
| Kasamatsu, T | 1 |
| Kohda, K | 1 |
| Kawazoe, Y | 1 |
| Ozaki, S | 7 |
| Cysyk, RL | 1 |
| Chisena, CA | 1 |
| Hyman, R | 1 |
| Monks, A | 1 |
| Watanabe, T | 1 |
| Itoh, S | 1 |
| Kong, X | 1 |
| Watanabe, Y | 3 |
| Hoshiko, T | 3 |
| Koga, T | 1 |
| Ogasawara, T | 3 |
| Takizawa, T | 1 |
| Fujisawa, H | 1 |
| Zhuk, R | 1 |
| Mao, XY | 1 |
| M'Soka, T | 1 |
| Shimono, Y | 1 |
| Nagata, T | 1 |
| Inamochi, H | 1 |
| Cao, DC | 1 |
| Hori, H | 1 |
| Kawasaki, H | 3 |
| Browder, T | 1 |
| Butterfield, CE | 1 |
| Kräling, BM | 1 |
| Shi, B | 1 |
| Marshall, B | 1 |
| O'Reilly, MS | 1 |
| Folkman, J | 1 |
| Goł b, J | 1 |
| Zagozdzon, R | 1 |
| Kamiński, R | 1 |
| Kozar, K | 1 |
| Gryska, K | 1 |
| Izycki, D | 1 |
| Mackiewicz, A | 1 |
| Stokłosa, T | 1 |
| Giermasz, A | 1 |
| Lasek, W | 1 |
| Jakóbisiak, M | 1 |
| Ooi, A | 1 |
| Kojima, M | 1 |
| Mikami, T | 1 |
| Kadowaki, M | 1 |
| Matsumoto, T | 1 |
| Suzuki, S | 1 |
| O'Toole, T | 1 |
| Kalaher, K | 1 |
| Chisholm, J | 1 |
| Ullman, B | 1 |
| Kirsch, J | 1 |
| Lelieveld, P | 1 |
| Pantarotto, C | 1 |
| Salmona, M | 1 |
| Spreafico, F | 1 |
| Chadwick, M | 2 |
| Chang, C | 1 |
| Wang, G | 1 |
| Washtien, WL | 1 |
| Glae, GR | 1 |
| Atkins, LM | 3 |
| Meischen, SJ | 3 |
| Smith, AB | 2 |
| Walker, EM | 3 |
| Kuhar, S | 1 |
| Bloch, A | 1 |
| Mandel, HG | 2 |
| Murinson, DS | 1 |
| Anderson, T | 1 |
| Schwartz, HS | 1 |
| Myers, CE | 1 |
| Chabner, BA | 1 |
| Davis, L | 1 |
| Peale, AL | 1 |
| Pujman, V | 2 |
| Cernochová, S | 1 |
| Shimizu, F | 1 |
| Arakawa, M | 1 |
| Bhuyan, BK | 1 |
| Blowers, CL | 1 |
| Neil, GL | 1 |
| Bono, VH | 1 |
| Day, KJ | 1 |
| Woolley, PV | 2 |
| Coit, R | 1 |
| Magno, M | 1 |
| Mokina, VD | 1 |
| Sidorova, TA | 1 |
| Nakamura, A | 2 |
| Wampler, GL | 2 |
| Carter, WH | 2 |
| Williams, VR | 1 |
| Connelly, K | 1 |
| Gale, GR | 3 |
| Schwartz, P | 1 |
| Fodstad, O | 1 |
| Pihl, A | 1 |
| Alate, AD | 1 |
| Khandalekar, DD | 1 |
| Amonkar, AJ | 1 |
| Adwankar, MK | 1 |
| Sahasrabudhe, MB | 1 |
| Garibjanian, BT | 1 |
| Johnson, RK | 1 |
| Vadlamudi, S | 1 |
| Gang, M | 3 |
| Camplejohn, RS | 1 |
| Wolf, W | 2 |
| Dombernowsky, P | 1 |
| Nissen, NI | 1 |
| Otter, GM | 1 |
| Stock, CC | 1 |
| Currie, VE | 1 |
| Dowling, MD | 1 |
| Fox, JJ | 2 |
| Krakoff, IH | 1 |
| Cook, ES | 1 |
| Nutini, LG | 1 |
| Fardon, JC | 1 |
| Proudfoot, MB | 1 |
| Poydock, ME | 1 |
| Bruckner, HW | 1 |
| Schreiber, C | 1 |
| Waxman, S | 1 |
| Horwitz, JP | 1 |
| McCormick, JJ | 1 |
| Philips, KD | 1 |
| Maher, VM | 1 |
| Otto, JR | 1 |
| Zemlicka, J | 1 |
| Carchman, RA | 1 |
| Harris, LS | 1 |
| Munson, AE | 1 |
| Sakamoto, O | 1 |
| Mori, H | 3 |
| Kitaichi, K | 1 |
| Koda, A | 1 |
| Kato, T | 2 |
| Konishi, Y | 2 |
| Kanamaru, R | 6 |
| Ishioka, C | 4 |
| Ishikawa, A | 1 |
| Shibata, H | 1 |
| Wakui, A | 6 |
| Dei, T | 2 |
| Chapekar, MS | 1 |
| Kakuta, H | 4 |
| Sato, T | 4 |
| Trave, F | 2 |
| Zakrzewski, SF | 1 |
| Petrelli, N | 1 |
| Herrera, L | 1 |
| Mittelman, A | 1 |
| Arbuck, SG | 1 |
| Creaven, PJ | 1 |
| Uchida, M | 1 |
| Ho, DH | 1 |
| Kamiya, K | 1 |
| Yoshimura, T | 1 |
| Sasaki, K | 1 |
| Tsutani, H | 1 |
| Nakamura, T | 1 |
| Imasaka, K | 1 |
| Ueda, H | 1 |
| Azuma, T | 1 |
| Nagai, T | 1 |
| Spears, CP | 1 |
| Shahinian, AH | 1 |
| Palmeri, S | 1 |
| Russello, O | 1 |
| Uehara, N | 1 |
| Baba, H | 1 |
| Nitta, K | 1 |
| Kunimoto, T | 1 |
| Takeuchi, M | 1 |
| Tanaka, T | 1 |
| Jackman, AL | 1 |
| Alison, DL | 1 |
| Calvert, AH | 1 |
| Harrap, KR | 2 |
| Hartmann, HR | 1 |
| Bollag, W | 1 |
| Keyomarsi, K | 3 |
| Ota, K | 1 |
| Nishimura, J | 1 |
| Kamiyama, T | 1 |
| Beránek, J | 1 |
| Furue, H | 1 |
| Niitani, H | 1 |
| Kurihara, M | 1 |
| Hasegawa, K | 1 |
| Nakao, I | 1 |
| Tsukagoshi, S | 1 |
| Fujita, H | 1 |
| Rahman, A | 1 |
| Roh, JK | 1 |
| Wolpert-DeFilippes, MK | 1 |
| Lobova, TG | 1 |
| Korbukh, IA | 1 |
| Preobrazhenskaia, MN | 1 |
| Garin, AM | 1 |
| Ahmad, S | 2 |
| Nagase, T | 4 |
| Tokuzen, R | 1 |
| Tamai, H | 2 |
| Campbell, ED | 1 |
| Radel, S | 1 |
| Campbell, J | 1 |
| Mayhew, E | 1 |
| Fitzgerald, GB | 1 |
| Wick, MM | 1 |
| Coates, A | 1 |
| Furukawa, H | 1 |
| Uemura, A | 1 |
| Ishikawa, K | 1 |
| Beljanski, M | 1 |
| Beljanski, MS | 1 |
| Russ, GA | 1 |
| Campione, MA | 1 |
| Stolfi, RL | 1 |
| Sawyer, RC | 1 |
| Martin, DS | 1 |
| Danhauser, LL | 1 |
| Machida, S | 1 |
| Ito, Y | 1 |
| Hoshino, A | 2 |
| Nobori, T | 1 |
| Kamiya, H | 1 |
| Osswald, H | 1 |
| Herrmann, R | 1 |
| Youssef, M | 1 |
| Yamauchi, S | 1 |
| Fujiwara, K | 1 |
| Tamura, Z | 1 |
| Woodman, RJ | 2 |
| Sirica, AE | 1 |
| Bellet, RE | 1 |
| Mastrangelo, MJ | 1 |
| Dixon, LM | 1 |
| Gosse, C | 1 |
| Le Pecq, JB | 1 |
| Dechambre, RP | 1 |
| Morizet, J | 1 |
| Rogers, WI | 1 |
| Jato, J | 1 |
| Windheuser, JJ | 1 |
| Bergsagel, DE | 1 |
| Reyes, P | 1 |
| Hall, TC | 2 |
| Imamura, H | 1 |
| Ikegami, K | 1 |
| Okumoto, T | 1 |
| Kram-Idsenga, LK | 1 |
| Pijpers-de Bruin, M | 1 |
| Nakamura, N | 1 |
| Pouillart, R | 1 |
| Huong, TH | 1 |
| Brugerie, E | 1 |
| Lheritier, J | 1 |
| Frei, E | 1 |
| Yancey, ST | 1 |
| Bleyer, WA | 1 |
| Jackson, RC | 1 |
| Connors, TA | 1 |
| Dodd, DC | 1 |
| Benckhuijsen, C | 1 |
| Waravdekar, VS | 1 |
| Higashi, H | 1 |
| Sirotnak, FM | 1 |
| Kurita, S | 1 |
| Sargent, MG | 1 |
| Sandberg, J | 1 |
| Howsden, L | 1 |
| Mellett, LB | 1 |
| Montgomery, JA | 1 |
| Lloyd, HH | 1 |
| Berenbaum, MC | 1 |
| Sartorelli, AC | 1 |
| Booth, BA | 1 |
| Goldberg, AR | 1 |
| Machledt, JH | 1 |
| Ittensohn, OL | 1 |
| Bjerregaard, MR | 1 |
| Mead, JA | 1 |
| Tyrer, DD | 1 |
| Albrecht, AM | 1 |
| Miller, N | 1 |
| Wempen, I | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase 2 Clinical Trial:Low -Dose-bevacizumab and Pemetrexed Versus Treatment of Physician's Choice in Metastatic HER2-negative Breast Cancer Patients After Failure of Taxanes and Anthracycline-containing Regimens[NCT02829008] | Phase 2 | 120 participants (Anticipated) | Interventional | 2016-04-30 | Active, not recruiting | ||
| Multicentre Randomized Phase II Study of Neoadjuvant Trastuzumab Plus Docetaxel With and Without Bevacizumab and Trastuzumab Plus Docetaxel Plus Non-pegylated Liposome-encapsulated Doxorubicin (NPLD) With and Without Bevacizumab in HER2-positive Early Bre[NCT01367028] | Phase 2 | 100 participants (Actual) | Interventional | 2011-06-30 | Completed | ||
| A Phase I Trial of 5-Fluorouracil Given With 776C85 (GW776) and Low-Dose Leucovorin in Adult Patients With Solid Tumors[NCT00001579] | Phase 1 | 50 participants | Interventional | 1997-06-30 | Completed | ||
| Phase I Trial of 5-Fluoro-2'-Deoxycytidine With Tetrahydrouridine[NCT00359606] | Phase 1 | 58 participants (Actual) | Interventional | 1999-04-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 reviews available for fluorouracil and Leukemia L 1210
| Article | Year |
|---|---|
BIOCHEMISTRY OF CANCER (METABOLIC ASPECTS).
Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents; Azaguanine; Azaserine; Carcinoma, Ehrlich Tum | 1963 |
Determinants of response to antimetabolites and their modulation by normal purine and pyrimidine metabolites.
Topics: Animals; Antimetabolites, Antineoplastic; Cytarabine; DNA, Neoplasm; Fluorodeoxyuridylate; Fluoroura | 1981 |
Synthesis and antitumor activity of 5-fluorouracil derivatives.
Topics: Animals; Antimetabolites, Antineoplastic; Drug Screening Assays, Antitumor; Fluorouracil; Leukemia L | 1996 |
A study on structure-activity relationships of nucleoside analogues.
Topics: Animals; Cells, Cultured; Cytarabine; DNA, Neoplasm; Escherichia coli; Fluorouracil; In Vitro Techni | 1986 |
[Mechanism of action of anti-cancer drugs from the viewpoint of RNA metabolism].
Topics: Animals; Antineoplastic Agents; Fluorouracil; Leukemia L1210; RNA, Neoplasm | 1988 |
An assessment of massive-dose chemotherapy of malignant disease.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Bone Marrow; Bone Marrow Cells; Cell Division; Cyclo | 1971 |
Chemotherapy and the life cycle of leukaemic cells. A comparison between the growth characteristics of human acute leukaemia and the murine leukaemia L 1210.
Topics: Anilides; Animals; Cell Division; Cyclophosphamide; Cytarabine; DNA, Neoplasm; Fluorouracil; Humans; | 1969 |
2 trials available for fluorouracil and Leukemia L 1210
| Article | Year |
|---|---|
Current studies of methotrexate and 5-fluorouracil and their interaction in human tumor cells.
Topics: Animals; Cells, Cultured; Colonic Neoplasms; Drug Administration Schedule; Drug Evaluation; Drug The | 1983 |
Sequential MTX and 5-FU: advance or myth?
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cells, Cultured; Clinical Trials as Topic; | 1986 |
211 other studies available for fluorouracil and Leukemia L 1210
| Article | Year |
|---|---|
Synthesis and biological activities of ftorafur metabolites. 3'- and 4'-hydroxyftorafur.
Topics: Animals; Antineoplastic Agents; Cell Division; Fluorouracil; HeLa Cells; Humans; Hydroxylation; Leuk | 1979 |
Nucleosides and nucleotides. 94. Radical deoxygenation of tert-alcohols in 1-(2-C-alkylpentofuranosyl) pyrimidines: synthesis of (2'S)-2'-deoxy-2'-C-methylcytidine, an antileukemic nucleoside.
Topics: Animals; Antimetabolites, Antineoplastic; Deoxycytidine; Drug Screening Assays, Antitumor; Humans; I | 1991 |
Heterocyclic quinones. 17. A new in vivo active antineoplastic drug: 6,7-bis(1-aziridinyl)-4-[[3-(N,N-dimethylamino)propyl]amino]-5,8- quinazolinedione.
Topics: Animals; Antineoplastic Agents; Aziridines; Breast Neoplasms; Cell Division; Cell Line; Drug Screeni | 1991 |
Nucleosides and nucleotides. 96. Synthesis and antitumor activity of 5-ethynyl-1-beta-D-ribofuranosylimidazole-4-carboxamide (EICAR) and its derivatives.
Topics: Animals; Antineoplastic Agents; Cell Line; Chemical Phenomena; Chemistry; Humans; Leukemia L1210; Le | 1991 |
Nucleosides and nucleotides. 97. Synthesis of new broad spectrum antineoplastic nucleosides, 2'-deoxy-2'-methylidenecytidine (DMDC) and its derivatives.
Topics: Animals; Antineoplastic Agents; Cells, Cultured; Chemical Phenomena; Chemistry; Deoxycytidine; Femal | 1991 |
Synthesis and antiviral and cytotoxic activity of iodohydrin and iodomethoxy derivatives of 5-vinyl-2'-deoxyuridines, 2'-fluoro-2'-deoxyuridine, and uridine.
Topics: Animals; Antimetabolites, Antineoplastic; Antiviral Agents; Biological Transport; Cell Survival; Che | 1990 |
Structure-activity relationships of antineoplastic agents in multidrug resistance.
Topics: Animals; Antineoplastic Agents; Cell Line; Cell Survival; Cricetinae; Dactinomycin; Drug Resistance; | 1990 |
2'-Fluorinated isonucleosides. 1. Synthesis and biological activity of some methyl 2'-deoxy-2'-fluoro-2'-pyrimidinyl-D-arabinopyranosides.
Topics: Animals; Arabinonucleosides; Chemical Phenomena; Chemistry; Chemistry, Physical; Chlorine; Female; F | 1989 |
In vivo antitumor activity of 6-benzyl-1,3-benzodioxole derivatives against the P388, L1210, B16, and M5076 murine models.
Topics: Animals; Antineoplastic Agents; Astrocytoma; Bucladesine; Cell Differentiation; Dioxoles; DNA Topois | 1987 |
Synthesis, structure, and antitumor and antiviral activities of a series of 5-halouridine cyclic 3',5'-monophosphates.
Topics: Animals; Antineoplastic Agents; Antiviral Agents; Humans; Leukemia L1210; Mice; Molecular Conformati | 1986 |
1-Amino-substituted 4-methyl-5H-pyrido[3',4':4,5]pyrrolo[3,2-c]pyridines: a new class of antineoplastic agents.
Topics: Animals; Antineoplastic Agents; Cell Line; DNA; Leukemia L1210; Leukemia P388; Pyridines; Pyrroles | 1987 |
Improved synthesis and antitumor activity of 1-deazaadenosine.
Topics: Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Line; Female; HeLa Cells; Humans; Leu | 1987 |
Synthesis and antitumor activity of a series of ftorafur analogues: the effect of varying electronegativity at the 1'-position.
Topics: Animals; Antineoplastic Agents; Cells, Cultured; Female; Fluorouracil; Leukemia L1210; Leukemia P388 | 1985 |
Synthesis and biological activity of 5'-substituted 5-fluoropyrimidine nucleosides.
Topics: Animals; Antineoplastic Agents; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; | 1982 |
Synthesis and in vivo antitumor activity of potential 5-fluorouracil prodrugs.
Topics: Animals; Antineoplastic Agents; Cell Survival; Chemical Phenomena; Chemistry; Fluorouracil; Leukemia | 1982 |
Synthesis and biological evaluation of 5-fluoro-2'-deoxyuridine phosphoramidate analogs.
Topics: Amides; Animals; Antineoplastic Agents; Floxuridine; Leukemia L1210; Magnetic Resonance Spectroscopy | 1995 |
Synthesis and biological evaluation of N4-substituted imidazo- and v-triazolo[4,5-d]pyridazine nucleosides.
Topics: Adenosine Deaminase Inhibitors; Animals; Antineoplastic Agents; Cattle; Humans; Leukemia L1210; Mela | 1993 |
Nucleosides and nucleotides. 122. 2'-C-cyano-2'-deoxy-1-beta-D-arabinofuranosylcytosine and its derivatives. A new class of nucleoside with a broad antitumor spectrum.
Topics: Adenine; Animals; Antineoplastic Agents; Cytarabine; Female; Fluorouracil; Humans; Leukemia L1210; L | 1993 |
Synthesis and biological activity of novel 5-fluoro-2'-deoxyuridine phosphoramidate prodrugs.
Topics: Amides; Animals; Antimetabolites, Antineoplastic; Cell Division; Drug Screening Assays, Antitumor; F | 2000 |
Synthesis and biological activity of the new 5-fluorocytosine derivatives, 5'-deoxy-N-alkyloxycarbonyl-5-fluorocytosine-5'-carboxylic acid.
Topics: Animals; Antineoplastic Agents; Cell Division; Drug Screening Assays, Antitumor; Flucytosine; Humans | 2002 |
Efficient synthesis and in vitro cytostatic activity of 4-substituted triazolyl-nucleosides.
Topics: Animals; Cell Line, Tumor; Cytostatic Agents; Humans; Leukemia L1210; Mice; Nucleosides; Structure-A | 2007 |
Synthesis, cytostatic and anti-HIV evaluations of the new unsaturated acyclic C-5 pyrimidine nucleoside analogues.
Topics: Animals; Anti-HIV Agents; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response | 2008 |
Cytotoxic analogues of 2,6-bis(arylidene)cyclohexanones.
Topics: Animals; Antineoplastic Agents; Benzene Derivatives; Cell Line; Cyclohexanones; Drug Screening Assay | 2003 |
ASSOCIATION OF INCREASED DIHYDROFOLATE REDUCTASE LEVELS AND CHROMOSOME ALTERATION IN AMETHOPTERIN-RESISTANT SUBLINES OF LEUKEMIA L1210.
Topics: Animals; Azaserine; Chromosomes; Fluorouracil; Folic Acid; Genetics; Leukemia L1210; Mercaptopurine; | 1963 |
SELECTION OF CHROMOSOMAL VARIANT IN AMETHOPTERIN-RESISTANT SUBLINES OF LEUKEMIA L1210 WITH INCREASED LEVELS OF DIHYDROFOLATE REDUCTASE.
Topics: Animals; Chromosomes; Fluorouracil; Genetics; Leukemia L1210; Mercaptopurine; Methotrexate; Mice; Ox | 1963 |
THE EFFECT OF A PHTHALANILIDE DERIVATIVE ON LIPIDE METABOLISM IN L1210 LEUKEMIA CELLS.
Topics: Anilides; Animals; Antineoplastic Agents; Carbon Isotopes; Cholesterol; Cyclophosphamide; Fatty Acid | 1964 |
EXPERIMENTAL CHEMOTHERAPY STUDIES. V. THE COLLATERAL SENSITIVITY TO ALKYLATING AGENTS OF SEVERAL ANTIMETABOLITE-RESISTANT ASCITES TUMORS IN MICE.
Topics: Alkylating Agents; Animals; Antimetabolites; Antineoplastic Agents; Ascites; Azaserine; Carcinoma, E | 1964 |
Schedule-dependent antitumor activity and toxicity of combinations of 5-fluorouracil and cisplatin/carboplatin against L1210 leukemia-bearing mice.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Ascites; Carboplatin | 2006 |
Evaluation of chemical agents against the plasma cell tumor LPC-1 in mice.
Topics: Alkylating Agents; Animals; Carcinoma 256, Walker; Cyclophosphamide; Electrophoresis; Fluorouracil; | 1967 |
Studies of 6-N-hydroxylamino-9-beta-D-ribofuranosylpurine in mouse leukemia.
Topics: Adenine; Animals; Body Weight; Cytarabine; Drug Antagonism; Drug Synergism; Fluorouracil; Guanine; L | 1967 |
Effect of antimetabolites on kinetic behavior of proliferating cultured L1210 leukemia cells.
Topics: Animals; Antimetabolites; Azaserine; Cell Division; Culture Techniques; Cytarabine; Fluorouracil; Ki | 1967 |
5-fluorouracil-methotrexate synergy: enhancement of 5-fluorodeoxyridylate binding to thymidylate synthase by dihydropteroylpolyglutamates.
Topics: Animals; Cell Survival; Drug Synergism; Floxuridine; Fluorouracil; Folic Acid; Leukemia L1210; Metho | 1980 |
The influence of methotrexate pretreatment on 5-fluorouracil metabolism in L1210 cells.
Topics: Animals; Biological Transport; Deoxyuridine; Fluorouracil; Kinetics; Leucovorin; Leukemia L1210; Met | 1981 |
The role of methotrexate and dihydrofolate polyglutamates in the enhancement of fluorouracil action by methotrexate.
Topics: Animals; Cell Line; Cell Survival; Drug Administration Schedule; Drug Therapy, Combination; Fluorode | 1981 |
Uptake, initial effects, and chemotherapeutic efficacy of harringtonine in murine leukemic cells sensitive and resistant to vincristine and other chemotherapeutic agents.
Topics: Alkaloids; Animals; Cell Line; Cyclophosphamide; Cytarabine; DNA; Doxorubicin; Fluorouracil; Harring | 1983 |
[Augmentation of antitumor activity of Lactobacillus casei YIT 8018 (LC 9018) in combination with various antitumor drugs].
Topics: Animals; Antineoplastic Agents; Bleomycin; Cyclophosphamide; Fluorouracil; Lacticaseibacillus casei; | 1984 |
Modulation of 1-beta-D-arabinofuranosylcytosine metabolism and cytotoxicity in L1210 cells by fluoropyrimidine pretreatment.
Topics: Animals; Arabinofuranosylcytosine Triphosphate; Cell Line; Cell Survival; Clone Cells; Cytarabine; D | 1982 |
Therapeutic response of leukemic mice treated with fluorinated pyrimidines and inhibitors of deoxyuridylate synthesis.
Topics: Animals; Antineoplastic Agents; Cells, Cultured; Chick Embryo; Cytosol; Deoxyuracil Nucleotides; Flo | 1982 |
Differential selectivity of 5-fluorouracil and 5'-deoxy-5-fluorouridine in cultured human B lymphocytes and mouse L1210 leukemia.
Topics: Animals; Antineoplastic Agents; Ascitic Fluid; B-Lymphocytes; Biotransformation; Cell Division; Cell | 1983 |
Hematoporphyrin derivative rescue from toxicity caused by chemotherapy or radiation in a murine leukemia model (L1210).
Topics: Animals; Antibody Formation; Antineoplastic Agents; Cyclophosphamide; Fluorouracil; Hemagglutination | 1984 |
5-fluorouracil and 5-fluoro-2'-deoxyuridine follow different metabolic pathways in the induction of cell lethality in L1210 leukaemia.
Topics: Animals; Cell Survival; Cells, Cultured; DNA, Neoplasm; Floxuridine; Fluorouracil; Isomerism; Leukem | 1984 |
Potentiation of the chemotherapeutic effect of 5-fluorouracil by combination with guanosine 5'-monophosphate.
Topics: Adenocarcinoma; Animals; Drug Therapy, Combination; Fluorouracil; Guanine Nucleotides; Guanosine Mon | 1983 |
Influence of molar ratio on the combination effect of 5-fluorouracil with guanosine 5'-monophosphate on P388 and L1210 leukemias.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Dose-Response Relationship, Drug; Fluoroura | 1984 |
Influence of some sulfhydryl compounds on the antineoplastic effectiveness of 5-fluorouracil and 6-mercaptopurine.
Topics: Animals; Cysteine; Drug Synergism; Fluorouracil; Glutathione; Insulin; Leukemia L1210; Mercaptopurin | 1984 |
Antitumor effect of 5-fluorouracil in combination with some additives which stimulate the formation of antineoplastic 5-fluorouracil nucleotides.
Topics: Animals; Carcinoma, Ehrlich Tumor; Cells, Cultured; Drug Therapy, Combination; Edetic Acid; Fluorour | 1983 |
[Effect of combination chemotherapy of nitrosourea MCNU with various anti-tumor agents].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carbazilquinone; Cell Line; Cyclophosphamid | 1984 |
Role of uridine phosphorylase for antitumor activity of 5'-deoxy-5-fluorouridine.
Topics: Animals; Biotransformation; Floxuridine; Fluorouracil; Leukemia L1210; Male; Mice; Pentosyltransfera | 1980 |
Methods for the complete analysis of 5-fluorouracil metabolites in cell extracts.
Topics: Animals; Biotransformation; Cell Extracts; Cells, Cultured; Chromatography, High Pressure Liquid; Fl | 1981 |
Isolation of fluoropyrimidine-resistant murine leukemic cell lines by one-step mutation and selection.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Line; Cell Separation; Cytological Techniques; Drug R | 1982 |
[Mode of action of fluoropyrimidines, in relation to their clinical application].
Topics: Animals; DNA Replication; Fluorouracil; Humans; Leukemia L1210; Mice; Neoplasms; Stomach Neoplasms; | 1984 |
[Effect of adenosine triphosphate on the proliferation of cultured tumor cells].
Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Cells, Cultured; D | 1984 |
Curability of mouse L1210 leukemia by combination of 5-fluorouracil, cis-diamminedichloroplatinum(II), and low doses of gamma-rays.
Topics: Animals; Cisplatin; Combined Modality Therapy; Fluorouracil; Gamma Rays; Leukemia L1210; Male; Mice; | 1984 |
Abnormal deoxyuridine suppression as a rapid predictor for antimetabolite chemosensitivity: correlation with in vitro tests of growth inhibition.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Division; Cell Line; Colony-Forming Units Assay; Deox | 1984 |
Thymosin alpha 1 restores NK-cell activity and prevents tumor progression in mice immunosuppressed by cytostatics or X-rays.
Topics: Animals; Carmustine; Fluorouracil; Immunosuppression Therapy; Killer Cells, Natural; Leukemia L1210; | 1983 |
In vitro assessment of cytotoxic agents in murine cancers: comparison between antiproliferative and antimetabolic assays.
Topics: Animals; Cell Line; Cell Survival; Cisplatin; DNA Replication; Doxorubicin; Fluorouracil; Kinetics; | 1984 |
Critical modulation by thymidine and hypoxanthine of sequential methotrexate-5-fluorouracil synergism in murine L1210 cells.
Topics: Animals; Cell Survival; Drug Synergism; Drug Therapy, Combination; Fluorouracil; Hypoxanthine; Hypox | 1983 |
Assessment of antimetabolite cytotoxicity: a comparison of clonogenic assays and tritiated deoxyuridine incorporation.
Topics: Animals; Cell Cycle; Cell Line; Cell Survival; Clone Cells; Cytarabine; Deoxyuridine; Dose-Response | 1983 |
Histidinol-mediated improvement in the specificity of 1-beta-D-arabinofuranosylcytosine and 5-fluorouracil in L 1210 leukemia-bearing mice.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Cell Survival; Clone Cells; Co | 1984 |
Evidence that intracellular synthesis of 5-fluorouridine-5'-phosphate from 5-fluorouracil and 5-fluorouridine is compartmentalized.
Topics: Animals; Cell Compartmentation; Cell Nucleus; Chromatography, Affinity; Chromatography, DEAE-Cellulo | 1984 |
Comparing cell kinetic studies of the effect of ftorafur and 5-fluorouracil on the L 1210 ascites tumor.
Topics: Animals; Cell Division; Female; Fluorouracil; Kinetics; Leukemia L1210; Mice; Mitosis; Neoplasm Tran | 1981 |
Combination chemotherapy with cyclophosphamide and ftorafur against advanced L1210 murine leukemia.
Topics: Animals; Cyclophosphamide; Drug Administration Schedule; Drug Synergism; Drug Therapy, Combination; | 1982 |
Use of uridine rescue to enhance the antitumor selectivity of 5-fluorouracil.
Topics: Animals; Bone Marrow; Deoxyuridine; Drug Therapy, Combination; Fluorouracil; Infusions, Parenteral; | 1983 |
Schedule-dependent cytotoxicity of 5-fluorouracil and cyclophosphamide in experimental cancer chemotherapy.
Topics: Animals; Cyclophosphamide; Drug Administration Schedule; Fluorouracil; Leukemia L1210; Lung Neoplasm | 1980 |
Concepts for controlling drug-resistant tumor cells.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Body Burden; Cisplatin; Cyclophosphamide; Dactinomyc | 1980 |
5-Fluorouracil and methotrexate combination chemotherapy: the effect of drug scheduling.
Topics: Animals; Body Weight; Drug Administration Schedule; Drug Therapy, Combination; Fluorouracil; Leukemi | 1981 |
Hypothetical mechanism of therapeutic synergism induced by the combination of 6-thioguanine and 3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-1-(2-chloroethyl)-1-nitrosourea hydrochloride.
Topics: Animals; Antineoplastic Agents; Bromodeoxyuridine; Drug Evaluation, Preclinical; Drug Therapy, Combi | 1982 |
Effect of concurrent calcium leucovorin infusion on 5-fluorouracil cytotoxicity against murine L1210 leukemia.
Topics: Animals; Antineoplastic Agents; Drug Synergism; Fluorouracil; Leucovorin; Leukemia L1210; Male; Meth | 1981 |
Clinical use of methotrexate--with emphasis on use of high doses.
Topics: Animals; Asparaginase; Brain Diseases; Child, Preschool; Cisplatin; Cytarabine; Drug Administration | 1981 |
Activity of a novel anthracenyl bishydrazone, 9,10-anthracenedicarboxyaldehyde Bis[(4,5-dihydro-1H-imidazol-2-yl)hydrazone] dihydrochloride, against experimental tumors in mice.
Topics: Animals; Anthracenes; Antineoplastic Agents; Doxorubicin; Drug Administration Schedule; Drug Evaluat | 1982 |
Biochemical characterization of fluoropyrimidine-resistant murine leukemic cell lines.
Topics: Animals; Antimetabolites, Antineoplastic; Biotransformation; Cell Line; Cell Separation; Drug Resist | 1982 |
Antitumor activity of 1-acyloxymethyl derivatives of 5-fluorouracil against L1210 leukemia.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Fluorouracil; Injections, Intraperitoneal; Leu | 1982 |
N-Alkylated derivatives of 5-fluorouracil.
Topics: Alkylation; Animals; Antineoplastic Agents; Cells, Cultured; Chemical Phenomena; Chemistry; Fluorour | 1982 |
Monitoring the effect of anti-cancer drugs on L1210 cells by a mitochondrial probe, rhodamine-123.
Topics: Animals; Antimetabolites, Antineoplastic; Cytarabine; DNA; Flow Cytometry; Fluorouracil; Leukemia L1 | 1982 |
Effect of pyrimidines, purines and their nucleosides on antitumor activity of 5-fluorouracil against L-1210 leukemia.
Topics: Animals; Drug Synergism; Drug Therapy, Combination; Fluorouracil; Guanosine; Leukemia L1210; Male; M | 1982 |
Search for the biochemical parameters of tumor cell sensitivity and resistance to antimetabolites.
Topics: Animals; Antimetabolites, Antineoplastic; Carcinoma, Ehrlich Tumor; Cell Line; Drug Resistance; Fluo | 1980 |
Basis of observed resistance of L1210 leukemia in mice: methotrexate, 6-thioguanine, 6-methylmercaptopurine riboside, 6-mercaptopurine, 5-fluorouracil, and 1-beta-D-arabinofuranosylcytosine administered in different combinations.
Topics: Animals; Antineoplastic Agents; Biotransformation; Cell Line; Cytarabine; Drug Evaluation, Preclinic | 1981 |
Antitumor activity of 1-alkoxycarbonylalkylcarbamoyl-5-fluorouracil derivatives by oral administration.
Topics: Adenocarcinoma; Administration, Oral; Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Fema | 1981 |
Single versus combination chemotherapy of L1210 leukemia.
Topics: Animals; Antineoplastic Agents; Cyclophosphamide; Cytarabine; Drug Therapy, Combination; Female; Flu | 1980 |
Carbocyclic analogues of 5-fluorouracil nucleosides.
Topics: Animals; Antineoplastic Agents; Fluorouracil; Leukemia L1210; Leukemia P388; Mice; Nucleosides; Thym | 1981 |
Cytotoxic effect of 5-fluorouracil plus cyclophosphamide against transplantable leukemias.
Topics: Animals; Cell Survival; Colony-Forming Units Assay; Cyclophosphamide; Dose-Response Relationship, Dr | 1981 |
Cell surface alterations associated with exposure of leukemia L1210 cells to fluorouracil.
Topics: Animals; Cell Membrane; Fluorouracil; Glycoproteins; Leukemia L1210; Membrane Proteins; Mice; Neopla | 1980 |
The effect of 5-fluorouracil on the synthesis and methylation of low molecular weight nuclear RNA in L1210 cells.
Topics: Adenosine; Animals; Cell Nucleus; Cells, Cultured; Dose-Response Relationship, Drug; Fluorouracil; L | 1980 |
Studies of the effects of treatment with 5-flourouracil alone and in combination with either cyclophosphamide, methotrexate, or methyl-CCNU on hepatic drug-metabolizing enzymes in murine L1210 leukemia.
Topics: Animals; Cyclophosphamide; Drug Interactions; Fluorouracil; Leukemia L1210; Liver; Male; Methotrexat | 1980 |
Antitumor activity of metabolites of 1-hexylcarbamoyl-5-fluorouracil and related compounds against L1210 leukemia in vivo and L5178Y lymphoma cells in vitro.
Topics: Animals; Antineoplastic Agents; Cells, Cultured; Fluorouracil; Leukemia L1210; Leukemia L5178; Male; | 1980 |
In the search for new anticancer drugs. XXV: Role of N-nitrosated amadori compounds derived from glucose-amino acid conjugates in cancer promotion or inhibition.
Topics: Amino Acids; Animals; Antineoplastic Agents; Carcinogenicity Tests; Carcinogens; Fluorouracil; Letha | 1993 |
Effects of 5-fluorouracil and a combination of tegafur and uracil (UFT) on nucleotide metabolism in L1210 ascites tumor.
Topics: Animals; Deoxyribonucleotides; Fluorouracil; Injections, Intraperitoneal; Leukemia L1210; Male; Mice | 1993 |
Goralatide (AcSDKP) selectively protects murine hematopoietic progenitors and stem cells against hyperthermic damage.
Topics: Amino Acid Sequence; Animals; Bone Marrow Purging; Cell Cycle; Cell Division; Cell Survival; Cells, | 1996 |
Comparison of chemically induced DNA breakage in cellular and subcellular systems using the comet assay.
Topics: 4-Nitroquinoline-1-oxide; Animals; Antimetabolites, Antineoplastic; Bleomycin; DNA; DNA Damage; Fluo | 1996 |
Tiazofurin enhances the anabolism and toxicity of 5-fluorouracil.
Topics: Animals; Antimetabolites, Antineoplastic; Dose-Response Relationship, Drug; Drug Synergism; Enzyme I | 1996 |
Synergistic effects of Actinobacillus suis cells in combination with 5-fluorouracil on mice bearing murine L1210 leukemia cells.
Topics: Actinobacillus; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Combined Modality T | 1997 |
5-Fluorouracil derivatives. XXII. Synthesis and antitumor activities of 1-carbamoyl-5-fluorouracils.
Topics: Animals; Antineoplastic Agents; Fluorouracil; Leukemia L1210; Male; Mice; Mice, Inbred Strains | 1997 |
Structure-activity relationship in Ftorafur (Tegafur) and related 5-FU prodrugs.
Topics: Animals; Antimetabolites, Antineoplastic; Fluorouracil; Humans; Indicators and Reagents; Leukemia L1 | 1998 |
Mechanism-based design of inosine 5-monophosphate dehydrogenase inhibitors: synthesis and biological activities of 5-ethynyl-1-beta-D-ribofuranosylimidazole-4-carboxamide (EICAR) and its derivatives.
Topics: Animals; Antineoplastic Agents; Catalysis; Drug Design; Fluorouracil; Humans; IMP Dehydrogenase; Inh | 1999 |
Enhanced cytotoxic interaction between 5-fluorouracil and 4-hydroperoxycyclophosphamide against L1210 murine leukemic cells: applicability to ex vivo purging.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherap | 1999 |
Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cornea; Cyclophosphamide; Drug Administration Schedule; D | 2000 |
Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cornea; Cyclophosphamide; Drug Administration Schedule; D | 2000 |
Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cornea; Cyclophosphamide; Drug Administration Schedule; D | 2000 |
Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cornea; Cyclophosphamide; Drug Administration Schedule; D | 2000 |
Potentiatied antitumor effectiveness of combined chemo-immunotherapy with interleukin-12 and 5-fluorouracil of L1210 leukemia in vivo.
Topics: Animals; Female; Fluorouracil; Interferon-gamma; Interleukin-12; Killer Cells, Natural; Leukemia L12 | 2001 |
Plasma, intestine and tumor levels of 5-fluorouracil in mice bearing L1210 ascites tumor following oral administration of 5-fluorouracil, UFT (mixed compound of tegafur and uracil), carmofur and 5'-deoxy-5-fluorouridine.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Drug Combinations; F | 2001 |
Dextran derivatives in single and combination chemotherapy against transplantable mouse ascites and solid tumors.
Topics: Animals; Antibody Formation; Antineoplastic Agents; Bleomycin; Carcinoma, Ehrlich Tumor; Cells, Cult | 1977 |
Synergistic effects of the combination of cis-platinum diamminodichloride and 2,2'-anhydro-1-beta-D-arabinofuranosyl-5-fluorocytosine in transplanted mouse leukemias.
Topics: Ancitabine; Animals; Cells, Cultured; Cisplatin; Cytarabine; Drug Resistance; Drug Synergism; Drug T | 1977 |
Metabolism of 5-fluorouracil in cultured cells. Protection from 5-fluorouracil cytotoxicity by purines.
Topics: Animals; Antineoplastic Agents; B-Lymphocytes; Cells, Cultured; Fluorouracil; Haplorhini; Leukemia L | 1979 |
Ftorafur: a self-limiting source of 5-fluorouracil?
Topics: Animals; Biotransformation; Fluorouracil; Hematopoietic Stem Cells; Lethal Dose 50; Leukemia L1210; | 1979 |
Comparative physiologic dispositions of 5-fluoro-2'-deoxyuridine and 5-fluorouracil in mice bearing solid L1210 lymphocytic leukemia.
Topics: Animals; Drug Administration Schedule; Floxuridine; Fluorouracil; Leukemia L1210; Mice | 1976 |
Selectivity of action of 5-FU: biochemical basis.
Topics: Animals; Colonic Neoplasms; Drug Resistance; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Humans | 1979 |
Assay of intracellular free and macromolecular-bound metabolites of 5-fluorodeoxyuridine and 5-fluorouracil.
Topics: Animals; Chromatography, Gel; Culture Techniques; Cytosol; Deoxyuracil Nucleotides; Floxuridine; Flu | 1979 |
Combination chemotherapy of L1210 leukemia with platinum compounds and cyclophosphamide plus other selected antineoplastic agents.
Topics: Animals; Cell Survival; Cisplatin; Cyclophosphamide; Cytarabine; Doxorubicin; Drug Evaluation, Precl | 1976 |
In vivo enhancement of 5-fluorouracil cytotoxicity to AKR leukemia cells by thymidine in mice.
Topics: Animals; Cell Survival; Colony-Forming Units Assay; Drug Synergism; Drug Therapy, Combination; Femal | 1978 |
Synthesis and biological activity of 5-fluoro- and 5-methyl-1,3-oxazine-2,6(3H)-dione.
Topics: Animals; Cell Division; Culture Media; Drug Stability; Escherichia coli; Fluorouracil; In Vitro Tech | 1979 |
Studies of the antitumor action of 5-fluorouracil (FU).
Topics: Animals; Antineoplastic Agents; Bone Marrow; Carcinoma 256, Walker; Colonic Neoplasms; Deoxyuridine; | 1979 |
A biochemical and pharmacological study of therapeutic synergism with 5-fluorouracil plus cyclophosphamide in murine L1210 leukemia.
Topics: Animals; Body Weight; Bone Marrow; Cyclophosphamide; DNA, Neoplasm; Drug Synergism; Drug Therapy, Co | 1979 |
Competitive binding radioassay for 5-fluorodeoxyuridine 5'-monophosphate in tissues.
Topics: Animals; Binding, Competitive; Deoxyuracil Nucleotides; Fluorodeoxyuridylate; Fluorouracil; Half-Lif | 1979 |
Enhanced 5-fluorouracil nucleotide formation after methotrexate administration: explanation for drug synergism.
Topics: Animals; Cells, Cultured; Drug Administration Schedule; Drug Synergism; Fluorouracil; Leukemia L1210 | 1979 |
The effect of 5-fluorouracil on the synthesis of nuclear RNA in L1210 cells in vitro.
Topics: Animals; Cell Nucleus; Fluorouracil; In Vitro Techniques; Leukemia L1210; Methylation; Mice; Mice, I | 1979 |
Combined therapy of L1210 leukemia with Damvar and cytostatics.
Topics: Animals; Antineoplastic Agents; Cyclophosphamide; Drug Therapy, Combination; Female; Fluorouracil; L | 1979 |
Antitumor activity of methyl 1-(5-fluoro-1H-2-oxopyrimidin-4-yl)-beta-D-glucopyranuronate against murine leukemia L1210.
Topics: Animals; Dose-Response Relationship, Drug; Drug Combinations; Fluorouracil; Glucose; Leukemia L1210; | 1978 |
Partial synchronization of L1210 cells by 5-fluorouracil and its use in drug combinations.
Topics: Animals; Cell Division; Cell Survival; Cytarabine; Doxorubicin; Drug Administration Schedule; Drug S | 1977 |
Possibilities for a role of L-glutamine and L-asparagine antagonists in the treatment of gastrointestinal cancer.
Topics: Animals; Asparagine; Azo Compounds; Drug Therapy, Combination; Fluorouracil; Gastrointestinal Neopla | 1979 |
[Comparison of free ribonucleotide pool in the spleens of C57BL and DBA/2 mice and in leukemia cells sensitive and resistant to 5-fluorouracil].
Topics: Animals; Fluorouracil; Leukemia L1210; Leukemia, Experimental; Mice; Mice, Inbred C57BL; Mice, Inbre | 1978 |
Antitumor activity of 1-alkylcarbamoyl derivatives of 5-fluorouracil against L1210 leukemia.
Topics: Animals; Female; Fluorouracil; Leukemia L1210; Mice; Structure-Activity Relationship | 1978 |
Mode of action of 5-fluorouridine 5'-phosphate in vivo and in vitro.
Topics: Animals; Antimetabolites, Antineoplastic; Cells, Cultured; Cytarabine; Fluorouracil; Leukemia L1210; | 1978 |
Combination chemotherapy: arriving at optimal treatment levels by incorporating side effect constraints.
Topics: Animals; Carmustine; Cyclophosphamide; Drug Administration Schedule; Drug Therapy, Combination; Fema | 1978 |
Effects of 5-fluorouracil on 5-fluorodeoxyuridine 5'-monophosphate and 2-deoxyuridine 5'-monophosphate pools, and DNA synthesis in solid mouse L1210 and rat Walker 256 tumors.
Topics: Animals; Bone Marrow; Carcinoma 256, Walker; Deoxyuracil Nucleotides; Deoxyuridine; DNA, Neoplasm; D | 1978 |
[Search for biochemical criteria of sensitivity and resistance of tumor cells to antimetabolites].
Topics: Animals; DNA, Neoplasm; Drug Resistance; Fluorouracil; Leukemia L1210; Leukemia, Experimental; Merca | 1978 |
Potentiating action of 5-fluorouracil when used in combination with platinium compounds and cyclophosphamide in treatment of advanced L1210 leukemia.
Topics: Animals; Cyclophosphamide; Drug Synergism; Fluorouracil; Leukemia L1210; Male; Mice; Mice, Inbred St | 1978 |
Effect of ricin and abrin on survival of L1210 leukemic mice and on leukemic and normal bone-marrow cells.
Topics: Abrin; Animals; Antineoplastic Agents; Bone Marrow Cells; Cell Line; Colony-Forming Units Assay; Dox | 1978 |
Rationale of chemotherapeutic adjuvant treatment.
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Carmustine; Cyclophosphamide; Drug Admi | 1978 |
A new anti-cancer principle isolated from Gymnosporia rothiana Laws, and its use in attaining cures in L1210 leukaemia in combination with "S" phase sensitive drugs.
Topics: Animals; Antineoplastic Agents; Cytarabine; Drug Evaluation, Preclinical; Drug Synergism; Drug Thera | 1978 |
Comparison of 5-fluorouracil and ftorafur. II. Therapeutic response and development of resistance in murine tumors.
Topics: Animals; Carcinoma; Cell Line; Drug Resistance; Drug Therapy, Combination; Female; Fluorouracil; Leu | 1976 |
In vivo cell synchrony in the L1210 mouse leukaemia studied with 5-fluorouracil or 5-fluorouracil followed by cold thymidine infusion.
Topics: Animals; Cell Division; DNA; Female; Fluorouracil; Leukemia L1210; Mice; Mitotic Index; Neoplasm Tra | 1977 |
A model for prediction of chemotherapy response to 5-fluorouracil based on the differential distribution of 5-[18F]fluorouracil in sensitive versus resistant lymphocytic leukemia in mice.
Topics: Animals; Drug Resistance; Female; Fluorouracil; Leukemia L1210; Mice; Mice, Inbred C57BL; Mice, Inbr | 1977 |
Combination chemotherapy with 4'Demethylepipodophyllotoxin 9-(4,6-0-ethylidene-beta-D-glucopyranoside), VP 16-213 (NSC 141540) in L1210 leukemia.
Topics: Animals; Antineoplastic Agents; Carmustine; Cyclophosphamide; Cytarabine; Dactinomycin; Daunorubicin | 1976 |
Deveopment of resistance to combinations of six antimetabolites in mice with L1210 leukemia.
Topics: Animals; Antimetabolites, Antineoplastic; Cytarabine; Drug Administration Schedule; Drug Resistance; | 1976 |
Antitumor activity of 1-hexylcarbamoyl-5-fluorouracil in a variety of experimental tumors.
Topics: Adenocarcinoma; Administration, Oral; Animals; Ascites; Carcinoma, Ehrlich Tumor; Female; Fluorourac | 1976 |
Experimental and clinical studies on nucleoside analogs as antitumor agents.
Topics: Aged; Animals; Cytarabine; Drug Resistance; Flucytosine; Fluorouracil; Humans; Leukemia L1210; Leuke | 1975 |
Offsetting toxicity of antineoplastic agents.
Topics: Animals; Biological Products; Bone Marrow; Bone Marrow Cells; Carcinoma, Krebs 2; Cells, Cultured; F | 1975 |
Interaction of chemotherapeutic agents with methotrexate and 5-fluorouracil and its effect on de novo DNA synthesis.
Topics: Animals; Bone Marrow; Bone Marrow Cells; Cephalosporins; Dexamethasone; DNA; DNA, Neoplasm; Fluorour | 1975 |
In vitro biological evaluation of the R and S isomers of 1-(Tetrahydrofuran-2-yl)-5-fluorouracil.
Topics: Animals; Cell Division; Cells, Cultured; Deoxyuridine; DNA, Neoplasm; Fibroblasts; Fluorouracil; Fur | 1975 |
Antitumor activity of carbamoyl derivatives of 5-fluorouracil by oral administration.
Topics: Administration, Oral; Animals; Carbamates; Fluorouracil; Leukemia L1210; Mice | 1975 |
The inhibition of DNA synthesis by cannabinoids.
Topics: Animals; Bone Marrow; Bone Marrow Cells; Cannabidiol; Cannabis; Cyclophosphamide; Cytarabine; DNA; D | 1976 |
Antitumor activity of two novel low immunosuppressive fluoropyrimidines UK-21 and UK-25.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Body Weight; Fluorouracil; Glycine; Leukemia L | 1992 |
Cytotoxicity of three novel fluoropyrimidines in cultured L1210 murine lymphocytic leukemia cells.
Topics: Animals; Drug Screening Assays, Antitumor; Fluorouracil; Leukemia L1210; Male; Mice; Microsomes, Liv | 1990 |
The changes in the levels of dihydrofolate reductase mRNA and its gene dosage in 5-fluorouracil-resistant L1210 cells.
Topics: Animals; Chromosome Aberrations; DNA, Neoplasm; Drug Resistance; Fluorouracil; Gene Amplification; L | 1990 |
Synergistic antitumor effect of fluoropyrimidines and polyinosinic-polycytidylic acid against L1210 leukemia.
Topics: 2',5'-Oligoadenylate Synthetase; Animals; Drug Synergism; Fluorouracil; Interferons; Leukemia L1210; | 1985 |
The efficacy of combined therapy with methotrexate and 5-fluorouracil from the view point of cellular PRPP level of L1210 cells and HeLa S3 cells.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule; Fluorouracil; | 1985 |
Mechanisms of action of 5-fluorouracil on metabolism of RNA in special reference to polysome of L1210 cells.
Topics: Animals; Cell Line; Fluorouracil; Leukemia L1210; Mice; Polyribosomes; Ribosomes; RNA; Tritium; Urid | 1986 |
Biochemical and pharmacologic basis for potentiation of 5-fluorouracil action by leucovorin.
Topics: Animals; Biotransformation; Cell Division; Colonic Neoplasms; DNA; Drug Synergism; Fluorouracil; Fol | 1987 |
Transport and intracellular metabolism of fluorinated pyrimidines in cultured cell lines.
Topics: Animals; Biological Transport; Erythrocytes; Floxuridine; Fluorouracil; HeLa Cells; Humans; Leukemia | 1989 |
Application of PHYCON 6600 to achieve sustained release of an antitumor drug (carmofur).
Topics: Animals; Antineoplastic Agents; Delayed-Action Preparations; Drug Implants; Excipients; Fluorouracil | 1989 |
Assay and time course of 5-fluorouracil incorporation into RNA of L1210/0 ascites cells in vivo.
Topics: Animals; Carbon Radioisotopes; DNA; Female; Fluorouracil; Kinetics; Leukemia L1210; Mice; Mice, Inbr | 1985 |
The role of drug sequence in therapeutic selectivity of the combination of 5-fluorouracil and cis-platin.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Colonic Neoplasms; Dose-Response | 1989 |
The therapeutic effects of orally administered 5'-deoxy-5-fluorouridine, 1-(2-tetrahydrofuryl)-5-fluorouracil and 5-fluorouracil on experimental murine tumors.
Topics: Animals; Antineoplastic Agents; Floxuridine; Fluorouracil; Leukemia L1210; Mice; Neoplasms, Experime | 1985 |
Increased thymidylate synthase in L1210 cells possessing acquired resistance to N10-propargyl-5,8-dideazafolic acid (CB3717): development, characterization, and cross-resistance studies.
Topics: Animals; Antineoplastic Agents; Cells, Cultured; Deoxyuridine; Drug Resistance; Floxuridine; Fluorou | 1986 |
Modulation of the effects of fluoropyrimidines on toxicity and tumor inhibition in rodents by uridine and thymidine.
Topics: Animals; Dose-Response Relationship, Drug; Female; Floxuridine; Fluorouracil; Leukemia L1210; Lung N | 1986 |
Folinic acid augmentation of the effects of fluoropyrimidines on murine and human leukemic cells.
Topics: Animals; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Drug Synergism; Floxuridine; Fl | 1986 |
[Effects of derivatives of Ara-C, 5-fluorouracil and nitrosourea against intracerebral implanted L1210 leukemia].
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Blood-Brain Barrier; | 1987 |
[Conversion of 5'-deoxy-5-fluorouridine to 5-FU by pyrimidine nucleoside phosphorylases in normal and tumor tissues from rodents bearing tumors and cancer patients].
Topics: Animals; Antineoplastic Agents; Carcinoma 256, Walker; Floxuridine; Fluorouracil; Humans; Leukemia L | 1987 |
Biochemical rationale for the synergism of 5-fluorouracil and folinic acid.
Topics: Animals; Cell Division; Cell Survival; Deoxyuracil Nucleotides; Drug Synergism; Floxuridine; Fluorou | 1987 |
Mechanism of the cytotoxic synergism of fluoropyrimidines and folinic acid in mouse leukemic cells.
Topics: Animals; Cell Survival; Drug Synergism; Floxuridine; Fluorouracil; Kinetics; Leucovorin; Leukemia L1 | 1988 |
5-Fluoro-5'-deoxyuridine is an inhibitor of uridylate nucleotidase in L1210 leukaemia.
Topics: 5'-Nucleotidase; Animals; Antimetabolites, Antineoplastic; Biotransformation; Cell Cycle; DNA, Neopl | 1986 |
[FO-152].
Topics: Absorption; Adenocarcinoma; Animals; Antineoplastic Agents; Cell Line; Dogs; Drug Evaluation; Female | 1987 |
Therapeutic and pharmacological studies of tetrachloro(d,l-trans)1,2-diaminocyclohexane platinum (IV) (tetraplatin), a new platinum analogue.
Topics: Animals; Antibiotics, Antineoplastic; Bile; Biological Transport; Drug Therapy, Combination; Fluorou | 1988 |
[Enhanced antitumor action of 5-fluorouracil when used in combination with 4-methylmercaptopyrazolo[3,4-d]pyrimidine 1-nucleoside].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Dose-Response Relationship, Drug; Drug Eval | 1988 |
A facile method for synthesis of N-acyloxymethyl-5-fluorouracils, as a class of antitumor agents.
Topics: Animals; Antineoplastic Agents; Chemical Phenomena; Chemistry; Fluorouracil; Leukemia L1210; Mice | 1987 |
5-Fluorouracil derivatives. XII. Synthesis and antitumor activity of alpha-alkylthiomethyl-, alpha-alkylsulfinylmethyl-, alpha-alkylsulfonylmethyl-, and alpha-acylthiomethyl-5-fluorouracils.
Topics: Animals; Antineoplastic Agents; Chemical Phenomena; Chemistry; Fluorouracil; Leukemia L1210; Male; M | 1987 |
Combination of 5-fluorouracil and cyclophosphamide in L1210 and P388 leukemias with changes in optimum treatments as a function of the age of the L1210 tumor at first treatment.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Fluorouracil; Leukemia L1 | 1987 |
Approaches to overcome in vivo anti-cancer drug resistance.
Topics: 3-Deazauridine; Animals; Antineoplastic Agents; Arabinofuranosylcytosine Triphosphate; Cell Line; Cy | 1986 |
Sequential inhibitory effects of antitumor agents related to levodopa and dopamine upon DNA synthetic enzymes.
Topics: Animals; Antineoplastic Agents; Dopamine; Fluorouracil; Hydroxyurea; Kinetics; Leukemia L1210; Levod | 1986 |
[The metabolism of high-molecular-weight substances in cells and the effect of anticancer drugs].
Topics: Animals; DNA Repair; DNA Replication; Fluorouracil; Leukemia L1210; Methotrexate; Mice; Molecular We | 1987 |
Synthesis and antitumor activity of 1- or 3-(alpha-hetero substituted)alkyl-5-fluorouracil derivatives.
Topics: Animals; Antineoplastic Agents; Fluorouracil; Indicators and Reagents; Leukemia L1210; Mice; Structu | 1987 |
5-Fluorouracil derivatives. X. Synthesis and antitumor activities of alpha-alkoxyalkyl-5-fluorouracils.
Topics: Animals; Antineoplastic Agents; Fluorouracil; Leukemia L1210; Male; Mice; Mice, Inbred Strains | 1986 |
The inhibitory effects of 5-fluorouracil on the metabolism of preribosomal and ribosomal RNA in L-1210 cells in vitro.
Topics: Animals; Cell Line; Centrifugation, Density Gradient; Fluorouracil; Leukemia L1210; Mice; RNA Proces | 1986 |
Three alkaloids as selective destroyers of cancer cells in mice. Synergy with classic anticancer drugs.
Topics: Alkaloids; Animals; Antineoplastic Combined Chemotherapy Protocols; Daunorubicin; Drug Synergism; Fl | 1986 |
Assessment of labeled 5-fluorouracils for nuclear scintigraphy.
Topics: Animals; Carbon Radioisotopes; Fluorouracil; Leukemia L1210; Mice; Neoplasm Transplantation; Radionu | 1986 |
Failure of L-histidinol to improve the therapeutic efficiency of 5-fluorouracil against murine breast tumors.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Cell Cycle; Female; Fluorour | 1987 |
Schedule-dependent antitumor and toxic effects of thymidine and 5-fluorouracil in AKR and L1210 leukemias.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Dose-Response Relationship, Drug; Female; F | 1986 |
Histidinol-mediated enhancement of the specificity of two anticancer drugs in mice bearing leukemic bone marrow disease.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Colony-Forming Units Assay; Cy | 1985 |
Lack of enhanced cytotoxicity of cultured L1210 cells using folinic acid in combination with sequential methotrexate and fluorouracil.
Topics: Animals; Cell Survival; DNA Replication; Drug Interactions; Fluorouracil; Kinetics; Leucovorin; Leuk | 1985 |
[Effects of combination chemotherapy of MCNU with various anti-cancer agents].
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Doxorubi | 1985 |
[Biochemical modulation in cancer chemotherapy].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Drug Synergism; Fluorouracil; H | 1985 |
Timing- and sequence-dependent synergism between etoposide and methotrexate or etoposide, methotrexate and 5-fluorouracil in advanced leukemia L1210.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Drug Synergism; Etoposide; Female; Fluorour | 1985 |
5-Fluorouracil derivatives. IX. Synthesis and antitumor activities of (alkylthio)carbonyl-5-fluorouracils.
Topics: Animals; Antineoplastic Agents; Chemical Phenomena; Chemistry; Fluorouracil; Leukemia L1210; Mice | 1985 |
Analysis of serum protein changes in patients with advanced gastric cancer with special reference to -globulin fractions.
Topics: Adrenocorticotropic Hormone; Alpha-Globulins; Animals; Blood Protein Electrophoresis; Cytarabine; Dr | 1972 |
The enhanced therapeutic effect of cis-platinum (II) diamminodichloride against L1210 leukemia when combined with cyclophosphamide or 1,2-bis(3,5-dioxopiperazine-1-yl)propane or several other antitumor agents.
Topics: Amines; Animals; Antineoplastic Agents; Azacitidine; Camptothecin; Carmustine; Chlorides; Cyclophosp | 1973 |
Potentially useful combinations of chemotherapy detected in mouse tumor systems.
Topics: Acetylcysteine; Animals; Antineoplastic Agents; Azauridine; Bleomycin; Camptothecin; Cyclic P-Oxides | 1974 |
Letter: ICRF 159.
Topics: Animals; Antimetabolites; Cyclophosphamide; Doxorubicin; Drug Synergism; Fluorouracil; Leukemia L121 | 1974 |
[Ethidium bromhydrate effect on L 1210 mouse leukemia].
Topics: Animals; Cyclophosphamide; Dactinomycin; Daunorubicin; Doxorubicin; Ellipticines; Ethidium; Female; | 1974 |
The physiological disposition of 5-fluorouracil in mice bearing solid L1210 lymphocytic leukemia.
Topics: Animals; Bone Marrow; Brain; Carbon Isotopes; Cerebellum; Chromatography, Ion Exchange; Chromatograp | 1972 |
5-Fluorouracil and derivatives in cancer chemotherapy. 3. In vivo enhancement of antitumor activity of 5-fluorouracil (FU) and 5-fluoro-2'-deoxyuridine (FUDR).
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Chromatography, Thin Layer; Deoxycytidine; Deoxyurid | 1973 |
Synthesis of 5-fluorouridine 5'-phosphate by a pyrimidine phosphoribosyltransferase of mammalian origin. II. Correlation between the tumor levels of the enzyme and the 5-fluorouracil-promoted increase in survival of tumor-bearing mice.
Topics: Animals; Fluorouracil; Leukemia L1210; Lymphoma; Mice; Neoplasm Transplantation; Neoplasms, Experime | 1969 |
Synergistic effects of bis(3-methylsulfonyloxypropyl)-amine toluenesulfonate (864-T) with 6-mercaptopurine and other antitumor agents.
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Chromomycins; Cyclophosphamide; Cytarabine; Drug | 1973 |
Proceedings: A comparison of the cell killing in the mouse after exposure to ftorafur and to 5-fluorouracil.
Topics: Animals; Fluorouracil; Furans; Hematopoietic Stem Cells; Hydrolysis; Lethal Dose 50; Leukemia L1210; | 1974 |
Antitumor activity of benzoyl and benzenesulfonyl derivatives of 5-fluorouracil.
Topics: Animals; Antineoplastic Agents; Benzene Derivatives; Benzoates; Fluorouracil; Leukemia L1210; Mice; | 1974 |
Sequential administration of two oncostatic drugs: study of modalities for pharmacodynamic potentiation.
Topics: Animals; Antineoplastic Agents; Carmustine; Cyclophosphamide; Cytarabine; Dactinomycin; Drug Synergi | 1974 |
Comparative chemotherapy of AKR lymphoma and human hematological neoplasia.
Topics: Animals; Antineoplastic Agents; Biological Assay; Carmustine; Cyclohexanes; Cyclophosphamide; Cytara | 1974 |
Characteristics and response to certain cancer chemotherapeutic agents of an acute lymphocytic leukemia arising in a BALB-c times DBA-2F1 mouse.
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Cyclophosphamide; Diethylamines; Disease Models, | 1974 |
Combination chemotherapy: the interaction of methotrexate and 5-fluorouracil.
Topics: Animals; Cell Line; Cells, Cultured; Drug Antagonism; Drug Interactions; Drug Therapy, Combination; | 1973 |
Some determinants of drug responsiveness in bovine leukemia cells.
Topics: Animals; Antineoplastic Agents; Cattle; Cells, Cultured; Cytidine; Cytosine Nucleotides; Drug Resist | 1973 |
Antileukemic synergism between cyclophosphamide and an antitumor platinum compound.
Topics: Animals; Body Weight; Cisplatin; Cyclophosphamide; Drug Synergism; Drug Therapy, Combination; Fluoro | 1973 |
Antileukemic properties of dichloro(1,2-diaminocyclohexane)platinum(II).
Topics: Animals; Carcinoma, Ehrlich Tumor; Cells, Cultured; Cisplatin; Cyclophosphamide; DNA, Neoplasm; Drug | 1974 |
Antitumor activity of cyclocytidine in a variety of tumors.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Cell Line; Cyclization; Cy | 1972 |
Enhanced response of leukemia (L1210) mice to combination chemotherapy with 5-(3,3-dimethyl-1-triazeno) imidazole-4-carboxamide (NSC-45388) and 5-fluorouracil (NSC-19893).
Topics: Animals; Azo Compounds; DNA, Neoplasm; Drug Synergism; Fluorouracil; Imidazoles; Leukemia L1210; Mal | 1971 |
Lack of effect of warfarin (NSC-59813) alone or in combination with 5-fluorouracil (NSC-19893) on primary and metastatic L1210 leukemia and adenocarcinoma 755.
Topics: Adenocarcinoma; Animals; Female; Fluorouracil; Leukemia L1210; Mice; Neoplasm Metastasis; Neoplasm T | 1971 |
Sequential biochemical alteration to antifolate resistance in L1210 leukaemia.
Topics: Animals; Biological Transport, Active; Cell Division; Cytogenetics; Drug Hypersensitivity; Fluoroura | 1967 |
The effect of fluoxidine on L1210 leukemia in mice.
Topics: Animals; Antimetabolites; Fluorouracil; Leukemia L1210; Male; Mice; Pyrimidines; Time Factors | 1970 |
Implications of biochemical, cytokinetic, pharmacologic, and toxicologic relationships in the design of optimal therapeutic schedules.
Topics: Animals; Antineoplastic Agents; Cyclophosphamide; Cytarabine; Dactinomycin; Daunorubicin; Disease Mo | 1970 |
Dose-response curves for agents that impair cell reproductive integrity. The relation between dose-response curves and the design of selective regimens in cancer chemotherapy.
Topics: Animals; Antineoplastic Agents; Cell Division; Cyclophosphamide; Fluorouracil; Growth; Hematopoietic | 1969 |
The synergistic anti-neoplastic activity of combinations of mitomycins with either 6-thioguanine or 5-fluorouracil.
Topics: Animals; Antineoplastic Agents; DNA, Neoplasm; Drug Synergism; Female; Fluorouracil; In Vitro Techni | 1965 |
On the action of fluorouracil on leukemia cells.
Topics: Animals; Culture Techniques; DNA, Neoplasm; Fluorouracil; Leukemia L1210; Mice; Phosphorus Isotopes; | 1966 |
Growth of L1210 mouse leukemia cells in vitro.
Topics: Animals; Chromosomes; Culture Techniques; Fluorouracil; Folic Acid; Leukemia L1210; Mercaptopurine; | 1966 |
The antileukemic effectiveness of 5-fluorouracil and methotrexate in the combination chemotherapy of advanced leukemia L1210 in mice.
Topics: Animals; Antineoplastic Agents; Fluorouracil; Leukemia L1210; Methotrexate; Mice | 1966 |
Fate of amethopterin-resistant mutants in L1210 mouse leukemia populations.
Topics: Animals; Drug Hypersensitivity; Fluorouracil; In Vitro Techniques; Leukemia L1210; Mercaptopurine; M | 1966 |
Nucleosides. XXIX. 1-beta-D-arabinofuranosyl-5-fluorocytosine and related arabino nucleosides.
Topics: Animals; Arabinose; Chemistry, Organic; Cytosine; Fluorouracil; Furans; Idoxuridine; Keratitis, Dend | 1966 |