Page last updated: 2024-10-27

fluorouracil and Leukemia L 1210

fluorouracil has been researched along with Leukemia L 1210 in 220 studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Research Excerpts

ExcerptRelevanceReference
"Different methods were compared for the in vitro evaluation of the therapeutic effects of the antineoplastic agents doxorubicin, cisplatin, fluorouracil, and vinblastine sulfate in a model system of murine tumor cell lines consisting of L1210 leukemia, P815 mast cell leukemia, and B16 melanoma."3.67In vitro assessment of cytotoxic agents in murine cancers: comparison between antiproliferative and antimetabolic assays. ( Atassi, G; Bernheim, JL; Roobol, C; Sips, HC; Theunissen, J, 1984)
"Mice BDF1 with L 1210 or mice BALB/c with plasmacytoma MOPS-406 after pretreatment with ineffective doses of 1-beta-D-ribofuranosyl-4-methylmercaptopyrazolo(3,4-d)pyramidin e (25 to 100 mg/kg per 5 days) were treated with 5-fluorouracil at the optimal dose 100 mg per day."3.67[Enhanced antitumor action of 5-fluorouracil when used in combination with 4-methylmercaptopyrazolo[3,4-d]pyrimidine 1-nucleoside]. ( Garin, AM; Korbukh, IA; Lobova, TG; Preobrazhenskaia, MN, 1988)
"A comparison has been made between the cloning capacity and changes in tritiated deoxyuridine (6-[3H]-UdR) incorporation of L1210 (murine leukaemia) and PMC-22 (human melanoma) cells treated with methotrexate (MTX), 5-fluorouracil (5-FU) and cytosine arabinoside (ARA-C)."3.66Assessment of antimetabolite cytotoxicity: a comparison of clonogenic assays and tritiated deoxyuridine incorporation. ( Perez, DJ; Tattersall, MH, 1983)
"We examined the ability of uridine to increase the therapeutic index of 5-fluorouracil (FUra) against C57BL/6 X DBA/2 F1 mice bearing a Day 1 B16 melanoma or L1210 leukemia."3.66Use of uridine rescue to enhance the antitumor selectivity of 5-fluorouracil. ( Cerna, I; Klubes, P, 1983)
"Antitumor activity of seven 5-fluorouracil derivatives having carbamoyl linkage with amino acid was examined against L-1210 leukemia, adenocarcinoma 755, ascites sarcoma 180, Ehrlich ascites carcinoma and Lewis lung carcinoma by oral administration."3.66Antitumor activity of 1-alkoxycarbonylalkylcarbamoyl-5-fluorouracil derivatives by oral administration. ( Ando, N; Hoshi, A; Iigo, M; Inomata, M; Kuretani, K, 1981)
" In combination therapy with mitomycin C, bleomycin, cyclophosphamide, and 5-fluorouracil, palmitoyldextran phosphate manifested strong synergistic effects against both Sarcoma 180 ascites and L1210 leukemic tumors."3.65Dextran derivatives in single and combination chemotherapy against transplantable mouse ascites and solid tumors. ( Kadowaki, M; Matsumoto, T; Mikami, T; Suzuki, M; Suzuki, S, 1977)
"Thymidine has been demonstrated to alter the pharmacokinetic parameters of 5-FU in man and in mice, but a selective modification of the antitumor activity of 5-FU has not yet been unequivocally demonstrated."2.36Determinants of response to antimetabolites and their modulation by normal purine and pyrimidine metabolites. ( Au, JL; Danhauser, L; Luccioni, C; Rustum, YM, 1981)
" However, it was repeatedly shown that the sequence of 5-FU followed by CDDP is more active and less toxic in tumor-bearing animals."1.33Schedule-dependent antitumor activity and toxicity of combinations of 5-fluorouracil and cisplatin/carboplatin against L1210 leukemia-bearing mice. ( Fujimoto, S, 2006)
" Thus, by using a dosing schedule of cyclophosphamide that provided more sustained apoptosis of endothelial cells within the vascular bed of a tumor, we show that a chemotherapeutic agent can more effectively control tumor growth in mice, regardless of whether the tumor cells are drug resistant."1.31Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer. ( Browder, T; Butterfield, CE; Folkman, J; Kräling, BM; Marshall, B; O'Reilly, MS; Shi, B, 2000)
" The dosage of the oral clinical use for human cancer of 5-FU, HCFU, 5'-DFUR and UFT as tegafur (FT) is 200-300mg/d, 600mg/d, 800-1,200mg/d and 300-600mg/d respectively."1.31Plasma, intestine and tumor levels of 5-fluorouracil in mice bearing L1210 ascites tumor following oral administration of 5-fluorouracil, UFT (mixed compound of tegafur and uracil), carmofur and 5'-deoxy-5-fluorouridine. ( Higashigawa, M; Kagawa, Y; Kakito, H; Kawasaki, H; Kojima, M; Ohkubo, T; Ooi, A; Sakurai, M, 2001)
" The antileukemic action of AS 15557, alone or in combination with 5-FU, against L1210 leukemia was superior to that of a streptococcal preparation (OK-432) and was almost the same as of bacillus Calmette-Guérin with or without 5-FU."1.30Synergistic effects of Actinobacillus suis cells in combination with 5-fluorouracil on mice bearing murine L1210 leukemia cells. ( Itoh, S; Watanabe, T, 1997)
" None of the four compounds caused a significant inhibition of cell growth, even at the maximum dosage of 10(-4) M."1.29In the search for new anticancer drugs. XXV: Role of N-nitrosated amadori compounds derived from glucose-amino acid conjugates in cancer promotion or inhibition. ( Gnewuch, CT; Ryoo, ES; Sosnovsky, G, 1993)
"Goralatide treatment (10(-8), 10(-9), and 10(-10) M) up to 24 hours had no effect on the growth kinetics and cell cycle distribution and consequently on the hyperthermic sensitivity of L1210 cells."1.29Goralatide (AcSDKP) selectively protects murine hematopoietic progenitors and stem cells against hyperthermic damage. ( Konings, AW; Wierenga, PK, 1996)
" The bioavailability of UK-21 given p."1.28Antitumor activity of two novel low immunosuppressive fluoropyrimidines UK-21 and UK-25. ( Kato, T; Kitaichi, K; Koda, A; Mori, H; Sakamoto, O, 1992)
"This study attempted to develop sustained release implantable dosage forms based on PHYCON 6600, a new silicone gel."1.28Application of PHYCON 6600 to achieve sustained release of an antitumor drug (carmofur). ( Azuma, T; Imasaka, K; Nagai, T; Ueda, H, 1989)
"Augmentation of antitumor activity of Lactobacillus casei YIT 9018 (LC 9018), which strongly inhibits the growth of transplantable allogeneic and syngeneic mouse tumors, in combination with antitumor drugs was investigated."1.27[Augmentation of antitumor activity of Lactobacillus casei YIT 8018 (LC 9018) in combination with various antitumor drugs]. ( Kato, I; Matsuzaki, T; Mutai, M; Yokokura, T, 1984)
" In this study leucovorin (folinic acid, LCV) was added to the MTX/FUra combination with the intention of generating elevated levels of methylenetetrahydrofolate to promote the formation of a stable fluorodeoxyuridylate-thymidylate synthetase ternary complex, thereby augmenting the cytotoxicity of the MTX-FUra sequence."1.27Lack of enhanced cytotoxicity of cultured L1210 cells using folinic acid in combination with sequential methotrexate and fluorouracil. ( Cadman, E; Danhauser, LL; Heimer, R, 1985)
"Studies have been conducted on liver microsomal enzymes of B6D2F(1) mice bearing a Day 4 L1210 ascites tumor after treatment with a single intraperitoneal injection of 5-fluorouracil (FUra) alone, and in combination with either cyclophosphamide (CP), methotrexate (MTX), or methyl-CCNU (MeCCNU)."1.26Studies of the effects of treatment with 5-flourouracil alone and in combination with either cyclophosphamide, methotrexate, or methyl-CCNU on hepatic drug-metabolizing enzymes in murine L1210 leukemia. ( Klubes, P; Miller, HG; Trevithick, J, 1980)
"This paper represents a method for determining optimal dose levels in a drug combination by analyzing the dose-response surfaces estimated from experimental data."1.26Combination chemotherapy: arriving at optimal treatment levels by incorporating side effect constraints. ( Carter, WH; Wampler, GL; Williams, VR, 1978)

Research

Studies (220)

TimeframeStudies, this research(%)All Research%
pre-1990188 (85.45)18.7374
1990's23 (10.45)18.2507
2000's9 (4.09)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Lin, AJ1
Benjamin, RS1
Rao, PN1
Loo, TL2
Matsuda, A5
Takenuki, K2
Sasaki, T5
Ueda, T3
Giorgi-Renault, S1
Renault, J1
Gebel-Servolles, P1
Baron, M1
Paoletti, C2
Cros, S1
Bissery, MC1
Lavelle, F1
Atassi, G2
Minakawa, N3
Takeda, T1
Tanaka, M2
Kumar, R1
Xu, LH1
Knaus, EE1
Wiebe, LI1
Tovell, DR1
Tyrrell, DL1
Allen, TM2
Selassie, CD1
Hansch, C1
Khwaja, TA1
Bobek, M2
An, SH1
Skrincosky, D1
De Clercq, E3
Bernacki, RJ1
Jurd, L1
Narayanan, VL1
Paull, KD1
Béres, J1
Bentrude, WG1
Kálmán, A1
Párkányi, L1
Balzarini, J4
Nguyen, CH1
Bisagni, E1
Pepin, O1
Pierré, A1
de Cointet, P1
Cristalli, G1
Franchetti, P1
Grifantini, M1
Vittori, S1
Bordoni, T1
Geroni, C1
Holshouser, MH2
Shipp, AM2
Ferguson, PW2
Ajmera, S1
Danenberg, PV4
Rosowsky, A1
Kim, SH1
Trites, D1
Wick, M1
Fries, KM1
Joswig, C2
Borch, RF2
Bussolari, JC1
Ramesh, K1
Stoeckler, JD1
Chen, SF1
Panzica, RP1
Azuma, A1
Nakajima, Y2
Nishizono, N1
Suzuki, M2
Hanaoka, K1
Kobayashi, T1
Freel Meyers, CL1
Hong, L1
Kim, KH1
Kim, JY1
Lee, KH1
Noh, MJ1
Kim, YC1
Park, HJ1
El Akri, K1
Bougrin, K1
Faraj, A1
Benhida, R1
Gazivoda, T1
Raić-Malić, S1
Kristafor, V1
Makuc, D1
Plavec, J1
Bratulić, S1
Kraljević-Pavelić, S1
Pavelić, K1
Naesens, L1
Andrei, G1
Snoeck, R1
Mintas, M1
Dimmock, JR1
Padmanilayam, MP1
Zello, GA1
Nienaber, KH1
Santos, CL1
Manavathu, EK1
Stables, JP1
SCHRECKER, AW2
VENDITTI, JM7
GREENBERG, NH1
BIEDLER, JL2
ROBINSON, DL2
HUTCHISON, DJ6
BROCKMAN, RW3
ANDERSON, EP1
GELLHORN, A1
WAGNER, M1
RECHLER, M1
KOREN, Z1
BENJAMIN, W1
RUTMAN, RJ1
Fujimoto, S2
Abraham, D1
Carbone, PP1
Kline, I6
Goldin, A8
Burchenal, JH3
Dollinger, M1
Butterbaugh, J1
Stoll, D1
Giner-Sorolla, A1
Wilkoff, LJ2
Wilcox, WS1
Burdeshaw, JA1
Dixon, GJ1
Dulmadge, EA1
Fernandes, DJ4
Bertino, JR3
Cadman, E4
Heimer, R3
Benz, C1
Moroson, BA1
Chou, TC1
Schmid, FA2
Feinberg, A1
Philips, FS1
Han, J1
Matsuzaki, T1
Kato, I1
Yokokura, T1
Mutai, M1
Grant, S1
Moran, RG4
Heidelberger, C5
Au, JL2
Rustum, YM6
Minowada, J1
Srivastava, BI1
Canti, G1
Franco, P1
Marelli, O1
Ricci, L1
Nicolin, A1
Roobol, C3
De Dobbeleer, GB2
Bernheim, JL3
Iigo, M16
Kuretani, K11
Hoshi, A18
Danysz, A1
Wierzba, K1
Wutkiewicz, M1
Pniewska, A1
Pragłowski, T1
Burba-Anczewska, I1
Tamemasa, O2
Tezuka, M2
Ninomiya, K1
Sekido, S1
Araki, T1
Ishitsuka, H3
Miwa, M2
Takemoto, K1
Fukuoka, K1
Itoga, A1
Maruyama, HB1
Pogolotti, AL1
Nolan, PA1
Santi, DV2
Mulkins, MA2
Suga, S2
Kimura, K1
Kubo, K1
Aoyama, H1
Inukai, N1
Kato, K1
Horiuchi, T1
Sawada, H1
Yokoyama, Y1
Ueno, H1
Dionet, C1
Verrelle, P1
Block, JB1
Chlebowski, RT1
Dietrich, MF1
Isacoff, WH1
Umeda, Y1
Sakamoto, A1
Nakamura, J1
Yagi, Y1
Sips, HC1
Theunissen, J1
Piper, AA1
Nott, SE1
Mackinnon, WB1
Tattersall, MH4
Perez, DJ1
Warrington, RC2
Muzyka, TG1
Fang, WD2
Shani, J3
Schultze, B2
Jellinghaus, W1
Weis, G1
Müller, V1
Maurer, W2
Grossie, VB1
Rosenblum, MG1
Klubes, P6
Cerna, I3
Mulder, JH2
Smink, T2
Ossewaarde, T1
van Putten, LM4
Schabel, FM3
Skipper, HE2
Trader, MW1
Laster, WR1
Corbett, TH1
Griswold, DP1
Ogawa, M1
Sakurai, Y1
Meldon, MA1
Danhauser, L2
Luccioni, C1
Citarella, RV1
Wallace, RE1
Murdock, KC1
Angier, RB1
Durr, FE1
Forbes, M1
Inomata, M4
Kanzawa, F2
Kundu, NG1
Schmitz, SA1
Bernal, SD1
Shapiro, HM1
Chen, LB1
Ando, N3
Belousova, AK2
Gerasimova, GK3
Kim, K1
Blechman, WJ1
Riddle, VG1
Pardee, AB2
Koza, I1
Balázová, E1
Ujházy, V1
Shealy, YF1
Frye, JL1
DuBois, NF1
Shaddix, SC1
Santelli, G3
Valeriote, F3
Vietti, T1
Coulter, D1
Kessel, D3
Glazer, RI3
Hartman, KD1
Trevithick, J1
Miller, HG1
Yoshida, M4
Sosnovsky, G1
Gnewuch, CT1
Ryoo, ES1
Kakito, H2
Ohkubo, T2
Kagawa, Y2
Inagaki, S1
Sumida, K1
Ooi, K1
Higashigawa, M3
Sakurai, M4
Wierenga, PK1
Konings, AW1
Kasamatsu, T1
Kohda, K1
Kawazoe, Y1
Ozaki, S7
Cysyk, RL1
Chisena, CA1
Hyman, R1
Monks, A1
Watanabe, T1
Itoh, S1
Kong, X1
Watanabe, Y3
Hoshiko, T3
Koga, T1
Ogasawara, T3
Takizawa, T1
Fujisawa, H1
Zhuk, R1
Mao, XY1
M'Soka, T1
Shimono, Y1
Nagata, T1
Inamochi, H1
Cao, DC1
Hori, H1
Kawasaki, H3
Browder, T1
Butterfield, CE1
Kräling, BM1
Shi, B1
Marshall, B1
O'Reilly, MS1
Folkman, J1
Goł b, J1
Zagozdzon, R1
Kamiński, R1
Kozar, K1
Gryska, K1
Izycki, D1
Mackiewicz, A1
Stokłosa, T1
Giermasz, A1
Lasek, W1
Jakóbisiak, M1
Ooi, A1
Kojima, M1
Mikami, T1
Kadowaki, M1
Matsumoto, T1
Suzuki, S1
O'Toole, T1
Kalaher, K1
Chisholm, J1
Ullman, B1
Kirsch, J1
Lelieveld, P1
Pantarotto, C1
Salmona, M1
Spreafico, F1
Chadwick, M2
Chang, C1
Wang, G1
Washtien, WL1
Glae, GR1
Atkins, LM3
Meischen, SJ3
Smith, AB2
Walker, EM3
Kuhar, S1
Bloch, A1
Mandel, HG2
Murinson, DS1
Anderson, T1
Schwartz, HS1
Myers, CE1
Chabner, BA1
Davis, L1
Peale, AL1
Pujman, V2
Cernochová, S1
Shimizu, F1
Arakawa, M1
Bhuyan, BK1
Blowers, CL1
Neil, GL1
Bono, VH1
Day, KJ1
Woolley, PV2
Coit, R1
Magno, M1
Mokina, VD1
Sidorova, TA1
Nakamura, A2
Wampler, GL2
Carter, WH2
Williams, VR1
Connelly, K1
Gale, GR3
Schwartz, P1
Fodstad, O1
Pihl, A1
Alate, AD1
Khandalekar, DD1
Amonkar, AJ1
Adwankar, MK1
Sahasrabudhe, MB1
Garibjanian, BT1
Johnson, RK1
Vadlamudi, S1
Gang, M3
Camplejohn, RS1
Wolf, W2
Dombernowsky, P1
Nissen, NI1
Otter, GM1
Stock, CC1
Currie, VE1
Dowling, MD1
Fox, JJ2
Krakoff, IH1
Cook, ES1
Nutini, LG1
Fardon, JC1
Proudfoot, MB1
Poydock, ME1
Bruckner, HW1
Schreiber, C1
Waxman, S1
Horwitz, JP1
McCormick, JJ1
Philips, KD1
Maher, VM1
Otto, JR1
Zemlicka, J1
Carchman, RA1
Harris, LS1
Munson, AE1
Sakamoto, O1
Mori, H3
Kitaichi, K1
Koda, A1
Kato, T2
Konishi, Y2
Kanamaru, R6
Ishioka, C4
Ishikawa, A1
Shibata, H1
Wakui, A6
Dei, T2
Chapekar, MS1
Kakuta, H4
Sato, T4
Trave, F2
Zakrzewski, SF1
Petrelli, N1
Herrera, L1
Mittelman, A1
Arbuck, SG1
Creaven, PJ1
Uchida, M1
Ho, DH1
Kamiya, K1
Yoshimura, T1
Sasaki, K1
Tsutani, H1
Nakamura, T1
Imasaka, K1
Ueda, H1
Azuma, T1
Nagai, T1
Spears, CP1
Shahinian, AH1
Palmeri, S1
Russello, O1
Uehara, N1
Baba, H1
Nitta, K1
Kunimoto, T1
Takeuchi, M1
Tanaka, T1
Jackman, AL1
Alison, DL1
Calvert, AH1
Harrap, KR2
Hartmann, HR1
Bollag, W1
Keyomarsi, K3
Ota, K1
Nishimura, J1
Kamiyama, T1
Beránek, J1
Furue, H1
Niitani, H1
Kurihara, M1
Hasegawa, K1
Nakao, I1
Tsukagoshi, S1
Fujita, H1
Rahman, A1
Roh, JK1
Wolpert-DeFilippes, MK1
Lobova, TG1
Korbukh, IA1
Preobrazhenskaia, MN1
Garin, AM1
Ahmad, S2
Nagase, T4
Tokuzen, R1
Tamai, H2
Campbell, ED1
Radel, S1
Campbell, J1
Mayhew, E1
Fitzgerald, GB1
Wick, MM1
Coates, A1
Furukawa, H1
Uemura, A1
Ishikawa, K1
Beljanski, M1
Beljanski, MS1
Russ, GA1
Campione, MA1
Stolfi, RL1
Sawyer, RC1
Martin, DS1
Danhauser, LL1
Machida, S1
Ito, Y1
Hoshino, A2
Nobori, T1
Kamiya, H1
Osswald, H1
Herrmann, R1
Youssef, M1
Yamauchi, S1
Fujiwara, K1
Tamura, Z1
Woodman, RJ2
Sirica, AE1
Bellet, RE1
Mastrangelo, MJ1
Dixon, LM1
Gosse, C1
Le Pecq, JB1
Dechambre, RP1
Morizet, J1
Rogers, WI1
Jato, J1
Windheuser, JJ1
Bergsagel, DE1
Reyes, P1
Hall, TC2
Imamura, H1
Ikegami, K1
Okumoto, T1
Kram-Idsenga, LK1
Pijpers-de Bruin, M1
Nakamura, N1
Pouillart, R1
Huong, TH1
Brugerie, E1
Lheritier, J1
Frei, E1
Yancey, ST1
Bleyer, WA1
Jackson, RC1
Connors, TA1
Dodd, DC1
Benckhuijsen, C1
Waravdekar, VS1
Higashi, H1
Sirotnak, FM1
Kurita, S1
Sargent, MG1
Sandberg, J1
Howsden, L1
Mellett, LB1
Montgomery, JA1
Lloyd, HH1
Berenbaum, MC1
Sartorelli, AC1
Booth, BA1
Goldberg, AR1
Machledt, JH1
Ittensohn, OL1
Bjerregaard, MR1
Mead, JA1
Tyrer, DD1
Albrecht, AM1
Miller, N1
Wempen, I1

Clinical Trials (4)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Phase 2 Clinical Trial:Low -Dose-bevacizumab and Pemetrexed Versus Treatment of Physician's Choice in Metastatic HER2-negative Breast Cancer Patients After Failure of Taxanes and Anthracycline-containing Regimens[NCT02829008]Phase 2120 participants (Anticipated)Interventional2016-04-30Active, not recruiting
Multicentre Randomized Phase II Study of Neoadjuvant Trastuzumab Plus Docetaxel With and Without Bevacizumab and Trastuzumab Plus Docetaxel Plus Non-pegylated Liposome-encapsulated Doxorubicin (NPLD) With and Without Bevacizumab in HER2-positive Early Bre[NCT01367028]Phase 2100 participants (Actual)Interventional2011-06-30Completed
A Phase I Trial of 5-Fluorouracil Given With 776C85 (GW776) and Low-Dose Leucovorin in Adult Patients With Solid Tumors[NCT00001579]Phase 150 participants Interventional1997-06-30Completed
Phase I Trial of 5-Fluoro-2'-Deoxycytidine With Tetrahydrouridine[NCT00359606]Phase 158 participants (Actual)Interventional1999-04-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

7 reviews available for fluorouracil and Leukemia L 1210

ArticleYear
BIOCHEMISTRY OF CANCER (METABOLIC ASPECTS).
    Annual review of biochemistry, 1963, Volume: 32

    Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents; Azaguanine; Azaserine; Carcinoma, Ehrlich Tum

1963
Determinants of response to antimetabolites and their modulation by normal purine and pyrimidine metabolites.
    Cancer treatment reports, 1981, Volume: 65 Suppl 3

    Topics: Animals; Antimetabolites, Antineoplastic; Cytarabine; DNA, Neoplasm; Fluorodeoxyuridylate; Fluoroura

1981
Synthesis and antitumor activity of 5-fluorouracil derivatives.
    Medicinal research reviews, 1996, Volume: 16, Issue:1

    Topics: Animals; Antimetabolites, Antineoplastic; Drug Screening Assays, Antitumor; Fluorouracil; Leukemia L

1996
A study on structure-activity relationships of nucleoside analogues.
    Drugs under experimental and clinical research, 1986, Volume: 12, Issue:4

    Topics: Animals; Cells, Cultured; Cytarabine; DNA, Neoplasm; Escherichia coli; Fluorouracil; In Vitro Techni

1986
[Mechanism of action of anti-cancer drugs from the viewpoint of RNA metabolism].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1988, Volume: 15, Issue:4 Pt 2-1

    Topics: Animals; Antineoplastic Agents; Fluorouracil; Leukemia L1210; RNA, Neoplasm

1988
An assessment of massive-dose chemotherapy of malignant disease.
    Canadian Medical Association journal, 1971, Jan-09, Volume: 104, Issue:1

    Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Bone Marrow; Bone Marrow Cells; Cell Division; Cyclo

1971
Chemotherapy and the life cycle of leukaemic cells. A comparison between the growth characteristics of human acute leukaemia and the murine leukaemia L 1210.
    Folia medica Neerlandica, 1969, Dec-02, Volume: 12, Issue:2

    Topics: Anilides; Animals; Cell Division; Cyclophosphamide; Cytarabine; DNA, Neoplasm; Fluorouracil; Humans;

1969

Trials

2 trials available for fluorouracil and Leukemia L 1210

ArticleYear
Current studies of methotrexate and 5-fluorouracil and their interaction in human tumor cells.
    Seminars in oncology, 1983, Volume: 10, Issue:2 Suppl 2

    Topics: Animals; Cells, Cultured; Colonic Neoplasms; Drug Administration Schedule; Drug Evaluation; Drug The

1983
Sequential MTX and 5-FU: advance or myth?
    European journal of cancer & clinical oncology, 1986, Volume: 22, Issue:2

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cells, Cultured; Clinical Trials as Topic;

1986

Other Studies

211 other studies available for fluorouracil and Leukemia L 1210

ArticleYear
Synthesis and biological activities of ftorafur metabolites. 3'- and 4'-hydroxyftorafur.
    Journal of medicinal chemistry, 1979, Volume: 22, Issue:9

    Topics: Animals; Antineoplastic Agents; Cell Division; Fluorouracil; HeLa Cells; Humans; Hydroxylation; Leuk

1979
Nucleosides and nucleotides. 94. Radical deoxygenation of tert-alcohols in 1-(2-C-alkylpentofuranosyl) pyrimidines: synthesis of (2'S)-2'-deoxy-2'-C-methylcytidine, an antileukemic nucleoside.
    Journal of medicinal chemistry, 1991, Volume: 34, Issue:1

    Topics: Animals; Antimetabolites, Antineoplastic; Deoxycytidine; Drug Screening Assays, Antitumor; Humans; I

1991
Heterocyclic quinones. 17. A new in vivo active antineoplastic drug: 6,7-bis(1-aziridinyl)-4-[[3-(N,N-dimethylamino)propyl]amino]-5,8- quinazolinedione.
    Journal of medicinal chemistry, 1991, Volume: 34, Issue:1

    Topics: Animals; Antineoplastic Agents; Aziridines; Breast Neoplasms; Cell Division; Cell Line; Drug Screeni

1991
Nucleosides and nucleotides. 96. Synthesis and antitumor activity of 5-ethynyl-1-beta-D-ribofuranosylimidazole-4-carboxamide (EICAR) and its derivatives.
    Journal of medicinal chemistry, 1991, Volume: 34, Issue:2

    Topics: Animals; Antineoplastic Agents; Cell Line; Chemical Phenomena; Chemistry; Humans; Leukemia L1210; Le

1991
Nucleosides and nucleotides. 97. Synthesis of new broad spectrum antineoplastic nucleosides, 2'-deoxy-2'-methylidenecytidine (DMDC) and its derivatives.
    Journal of medicinal chemistry, 1991, Volume: 34, Issue:2

    Topics: Animals; Antineoplastic Agents; Cells, Cultured; Chemical Phenomena; Chemistry; Deoxycytidine; Femal

1991
Synthesis and antiviral and cytotoxic activity of iodohydrin and iodomethoxy derivatives of 5-vinyl-2'-deoxyuridines, 2'-fluoro-2'-deoxyuridine, and uridine.
    Journal of medicinal chemistry, 1990, Volume: 33, Issue:2

    Topics: Animals; Antimetabolites, Antineoplastic; Antiviral Agents; Biological Transport; Cell Survival; Che

1990
Structure-activity relationships of antineoplastic agents in multidrug resistance.
    Journal of medicinal chemistry, 1990, Volume: 33, Issue:7

    Topics: Animals; Antineoplastic Agents; Cell Line; Cell Survival; Cricetinae; Dactinomycin; Drug Resistance;

1990
2'-Fluorinated isonucleosides. 1. Synthesis and biological activity of some methyl 2'-deoxy-2'-fluoro-2'-pyrimidinyl-D-arabinopyranosides.
    Journal of medicinal chemistry, 1989, Volume: 32, Issue:4

    Topics: Animals; Arabinonucleosides; Chemical Phenomena; Chemistry; Chemistry, Physical; Chlorine; Female; F

1989
In vivo antitumor activity of 6-benzyl-1,3-benzodioxole derivatives against the P388, L1210, B16, and M5076 murine models.
    Journal of medicinal chemistry, 1987, Volume: 30, Issue:10

    Topics: Animals; Antineoplastic Agents; Astrocytoma; Bucladesine; Cell Differentiation; Dioxoles; DNA Topois

1987
Synthesis, structure, and antitumor and antiviral activities of a series of 5-halouridine cyclic 3',5'-monophosphates.
    Journal of medicinal chemistry, 1986, Volume: 29, Issue:4

    Topics: Animals; Antineoplastic Agents; Antiviral Agents; Humans; Leukemia L1210; Mice; Molecular Conformati

1986
1-Amino-substituted 4-methyl-5H-pyrido[3',4':4,5]pyrrolo[3,2-c]pyridines: a new class of antineoplastic agents.
    Journal of medicinal chemistry, 1987, Volume: 30, Issue:9

    Topics: Animals; Antineoplastic Agents; Cell Line; DNA; Leukemia L1210; Leukemia P388; Pyridines; Pyrroles

1987
Improved synthesis and antitumor activity of 1-deazaadenosine.
    Journal of medicinal chemistry, 1987, Volume: 30, Issue:9

    Topics: Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Line; Female; HeLa Cells; Humans; Leu

1987
Synthesis and antitumor activity of a series of ftorafur analogues: the effect of varying electronegativity at the 1'-position.
    Journal of medicinal chemistry, 1985, Volume: 28, Issue:2

    Topics: Animals; Antineoplastic Agents; Cells, Cultured; Female; Fluorouracil; Leukemia L1210; Leukemia P388

1985
Synthesis and biological activity of 5'-substituted 5-fluoropyrimidine nucleosides.
    Journal of medicinal chemistry, 1982, Volume: 25, Issue:8

    Topics: Animals; Antineoplastic Agents; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid;

1982
Synthesis and in vivo antitumor activity of potential 5-fluorouracil prodrugs.
    Journal of medicinal chemistry, 1982, Volume: 25, Issue:9

    Topics: Animals; Antineoplastic Agents; Cell Survival; Chemical Phenomena; Chemistry; Fluorouracil; Leukemia

1982
Synthesis and biological evaluation of 5-fluoro-2'-deoxyuridine phosphoramidate analogs.
    Journal of medicinal chemistry, 1995, Jul-07, Volume: 38, Issue:14

    Topics: Amides; Animals; Antineoplastic Agents; Floxuridine; Leukemia L1210; Magnetic Resonance Spectroscopy

1995
Synthesis and biological evaluation of N4-substituted imidazo- and v-triazolo[4,5-d]pyridazine nucleosides.
    Journal of medicinal chemistry, 1993, Dec-10, Volume: 36, Issue:25

    Topics: Adenosine Deaminase Inhibitors; Animals; Antineoplastic Agents; Cattle; Humans; Leukemia L1210; Mela

1993
Nucleosides and nucleotides. 122. 2'-C-cyano-2'-deoxy-1-beta-D-arabinofuranosylcytosine and its derivatives. A new class of nucleoside with a broad antitumor spectrum.
    Journal of medicinal chemistry, 1993, Dec-24, Volume: 36, Issue:26

    Topics: Adenine; Animals; Antineoplastic Agents; Cytarabine; Female; Fluorouracil; Humans; Leukemia L1210; L

1993
Synthesis and biological activity of novel 5-fluoro-2'-deoxyuridine phosphoramidate prodrugs.
    Journal of medicinal chemistry, 2000, Nov-02, Volume: 43, Issue:22

    Topics: Amides; Animals; Antimetabolites, Antineoplastic; Cell Division; Drug Screening Assays, Antitumor; F

2000
Synthesis and biological activity of the new 5-fluorocytosine derivatives, 5'-deoxy-N-alkyloxycarbonyl-5-fluorocytosine-5'-carboxylic acid.
    Bioorganic & medicinal chemistry letters, 2002, Feb-11, Volume: 12, Issue:3

    Topics: Animals; Antineoplastic Agents; Cell Division; Drug Screening Assays, Antitumor; Flucytosine; Humans

2002
Efficient synthesis and in vitro cytostatic activity of 4-substituted triazolyl-nucleosides.
    Bioorganic & medicinal chemistry letters, 2007, Dec-01, Volume: 17, Issue:23

    Topics: Animals; Cell Line, Tumor; Cytostatic Agents; Humans; Leukemia L1210; Mice; Nucleosides; Structure-A

2007
Synthesis, cytostatic and anti-HIV evaluations of the new unsaturated acyclic C-5 pyrimidine nucleoside analogues.
    Bioorganic & medicinal chemistry, 2008, May-15, Volume: 16, Issue:10

    Topics: Animals; Anti-HIV Agents; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response

2008
Cytotoxic analogues of 2,6-bis(arylidene)cyclohexanones.
    European journal of medicinal chemistry, 2003, Volume: 38, Issue:2

    Topics: Animals; Antineoplastic Agents; Benzene Derivatives; Cell Line; Cyclohexanones; Drug Screening Assay

2003
ASSOCIATION OF INCREASED DIHYDROFOLATE REDUCTASE LEVELS AND CHROMOSOME ALTERATION IN AMETHOPTERIN-RESISTANT SUBLINES OF LEUKEMIA L1210.
    Journal of the National Cancer Institute, 1963, Volume: 31

    Topics: Animals; Azaserine; Chromosomes; Fluorouracil; Folic Acid; Genetics; Leukemia L1210; Mercaptopurine;

1963
SELECTION OF CHROMOSOMAL VARIANT IN AMETHOPTERIN-RESISTANT SUBLINES OF LEUKEMIA L1210 WITH INCREASED LEVELS OF DIHYDROFOLATE REDUCTASE.
    Journal of the National Cancer Institute, 1963, Volume: 31

    Topics: Animals; Chromosomes; Fluorouracil; Genetics; Leukemia L1210; Mercaptopurine; Methotrexate; Mice; Ox

1963
THE EFFECT OF A PHTHALANILIDE DERIVATIVE ON LIPIDE METABOLISM IN L1210 LEUKEMIA CELLS.
    Cancer research, 1964, Volume: 24

    Topics: Anilides; Animals; Antineoplastic Agents; Carbon Isotopes; Cholesterol; Cyclophosphamide; Fatty Acid

1964
EXPERIMENTAL CHEMOTHERAPY STUDIES. V. THE COLLATERAL SENSITIVITY TO ALKYLATING AGENTS OF SEVERAL ANTIMETABOLITE-RESISTANT ASCITES TUMORS IN MICE.
    Cancer research, 1964, Volume: 24

    Topics: Alkylating Agents; Animals; Antimetabolites; Antineoplastic Agents; Ascites; Azaserine; Carcinoma, E

1964
Schedule-dependent antitumor activity and toxicity of combinations of 5-fluorouracil and cisplatin/carboplatin against L1210 leukemia-bearing mice.
    Biological & pharmaceutical bulletin, 2006, Volume: 29, Issue:11

    Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Ascites; Carboplatin

2006
Evaluation of chemical agents against the plasma cell tumor LPC-1 in mice.
    Biochemical pharmacology, 1967, Volume: 16, Issue:4

    Topics: Alkylating Agents; Animals; Carcinoma 256, Walker; Cyclophosphamide; Electrophoresis; Fluorouracil;

1967
Studies of 6-N-hydroxylamino-9-beta-D-ribofuranosylpurine in mouse leukemia.
    Biochemical pharmacology, 1967, Volume: 16, Issue:3

    Topics: Adenine; Animals; Body Weight; Cytarabine; Drug Antagonism; Drug Synergism; Fluorouracil; Guanine; L

1967
Effect of antimetabolites on kinetic behavior of proliferating cultured L1210 leukemia cells.
    Journal of the National Cancer Institute, 1967, Volume: 39, Issue:5

    Topics: Animals; Antimetabolites; Azaserine; Cell Division; Culture Techniques; Cytarabine; Fluorouracil; Ki

1967
5-fluorouracil-methotrexate synergy: enhancement of 5-fluorodeoxyridylate binding to thymidylate synthase by dihydropteroylpolyglutamates.
    Proceedings of the National Academy of Sciences of the United States of America, 1980, Volume: 77, Issue:10

    Topics: Animals; Cell Survival; Drug Synergism; Floxuridine; Fluorouracil; Folic Acid; Leukemia L1210; Metho

1980
The influence of methotrexate pretreatment on 5-fluorouracil metabolism in L1210 cells.
    The Journal of biological chemistry, 1981, Feb-25, Volume: 256, Issue:4

    Topics: Animals; Biological Transport; Deoxyuridine; Fluorouracil; Kinetics; Leucovorin; Leukemia L1210; Met

1981
The role of methotrexate and dihydrofolate polyglutamates in the enhancement of fluorouracil action by methotrexate.
    Cancer treatment reports, 1981, Volume: 65 Suppl 1

    Topics: Animals; Cell Line; Cell Survival; Drug Administration Schedule; Drug Therapy, Combination; Fluorode

1981
Uptake, initial effects, and chemotherapeutic efficacy of harringtonine in murine leukemic cells sensitive and resistant to vincristine and other chemotherapeutic agents.
    Cancer research, 1983, Volume: 43, Issue:7

    Topics: Alkaloids; Animals; Cell Line; Cyclophosphamide; Cytarabine; DNA; Doxorubicin; Fluorouracil; Harring

1983
[Augmentation of antitumor activity of Lactobacillus casei YIT 8018 (LC 9018) in combination with various antitumor drugs].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1984, Volume: 11, Issue:3

    Topics: Animals; Antineoplastic Agents; Bleomycin; Cyclophosphamide; Fluorouracil; Lacticaseibacillus casei;

1984
Modulation of 1-beta-D-arabinofuranosylcytosine metabolism and cytotoxicity in L1210 cells by fluoropyrimidine pretreatment.
    Cancer research, 1982, Volume: 42, Issue:9

    Topics: Animals; Arabinofuranosylcytosine Triphosphate; Cell Line; Cell Survival; Clone Cells; Cytarabine; D

1982
Therapeutic response of leukemic mice treated with fluorinated pyrimidines and inhibitors of deoxyuridylate synthesis.
    Biochemical pharmacology, 1982, Sep-15, Volume: 31, Issue:18

    Topics: Animals; Antineoplastic Agents; Cells, Cultured; Chick Embryo; Cytosol; Deoxyuracil Nucleotides; Flo

1982
Differential selectivity of 5-fluorouracil and 5'-deoxy-5-fluorouridine in cultured human B lymphocytes and mouse L1210 leukemia.
    Biochemical pharmacology, 1983, Feb-01, Volume: 32, Issue:3

    Topics: Animals; Antineoplastic Agents; Ascitic Fluid; B-Lymphocytes; Biotransformation; Cell Division; Cell

1983
Hematoporphyrin derivative rescue from toxicity caused by chemotherapy or radiation in a murine leukemia model (L1210).
    Cancer research, 1984, Volume: 44, Issue:4

    Topics: Animals; Antibody Formation; Antineoplastic Agents; Cyclophosphamide; Fluorouracil; Hemagglutination

1984
5-fluorouracil and 5-fluoro-2'-deoxyuridine follow different metabolic pathways in the induction of cell lethality in L1210 leukaemia.
    British journal of cancer, 1984, Volume: 49, Issue:6

    Topics: Animals; Cell Survival; Cells, Cultured; DNA, Neoplasm; Floxuridine; Fluorouracil; Isomerism; Leukem

1984
Potentiation of the chemotherapeutic effect of 5-fluorouracil by combination with guanosine 5'-monophosphate.
    Gan, 1983, Volume: 74, Issue:2

    Topics: Adenocarcinoma; Animals; Drug Therapy, Combination; Fluorouracil; Guanine Nucleotides; Guanosine Mon

1983
Influence of molar ratio on the combination effect of 5-fluorouracil with guanosine 5'-monophosphate on P388 and L1210 leukemias.
    European journal of cancer & clinical oncology, 1984, Volume: 20, Issue:3

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Dose-Response Relationship, Drug; Fluoroura

1984
Influence of some sulfhydryl compounds on the antineoplastic effectiveness of 5-fluorouracil and 6-mercaptopurine.
    Archivum immunologiae et therapiae experimentalis, 1984, Volume: 32, Issue:3

    Topics: Animals; Cysteine; Drug Synergism; Fluorouracil; Glutathione; Insulin; Leukemia L1210; Mercaptopurin

1984
Antitumor effect of 5-fluorouracil in combination with some additives which stimulate the formation of antineoplastic 5-fluorouracil nucleotides.
    Gan, 1983, Volume: 74, Issue:2

    Topics: Animals; Carcinoma, Ehrlich Tumor; Cells, Cultured; Drug Therapy, Combination; Edetic Acid; Fluorour

1983
[Effect of combination chemotherapy of nitrosourea MCNU with various anti-tumor agents].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1984, Volume: 11, Issue:6

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carbazilquinone; Cell Line; Cyclophosphamid

1984
Role of uridine phosphorylase for antitumor activity of 5'-deoxy-5-fluorouridine.
    Gan, 1980, Volume: 71, Issue:1

    Topics: Animals; Biotransformation; Floxuridine; Fluorouracil; Leukemia L1210; Male; Mice; Pentosyltransfera

1980
Methods for the complete analysis of 5-fluorouracil metabolites in cell extracts.
    Analytical biochemistry, 1981, Volume: 117, Issue:1

    Topics: Animals; Biotransformation; Cell Extracts; Cells, Cultured; Chromatography, High Pressure Liquid; Fl

1981
Isolation of fluoropyrimidine-resistant murine leukemic cell lines by one-step mutation and selection.
    Cancer research, 1982, Volume: 42, Issue:3

    Topics: Animals; Antimetabolites, Antineoplastic; Cell Line; Cell Separation; Cytological Techniques; Drug R

1982
[Mode of action of fluoropyrimidines, in relation to their clinical application].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1984, Volume: 11, Issue:11

    Topics: Animals; DNA Replication; Fluorouracil; Humans; Leukemia L1210; Mice; Neoplasms; Stomach Neoplasms;

1984
[Effect of adenosine triphosphate on the proliferation of cultured tumor cells].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 1984, Volume: 104, Issue:11

    Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Cells, Cultured; D

1984
Curability of mouse L1210 leukemia by combination of 5-fluorouracil, cis-diamminedichloroplatinum(II), and low doses of gamma-rays.
    Cancer research, 1984, Volume: 44, Issue:2

    Topics: Animals; Cisplatin; Combined Modality Therapy; Fluorouracil; Gamma Rays; Leukemia L1210; Male; Mice;

1984
Abnormal deoxyuridine suppression as a rapid predictor for antimetabolite chemosensitivity: correlation with in vitro tests of growth inhibition.
    Cancer treatment reports, 1984, Volume: 68, Issue:4

    Topics: Animals; Antimetabolites, Antineoplastic; Cell Division; Cell Line; Colony-Forming Units Assay; Deox

1984
Thymosin alpha 1 restores NK-cell activity and prevents tumor progression in mice immunosuppressed by cytostatics or X-rays.
    Cancer immunology, immunotherapy : CII, 1983, Volume: 15, Issue:2

    Topics: Animals; Carmustine; Fluorouracil; Immunosuppression Therapy; Killer Cells, Natural; Leukemia L1210;

1983
In vitro assessment of cytotoxic agents in murine cancers: comparison between antiproliferative and antimetabolic assays.
    Journal of the National Cancer Institute, 1984, Volume: 72, Issue:3

    Topics: Animals; Cell Line; Cell Survival; Cisplatin; DNA Replication; Doxorubicin; Fluorouracil; Kinetics;

1984
Critical modulation by thymidine and hypoxanthine of sequential methotrexate-5-fluorouracil synergism in murine L1210 cells.
    Cancer research, 1983, Volume: 43, Issue:11

    Topics: Animals; Cell Survival; Drug Synergism; Drug Therapy, Combination; Fluorouracil; Hypoxanthine; Hypox

1983
Assessment of antimetabolite cytotoxicity: a comparison of clonogenic assays and tritiated deoxyuridine incorporation.
    European journal of cancer & clinical oncology, 1983, Volume: 19, Issue:3

    Topics: Animals; Cell Cycle; Cell Line; Cell Survival; Clone Cells; Cytarabine; Deoxyuridine; Dose-Response

1983
Histidinol-mediated improvement in the specificity of 1-beta-D-arabinofuranosylcytosine and 5-fluorouracil in L 1210 leukemia-bearing mice.
    Cancer research, 1984, Volume: 44, Issue:7

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Cell Survival; Clone Cells; Co

1984
Evidence that intracellular synthesis of 5-fluorouridine-5'-phosphate from 5-fluorouracil and 5-fluorouridine is compartmentalized.
    Biochemical and biophysical research communications, 1984, Jul-18, Volume: 122, Issue:1

    Topics: Animals; Cell Compartmentation; Cell Nucleus; Chromatography, Affinity; Chromatography, DEAE-Cellulo

1984
Comparing cell kinetic studies of the effect of ftorafur and 5-fluorouracil on the L 1210 ascites tumor.
    Journal of cancer research and clinical oncology, 1981, Volume: 100, Issue:1

    Topics: Animals; Cell Division; Female; Fluorouracil; Kinetics; Leukemia L1210; Mice; Mitosis; Neoplasm Tran

1981
Combination chemotherapy with cyclophosphamide and ftorafur against advanced L1210 murine leukemia.
    Cancer treatment reports, 1982, Volume: 66, Issue:8

    Topics: Animals; Cyclophosphamide; Drug Administration Schedule; Drug Synergism; Drug Therapy, Combination;

1982
Use of uridine rescue to enhance the antitumor selectivity of 5-fluorouracil.
    Cancer research, 1983, Volume: 43, Issue:7

    Topics: Animals; Bone Marrow; Deoxyuridine; Drug Therapy, Combination; Fluorouracil; Infusions, Parenteral;

1983
Schedule-dependent cytotoxicity of 5-fluorouracil and cyclophosphamide in experimental cancer chemotherapy.
    European journal of cancer, 1980, Volume: 16, Issue:5

    Topics: Animals; Cyclophosphamide; Drug Administration Schedule; Fluorouracil; Leukemia L1210; Lung Neoplasm

1980
Concepts for controlling drug-resistant tumor cells.
    European journal of cancer, 1980, Volume: Suppl 1

    Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Body Burden; Cisplatin; Cyclophosphamide; Dactinomyc

1980
5-Fluorouracil and methotrexate combination chemotherapy: the effect of drug scheduling.
    European journal of cancer & clinical oncology, 1981, Volume: 17, Issue:7

    Topics: Animals; Body Weight; Drug Administration Schedule; Drug Therapy, Combination; Fluorouracil; Leukemi

1981
Hypothetical mechanism of therapeutic synergism induced by the combination of 6-thioguanine and 3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-1-(2-chloroethyl)-1-nitrosourea hydrochloride.
    Cancer research, 1982, Volume: 42, Issue:10

    Topics: Animals; Antineoplastic Agents; Bromodeoxyuridine; Drug Evaluation, Preclinical; Drug Therapy, Combi

1982
Effect of concurrent calcium leucovorin infusion on 5-fluorouracil cytotoxicity against murine L1210 leukemia.
    Cancer chemotherapy and pharmacology, 1981, Volume: 6, Issue:2

    Topics: Animals; Antineoplastic Agents; Drug Synergism; Fluorouracil; Leucovorin; Leukemia L1210; Male; Meth

1981
Clinical use of methotrexate--with emphasis on use of high doses.
    Cancer treatment reports, 1981, Volume: 65 Suppl 1

    Topics: Animals; Asparaginase; Brain Diseases; Child, Preschool; Cisplatin; Cytarabine; Drug Administration

1981
Activity of a novel anthracenyl bishydrazone, 9,10-anthracenedicarboxyaldehyde Bis[(4,5-dihydro-1H-imidazol-2-yl)hydrazone] dihydrochloride, against experimental tumors in mice.
    Cancer research, 1982, Volume: 42, Issue:2

    Topics: Animals; Anthracenes; Antineoplastic Agents; Doxorubicin; Drug Administration Schedule; Drug Evaluat

1982
Biochemical characterization of fluoropyrimidine-resistant murine leukemic cell lines.
    Cancer research, 1982, Volume: 42, Issue:3

    Topics: Animals; Antimetabolites, Antineoplastic; Biotransformation; Cell Line; Cell Separation; Drug Resist

1982
Antitumor activity of 1-acyloxymethyl derivatives of 5-fluorouracil against L1210 leukemia.
    Journal of pharmacobio-dynamics, 1982, Volume: 5, Issue:3

    Topics: Administration, Oral; Animals; Antineoplastic Agents; Fluorouracil; Injections, Intraperitoneal; Leu

1982
N-Alkylated derivatives of 5-fluorouracil.
    Journal of pharmaceutical sciences, 1982, Volume: 71, Issue:8

    Topics: Alkylation; Animals; Antineoplastic Agents; Cells, Cultured; Chemical Phenomena; Chemistry; Fluorour

1982
Monitoring the effect of anti-cancer drugs on L1210 cells by a mitochondrial probe, rhodamine-123.
    International journal of cancer, 1982, Aug-15, Volume: 30, Issue:2

    Topics: Animals; Antimetabolites, Antineoplastic; Cytarabine; DNA; Flow Cytometry; Fluorouracil; Leukemia L1

1982
Effect of pyrimidines, purines and their nucleosides on antitumor activity of 5-fluorouracil against L-1210 leukemia.
    Journal of pharmacobio-dynamics, 1982, Volume: 5, Issue:7

    Topics: Animals; Drug Synergism; Drug Therapy, Combination; Fluorouracil; Guanosine; Leukemia L1210; Male; M

1982
Search for the biochemical parameters of tumor cell sensitivity and resistance to antimetabolites.
    Antibiotics and chemotherapy, 1980, Volume: 28

    Topics: Animals; Antimetabolites, Antineoplastic; Carcinoma, Ehrlich Tumor; Cell Line; Drug Resistance; Fluo

1980
Basis of observed resistance of L1210 leukemia in mice: methotrexate, 6-thioguanine, 6-methylmercaptopurine riboside, 6-mercaptopurine, 5-fluorouracil, and 1-beta-D-arabinofuranosylcytosine administered in different combinations.
    Cancer research, 1981, Volume: 41, Issue:11 Pt 1

    Topics: Animals; Antineoplastic Agents; Biotransformation; Cell Line; Cytarabine; Drug Evaluation, Preclinic

1981
Antitumor activity of 1-alkoxycarbonylalkylcarbamoyl-5-fluorouracil derivatives by oral administration.
    Journal of pharmacobio-dynamics, 1981, Volume: 4, Issue:3

    Topics: Adenocarcinoma; Administration, Oral; Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Fema

1981
Single versus combination chemotherapy of L1210 leukemia.
    Neoplasma, 1980, Volume: 27, Issue:6

    Topics: Animals; Antineoplastic Agents; Cyclophosphamide; Cytarabine; Drug Therapy, Combination; Female; Flu

1980
Carbocyclic analogues of 5-fluorouracil nucleosides.
    Journal of medicinal chemistry, 1981, Volume: 24, Issue:9

    Topics: Animals; Antineoplastic Agents; Fluorouracil; Leukemia L1210; Leukemia P388; Mice; Nucleosides; Thym

1981
Cytotoxic effect of 5-fluorouracil plus cyclophosphamide against transplantable leukemias.
    European journal of cancer, 1981, Volume: 17, Issue:6

    Topics: Animals; Cell Survival; Colony-Forming Units Assay; Cyclophosphamide; Dose-Response Relationship, Dr

1981
Cell surface alterations associated with exposure of leukemia L1210 cells to fluorouracil.
    Cancer research, 1980, Volume: 40, Issue:2

    Topics: Animals; Cell Membrane; Fluorouracil; Glycoproteins; Leukemia L1210; Membrane Proteins; Mice; Neopla

1980
The effect of 5-fluorouracil on the synthesis and methylation of low molecular weight nuclear RNA in L1210 cells.
    Molecular pharmacology, 1980, Volume: 17, Issue:2

    Topics: Adenosine; Animals; Cell Nucleus; Cells, Cultured; Dose-Response Relationship, Drug; Fluorouracil; L

1980
Studies of the effects of treatment with 5-flourouracil alone and in combination with either cyclophosphamide, methotrexate, or methyl-CCNU on hepatic drug-metabolizing enzymes in murine L1210 leukemia.
    Archives internationales de pharmacodynamie et de therapie, 1980, Volume: 246, Issue:1

    Topics: Animals; Cyclophosphamide; Drug Interactions; Fluorouracil; Leukemia L1210; Liver; Male; Methotrexat

1980
Antitumor activity of metabolites of 1-hexylcarbamoyl-5-fluorouracil and related compounds against L1210 leukemia in vivo and L5178Y lymphoma cells in vitro.
    Journal of pharmacobio-dynamics, 1980, Volume: 3, Issue:9

    Topics: Animals; Antineoplastic Agents; Cells, Cultured; Fluorouracil; Leukemia L1210; Leukemia L5178; Male;

1980
In the search for new anticancer drugs. XXV: Role of N-nitrosated amadori compounds derived from glucose-amino acid conjugates in cancer promotion or inhibition.
    Journal of pharmaceutical sciences, 1993, Volume: 82, Issue:6

    Topics: Amino Acids; Animals; Antineoplastic Agents; Carcinogenicity Tests; Carcinogens; Fluorouracil; Letha

1993
Effects of 5-fluorouracil and a combination of tegafur and uracil (UFT) on nucleotide metabolism in L1210 ascites tumor.
    Cancer investigation, 1993, Volume: 11, Issue:5

    Topics: Animals; Deoxyribonucleotides; Fluorouracil; Injections, Intraperitoneal; Leukemia L1210; Male; Mice

1993
Goralatide (AcSDKP) selectively protects murine hematopoietic progenitors and stem cells against hyperthermic damage.
    Experimental hematology, 1996, Volume: 24, Issue:2

    Topics: Amino Acid Sequence; Animals; Bone Marrow Purging; Cell Cycle; Cell Division; Cell Survival; Cells,

1996
Comparison of chemically induced DNA breakage in cellular and subcellular systems using the comet assay.
    Mutation research, 1996, Jul-10, Volume: 369, Issue:1-2

    Topics: 4-Nitroquinoline-1-oxide; Animals; Antimetabolites, Antineoplastic; Bleomycin; DNA; DNA Damage; Fluo

1996
Tiazofurin enhances the anabolism and toxicity of 5-fluorouracil.
    Cancer letters, 1996, Dec-03, Volume: 109, Issue:1-2

    Topics: Animals; Antimetabolites, Antineoplastic; Dose-Response Relationship, Drug; Drug Synergism; Enzyme I

1996
Synergistic effects of Actinobacillus suis cells in combination with 5-fluorouracil on mice bearing murine L1210 leukemia cells.
    Cancer immunology, immunotherapy : CII, 1997, Volume: 44, Issue:4

    Topics: Actinobacillus; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Combined Modality T

1997
5-Fluorouracil derivatives. XXII. Synthesis and antitumor activities of 1-carbamoyl-5-fluorouracils.
    Chemical & pharmaceutical bulletin, 1997, Volume: 45, Issue:8

    Topics: Animals; Antineoplastic Agents; Fluorouracil; Leukemia L1210; Male; Mice; Mice, Inbred Strains

1997
Structure-activity relationship in Ftorafur (Tegafur) and related 5-FU prodrugs.
    Advances in experimental medicine and biology, 1998, Volume: 431

    Topics: Animals; Antimetabolites, Antineoplastic; Fluorouracil; Humans; Indicators and Reagents; Leukemia L1

1998
Mechanism-based design of inosine 5-monophosphate dehydrogenase inhibitors: synthesis and biological activities of 5-ethynyl-1-beta-D-ribofuranosylimidazole-4-carboxamide (EICAR) and its derivatives.
    Current medicinal chemistry, 1999, Volume: 6, Issue:7

    Topics: Animals; Antineoplastic Agents; Catalysis; Drug Design; Fluorouracil; Humans; IMP Dehydrogenase; Inh

1999
Enhanced cytotoxic interaction between 5-fluorouracil and 4-hydroperoxycyclophosphamide against L1210 murine leukemic cells: applicability to ex vivo purging.
    Cancer investigation, 1999, Volume: 17, Issue:7

    Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherap

1999
Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer.
    Cancer research, 2000, Apr-01, Volume: 60, Issue:7

    Topics: Animals; Antineoplastic Agents; Apoptosis; Cornea; Cyclophosphamide; Drug Administration Schedule; D

2000
Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer.
    Cancer research, 2000, Apr-01, Volume: 60, Issue:7

    Topics: Animals; Antineoplastic Agents; Apoptosis; Cornea; Cyclophosphamide; Drug Administration Schedule; D

2000
Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer.
    Cancer research, 2000, Apr-01, Volume: 60, Issue:7

    Topics: Animals; Antineoplastic Agents; Apoptosis; Cornea; Cyclophosphamide; Drug Administration Schedule; D

2000
Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer.
    Cancer research, 2000, Apr-01, Volume: 60, Issue:7

    Topics: Animals; Antineoplastic Agents; Apoptosis; Cornea; Cyclophosphamide; Drug Administration Schedule; D

2000
Potentiatied antitumor effectiveness of combined chemo-immunotherapy with interleukin-12 and 5-fluorouracil of L1210 leukemia in vivo.
    Leukemia, 2001, Volume: 15, Issue:4

    Topics: Animals; Female; Fluorouracil; Interferon-gamma; Interleukin-12; Killer Cells, Natural; Leukemia L12

2001
Plasma, intestine and tumor levels of 5-fluorouracil in mice bearing L1210 ascites tumor following oral administration of 5-fluorouracil, UFT (mixed compound of tegafur and uracil), carmofur and 5'-deoxy-5-fluorouridine.
    Biological & pharmaceutical bulletin, 2001, Volume: 24, Issue:11

    Topics: Administration, Oral; Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Drug Combinations; F

2001
Dextran derivatives in single and combination chemotherapy against transplantable mouse ascites and solid tumors.
    Cancer research, 1977, Volume: 37, Issue:9

    Topics: Animals; Antibody Formation; Antineoplastic Agents; Bleomycin; Carcinoma, Ehrlich Tumor; Cells, Cult

1977
Synergistic effects of the combination of cis-platinum diamminodichloride and 2,2'-anhydro-1-beta-D-arabinofuranosyl-5-fluorocytosine in transplanted mouse leukemias.
    Cancer research, 1977, Volume: 37, Issue:11

    Topics: Ancitabine; Animals; Cells, Cultured; Cisplatin; Cytarabine; Drug Resistance; Drug Synergism; Drug T

1977
Metabolism of 5-fluorouracil in cultured cells. Protection from 5-fluorouracil cytotoxicity by purines.
    Molecular pharmacology, 1979, Volume: 15, Issue:2

    Topics: Animals; Antineoplastic Agents; B-Lymphocytes; Cells, Cultured; Fluorouracil; Haplorhini; Leukemia L

1979
Ftorafur: a self-limiting source of 5-fluorouracil?
    Cancer chemotherapy and pharmacology, 1979, Volume: 3, Issue:1

    Topics: Animals; Biotransformation; Fluorouracil; Hematopoietic Stem Cells; Lethal Dose 50; Leukemia L1210;

1979
Comparative physiologic dispositions of 5-fluoro-2'-deoxyuridine and 5-fluorouracil in mice bearing solid L1210 lymphocytic leukemia.
    Cancer treatment reports, 1976, Volume: 60, Issue:7

    Topics: Animals; Drug Administration Schedule; Floxuridine; Fluorouracil; Leukemia L1210; Mice

1976
Selectivity of action of 5-FU: biochemical basis.
    Bulletin du cancer, 1979, Volume: 66, Issue:1

    Topics: Animals; Colonic Neoplasms; Drug Resistance; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Humans

1979
Assay of intracellular free and macromolecular-bound metabolites of 5-fluorodeoxyuridine and 5-fluorouracil.
    Cancer research, 1979, Volume: 39, Issue:9

    Topics: Animals; Chromatography, Gel; Culture Techniques; Cytosol; Deoxyuracil Nucleotides; Floxuridine; Flu

1979
Combination chemotherapy of L1210 leukemia with platinum compounds and cyclophosphamide plus other selected antineoplastic agents.
    Journal of the National Cancer Institute, 1976, Volume: 57, Issue:6

    Topics: Animals; Cell Survival; Cisplatin; Cyclophosphamide; Cytarabine; Doxorubicin; Drug Evaluation, Precl

1976
In vivo enhancement of 5-fluorouracil cytotoxicity to AKR leukemia cells by thymidine in mice.
    Journal of the National Cancer Institute, 1978, Volume: 61, Issue:3

    Topics: Animals; Cell Survival; Colony-Forming Units Assay; Drug Synergism; Drug Therapy, Combination; Femal

1978
Synthesis and biological activity of 5-fluoro- and 5-methyl-1,3-oxazine-2,6(3H)-dione.
    Journal of medicinal chemistry, 1979, Volume: 22, Issue:5

    Topics: Animals; Cell Division; Culture Media; Drug Stability; Escherichia coli; Fluorouracil; In Vitro Tech

1979
Studies of the antitumor action of 5-fluorouracil (FU).
    Bulletin du cancer, 1979, Volume: 66, Issue:1

    Topics: Animals; Antineoplastic Agents; Bone Marrow; Carcinoma 256, Walker; Colonic Neoplasms; Deoxyuridine;

1979
A biochemical and pharmacological study of therapeutic synergism with 5-fluorouracil plus cyclophosphamide in murine L1210 leukemia.
    Cancer research, 1979, Volume: 39, Issue:4

    Topics: Animals; Body Weight; Bone Marrow; Cyclophosphamide; DNA, Neoplasm; Drug Synergism; Drug Therapy, Co

1979
Competitive binding radioassay for 5-fluorodeoxyuridine 5'-monophosphate in tissues.
    Cancer research, 1979, Volume: 39, Issue:7 Pt 1

    Topics: Animals; Binding, Competitive; Deoxyuracil Nucleotides; Fluorodeoxyuridylate; Fluorouracil; Half-Lif

1979
Enhanced 5-fluorouracil nucleotide formation after methotrexate administration: explanation for drug synergism.
    Science (New York, N.Y.), 1979, Sep-14, Volume: 205, Issue:4411

    Topics: Animals; Cells, Cultured; Drug Administration Schedule; Drug Synergism; Fluorouracil; Leukemia L1210

1979
The effect of 5-fluorouracil on the synthesis of nuclear RNA in L1210 cells in vitro.
    Molecular pharmacology, 1979, Volume: 16, Issue:1

    Topics: Animals; Cell Nucleus; Fluorouracil; In Vitro Techniques; Leukemia L1210; Methylation; Mice; Mice, I

1979
Combined therapy of L1210 leukemia with Damvar and cytostatics.
    Neoplasma, 1979, Volume: 26, Issue:5

    Topics: Animals; Antineoplastic Agents; Cyclophosphamide; Drug Therapy, Combination; Female; Fluorouracil; L

1979
Antitumor activity of methyl 1-(5-fluoro-1H-2-oxopyrimidin-4-yl)-beta-D-glucopyranuronate against murine leukemia L1210.
    Gan, 1978, Volume: 69, Issue:5

    Topics: Animals; Dose-Response Relationship, Drug; Drug Combinations; Fluorouracil; Glucose; Leukemia L1210;

1978
Partial synchronization of L1210 cells by 5-fluorouracil and its use in drug combinations.
    Cancer research, 1977, Volume: 37, Issue:9

    Topics: Animals; Cell Division; Cell Survival; Cytarabine; Doxorubicin; Drug Administration Schedule; Drug S

1977
Possibilities for a role of L-glutamine and L-asparagine antagonists in the treatment of gastrointestinal cancer.
    Cancer treatment reports, 1979, Volume: 63, Issue:6

    Topics: Animals; Asparagine; Azo Compounds; Drug Therapy, Combination; Fluorouracil; Gastrointestinal Neopla

1979
[Comparison of free ribonucleotide pool in the spleens of C57BL and DBA/2 mice and in leukemia cells sensitive and resistant to 5-fluorouracil].
    Biokhimiia (Moscow, Russia), 1978, Volume: 43, Issue:1

    Topics: Animals; Fluorouracil; Leukemia L1210; Leukemia, Experimental; Mice; Mice, Inbred C57BL; Mice, Inbre

1978
Antitumor activity of 1-alkylcarbamoyl derivatives of 5-fluorouracil against L1210 leukemia.
    Chemical & pharmaceutical bulletin, 1978, Volume: 26, Issue:1

    Topics: Animals; Female; Fluorouracil; Leukemia L1210; Mice; Structure-Activity Relationship

1978
Mode of action of 5-fluorouridine 5'-phosphate in vivo and in vitro.
    Chemical & pharmaceutical bulletin, 1978, Volume: 26, Issue:2

    Topics: Animals; Antimetabolites, Antineoplastic; Cells, Cultured; Cytarabine; Fluorouracil; Leukemia L1210;

1978
Combination chemotherapy: arriving at optimal treatment levels by incorporating side effect constraints.
    Cancer treatment reports, 1978, Volume: 62, Issue:3

    Topics: Animals; Carmustine; Cyclophosphamide; Drug Administration Schedule; Drug Therapy, Combination; Fema

1978
Effects of 5-fluorouracil on 5-fluorodeoxyuridine 5'-monophosphate and 2-deoxyuridine 5'-monophosphate pools, and DNA synthesis in solid mouse L1210 and rat Walker 256 tumors.
    Cancer research, 1978, Volume: 38, Issue:8

    Topics: Animals; Bone Marrow; Carcinoma 256, Walker; Deoxyuracil Nucleotides; Deoxyuridine; DNA, Neoplasm; D

1978
[Search for biochemical criteria of sensitivity and resistance of tumor cells to antimetabolites].
    Vestnik Akademii meditsinskikh nauk SSSR, 1978, Issue:5

    Topics: Animals; DNA, Neoplasm; Drug Resistance; Fluorouracil; Leukemia L1210; Leukemia, Experimental; Merca

1978
Potentiating action of 5-fluorouracil when used in combination with platinium compounds and cyclophosphamide in treatment of advanced L1210 leukemia.
    Bioinorganic chemistry, 1978, Volume: 8, Issue:5

    Topics: Animals; Cyclophosphamide; Drug Synergism; Fluorouracil; Leukemia L1210; Male; Mice; Mice, Inbred St

1978
Effect of ricin and abrin on survival of L1210 leukemic mice and on leukemic and normal bone-marrow cells.
    International journal of cancer, 1978, Nov-15, Volume: 22, Issue:5

    Topics: Abrin; Animals; Antineoplastic Agents; Bone Marrow Cells; Cell Line; Colony-Forming Units Assay; Dox

1978
Rationale of chemotherapeutic adjuvant treatment.
    Archiv fur Geschwulstforschung, 1978, Volume: 48, Issue:7

    Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Carmustine; Cyclophosphamide; Drug Admi

1978
A new anti-cancer principle isolated from Gymnosporia rothiana Laws, and its use in attaining cures in L1210 leukaemia in combination with "S" phase sensitive drugs.
    Biomedicine / [publiee pour l'A.A.I.C.I.G.], 1978, Volume: 28, Issue:5

    Topics: Animals; Antineoplastic Agents; Cytarabine; Drug Evaluation, Preclinical; Drug Synergism; Drug Thera

1978
Comparison of 5-fluorouracil and ftorafur. II. Therapeutic response and development of resistance in murine tumors.
    Cancer treatment reports, 1976, Volume: 60, Issue:9

    Topics: Animals; Carcinoma; Cell Line; Drug Resistance; Drug Therapy, Combination; Female; Fluorouracil; Leu

1976
In vivo cell synchrony in the L1210 mouse leukaemia studied with 5-fluorouracil or 5-fluorouracil followed by cold thymidine infusion.
    British journal of cancer, 1977, Volume: 35, Issue:5

    Topics: Animals; Cell Division; DNA; Female; Fluorouracil; Leukemia L1210; Mice; Mitotic Index; Neoplasm Tra

1977
A model for prediction of chemotherapy response to 5-fluorouracil based on the differential distribution of 5-[18F]fluorouracil in sensitive versus resistant lymphocytic leukemia in mice.
    Cancer research, 1977, Volume: 37, Issue:7 Pt 1

    Topics: Animals; Drug Resistance; Female; Fluorouracil; Leukemia L1210; Mice; Mice, Inbred C57BL; Mice, Inbr

1977
Combination chemotherapy with 4'Demethylepipodophyllotoxin 9-(4,6-0-ethylidene-beta-D-glucopyranoside), VP 16-213 (NSC 141540) in L1210 leukemia.
    European journal of cancer, 1976, Volume: 12, Issue:3

    Topics: Animals; Antineoplastic Agents; Carmustine; Cyclophosphamide; Cytarabine; Dactinomycin; Daunorubicin

1976
Deveopment of resistance to combinations of six antimetabolites in mice with L1210 leukemia.
    Cancer treatment reports, 1976, Volume: 60, Issue:1

    Topics: Animals; Antimetabolites, Antineoplastic; Cytarabine; Drug Administration Schedule; Drug Resistance;

1976
Antitumor activity of 1-hexylcarbamoyl-5-fluorouracil in a variety of experimental tumors.
    Gan, 1976, Volume: 67, Issue:5

    Topics: Adenocarcinoma; Administration, Oral; Animals; Ascites; Carcinoma, Ehrlich Tumor; Female; Fluorourac

1976
Experimental and clinical studies on nucleoside analogs as antitumor agents.
    Annals of the New York Academy of Sciences, 1975, Aug-08, Volume: 255

    Topics: Aged; Animals; Cytarabine; Drug Resistance; Flucytosine; Fluorouracil; Humans; Leukemia L1210; Leuke

1975
Offsetting toxicity of antineoplastic agents.
    Journal of surgical oncology, 1975, Volume: 7, Issue:5

    Topics: Animals; Biological Products; Bone Marrow; Bone Marrow Cells; Carcinoma, Krebs 2; Cells, Cultured; F

1975
Interaction of chemotherapeutic agents with methotrexate and 5-fluorouracil and its effect on de novo DNA synthesis.
    Cancer research, 1975, Volume: 35, Issue:3

    Topics: Animals; Bone Marrow; Bone Marrow Cells; Cephalosporins; Dexamethasone; DNA; DNA, Neoplasm; Fluorour

1975
In vitro biological evaluation of the R and S isomers of 1-(Tetrahydrofuran-2-yl)-5-fluorouracil.
    Cancer research, 1975, Volume: 35, Issue:5

    Topics: Animals; Cell Division; Cells, Cultured; Deoxyuridine; DNA, Neoplasm; Fibroblasts; Fluorouracil; Fur

1975
Antitumor activity of carbamoyl derivatives of 5-fluorouracil by oral administration.
    Gan, 1975, Volume: 66, Issue:6

    Topics: Administration, Oral; Animals; Carbamates; Fluorouracil; Leukemia L1210; Mice

1975
The inhibition of DNA synthesis by cannabinoids.
    Cancer research, 1976, Volume: 36, Issue:1

    Topics: Animals; Bone Marrow; Bone Marrow Cells; Cannabidiol; Cannabis; Cyclophosphamide; Cytarabine; DNA; D

1976
Antitumor activity of two novel low immunosuppressive fluoropyrimidines UK-21 and UK-25.
    Japanese journal of pharmacology, 1992, Volume: 59, Issue:4

    Topics: Administration, Oral; Animals; Antineoplastic Agents; Body Weight; Fluorouracil; Glycine; Leukemia L

1992
Cytotoxicity of three novel fluoropyrimidines in cultured L1210 murine lymphocytic leukemia cells.
    Pharmaceutical research, 1990, Volume: 7, Issue:12

    Topics: Animals; Drug Screening Assays, Antitumor; Fluorouracil; Leukemia L1210; Male; Mice; Microsomes, Liv

1990
The changes in the levels of dihydrofolate reductase mRNA and its gene dosage in 5-fluorouracil-resistant L1210 cells.
    The Tohoku journal of experimental medicine, 1990, Volume: 161, Issue:1

    Topics: Animals; Chromosome Aberrations; DNA, Neoplasm; Drug Resistance; Fluorouracil; Gene Amplification; L

1990
Synergistic antitumor effect of fluoropyrimidines and polyinosinic-polycytidylic acid against L1210 leukemia.
    Cancer research, 1985, Volume: 45, Issue:9

    Topics: 2',5'-Oligoadenylate Synthetase; Animals; Drug Synergism; Fluorouracil; Interferons; Leukemia L1210;

1985
The efficacy of combined therapy with methotrexate and 5-fluorouracil from the view point of cellular PRPP level of L1210 cells and HeLa S3 cells.
    The science reports of the research institutes, Tohoku University. Ser. C, Medicine. Tohoku Daigaku, 1985, Volume: 32, Issue:1-4

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule; Fluorouracil;

1985
Mechanisms of action of 5-fluorouracil on metabolism of RNA in special reference to polysome of L1210 cells.
    The science reports of the research institutes, Tohoku University. Ser. C, Medicine. Tohoku Daigaku, 1986, Volume: 33, Issue:1-4

    Topics: Animals; Cell Line; Fluorouracil; Leukemia L1210; Mice; Polyribosomes; Ribosomes; RNA; Tritium; Urid

1986
Biochemical and pharmacologic basis for potentiation of 5-fluorouracil action by leucovorin.
    NCI monographs : a publication of the National Cancer Institute, 1987, Issue:5

    Topics: Animals; Biotransformation; Cell Division; Colonic Neoplasms; DNA; Drug Synergism; Fluorouracil; Fol

1987
Transport and intracellular metabolism of fluorinated pyrimidines in cultured cell lines.
    Advances in experimental medicine and biology, 1989, Volume: 253B

    Topics: Animals; Biological Transport; Erythrocytes; Floxuridine; Fluorouracil; HeLa Cells; Humans; Leukemia

1989
Application of PHYCON 6600 to achieve sustained release of an antitumor drug (carmofur).
    Drug design and delivery, 1989, Volume: 5, Issue:2

    Topics: Animals; Antineoplastic Agents; Delayed-Action Preparations; Drug Implants; Excipients; Fluorouracil

1989
Assay and time course of 5-fluorouracil incorporation into RNA of L1210/0 ascites cells in vivo.
    Molecular pharmacology, 1985, Volume: 27, Issue:2

    Topics: Animals; Carbon Radioisotopes; DNA; Female; Fluorouracil; Kinetics; Leukemia L1210; Mice; Mice, Inbr

1985
The role of drug sequence in therapeutic selectivity of the combination of 5-fluorouracil and cis-platin.
    Selective cancer therapeutics, 1989,Winter, Volume: 5, Issue:4

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Colonic Neoplasms; Dose-Response

1989
The therapeutic effects of orally administered 5'-deoxy-5-fluorouridine, 1-(2-tetrahydrofuryl)-5-fluorouracil and 5-fluorouracil on experimental murine tumors.
    Japanese journal of cancer research : Gann, 1985, Volume: 76, Issue:10

    Topics: Animals; Antineoplastic Agents; Floxuridine; Fluorouracil; Leukemia L1210; Mice; Neoplasms, Experime

1985
Increased thymidylate synthase in L1210 cells possessing acquired resistance to N10-propargyl-5,8-dideazafolic acid (CB3717): development, characterization, and cross-resistance studies.
    Cancer research, 1986, Volume: 46, Issue:6

    Topics: Animals; Antineoplastic Agents; Cells, Cultured; Deoxyuridine; Drug Resistance; Floxuridine; Fluorou

1986
Modulation of the effects of fluoropyrimidines on toxicity and tumor inhibition in rodents by uridine and thymidine.
    Medical oncology and tumor pharmacotherapy, 1986, Volume: 3, Issue:2

    Topics: Animals; Dose-Response Relationship, Drug; Female; Floxuridine; Fluorouracil; Leukemia L1210; Lung N

1986
Folinic acid augmentation of the effects of fluoropyrimidines on murine and human leukemic cells.
    Cancer research, 1986, Volume: 46, Issue:10

    Topics: Animals; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Drug Synergism; Floxuridine; Fl

1986
[Effects of derivatives of Ara-C, 5-fluorouracil and nitrosourea against intracerebral implanted L1210 leukemia].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1987, Volume: 14, Issue:2

    Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Blood-Brain Barrier;

1987
[Conversion of 5'-deoxy-5-fluorouridine to 5-FU by pyrimidine nucleoside phosphorylases in normal and tumor tissues from rodents bearing tumors and cancer patients].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1987, Volume: 14, Issue:10

    Topics: Animals; Antineoplastic Agents; Carcinoma 256, Walker; Floxuridine; Fluorouracil; Humans; Leukemia L

1987
Biochemical rationale for the synergism of 5-fluorouracil and folinic acid.
    NCI monographs : a publication of the National Cancer Institute, 1987, Issue:5

    Topics: Animals; Cell Division; Cell Survival; Deoxyuracil Nucleotides; Drug Synergism; Floxuridine; Fluorou

1987
Mechanism of the cytotoxic synergism of fluoropyrimidines and folinic acid in mouse leukemic cells.
    The Journal of biological chemistry, 1988, Oct-05, Volume: 263, Issue:28

    Topics: Animals; Cell Survival; Drug Synergism; Floxuridine; Fluorouracil; Kinetics; Leucovorin; Leukemia L1

1988
5-Fluoro-5'-deoxyuridine is an inhibitor of uridylate nucleotidase in L1210 leukaemia.
    Advances in experimental medicine and biology, 1986, Volume: 195 Pt B

    Topics: 5'-Nucleotidase; Animals; Antimetabolites, Antineoplastic; Biotransformation; Cell Cycle; DNA, Neopl

1986
[FO-152].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1987, Volume: 14, Issue:7

    Topics: Absorption; Adenocarcinoma; Animals; Antineoplastic Agents; Cell Line; Dogs; Drug Evaluation; Female

1987
Therapeutic and pharmacological studies of tetrachloro(d,l-trans)1,2-diaminocyclohexane platinum (IV) (tetraplatin), a new platinum analogue.
    Cancer research, 1988, Apr-01, Volume: 48, Issue:7

    Topics: Animals; Antibiotics, Antineoplastic; Bile; Biological Transport; Drug Therapy, Combination; Fluorou

1988
[Enhanced antitumor action of 5-fluorouracil when used in combination with 4-methylmercaptopyrazolo[3,4-d]pyrimidine 1-nucleoside].
    Eksperimental'naia onkologiia, 1988, Volume: 10, Issue:4

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Dose-Response Relationship, Drug; Drug Eval

1988
A facile method for synthesis of N-acyloxymethyl-5-fluorouracils, as a class of antitumor agents.
    Chemical & pharmaceutical bulletin, 1987, Volume: 35, Issue:10

    Topics: Animals; Antineoplastic Agents; Chemical Phenomena; Chemistry; Fluorouracil; Leukemia L1210; Mice

1987
5-Fluorouracil derivatives. XII. Synthesis and antitumor activity of alpha-alkylthiomethyl-, alpha-alkylsulfinylmethyl-, alpha-alkylsulfonylmethyl-, and alpha-acylthiomethyl-5-fluorouracils.
    Chemical & pharmaceutical bulletin, 1987, Volume: 35, Issue:9

    Topics: Animals; Antineoplastic Agents; Chemical Phenomena; Chemistry; Fluorouracil; Leukemia L1210; Male; M

1987
Combination of 5-fluorouracil and cyclophosphamide in L1210 and P388 leukemias with changes in optimum treatments as a function of the age of the L1210 tumor at first treatment.
    Cancer investigation, 1987, Volume: 5, Issue:6

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Fluorouracil; Leukemia L1

1987
Approaches to overcome in vivo anti-cancer drug resistance.
    Progress in clinical and biological research, 1986, Volume: 223

    Topics: 3-Deazauridine; Animals; Antineoplastic Agents; Arabinofuranosylcytosine Triphosphate; Cell Line; Cy

1986
Sequential inhibitory effects of antitumor agents related to levodopa and dopamine upon DNA synthetic enzymes.
    Biochemical pharmacology, 1986, Jan-15, Volume: 35, Issue:2

    Topics: Animals; Antineoplastic Agents; Dopamine; Fluorouracil; Hydroxyurea; Kinetics; Leukemia L1210; Levod

1986
[The metabolism of high-molecular-weight substances in cells and the effect of anticancer drugs].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1987, Volume: 14, Issue:3 Pt 2

    Topics: Animals; DNA Repair; DNA Replication; Fluorouracil; Leukemia L1210; Methotrexate; Mice; Molecular We

1987
Synthesis and antitumor activity of 1- or 3-(alpha-hetero substituted)alkyl-5-fluorouracil derivatives.
    Nucleic acids symposium series, 1987, Issue:18

    Topics: Animals; Antineoplastic Agents; Fluorouracil; Indicators and Reagents; Leukemia L1210; Mice; Structu

1987
5-Fluorouracil derivatives. X. Synthesis and antitumor activities of alpha-alkoxyalkyl-5-fluorouracils.
    Chemical & pharmaceutical bulletin, 1986, Volume: 34, Issue:1

    Topics: Animals; Antineoplastic Agents; Fluorouracil; Leukemia L1210; Male; Mice; Mice, Inbred Strains

1986
The inhibitory effects of 5-fluorouracil on the metabolism of preribosomal and ribosomal RNA in L-1210 cells in vitro.
    Cancer chemotherapy and pharmacology, 1986, Volume: 17, Issue:1

    Topics: Animals; Cell Line; Centrifugation, Density Gradient; Fluorouracil; Leukemia L1210; Mice; RNA Proces

1986
Three alkaloids as selective destroyers of cancer cells in mice. Synergy with classic anticancer drugs.
    Oncology, 1986, Volume: 43, Issue:3

    Topics: Alkaloids; Animals; Antineoplastic Combined Chemotherapy Protocols; Daunorubicin; Drug Synergism; Fl

1986
Assessment of labeled 5-fluorouracils for nuclear scintigraphy.
    International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology, 1986, Volume: 13, Issue:3

    Topics: Animals; Carbon Radioisotopes; Fluorouracil; Leukemia L1210; Mice; Neoplasm Transplantation; Radionu

1986
Failure of L-histidinol to improve the therapeutic efficiency of 5-fluorouracil against murine breast tumors.
    Cancer research, 1987, Jan-01, Volume: 47, Issue:1

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Cell Cycle; Female; Fluorour

1987
Schedule-dependent antitumor and toxic effects of thymidine and 5-fluorouracil in AKR and L1210 leukemias.
    Cancer chemotherapy and pharmacology, 1986, Volume: 18, Issue:2

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Dose-Response Relationship, Drug; Female; F

1986
Histidinol-mediated enhancement of the specificity of two anticancer drugs in mice bearing leukemic bone marrow disease.
    Journal of the National Cancer Institute, 1985, Volume: 74, Issue:5

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Colony-Forming Units Assay; Cy

1985
Lack of enhanced cytotoxicity of cultured L1210 cells using folinic acid in combination with sequential methotrexate and fluorouracil.
    Cancer chemotherapy and pharmacology, 1985, Volume: 15, Issue:3

    Topics: Animals; Cell Survival; DNA Replication; Drug Interactions; Fluorouracil; Kinetics; Leucovorin; Leuk

1985
[Effects of combination chemotherapy of MCNU with various anti-cancer agents].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1985, Volume: 12, Issue:2

    Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Doxorubi

1985
[Biochemical modulation in cancer chemotherapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1985, Volume: 12, Issue:4

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Drug Synergism; Fluorouracil; H

1985
Timing- and sequence-dependent synergism between etoposide and methotrexate or etoposide, methotrexate and 5-fluorouracil in advanced leukemia L1210.
    Cancer letters, 1985, Volume: 29, Issue:3

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Drug Synergism; Etoposide; Female; Fluorour

1985
5-Fluorouracil derivatives. IX. Synthesis and antitumor activities of (alkylthio)carbonyl-5-fluorouracils.
    Chemical & pharmaceutical bulletin, 1985, Volume: 33, Issue:7

    Topics: Animals; Antineoplastic Agents; Chemical Phenomena; Chemistry; Fluorouracil; Leukemia L1210; Mice

1985
Analysis of serum protein changes in patients with advanced gastric cancer with special reference to -globulin fractions.
    Cancer research, 1972, Volume: 32, Issue:2

    Topics: Adrenocorticotropic Hormone; Alpha-Globulins; Animals; Blood Protein Electrophoresis; Cytarabine; Dr

1972
The enhanced therapeutic effect of cis-platinum (II) diamminodichloride against L1210 leukemia when combined with cyclophosphamide or 1,2-bis(3,5-dioxopiperazine-1-yl)propane or several other antitumor agents.
    Chemotherapy, 1973, Volume: 18, Issue:3

    Topics: Amines; Animals; Antineoplastic Agents; Azacitidine; Camptothecin; Carmustine; Chlorides; Cyclophosp

1973
Potentially useful combinations of chemotherapy detected in mouse tumor systems.
    Cancer chemotherapy reports. Part 2, 1974, Volume: 4, Issue:1

    Topics: Acetylcysteine; Animals; Antineoplastic Agents; Azauridine; Bleomycin; Camptothecin; Cyclic P-Oxides

1974
Letter: ICRF 159.
    Lancet (London, England), 1974, May-11, Volume: 1, Issue:7863

    Topics: Animals; Antimetabolites; Cyclophosphamide; Doxorubicin; Drug Synergism; Fluorouracil; Leukemia L121

1974
[Ethidium bromhydrate effect on L 1210 mouse leukemia].
    Comptes rendus hebdomadaires des seances de l'Academie des sciences. Serie D: Sciences naturelles, 1974, Sep-23, Volume: 279, Issue:13

    Topics: Animals; Cyclophosphamide; Dactinomycin; Daunorubicin; Doxorubicin; Ellipticines; Ethidium; Female;

1974
The physiological disposition of 5-fluorouracil in mice bearing solid L1210 lymphocytic leukemia.
    Cancer research, 1972, Volume: 32, Issue:5

    Topics: Animals; Bone Marrow; Brain; Carbon Isotopes; Cerebellum; Chromatography, Ion Exchange; Chromatograp

1972
5-Fluorouracil and derivatives in cancer chemotherapy. 3. In vivo enhancement of antitumor activity of 5-fluorouracil (FU) and 5-fluoro-2'-deoxyuridine (FUDR).
    Journal of pharmaceutical sciences, 1973, Volume: 62, Issue:12

    Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Chromatography, Thin Layer; Deoxycytidine; Deoxyurid

1973
Synthesis of 5-fluorouridine 5'-phosphate by a pyrimidine phosphoribosyltransferase of mammalian origin. II. Correlation between the tumor levels of the enzyme and the 5-fluorouracil-promoted increase in survival of tumor-bearing mice.
    Biochemical pharmacology, 1969, Volume: 18, Issue:10

    Topics: Animals; Fluorouracil; Leukemia L1210; Lymphoma; Mice; Neoplasm Transplantation; Neoplasms, Experime

1969
Synergistic effects of bis(3-methylsulfonyloxypropyl)-amine toluenesulfonate (864-T) with 6-mercaptopurine and other antitumor agents.
    Gan, 1973, Volume: 64, Issue:5

    Topics: Alkylating Agents; Animals; Antineoplastic Agents; Chromomycins; Cyclophosphamide; Cytarabine; Drug

1973
Proceedings: A comparison of the cell killing in the mouse after exposure to ftorafur and to 5-fluorouracil.
    British journal of cancer, 1974, Volume: 30, Issue:2

    Topics: Animals; Fluorouracil; Furans; Hematopoietic Stem Cells; Hydrolysis; Lethal Dose 50; Leukemia L1210;

1974
Antitumor activity of benzoyl and benzenesulfonyl derivatives of 5-fluorouracil.
    Gan, 1974, Volume: 65, Issue:5

    Topics: Animals; Antineoplastic Agents; Benzene Derivatives; Benzoates; Fluorouracil; Leukemia L1210; Mice;

1974
Sequential administration of two oncostatic drugs: study of modalities for pharmacodynamic potentiation.
    Biomedicine / [publiee pour l'A.A.I.C.I.G.], 1974, Dec-10, Volume: 21, Issue:12

    Topics: Animals; Antineoplastic Agents; Carmustine; Cyclophosphamide; Cytarabine; Dactinomycin; Drug Synergi

1974
Comparative chemotherapy of AKR lymphoma and human hematological neoplasia.
    Cancer research, 1974, Volume: 34, Issue:1

    Topics: Animals; Antineoplastic Agents; Biological Assay; Carmustine; Cyclohexanes; Cyclophosphamide; Cytara

1974
Characteristics and response to certain cancer chemotherapeutic agents of an acute lymphocytic leukemia arising in a BALB-c times DBA-2F1 mouse.
    Cancer research, 1974, Volume: 34, Issue:8

    Topics: Alkylating Agents; Animals; Antineoplastic Agents; Cyclophosphamide; Diethylamines; Disease Models,

1974
Combination chemotherapy: the interaction of methotrexate and 5-fluorouracil.
    European journal of cancer, 1973, Volume: 9, Issue:10

    Topics: Animals; Cell Line; Cells, Cultured; Drug Antagonism; Drug Interactions; Drug Therapy, Combination;

1973
Some determinants of drug responsiveness in bovine leukemia cells.
    Biochemical pharmacology, 1973, May-15, Volume: 22, Issue:10

    Topics: Animals; Antineoplastic Agents; Cattle; Cells, Cultured; Cytidine; Cytosine Nucleotides; Drug Resist

1973
Antileukemic synergism between cyclophosphamide and an antitumor platinum compound.
    Research communications in chemical pathology and pharmacology, 1973, Volume: 6, Issue:2

    Topics: Animals; Body Weight; Cisplatin; Cyclophosphamide; Drug Synergism; Drug Therapy, Combination; Fluoro

1973
Antileukemic properties of dichloro(1,2-diaminocyclohexane)platinum(II).
    Research communications in chemical pathology and pharmacology, 1974, Volume: 7, Issue:3

    Topics: Animals; Carcinoma, Ehrlich Tumor; Cells, Cultured; Cisplatin; Cyclophosphamide; DNA, Neoplasm; Drug

1974
Antitumor activity of cyclocytidine in a variety of tumors.
    Gan, 1972, Volume: 63, Issue:3

    Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Cell Line; Cyclization; Cy

1972
Enhanced response of leukemia (L1210) mice to combination chemotherapy with 5-(3,3-dimethyl-1-triazeno) imidazole-4-carboxamide (NSC-45388) and 5-fluorouracil (NSC-19893).
    Cancer, 1971, Volume: 27, Issue:6

    Topics: Animals; Azo Compounds; DNA, Neoplasm; Drug Synergism; Fluorouracil; Imidazoles; Leukemia L1210; Mal

1971
Lack of effect of warfarin (NSC-59813) alone or in combination with 5-fluorouracil (NSC-19893) on primary and metastatic L1210 leukemia and adenocarcinoma 755.
    Cancer chemotherapy reports, 1971, Volume: 55, Issue:1

    Topics: Adenocarcinoma; Animals; Female; Fluorouracil; Leukemia L1210; Mice; Neoplasm Metastasis; Neoplasm T

1971
Sequential biochemical alteration to antifolate resistance in L1210 leukaemia.
    Nature, 1967, Dec-23, Volume: 216, Issue:5121

    Topics: Animals; Biological Transport, Active; Cell Division; Cytogenetics; Drug Hypersensitivity; Fluoroura

1967
The effect of fluoxidine on L1210 leukemia in mice.
    Neoplasma, 1970, Volume: 17, Issue:2

    Topics: Animals; Antimetabolites; Fluorouracil; Leukemia L1210; Male; Mice; Pyrimidines; Time Factors

1970
Implications of biochemical, cytokinetic, pharmacologic, and toxicologic relationships in the design of optimal therapeutic schedules.
    Cancer chemotherapy reports, 1970, Volume: 54, Issue:6

    Topics: Animals; Antineoplastic Agents; Cyclophosphamide; Cytarabine; Dactinomycin; Daunorubicin; Disease Mo

1970
Dose-response curves for agents that impair cell reproductive integrity. The relation between dose-response curves and the design of selective regimens in cancer chemotherapy.
    British journal of cancer, 1969, Volume: 23, Issue:2

    Topics: Animals; Antineoplastic Agents; Cell Division; Cyclophosphamide; Fluorouracil; Growth; Hematopoietic

1969
The synergistic anti-neoplastic activity of combinations of mitomycins with either 6-thioguanine or 5-fluorouracil.
    Cancer research, 1965, Volume: 25, Issue:9

    Topics: Animals; Antineoplastic Agents; DNA, Neoplasm; Drug Synergism; Female; Fluorouracil; In Vitro Techni

1965
On the action of fluorouracil on leukemia cells.
    Cancer research, 1966, Volume: 26, Issue:8

    Topics: Animals; Culture Techniques; DNA, Neoplasm; Fluorouracil; Leukemia L1210; Mice; Phosphorus Isotopes;

1966
Growth of L1210 mouse leukemia cells in vitro.
    Experimental cell research, 1966, Volume: 42, Issue:1

    Topics: Animals; Chromosomes; Culture Techniques; Fluorouracil; Folic Acid; Leukemia L1210; Mercaptopurine;

1966
The antileukemic effectiveness of 5-fluorouracil and methotrexate in the combination chemotherapy of advanced leukemia L1210 in mice.
    Cancer research, 1966, Volume: 26, Issue:5

    Topics: Animals; Antineoplastic Agents; Fluorouracil; Leukemia L1210; Methotrexate; Mice

1966
Fate of amethopterin-resistant mutants in L1210 mouse leukemia populations.
    Cancer research, 1966, Volume: 26, Issue:5

    Topics: Animals; Drug Hypersensitivity; Fluorouracil; In Vitro Techniques; Leukemia L1210; Mercaptopurine; M

1966
Nucleosides. XXIX. 1-beta-D-arabinofuranosyl-5-fluorocytosine and related arabino nucleosides.
    Journal of medicinal chemistry, 1966, Volume: 9, Issue:1

    Topics: Animals; Arabinose; Chemistry, Organic; Cytosine; Fluorouracil; Furans; Idoxuridine; Keratitis, Dend

1966