fluorouracil has been researched along with Leukemia, Radiation-Induced in 7 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Leukemia, Radiation-Induced: Leukemia produced by exposure to IONIZING RADIATION or NON-IONIZING RADIATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Between 1974 and 1989, 1,474 patients with stage II or III breast cancer were treated in six prospective trials of adjuvant (n = 4) or neoadjuvant (n = 2) chemotherapy with fluorouracil, doxorubicin, and cyclophosphamide (CTX) (FAC) with or without other drugs." | 7.69 | Treatment-related leukemia in breast cancer patients treated with fluorouracil-doxorubicin-cyclophosphamide combination adjuvant chemotherapy: the University of Texas M.D. Anderson Cancer Center experience. ( Buzdar, AU; Diamandidou, E; Frye, D; Hortobagyi, GN; Smith, TL; Witjaksono, M, 1996) |
| "Between 1974 and 1989, 1,474 patients with stage II or III breast cancer were treated in six prospective trials of adjuvant (n = 4) or neoadjuvant (n = 2) chemotherapy with fluorouracil, doxorubicin, and cyclophosphamide (CTX) (FAC) with or without other drugs." | 3.69 | Treatment-related leukemia in breast cancer patients treated with fluorouracil-doxorubicin-cyclophosphamide combination adjuvant chemotherapy: the University of Texas M.D. Anderson Cancer Center experience. ( Buzdar, AU; Diamandidou, E; Frye, D; Hortobagyi, GN; Smith, TL; Witjaksono, M, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (71.43) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kara, O | 1 |
| Ozdemir, E | 1 |
| Arslan, C | 1 |
| Dogan, E | 1 |
| Altundag, K | 1 |
| Weldon, CB | 1 |
| Jaffe, BM | 1 |
| Kahn, MJ | 1 |
| Sack, H | 1 |
| Joshi, SV | 1 |
| Vaidya, SG | 1 |
| Nerurkar, VR | 1 |
| Soman, C | 1 |
| Lee, BC | 1 |
| Shav-Tal, Y | 1 |
| Peled, A | 1 |
| Gothelf, Y | 1 |
| Jiang, W | 1 |
| Toledo, J | 1 |
| Ploemacher, RE | 1 |
| Haran-Ghera, N | 1 |
| Zipori, D | 1 |
| Diamandidou, E | 1 |
| Buzdar, AU | 1 |
| Smith, TL | 1 |
| Frye, D | 1 |
| Witjaksono, M | 1 |
| Hortobagyi, GN | 1 |
| Sugimoto, K | 1 |
| Taniguchi, S | 1 |
| Ogata, H | 1 |
| Ikehara, S | 1 |
| Fujita, J | 1 |
| Mori, KJ | 1 |
7 other studies available for fluorouracil and Leukemia, Radiation-Induced
| Article | Year |
|---|---|
Acute promyelocytic leukemia in a young patient with breast cancer.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Epirubici | 2011 |
Therapy-induced leukemias and myelodysplastic syndromes after breast cancer treatment: an underemphasized clinical problem.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Breast Neoplasms; Carci | 2002 |
[Leukemia in patients with breast carcinoma after adjuvant chemotherapy and/or postoperative radiotherapy].
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvan | 1995 |
Treatment of gamma radiation-induced transplanted leukemia in ICRC mice by liposomally encapsulated 5-fluoro uracil.
Topics: Animals; Chemistry, Pharmaceutical; Disease Models, Animal; Drug Carriers; Drug Stability; Female; F | 1993 |
A hematopoietic organ-specific 49-kD nuclear antigen: predominance in immature normal and tumor granulocytes and detection in hematopoietic precursor cells.
Topics: Acute Disease; Animals; Antigens, Neoplasm; Bone Marrow; Cell Differentiation; Cell Nucleus; Cells, | 1996 |
Treatment-related leukemia in breast cancer patients treated with fluorouracil-doxorubicin-cyclophosphamide combination adjuvant chemotherapy: the University of Texas M.D. Anderson Cancer Center experience.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Dox | 1996 |
Production of a negative regulator of IL-3 by bone marrow cells in response to the supernatant of IL-3-producing STIL-3 leukemia cells.
Topics: Animals; Bone Marrow; Bone Marrow Cells; Colony-Forming Units Assay; Culture Media, Conditioned; Flu | 1992 |