fluorouracil and Leukemia, Myelomonocytic, Acute studies

fluorouracil and Leukemia, Myelomonocytic, Acute

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Leukemia, Myelomonocytic, Acute: A pediatric acute myeloid leukemia involving both myeloid and monocytoid precursors. At least 20% of non-erythroid cells are of monocytic origin.

Research Excerpts

Excerpt	Relevance	Reference
"We report a breast cancer patient who developed acute myeloid leukemia (AML) one year following her adjuvant chemotherapy consisting of cyclophosphamide, adriamycin and 5-fluorouracil."	3.73	t(8;16) AML developed subsequent to breast cancer therapy. ( Akçali, Z; Boğa, S; DemIrhan, B; Karakuş, S; Sahin, FI; Yilmaz, Z, 2006)

Research

Studies (3)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	1 (33.33)	18.2507
2000's	2 (66.67)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Timeframe

Studies, this research(%)

All Research%

pre-1990

0 (0.00)

18.7374

1990's

1 (33.33)

18.2507

2000's

2 (66.67)

29.6817

2010's

0 (0.00)

24.3611

2020's

0 (0.00)

2.80

Authors

Authors	Studies
Bonneterre, JM	1
Sahin, FI	1
Yilmaz, Z	1
Karakuş, S	1
Boğa, S	1
Akçali, Z	1
DemIrhan, B	1
Xia, T	1
Jiang, D	1

Studies

Bonneterre, JM

Sahin, FI

Yilmaz, Z

Karakuş, S

Boğa, S

Akçali, Z

DemIrhan, B

Xia, T

Jiang, D

Trials

1 trial available for fluorouracil and Leukemia, Myelomonocytic, Acute

Article	Year
Long-term efficacy and toxicity of the FEC100 regimen. Oncology (Williston Park, N.Y.), 2004, Volume: 18, Issue:14 Suppl 1 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cost-Benefit Analysis	2004

Article

Year

Long-term efficacy and toxicity of the FEC100 regimen.

Oncology (Williston Park, N.Y.), 2004, Volume: 18, Issue:14 Suppl 1

Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cost-Benefit Analysis

2004

Other Studies

2 other studies available for fluorouracil and Leukemia, Myelomonocytic, Acute

Article	Year
t(8;16) AML developed subsequent to breast cancer therapy. Hematology (Amsterdam, Netherlands), 2006, Volume: 11, Issue:3 Topics: Anastrozole; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Bone M	2006
[Culture of murine HPP-CFC in vitro using conditioned medium substitutefor recombinant growth factors]. Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University, 1998, Volume: 23, Issue:2 Topics: Animals; Cells, Cultured; Culture Media, Conditioned; Female; Fluorouracil; Granulocyte-Macrophage C	1998

Article

Year

t(8;16) AML developed subsequent to breast cancer therapy.

Hematology (Amsterdam, Netherlands), 2006, Volume: 11, Issue:3

Topics: Anastrozole; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Bone M

2006

[Culture of murine HPP-CFC in vitro using conditioned medium substitutefor recombinant growth factors].

Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University, 1998, Volume: 23, Issue:2

Topics: Animals; Cells, Cultured; Culture Media, Conditioned; Female; Fluorouracil; Granulocyte-Macrophage C

1998