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fluorouracil and Leukemia, Myeloid, Acute, M4

fluorouracil has been researched along with Leukemia, Myeloid, Acute, M4 in 3 studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Research Excerpts

ExcerptRelevanceReference
"We report a breast cancer patient who developed acute myeloid leukemia (AML) one year following her adjuvant chemotherapy consisting of cyclophosphamide, adriamycin and 5-fluorouracil."3.73t(8;16) AML developed subsequent to breast cancer therapy. ( Akçali, Z; Boğa, S; DemIrhan, B; Karakuş, S; Sahin, FI; Yilmaz, Z, 2006)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (33.33)18.2507
2000's2 (66.67)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bonneterre, JM1
Sahin, FI1
Yilmaz, Z1
Karakuş, S1
Boğa, S1
Akçali, Z1
DemIrhan, B1
Xia, T1
Jiang, D1

Trials

1 trial available for fluorouracil and Leukemia, Myeloid, Acute, M4

ArticleYear
Long-term efficacy and toxicity of the FEC100 regimen.
    Oncology (Williston Park, N.Y.), 2004, Volume: 18, Issue:14 Suppl 1

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cost-Benefit Analysis

2004

Other Studies

2 other studies available for fluorouracil and Leukemia, Myeloid, Acute, M4

ArticleYear
t(8;16) AML developed subsequent to breast cancer therapy.
    Hematology (Amsterdam, Netherlands), 2006, Volume: 11, Issue:3

    Topics: Anastrozole; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Bone M

2006
[Culture of murine HPP-CFC in vitro using conditioned medium substitutefor recombinant growth factors].
    Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University, 1998, Volume: 23, Issue:2

    Topics: Animals; Cells, Cultured; Culture Media, Conditioned; Female; Fluorouracil; Granulocyte-Macrophage C

1998