fluorouracil has been researched along with Leukemia, Myeloid, Acute, M4 in 3 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Excerpt | Relevance | Reference |
---|---|---|
"We report a breast cancer patient who developed acute myeloid leukemia (AML) one year following her adjuvant chemotherapy consisting of cyclophosphamide, adriamycin and 5-fluorouracil." | 3.73 | t(8;16) AML developed subsequent to breast cancer therapy. ( Akçali, Z; Boğa, S; DemIrhan, B; Karakuş, S; Sahin, FI; Yilmaz, Z, 2006) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 1 (33.33) | 18.2507 |
2000's | 2 (66.67) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Bonneterre, JM | 1 |
Sahin, FI | 1 |
Yilmaz, Z | 1 |
Karakuş, S | 1 |
Boğa, S | 1 |
Akçali, Z | 1 |
DemIrhan, B | 1 |
Xia, T | 1 |
Jiang, D | 1 |
1 trial available for fluorouracil and Leukemia, Myeloid, Acute, M4
Article | Year |
---|---|
Long-term efficacy and toxicity of the FEC100 regimen.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cost-Benefit Analysis | 2004 |
2 other studies available for fluorouracil and Leukemia, Myeloid, Acute, M4
Article | Year |
---|---|
t(8;16) AML developed subsequent to breast cancer therapy.
Topics: Anastrozole; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Bone M | 2006 |
[Culture of murine HPP-CFC in vitro using conditioned medium substitutefor recombinant growth factors].
Topics: Animals; Cells, Cultured; Culture Media, Conditioned; Female; Fluorouracil; Granulocyte-Macrophage C | 1998 |