fluorouracil has been researched along with Leukemia, Lymphocytic in 31 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Human lymphocytic leukemia CCRF-CEM cells were exposed to MTX or TMTX for 24 hours and to 5-FU during the last 4 hours of antifolate exposure." | 1.28 | Leucovorin enhances cytotoxicity of trimetrexate/fluorouracil, but not methotrexate/fluorouracil, in CCRF-CEM cells. ( Bertino, JR; Colofiore, JR; Li, WW; Romanini, A, 1992) |
| "A line of human lymphocytic leukemia cells (CCRF-CEM) has been obtained which is 140-fold resistant to the potent cell growth inhibitor 5-fluoro-2'-deoxyuridine (FdUrd)." | 1.27 | Human leukemic cells resistant to 5-fluoro-2'-deoxyuridine contain a thymidylate synthetase with lower affinity for nucleotides. ( Bapat, AR; Danenberg, PV; Zarow, C, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 29 (93.55) | 18.7374 |
| 1990's | 2 (6.45) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lee, KH | 1 |
| Mar, EC | 1 |
| Okamoto, M | 1 |
| Hall, IH | 1 |
| ROOSA, RA | 1 |
| BRADLEY, TR | 1 |
| LAW, LW | 1 |
| HERZENBERG, LA | 1 |
| CHIRIGOS, MA | 1 |
| RAUSCHER, FJ | 1 |
| KAMEL, IA | 1 |
| FANNING, GR | 1 |
| GOLDIN, A | 2 |
| FALKSON, G | 1 |
| SNYMAN, HJ | 1 |
| Bapat, AR | 1 |
| Zarow, C | 1 |
| Danenberg, PV | 1 |
| Bertino, JR | 5 |
| Joshi, SV | 1 |
| Vaidya, SG | 1 |
| Nerurkar, VR | 1 |
| Soman, C | 1 |
| Romanini, A | 1 |
| Li, WW | 1 |
| Colofiore, JR | 1 |
| Lowenthal, RM | 1 |
| Jestrimski, KW | 1 |
| Bertrand, R | 1 |
| Jolivet, J | 1 |
| Mini, E | 3 |
| Moroson, BA | 2 |
| Mazzei, T | 1 |
| Coronnello, M | 1 |
| Criscuoli, L | 1 |
| Gualtieri, M | 1 |
| Periti, P | 1 |
| Dombrowski, J | 1 |
| Veselỳ, J | 1 |
| Cihák, A | 1 |
| Grignani, F | 1 |
| Martelli, M | 1 |
| Tonato, M | 1 |
| Danieli, G | 1 |
| Rieche, K | 1 |
| Arndt, A | 1 |
| Bergsagel, DE | 1 |
| Frei, E | 1 |
| Schabel, FM | 1 |
| Yancey, ST | 1 |
| Bleyer, WA | 1 |
| Miller, DR | 1 |
| Sonley, M | 1 |
| Karon, M | 1 |
| Breslow, N | 1 |
| Hammond, D | 1 |
| Tattersall, MH | 2 |
| Jackson, RC | 1 |
| Connors, TA | 1 |
| Harrap, KR | 2 |
| Wilmanns, W | 1 |
| Carević, O | 1 |
| Sverko, V | 1 |
| Boranić, M | 1 |
| Wodinsky, I | 1 |
| Swiniarski, J | 1 |
| Kensler, CJ | 1 |
| Venditti, JM | 1 |
| Goto, M | 1 |
| Muramoto, S | 1 |
| Nakagaki, K | 1 |
| Benckhuijsen, C | 1 |
| Goldfinger, D | 1 |
| McGinniss, MH | 1 |
| Brambilla, G | 1 |
| Caraceni, CE | 1 |
| Cavanna, M | 1 |
| Parodi, S | 1 |
5 reviews available for fluorouracil and Leukemia, Lymphocytic
| Article | Year |
|---|---|
Corticosteroid drugs: their role in oncological practice.
Topics: Adrenal Cortex Hormones; Animals; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Breast | 1986 |
Resistance of mammalian tumour cells toward pyrimidine analogues. A review.
Topics: Animals; Antimetabolites; Azacitidine; Azauridine; Bromouracil; Carcinoma, Ehrlich Tumor; Cell Line; | 1973 |
An assessment of massive-dose chemotherapy of malignant disease.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Bone Marrow; Bone Marrow Cells; Cell Division; Cyclo | 1971 |
[Current status of cytostatic therapy].
Topics: Adrenal Cortex Hormones; Alkylating Agents; Antibiotics, Antineoplastic; Antineoplastic Agents; Cyta | 1974 |
Chemotherapy and the life cycle of leukaemic cells. A comparison between the growth characteristics of human acute leukaemia and the murine leukaemia L 1210.
Topics: Anilides; Animals; Cell Division; Cyclophosphamide; Cytarabine; DNA, Neoplasm; Fluorouracil; Humans; | 1969 |
1 trial available for fluorouracil and Leukemia, Lymphocytic
| Article | Year |
|---|---|
Remission induction in childhood leukemia with second course vincristine (NSC-67574) and prednisone (NSC-10023) therapy.
Topics: Adolescent; Antibiotics, Antineoplastic; Child; Child, Preschool; Clinical Trials as Topic; Colonic | 1970 |
25 other studies available for fluorouracil and Leukemia, Lymphocytic
| Article | Year |
|---|---|
Antitumor agents 32. Synthesis and antitumor activity of cyclopentenone derivatives related to helenalin.
Topics: Animals; Antineoplastic Agents, Phytogenic; Carcinoma 256, Walker; Cells, Cultured; Cyclopentanes; L | 1978 |
Characterization of resistance to amethopterin, 8-azaguanine and several fluorinated pyrimidines in the murine lymphocytic neoplasm, P388.
Topics: Animals; Antineoplastic Agents; Azaguanine; Fluorouracil; Leukemia; Leukemia, Lymphoid; Lymphoma; Me | 1962 |
STUDIES WITH THE MURINE LEUKEMOGENIC RAUSCHER VIRUS. II. CHEMOTHERAPY OF VIRUS-INDUCED LYMPHOID LEUKEMIA.
Topics: Animals; Antineoplastic Agents; Antiviral Agents; Cyclophosphamide; Fluorouracil; Leukemia; Leukemia | 1963 |
EXPERIENCE WITH CHEMOTHERAPY OF CANCER AT THE UNIVERSITY OF PRETORIA.
Topics: Antineoplastic Agents; Aziridines; Breast Neoplasms; Cyclophosphamide; Dactinomycin; Fluorouracil; H | 1964 |
Human leukemic cells resistant to 5-fluoro-2'-deoxyuridine contain a thymidylate synthetase with lower affinity for nucleotides.
Topics: Cell Line; Deoxyribonucleotides; Drug Resistance; Floxuridine; Fluorouracil; Humans; Kinetics; Leuke | 1983 |
Clinical use of methotrexate--with emphasis on use of high doses.
Topics: Animals; Asparaginase; Brain Diseases; Child, Preschool; Cisplatin; Cytarabine; Drug Administration | 1981 |
Treatment of gamma radiation-induced transplanted leukemia in ICRC mice by liposomally encapsulated 5-fluoro uracil.
Topics: Animals; Chemistry, Pharmaceutical; Disease Models, Animal; Drug Carriers; Drug Stability; Female; F | 1993 |
Leucovorin enhances cytotoxicity of trimetrexate/fluorouracil, but not methotrexate/fluorouracil, in CCRF-CEM cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cell Survival; Dose-Response Relationship, Drug; Dru | 1992 |
Lack of interference by the unnatural isomer of 5-formyltetrahydrofolate with the effects of the natural isomer in leucovorin preparations.
Topics: Cell Division; Drug Synergism; Fluorouracil; Humans; Leucovorin; Leukemia, Lymphoid; Stereoisomerism | 1989 |
Cytotoxicity of floxuridine and 5-fluorouracil in human T-lymphoblast leukemia cells: enhancement by leucovorin.
Topics: Cell Division; Cell Line; Cell Survival; Drug Synergism; Floxuridine; Fluorouracil; Humans; Leucovor | 1987 |
Effects of 5-methyltetrahydrofolate on the activity of fluoropyrimidines against human leukemia (CCRF-CEM) cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cell Division; Cell Line; Dose-Response Relationship | 1987 |
Cytotoxic effects of hyperthermia, 5-fluorouracil and their combination on a human leukemia T-lymphoblast cell line, CCRF-CEM.
Topics: Cell Line; Combined Modality Therapy; Fluorouracil; Humans; Hyperthermia, Induced; In Vitro Techniqu | 1986 |
[Antimetabolites in the treatment of acute human leukoses. Mechanism of action and conditioning factors in the cellular response to drugs. II].
Topics: Antimetabolites; Azacitidine; Azaguanine; Azauridine; Cell Membrane Permeability; Cytarabine; DNA, N | 1974 |
[1973 treatment of acute leukemias].
Topics: Chlorambucil; Colchicine; Cyclophosphamide; Cytarabine; Dactinomycin; Daunorubicin; Doxorubicin; Dru | 1974 |
[The effect of the clinically usual cytostatic therapy on cell-mediated immune reactions in tumor patients].
Topics: Breast Neoplasms; Bronchial Neoplasms; Cell Migration Inhibition; Cyclophosphamide; Drug Therapy, Co | 1973 |
Comparative chemotherapy of AKR lymphoma and human hematological neoplasia.
Topics: Animals; Antineoplastic Agents; Biological Assay; Carmustine; Cyclohexanes; Cyclophosphamide; Cytara | 1974 |
Characteristics and response to certain cancer chemotherapeutic agents of an acute lymphocytic leukemia arising in a BALB-c times DBA-2F1 mouse.
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Cyclophosphamide; Diethylamines; Disease Models, | 1974 |
Additive therapy in the maintenance of remission in acute lymphoblastic leukemia of childhood: the effect of the initial leukocyte count.
Topics: Adolescent; Age Factors; Blood; Brain Neoplasms; Child; Child, Preschool; Dactinomycin; Digestive Sy | 1974 |
Combination chemotherapy: the interaction of methotrexate and 5-fluorouracil.
Topics: Animals; Cell Line; Cells, Cultured; Drug Antagonism; Drug Interactions; Drug Therapy, Combination; | 1973 |
Changes in the deoxyribonucleoside triphosphate pools of mouse 5178Y lymphoma cells following exposure to methotrexate or 5-fluorouracil.
Topics: Adenosine Triphosphate; Animals; Cell Line; Cells, Cultured; Deoxyadenosines; Deoxycytidine; Deoxyri | 1973 |
Effect of Ftorafur on acid phosphatase activity in the liver of mice with transplanted lymphatic leukaemia.
Topics: Acid Phosphatase; Animals; Female; Fluorouracil; Leukemia, Experimental; Leukemia, Lymphoid; Liver; | 1974 |
Combination radiotherapy and chemotherapy for P388 lymphocytic leukemia in vivo.
Topics: Alanine; Animals; Cisplatin; Cobalt Radioisotopes; Cyclophosphamide; Cytarabine; Female; Fluorouraci | 1974 |
[Experience with 5-fluorouracil in malignant skin tumors].
Topics: Adult; Aged; Female; Fluorouracil; Humans; Leukemia, Lymphoid; Lymphoma, Large B-Cell, Diffuse; Male | 1967 |
Rh-incompatible platelet transfusions--risks and consequences of sensitizing immunosuppressed patients.
Topics: Adolescent; Adult; Aged; Anemia, Aplastic; Antibodies; Antibody Formation; Blood Group Incompatibili | 1971 |
[Evaluation, in newborn Swiss mice, of the carcinogenic activity of some antineoplastic and immunosuppressive compounds].
Topics: Adenoma; Animals; Animals, Newborn; Antineoplastic Agents; Asparaginase; Azathioprine; Fluorouracil; | 1971 |