fluorouracil has been researched along with Leukemia, Erythroblastic, Acute in 14 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Leukemia, Erythroblastic, Acute: A myeloproliferative disorder characterized by neoplastic proliferation of erythroblastic and myeloblastic elements with atypical erythroblasts and myeloblasts in the peripheral blood.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We used three different erythroleukemia cell lines in which COX-2 expression was modulated by transfection with either COX-2 siRNA or COX-2 cDNA." | 1.39 | Cyclooxygenase-2 positively regulates Akt signalling and enhances survival of erythroleukemia cells exposed to anticancer agents. ( Beneytout, JL; Bertrand, J; Ghezali, L; Leger, DY; Liagre, B, 2013) |
| "5-Fluorouracil (5-FU) is a chemotherapeutic agent known to retard embryonic growth and induce cleft palate and limb deformities." | 1.30 | Nucleoside-mediated mitigation of 5-fluorouracil-induced toxicity in synchronized murine erythroleukemic cells. ( Elstein, KH; Kavlock, RJ; Lau, C; Mole, ML; Rogers, JM; Setzer, RW; Zucker, RM, 1997) |
| "In exponentially growing human erythroleukemia cells (HEL), the addition of PF 4 prolonged cell cycle progression and therefore resulted in an increased cell population in S phase, as determined by flow cytometric analysis." | 1.29 | [Platelet factor 4 acts as both inhibitor and protector of hematopoietic precursor cells: possible mechanism of action]. ( Caen, JP; Gu, GL; Han, ZC; Jiang, LZ; Jiang, S; Lu, M; Wang, XM; Xi, XD; Zhang, XJ, 1995) |
| "Thirteen cases of acute nonlymphocytic leukemia occurred among 5455 patients, as compared to 0." | 1.26 | Acute leukemia after alkylating-agent therapy of ovarian cancer. ( Fraumeni, JF; Hoover, R; Reimer, RR; Young, RC, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (35.71) | 18.7374 |
| 1990's | 7 (50.00) | 18.2507 |
| 2000's | 1 (7.14) | 29.6817 |
| 2010's | 1 (7.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bertrand, J | 1 |
| Liagre, B | 1 |
| Ghezali, L | 1 |
| Beneytout, JL | 1 |
| Leger, DY | 1 |
| Giuntoli, S | 1 |
| Rovida, E | 1 |
| Gozzini, A | 1 |
| Barbetti, V | 1 |
| Cipolleschi, MG | 1 |
| Olivotto, M | 1 |
| Dello Sbarba, P | 1 |
| Waxman, S | 2 |
| Bruckner, H | 1 |
| Yang, YW | 1 |
| Chang, YH | 1 |
| Elstein, KH | 2 |
| Zucker, RM | 2 |
| Shuey, DL | 1 |
| Lau, C | 2 |
| Chernoff, N | 1 |
| Rogers, JM | 2 |
| Han, ZC | 1 |
| Zhang, XJ | 1 |
| Xi, XD | 1 |
| Lu, M | 1 |
| Jiang, S | 1 |
| Jiang, LZ | 1 |
| Wang, XM | 1 |
| Gu, GL | 1 |
| Caen, JP | 1 |
| Mole, ML | 1 |
| Setzer, RW | 1 |
| Kavlock, RJ | 1 |
| Feng, J | 1 |
| Ci, YX | 1 |
| Lou, JL | 1 |
| Zhang, XQ | 1 |
| Reimer, RR | 1 |
| Hoover, R | 1 |
| Fraumeni, JF | 1 |
| Young, RC | 1 |
| Jin, YZ | 1 |
| Ding, L | 1 |
| Shen, ZF | 1 |
| Cai, RM | 1 |
| Xu, LM | 1 |
| Yang, JK | 1 |
| Jin, XQ | 1 |
| Lu, WQ | 1 |
| Xu, JF | 1 |
| Scher, BM | 1 |
| Hellinger, N | 1 |
| Scher, W | 1 |
| Pályi, I | 1 |
| Gresser, I | 1 |
| Maury, C | 1 |
| Belardelli, F | 1 |
| Maunoury, MT | 1 |
| Machover, D | 1 |
| Iwata, T | 1 |
| Watanabe, T | 1 |
| Kufe, DW | 1 |
14 other studies available for fluorouracil and Leukemia, Erythroblastic, Acute
| Article | Year |
|---|---|
Cyclooxygenase-2 positively regulates Akt signalling and enhances survival of erythroleukemia cells exposed to anticancer agents.
Topics: Apoptosis; Arsenic Trioxide; Arsenicals; Casein Kinase II; Cell Line, Tumor; Cell Proliferation; Cel | 2013 |
Severe hypoxia defines heterogeneity and selects highly immature progenitors within clonal erythroleukemia cells.
Topics: Animals; Apoptosis; Cell Cycle; Cell Hypoxia; Cell Line, Tumor; Clone Cells; Colony-Forming Units As | 2007 |
The enhancement of 5-fluorouracil anti-metabolic activity by leucovorin, menadione and alpha-tocopherol.
Topics: Animals; Antimetabolites; Cell Count; Cell Division; Cell Line; Deoxyuridine; DNA, Neoplasm; Dose-Re | 1982 |
Induction of erythroid differentiation by 5-fluorouracil in K562 leukemia cells.
Topics: Cell Differentiation; Cell Division; Erythropoiesis; Fluorouracil; Fusion Proteins, bcr-abl; Gene Ex | 1995 |
Utility of the murine erythroleukemic cell (MELC) in assessing mechanisms of action of DNA-active developmental toxicants: application to 5-fluorouracil.
Topics: Animals; Azacitidine; Cell Cycle; Cell Survival; Culture Techniques; Cyclophosphamide; Decitabine; D | 1993 |
[Platelet factor 4 acts as both inhibitor and protector of hematopoietic precursor cells: possible mechanism of action].
Topics: Animals; Antigens, CD34; Antimetabolites, Antineoplastic; Coagulants; Colony-Forming Units Assay; Fe | 1995 |
Nucleoside-mediated mitigation of 5-fluorouracil-induced toxicity in synchronized murine erythroleukemic cells.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Cycle; Deoxycytidine; Deoxyguanine Nucleotides; Embry | 1997 |
Voltammetric behavior of mammalian tumor cells and bioanalytical applications in cell metabolism.
Topics: Antimetabolites, Antineoplastic; Buffers; Cell Division; Cell Membrane; Electrodes; Electrophysiolog | 1999 |
Acute leukemia after alkylating-agent therapy of ovarian cancer.
Topics: Acute Disease; Alkylating Agents; Altretamine; Chlorambucil; Cyclophosphamide; Female; Fluorouracil; | 1977 |
Effects of glutathione depletion using buthionine sulphoximine on the cytotoxicity in mammalian cells and human tumor cells in vitro.
Topics: Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Buthionine Sulfoximine; Cell Hypoxia; | 1992 |
Combination cytotoxic-differentiation therapy of mouse erythroleukemia cells with 5-fluorouracil and hexamethylene bisacetamide.
Topics: Acetamides; Animals; Cell Count; Cell Differentiation; Cell Division; Dexamethasone; Dimethyl Sulfox | 1990 |
Heterogeneity of the response to inducers of differentiation and to cytostatics of tumor cell populations.
Topics: Antineoplastic Agents; Cell Differentiation; Cisplatin; Cytarabine; Dacarbazine; Dimethyl Sulfoxide; | 1988 |
Effectiveness of mouse interferon alpha/beta compared to single-agent chemotherapy in increasing survival time of mice after intravenous inoculation of Friend erythroleukemia cells.
Topics: Animals; Antineoplastic Agents; Fluorouracil; Friend murine leukemia virus; Interferon Type I; Leuke | 1988 |
Effects of 5-fluorouracil on globin mRNA synthesis in murine erythroleukemia cells.
Topics: Animals; Cell Line; Dimethyl Sulfoxide; Fluorouracil; Globins; Kinetics; Leukemia, Erythroblastic, A | 1986 |