fluorouracil has been researched along with Lethargy in 2 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Lethargy: A general state of sluggishness, listless, or uninterested, with being tired, and having difficulty concentrating and doing simple tasks. It may be related to DEPRESSION or DRUG ADDICTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In this multicentre, open-label, phase III, randomised controlled trial, 4162 women (aged >18 years) with node-positive or high-risk node-negative operable early breast cancer were randomly assigned by computer-generated permuted block randomisation to receive FEC (fluorouracil 600 mg/m(2), epirubicin 60 mg/m(2), cyclophosphamide 600 mg/m(2) at 3-weekly intervals) for four cycles followed by docetaxel (100 mg/m(2) at 3-weekly intervals) for four cycles (n=2073) or control (n=2089)." | 5.14 | Sequential docetaxel as adjuvant chemotherapy for early breast cancer (TACT): an open-label, phase III, randomised controlled trial. ( Barrett-Lee, P; Bartlett, JM; Bliss, JM; Bloomfield, D; Cameron, D; Canney, P; Coleman, R; Dowsett, M; Earl, H; Ellis, I; Ellis, P; Hall, E; Hopwood, P; Johnson, L; Johnston, S; O'Reilly, S; Peckitt, C; Poole, C; Smith, I; Twelves, C; Verrill, M; Wardley, A; Yarnold, J, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hubner, RA | 1 |
| Worsnop, F | 1 |
| Cunningham, D | 1 |
| Chau, I | 1 |
| Ellis, P | 1 |
| Barrett-Lee, P | 1 |
| Johnson, L | 1 |
| Cameron, D | 1 |
| Wardley, A | 1 |
| O'Reilly, S | 1 |
| Verrill, M | 1 |
| Smith, I | 1 |
| Yarnold, J | 1 |
| Coleman, R | 1 |
| Earl, H | 1 |
| Canney, P | 1 |
| Twelves, C | 1 |
| Poole, C | 1 |
| Bloomfield, D | 1 |
| Hopwood, P | 1 |
| Johnston, S | 1 |
| Dowsett, M | 1 |
| Bartlett, JM | 1 |
| Ellis, I | 1 |
| Peckitt, C | 1 |
| Hall, E | 1 |
| Bliss, JM | 1 |
1 trial available for fluorouracil and Lethargy
| Article | Year |
|---|---|
Sequential docetaxel as adjuvant chemotherapy for early breast cancer (TACT): an open-label, phase III, randomised controlled trial.
Topics: Adult; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Belgium; Breast Neopla | 2009 |
1 other study available for fluorouracil and Lethargy
| Article | Year |
|---|---|
Gemcitabine plus capecitabine in unselected patients with advanced pancreatic cancer.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Deoxyc | 2013 |