Page last updated: 2024-10-27

fluorouracil and Lentigo

fluorouracil has been researched along with Lentigo in 2 studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Lentigo: Small circumscribed melanoses resembling, but differing histologically from, freckles. The concept includes senile lentigo ('liver spots') and nevoid lentigo (nevus spilus, lentigo simplex) and may also occur in association with multiple congenital defects or congenital syndromes (e.g., Peutz-Jeghers syndrome).

Research Excerpts

ExcerptRelevanceReference
"Three patients with biopsy-proven lentigo maligna were treated with topical 5-fluorouracil."7.65Topical chemotherapy of lentigo maligna with 5-fluorouracil. ( Krementz, ET; Litwin, MS; Mansell, PW; Reed, RJ, 1975)
"Three patients with biopsy-proven lentigo maligna were treated with topical 5-fluorouracil."3.65Topical chemotherapy of lentigo maligna with 5-fluorouracil. ( Krementz, ET; Litwin, MS; Mansell, PW; Reed, RJ, 1975)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19902 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Katz, H1
Redding, KG1
Litwin, MS1
Krementz, ET1
Mansell, PW1
Reed, RJ1

Other Studies

2 other studies available for fluorouracil and Lentigo

ArticleYear
Therapeutic challenge of premalignant and malignant skin lesions.
    Geriatrics, 1975, Volume: 30, Issue:3

    Topics: Acetates; Adrenal Cortex Hormones; Adult; Aged; Balanitis; Bowen's Disease; Clioquinol; Cryosurgery;

1975
Topical chemotherapy of lentigo maligna with 5-fluorouracil.
    Cancer, 1975, Volume: 35, Issue:3

    Topics: Aged; Evaluation Studies as Topic; Female; Fluorouracil; Follow-Up Studies; Humans; Immunity, Cellul

1975