fluorouracil has been researched along with Lactose Intolerance in 1 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Lactose Intolerance: The condition resulting from the absence or deficiency of LACTASE in the MUCOSA cells of the GASTROINTESTINAL TRACT, and the inability to break down LACTOSE in milk for ABSORPTION. Bacterial fermentation of the unabsorbed lactose leads to symptoms that range from a mild indigestion (DYSPEPSIA) to severe DIARRHEA. Lactose intolerance may be an inborn error or acquired.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Bowel mucosal injury associated with 5-fluorouracil (5-FU) treatment might result in secondary lactose intolerance." | 9.11 | Lactose intolerance associated with adjuvant 5-fluorouracil-based chemotherapy for colorectal cancer. ( Elomaa, I; Ikonen, M; Joensuu, H; Korpela, R; Ollus, A; Osterlund, P; Peuhkuri, K; Ruotsalainen, T, 2004) |
| "Bowel mucosal injury associated with 5-fluorouracil (5-FU) treatment might result in secondary lactose intolerance." | 5.11 | Lactose intolerance associated with adjuvant 5-fluorouracil-based chemotherapy for colorectal cancer. ( Elomaa, I; Ikonen, M; Joensuu, H; Korpela, R; Ollus, A; Osterlund, P; Peuhkuri, K; Ruotsalainen, T, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Osterlund, P | 1 |
| Ruotsalainen, T | 1 |
| Peuhkuri, K | 1 |
| Korpela, R | 1 |
| Ollus, A | 1 |
| Ikonen, M | 1 |
| Joensuu, H | 1 |
| Elomaa, I | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Multicenter, Double-Blind, Placebo-Controlled Trial to Evaluate the Frequency of Genetic Sucrase-Isomaltase Deficiency Genotypes, and the Efficacy and Safety of Sucraid® (Sacrosidase) Oral Solution in Subjects With Chronic Diarrhea and Sucrase Deficienc[NCT02784067] | Phase 4 | 0 participants (Actual) | Interventional | 2016-05-31 | Withdrawn (stopped due to Clinical Trial Material) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for fluorouracil and Lactose Intolerance
| Article | Year |
|---|---|
Lactose intolerance associated with adjuvant 5-fluorouracil-based chemotherapy for colorectal cancer.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Colorectal Neoplasms; Dietary Fiber; Dietary Supplemen | 2004 |