fluorouracil has been researched along with Lactic Acidosis in 3 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Fukuda, M | 1 |
| Nabeta, M | 1 |
| Muta, T | 1 |
| Cho, T | 1 |
| Shimamatsu, Y | 1 |
| Shimotsuura, Y | 1 |
| Fukami, K | 1 |
| Takasu, O | 1 |
| Ito, A | 1 |
| Kawamoto, K | 1 |
| Park, T | 1 |
| Ito, T | 1 |
| Valik, D | 1 |
3 other studies available for fluorouracil and Lactic Acidosis
| Article | Year |
|---|---|
Disturbance of consciousness due to hyperammonemia and lactic acidosis during mFOLFOX6 regimen: Case report.
Topics: Acidosis, Lactic; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protoc | 2020 |
[A case of mFOLFOX6-induced lactic acidosis in a patient with colon cancer].
Topics: Acidosis, Lactic; Antineoplastic Combined Chemotherapy Protocols; Fluorouracil; Humans; Leucovorin; | 2014 |
Encephalopathy, lactic acidosis, hyperammonaemia and 5-fluorouracil toxicity.
Topics: Acidosis, Lactic; Ammonia; Brain Diseases; Chemical and Drug Induced Liver Injury; Citric Acid Cycle | 1998 |