fluorouracil has been researched along with Lacrimal Duct Obstruction in 10 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Lacrimal Duct Obstruction: Interference with the secretion of tears by the lacrimal glands. Obstruction of the LACRIMAL SAC or NASOLACRIMAL DUCT causing acute or chronic inflammation of the lacrimal sac (DACRYOCYSTITIS). It is caused also in infants by failure of the nasolacrimal duct to open into the inferior meatus and occurs about the third week of life. In adults occlusion may occur spontaneously or after injury or nasal disease. (Newell, Ophthalmology: Principles and Concepts, 7th ed, p250)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Canalicular obstruction may follow systemic use of 5-fluorouracil due to squamous metaplasia." | 7.71 | Squamous metaplasia of the canaliculi associated with 5-fluorouracil: a clinicopathologic case report. ( Agarwal, MR; Burnstine, MA; Esmaeli, B, 2002) |
| "5-Fluorouracil is a pyrimidine analogue that inhibits DNA synthesis and is commonly used in the treatment of carcinomas of the breast, gastrointestinal tract and genitourinary tract." | 6.40 | Sclerosing canaliculitis after 5-fluorouracil breast cancer chemotherapy. ( Bentley, CR; Lee, V; Olver, JM, 1998) |
| "Capecitabine was discontinued 287 days after initiation owing to exacerbation of the hand-foot syndrome." | 5.42 | [A case of lacrimal duct obstruction caused by capecitabine]. ( Kawara, H; Mitani, T; Noguchi, Y; Shimizu, Y; Tamura, Y; Tokuyama, Y; Uchiyama, K, 2015) |
| "Ocular side effects of systemic fluorouracil include excessive lacrimation, due to punctal and canalicular stenosis and fibrosis." | 4.79 | Punctal and canalicular stenosis associated with systemic fluorouracil therapy. Report of five cases and review of the literature. ( Beex, LV; Brink, HM, 1995) |
| "Canalicular obstruction may follow systemic use of 5-fluorouracil due to squamous metaplasia." | 3.71 | Squamous metaplasia of the canaliculi associated with 5-fluorouracil: a clinicopathologic case report. ( Agarwal, MR; Burnstine, MA; Esmaeli, B, 2002) |
| "5-Fluorouracil (5-FU) has been reported to cause punctal-canalicular fibrosis with resultant severe epiphora." | 3.67 | Surgical treatment of punctal-canalicular fibrosis from 5-fluorouracil therapy. ( Adams, T; Seiff, SR; Shorr, N, 1985) |
| "5-Fluorouracil is a pyrimidine analogue that inhibits DNA synthesis and is commonly used in the treatment of carcinomas of the breast, gastrointestinal tract and genitourinary tract." | 2.40 | Sclerosing canaliculitis after 5-fluorouracil breast cancer chemotherapy. ( Bentley, CR; Lee, V; Olver, JM, 1998) |
| "Capecitabine was discontinued 287 days after initiation owing to exacerbation of the hand-foot syndrome." | 1.42 | [A case of lacrimal duct obstruction caused by capecitabine]. ( Kawara, H; Mitani, T; Noguchi, Y; Shimizu, Y; Tamura, Y; Tokuyama, Y; Uchiyama, K, 2015) |
| "Nineteen patients (16 with colon cancer and 3 with breast cancer) who were treated with systemic 5-FU with complaints of tearing were studied retrospectively." | 1.30 | The treatment of punctal and canalicular stenosis in patients on systemic 5-FU. ( Fezza, JP; Klippenstein, KA; Wesley, RE, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (20.00) | 18.7374 |
| 1990's | 3 (30.00) | 18.2507 |
| 2000's | 4 (40.00) | 29.6817 |
| 2010's | 1 (10.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Noguchi, Y | 1 |
| Mitani, T | 1 |
| Kawara, H | 1 |
| Tokuyama, Y | 1 |
| Tamura, Y | 1 |
| Uchiyama, K | 1 |
| Shimizu, Y | 1 |
| Agarwal, MR | 1 |
| Esmaeli, B | 1 |
| Burnstine, MA | 1 |
| Bakri, K | 1 |
| Jones, NS | 1 |
| Downes, R | 1 |
| Sadiq, SA | 1 |
| Caravella, LP | 1 |
| Burns, JA | 1 |
| Zangmeister, M | 1 |
| Brink, HM | 1 |
| Beex, LV | 1 |
| Lee, V | 1 |
| Bentley, CR | 1 |
| Olver, JM | 1 |
| Fezza, JP | 1 |
| Wesley, RE | 1 |
| Klippenstein, KA | 1 |
| Prasad, S | 1 |
| Kamath, GG | 1 |
| Phillips, RP | 1 |
| Stevens, A | 1 |
| Spooner, D | 1 |
| Seiff, SR | 1 |
| Shorr, N | 1 |
| Adams, T | 1 |
4 reviews available for fluorouracil and Lacrimal Duct Obstruction
| Article | Year |
|---|---|
Punctal and canalicular stenosis associated with systemic fluorouracil therapy. Report of five cases and review of the literature.
Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Breast Neopla | 1995 |
Sclerosing canaliculitis after 5-fluorouracil breast cancer chemotherapy.
Topics: Aged; Antimetabolites, Antineoplastic; Breast Neoplasms; Dacryocystorhinostomy; Female; Fluorouracil | 1998 |
Lacrimal canalicular stenosis associated with systemic 5-fluorouacil therapy.
Topics: Aged; Carcinoma; Colectomy; Colonic Neoplasms; Dacryocystorhinostomy; Female; Fluorouracil; Humans; | 2000 |
Lacrimal duct stenosis and other ocular toxicity associated with adjuvant cyclophosphamide, methotrexate and 5-fluorouracil combination chemotherapy for early stage breast cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvant; Cyclophosp | 2001 |
1 trial available for fluorouracil and Lacrimal Duct Obstruction
| Article | Year |
|---|---|
Intraoperative fluorouracil in endonasal laser dacryocystorhinostomy.
Topics: Administration, Topical; Dacryocystitis; Dacryocystorhinostomy; Double-Blind Method; Female; Fluorou | 2003 |
5 other studies available for fluorouracil and Lacrimal Duct Obstruction
| Article | Year |
|---|---|
[A case of lacrimal duct obstruction caused by capecitabine].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Breast Neoplasms; Capecitabine | 2015 |
Squamous metaplasia of the canaliculi associated with 5-fluorouracil: a clinicopathologic case report.
Topics: Aged; Antimetabolites, Antineoplastic; Colonic Neoplasms; Dacryocystorhinostomy; Epithelial Cells; F | 2002 |
Punctal-canalicular stenosis related to systemic fluorouracil therapy.
Topics: Adenocarcinoma; Adult; Breast Neoplasms; Female; Fluorouracil; Humans; Intestinal Neoplasms; Lacrima | 1981 |
The treatment of punctal and canalicular stenosis in patients on systemic 5-FU.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Breast Neoplasms; Colonic Neoplasms | 1999 |
Surgical treatment of punctal-canalicular fibrosis from 5-fluorouracil therapy.
Topics: Aged; Conjunctiva; Dacryocystorhinostomy; Female; Fluorouracil; Humans; Lacrimal Apparatus Diseases; | 1985 |