fluorouracil and Keratoderma Blennorrhagicum studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Research Excerpts

Excerpt	Relevance	Reference
"5% fluorouracil before cryosurgery is significantly more effective in reducing patients' numbers of actinic keratosis lesions 6 months after treatment than cryosurgery alone."	9.11	Effect of a 1-week treatment with 0.5% topical fluorouracil on occurrence of actinic keratosis after cryosurgery: a randomized, vehicle-controlled clinical trial. ( Furst, K; Jorizzo, J; Levy, SF; VandePol, C; Weiss, J, 2004)
"5% and 5% fluorouracil creams in the treatment of actinic keratosis (AK)."	9.10	Evaluation of the efficacy and tolerability of 0.5% fluorouracil cream and 5% fluorouracil cream applied to each side of the face in patients with actinic keratosis. ( Furst, K; Levy, S; Loven, K; Stein, L, 2002)
"5% fluorouracil topical cream were compared with vehicle control for the treatment of actinic keratosis (AK)."	9.10	Randomized trial evaluating a new 0.5% fluorouracil formulation demonstrates efficacy after 1-, 2-, or 4-week treatment in patients with actinic keratosis. ( Bucko, A; Connolly, M; Davis, SA; Espy, P; Furst, K; Hino, P; Jorizzo, J; Levy, S; Rodriguez, D; Savin, R; Stewart, D; Stough, D, 2002)
"Several formulations and concentrations of topical fluorouracil have received US Food and Drug Administration (FDA) approval for the treatment of actinic keratosis (AK)."	8.82	Fluorouracil 5% and 0.5% creams for the treatment of actinic keratosis: equivalent efficacy with a lower concentration and more convenient dosing schedule. ( Carney, PS; Jorizzo, JL; Ko, WT; Robins, P; Weinkle, SH; Werschler, WP, 2004)
"A cumulative meta-analysis was performed to determine the efficacy of imiquimod 5% cream, which presents a new alternative topical therapy for actinic keratosis, and to compare it to 5-fluorouracil for the treatment of actinic keratosis lesions of the face and scalp."	8.82	Evaluation of the effectiveness of imiquimod and 5-fluorouracil for the treatment of actinic keratosis: Critical review and meta-analysis of efficacy studies. ( Davey, V; Gupta, AK; Mcphail, H, 2005)
"Topical application of 5-fluorouracil (5-FU) is one of the most effective clinical strategies available to treat actinic keratosis (AK)."	7.73	Actinic keratosis and capecitabine therapy. ( Abraham, J; Higa, GM; Kovach, RF, 2005)
"A case of arsenical keratosis with multiple lesions of Bowen's disease and squamous cell carcinoma is described."	7.72	Successful treatment of multiple premalignant and malignant lesions in arsenical keratosis with a combination of acitretin and intralesional 5-fluorouracil. ( Khandpur, S; Sharma, VK, 2003)
"A selective inflammatory reaction involving actinic keratosis may occur in patients receiving systemic 5-fluorouracil as part of a chemotherapeutic protocol."	7.70	Selective inflammatory effect of systemic fluorouracil in actinic keratosis. ( Mehregan, D; Mohindra, R; Nabai, H, 1999)
"Fluorouracil is a common cause of acral erythema and a variety of pigmentary anomalies."	7.68	Combination chemotherapy with 5-fluorouracil, folinic acid, and alpha-interferon producing histologic features of graft-versus-host disease. ( Beard, JS; Skelton, HG; Smith, KJ, 1993)
"An allergic contact dermatitis from fluorouracil developed in two patients 8 and 18 days respectively after institution of topical fluorouracil therapy."	7.65	Allergic contact dermatitis from topical fluorouracil. ( Goette, DK; Odom, RB; Owens, R, 1977)
"We designed a prospective and retrospective study to determine the incidence of allergic contact dermatitis to topical application of fluorouracil."	7.65	Allergic contact dermatitis to topical fluorouracil. ( Goette, DK; Odom, RB, 1977)
"The present study was conducted to determine the pharmacokinetic profile and tolerability of a new topical 0."	6.70	A pharmacokinetic evaluation of 0.5% and 5% fluorouracil topical cream in patients with actinic keratosis. ( Chern, W; Furst, K; Levy, S, 2001)
"5-fluorouracil (5-FU) and imiquimod creams are accepted topical therapies for actinic keratosis (AK)."	5.12	The treatment of actinic keratoses with a combination of 5-fluorouracil and imiquimod creams. ( Price, NM, 2007)
"Topical fluorouracil is currently approved for the treatment of actinic keratosis (AK) and is often used prior to or following cryosurgery as interval therapy in patients with severe AK lesions."	5.12	One-week treatment with 0.5% fluorouracil cream prior to cryosurgery in patients with actinic keratoses: a double-blind, vehicle-controlled, long-term study. ( Jorizzo, J; Vamvakias, G; Weiss, J, 2006)
"It is timely to compare the efficacy and tolerability of 2 actinic keratosis (AK) therapies--5% 5-fluorouracil (5-FU) cream and imiquimod cream."	5.12	Comparison of 5% 5-fluorouracil cream and 5% imiquimod cream in the management of actinic keratoses on the face and scalp. ( Tanghetti, E; Werschler, P, 2007)
"5% fluorouracil before cryosurgery is significantly more effective in reducing patients' numbers of actinic keratosis lesions 6 months after treatment than cryosurgery alone."	5.11	Effect of a 1-week treatment with 0.5% topical fluorouracil on occurrence of actinic keratosis after cryosurgery: a randomized, vehicle-controlled clinical trial. ( Furst, K; Jorizzo, J; Levy, SF; VandePol, C; Weiss, J, 2004)
"5% and 5% fluorouracil creams in the treatment of actinic keratosis (AK)."	5.10	Evaluation of the efficacy and tolerability of 0.5% fluorouracil cream and 5% fluorouracil cream applied to each side of the face in patients with actinic keratosis. ( Furst, K; Levy, S; Loven, K; Stein, L, 2002)
"5% fluorouracil topical cream were compared with vehicle control for the treatment of actinic keratosis (AK)."	5.10	Randomized trial evaluating a new 0.5% fluorouracil formulation demonstrates efficacy after 1-, 2-, or 4-week treatment in patients with actinic keratosis. ( Bucko, A; Connolly, M; Davis, SA; Espy, P; Furst, K; Hino, P; Jorizzo, J; Levy, S; Rodriguez, D; Savin, R; Stewart, D; Stough, D, 2002)
"Several formulations and concentrations of topical fluorouracil have received US Food and Drug Administration (FDA) approval for the treatment of actinic keratosis (AK)."	4.82	Fluorouracil 5% and 0.5% creams for the treatment of actinic keratosis: equivalent efficacy with a lower concentration and more convenient dosing schedule. ( Carney, PS; Jorizzo, JL; Ko, WT; Robins, P; Weinkle, SH; Werschler, WP, 2004)
"A cumulative meta-analysis was performed to determine the efficacy of imiquimod 5% cream, which presents a new alternative topical therapy for actinic keratosis, and to compare it to 5-fluorouracil for the treatment of actinic keratosis lesions of the face and scalp."	4.82	Evaluation of the effectiveness of imiquimod and 5-fluorouracil for the treatment of actinic keratosis: Critical review and meta-analysis of efficacy studies. ( Davey, V; Gupta, AK; Mcphail, H, 2005)
"Topical application of 5-fluorouracil (5-FU) is one of the most effective clinical strategies available to treat actinic keratosis (AK)."	3.73	Actinic keratosis and capecitabine therapy. ( Abraham, J; Higa, GM; Kovach, RF, 2005)
" The lesions appeared during oncology treatment of bilateral breast cancer with lymphatic metastases with paclitaxel every three weeks and capecitabine daily."	3.73	[Onycholysis with hyponychium exudate secondary to chemotherapy with paclitaxel and capecitabine]. ( Bosch, RJ; Herrera, E; López, N; Tejera, A, 2006)
"A case of arsenical keratosis with multiple lesions of Bowen's disease and squamous cell carcinoma is described."	3.72	Successful treatment of multiple premalignant and malignant lesions in arsenical keratosis with a combination of acitretin and intralesional 5-fluorouracil. ( Khandpur, S; Sharma, VK, 2003)
"A selective inflammatory reaction involving actinic keratosis may occur in patients receiving systemic 5-fluorouracil as part of a chemotherapeutic protocol."	3.70	Selective inflammatory effect of systemic fluorouracil in actinic keratosis. ( Mehregan, D; Mohindra, R; Nabai, H, 1999)
"Fluorouracil is a common cause of acral erythema and a variety of pigmentary anomalies."	3.68	Combination chemotherapy with 5-fluorouracil, folinic acid, and alpha-interferon producing histologic features of graft-versus-host disease. ( Beard, JS; Skelton, HG; Smith, KJ, 1993)
"15 patients with superficial basaliomas or premalignant epithelial neoplastic disorders (actinic keratosis, leukoplakia, Bowen's disease) were treated locally over three weeks with retinoic acid (RA) alone or in combination with 5-fluorouracil (5-FU)."	3.66	[Vitamin A acid for the topical management of epithelial neoplasms. Combination with 5-fluorouracil]. ( Kurka, M; Orfanos, CE; Pullmann, H, 1978)
"An allergic contact dermatitis from fluorouracil developed in two patients 8 and 18 days respectively after institution of topical fluorouracil therapy."	3.65	Allergic contact dermatitis from topical fluorouracil. ( Goette, DK; Odom, RB; Owens, R, 1977)
"We designed a prospective and retrospective study to determine the incidence of allergic contact dermatitis to topical application of fluorouracil."	3.65	Allergic contact dermatitis to topical fluorouracil. ( Goette, DK; Odom, RB, 1977)
"Imiquimod treatment of AK resulted in superior sustained clearance and cosmetic outcomes compared with cryosurgery and 5-FU."	2.73	A randomised study of topical 5% imiquimod vs. topical 5-fluorouracil vs. cryosurgery in immunocompetent patients with actinic keratoses: a comparison of clinical and histological outcomes including 1-year follow-up. ( Krawtchenko, N; Mann, I; Roewert-Huber, J; Sterry, W; Stockfleth, E; Ulrich, M, 2007)
"Treatment with fluorouracil, trichloroacetic acid, or carbon dioxide laser resulted in an 83% to 92% reduction in AKs (P< or =."	2.72	Facial resurfacing for nonmelanoma skin cancer prophylaxis. ( Cooper, ZA; Hantash, BM; Koch, RJ; Rehmus, WE; Stewart, DB; Swetter, SM, 2006)
"The present study was conducted to determine the pharmacokinetic profile and tolerability of a new topical 0."	2.70	A pharmacokinetic evaluation of 0.5% and 5% fluorouracil topical cream in patients with actinic keratosis. ( Chern, W; Furst, K; Levy, S, 2001)
" Visible AK were counted, random skin biopsies performed, adverse effects monitored, and patients questioned about preference and perception of efficacy."	2.68	A comparison of the efficacy and safety of Jessner's solution and 35% trichloroacetic acid vs 5% fluorouracil in the treatment of widespread facial actinic keratoses. ( Cockerell, CJ; Cox, SE; Cruz, PD; Freeman, RG; Lawrence, N, 1995)
"The tretinoin-treated arms had 15."	2.66	Topical chemotherapy of actinic keratoses of the upper extremity with tretinoin and 5-fluorouracil: a double-blind controlled study. ( Bercovitch, L, 1987)
"Fluorouracil has been the traditional topical treatment for actinic keratoses, although imiquimod 5% cream and diclofenac 3% gel are effective alternative therapies."	2.44	Treatment options for actinic keratoses. ( Bedwell, SA; Downs, MR; McIntyre, WJ, 2007)
"Actinic keratosis is a precancerous lesion that is commonly seen in the elderly patient and requires treatment."	2.43	[Actinic keratosis]. ( Dissemond, J; Grabbe, S, 2006)
"Actinic keratosis is currently believed to be an early stage in the evolution of squamous cell carcinoma."	2.42	Topical and light-based treatments for actinic keratoses. ( Alam, M; Goldberg, LH; Silapunt, S, 2003)
"The ability to manage non-melanoma skin cancers and pre-malignant lesions with topical pharmacologic agents is highly compelling."	2.42	Topical treatment strategies for non-melanoma skin cancer and precursor lesions. ( Fein, H; McGillis, ST, 2004)
"Actinic keratoses are superficial squamous cell carcinomas."	2.42	Optimum treatment strategies for actinic keratosis (intraepidermal squamous cell carcinoma). ( Fenske, NA; Lober, BA, 2004)
"As with treatment of psoriasis affecting skin, relapse is common and therapies may need to be maintained or repeated."	2.41	Management of nail psoriasis. ( de Berker, D, 2000)
"Managing patients with diffuse squamous cell carcinoma (SCC) and actinic damage on their extremities is challenging because SCCs may be ill-defined, confluent, and only amenable to radical surgery."	1.35	Chemowraps as an adjuvant to surgery for patients with diffuse squamous cell carcinoma of the extremities. ( Berk, DR; Mann, M; Petersen, J, 2008)
"5-fluorouracil (5-FU) treatment is also widely utilized."	1.31	Cryopeeling (extensive cryosurgery) for treatment of actinic keratoses: an update and comparison. ( Chiarello, SE, 2000)
"We report a typical case with a squamous cell carcinoma of the tongue and classical cutaneous symptoms disappearing with the treatment of the tumour."	1.31	Bazex syndrome. ( Buxtorf, K; Hübscher, E; Panizzon, R, 2001)
"5-Fluorouracil was used at 3."	1.30	Destructive procedures are the standard of care for treatment of actinic keratoses. ( Feldman, SR; Fleischer, AB; Jorizzo, JL; Williford, PM, 1999)
"5-Fluorouracil therapy is an efficacious treatment for actinic keratoses."	1.29	Short-term intensive 5-fluorouracil treatment of actinic keratoses. ( Unis, ME, 1995)
"Ten patients completed a weekly pulse dosing regimen for topical 5-fluorouracil therapy for multiple facial actinic keratoses."	1.28	Weekly pulse dosing: effective and comfortable topical 5-fluorouracil treatment of multiple facial actinic keratoses. ( Pearlman, DL, 1991)
"In white persons, most skin cancer occurs in sites that have been exposed to sunlight for long periods."	1.26	Dysplastic epidermal keratosis in a black woman. ( Kelly, AP; Lopansri, S; Weaver, SM, 1981)
"The increased incidence of skin cancer and its possible cause is briefly discussed and the role of immunobiologic factors in the development of squamous cell carcinomas is mentioned."	1.26	Squamous cell carcinoma. Case report of an unusually aggressive skin cancer. ( Biro, L; Price, E, 1979)

Timeframe	Studies, this research(%)	All Research%
pre-1990	128 (59.53)	18.7374
1990's	28 (13.02)	18.2507
2000's	55 (25.58)	29.6817
2010's	4 (1.86)	24.3611
2020's	0 (0.00)	2.80

Trial	Phase	Enrollment	Study Type	Start Date	Status
Evaluation of Topical Application of 5% Imiquimod, 0.05% Imiquimod and 0.05% Nanoencapsulated Imiquimod Gel in the Treatment of Actinic Cheilitis: a Randomized Controlled Trial[NCT04219358]	Phase 1	49 participants (Actual)	Interventional	2019-03-23	Terminated (stopped due to Study terminated because of COVID19 pandemics.)
TreatMent of ActInic KerAtosis Lesions : pharmacoepiDemiological Study of the Impact in Real Life of ingenOl Mebutate Gel (Picato®) on Patients Satisfaction[NCT04202445]		1,218 participants (Actual)	Observational	2014-04-30	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
JAAD Grand Rounds quiz: Red-brown hyperkeratotic papules in a 69-year-old man. Journal of the American Academy of Dermatology, 2015, Volume: 73, Issue:2 Topics: Aged; Biopsy, Needle; Disease Progression; Exanthema; Fluorouracil; Follow-Up Studies; Humans; Immun	2015
One-week treatment with once-daily fluorouracil cream 0.5% in participants with actinic keratoses. Cutis, 2008, Volume: 81, Issue:6 Topics: Administration, Cutaneous; Drug Administration Schedule; Drug Carriers; Fluorouracil; Humans; Immuno	2008
Topical therapy for actinic keratoses, I: 5-Fluorouracil and imiquimod. Cutis, 2003, Volume: 71, Issue:5 Topics: Administration, Cutaneous; Aminoquinolines; Antimetabolites, Antineoplastic; Antineoplastic Agents;	2003
[Cutaneous neoplasms]. Praxis, 2003, Sep-03, Volume: 92, Issue:36 Topics: Adjuvants, Immunologic; Aminoquinolines; Antimetabolites, Antineoplastic; Antineoplastic Agents; Bio	2003
Topical and light-based treatments for actinic keratoses. Seminars in cutaneous medicine and surgery, 2003, Volume: 22, Issue:3 Topics: Adjuvants, Immunologic; Administration, Topical; Aminolevulinic Acid; Aminoquinolines; Antineoplasti	2003
Topical treatment strategies for non-melanoma skin cancer and precursor lesions. Seminars in cutaneous medicine and surgery, 2004, Volume: 23, Issue:3 Topics: Administration, Topical; Aminoquinolines; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Ag	2004
Current and novel treatment options for actinic keratosis. Journal of cutaneous medicine and surgery, 2004, Volume: 8 Suppl 3 Topics: Aminolevulinic Acid; Aminoquinolines; Cryotherapy; Diclofenac; Fluorouracil; Gels; Humans; Imiquimod	2004
Optimum treatment strategies for actinic keratosis (intraepidermal squamous cell carcinoma). American journal of clinical dermatology, 2004, Volume: 5, Issue:6 Topics: Administration, Cutaneous; Anti-Inflammatory Agents, Non-Steroidal; Antimetabolites, Antineoplastic;	2004
Fluorouracil 5% and 0.5% creams for the treatment of actinic keratosis: equivalent efficacy with a lower concentration and more convenient dosing schedule. Cutis, 2004, Volume: 74, Issue:6 Suppl Topics: Administration, Cutaneous; Antimetabolites, Antineoplastic; Drug Administration Schedule; Emulsions;	2004
Mechanisms of action of new treatment modalities for actinic keratosis. Journal of drugs in dermatology : JDD, 2006, Volume: 5, Issue:2 Topics: Aminoquinolines; Anti-Inflammatory Agents, Non-Steroidal; Antimetabolites; Antineoplastic Agents; Di	2006
Evaluation of the effectiveness of imiquimod and 5-fluorouracil for the treatment of actinic keratosis: Critical review and meta-analysis of efficacy studies. Journal of cutaneous medicine and surgery, 2005, Volume: 9, Issue:5 Topics: Adjuvants, Immunologic; Aminoquinolines; Clinical Trials, Phase III as Topic; Confidence Intervals;	2005
Actinic keratoses: sequelae and treatments. Recommendations from a consensus panel. The Journal of family practice, 2006, Volume: 55, Issue:5 Topics: Administration, Cutaneous; Aminoquinolines; Antineoplastic Agents; Carcinoma, Squamous Cell; Consens	2006
[Actinic keratosis]. MMW Fortschritte der Medizin, 2006, Jun-15, Volume: 148, Issue:24 Topics: Adjuvants, Immunologic; Age Factors; Aged; Aminoquinolines; Antimetabolites, Antineoplastic; Antineo	2006
Treatment options for actinic keratoses. American family physician, 2007, Sep-01, Volume: 76, Issue:5 Topics: Administration, Topical; Aminoquinolines; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Ag	2007
Topical therapy for actinic keratoses: current and evolving therapies. Reviews on recent clinical trials, 2006, Volume: 1, Issue:1 Topics: Administration, Cutaneous; Administration, Topical; Aminoquinolines; Antineoplastic Agents; Carcinom	2006
Dermatological aspects of aging. The Medical clinics of North America, 1983, Volume: 67, Issue:2 Topics: Adult; Aged; Aging; Animals; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Dermatitis; Female; Fl	1983
Therapeutic perspectives in actinic and other keratoses. International journal of dermatology, 1996, Volume: 35, Issue:8 Topics: Administration, Cutaneous; Antimetabolites, Antineoplastic; Cryosurgery; Fluorouracil; Humans; Kerat	1996
Actinic keratoses. Differential diagnosis and treatment. Drugs & aging, 1997, Volume: 11, Issue:3 Topics: Aging; Chemexfoliation; Combined Modality Therapy; Cryosurgery; Curettage; Dermabrasion; Diagnosis,	1997
Management of nail psoriasis. Clinical and experimental dermatology, 2000, Volume: 25, Issue:5 Topics: Administration, Topical; Anti-Inflammatory Agents; Antifungal Agents; Cyclosporine; Dermatologic Age	2000
5-fluorouracil 0.5% cream for multiple actinic or solar keratoses of the face and anterior scalp. Skin therapy letter, 2001, Volume: 6, Issue:9 Topics: Facial Dermatoses; Fluorouracil; Humans; Keratosis; Scalp Dermatoses	2001
Current dermatologic therapy. Cutis, 1976, Volume: 18, Issue:4 Topics: Acne Vulgaris; Administration, Topical; Adrenal Cortex Hormones; Anti-Bacterial Agents; Antifungal A	1976
A review of lower genital intraepithelial neoplasia and the use of topical 5-fluorouracil. Obstetrical & gynecological survey, 1985, Volume: 40, Issue:4 Topics: Acquired Immunodeficiency Syndrome; Administration, Topical; Adult; Anal Canal; Anus Neoplasms; Carc	1985
The action of antimetabolites in the skin: methotrexate for psoriasis. Advances in biology of skin, 1972, Volume: 12 Topics: Carcinoma, Basal Cell; Cell Division; DNA; Fluorouracil; Humans; Injections, Intradermal; Keratosis;	1972
Topical treatment of skin tumours with 5-fluorouracil. The British journal of dermatology, 1970, Volume: 82, Issue:2 Topics: Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Fluorouracil; Humans; Keratosis; Skin Neoplasms	1970
Topical antimetabolites. Annual review of medicine, 1970, Volume: 21 Topics: Antimetabolites; Antineoplastic Agents; Carcinoma, Basal Cell; Fluorouracil; Folic Acid Antagonists;	1970

Article	Year
Evaluation of the efficacy and tolerability of 0.5% fluorouracil cream and 5% fluorouracil cream applied to each side of the face in patients with actinic keratosis. Clinical therapeutics, 2002, Volume: 24, Issue:6 Topics: Administration, Topical; Aged; Antimetabolites, Antineoplastic; Chemistry, Pharmaceutical; Dose-Resp	2002
Effective treatment of actinic keratosis with 0.5% fluorouracil cream for 1, 2, or 4 weeks. Cutis, 2002, Volume: 70, Issue:2 Suppl Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Double-Bli	2002
Randomized trial evaluating a new 0.5% fluorouracil formulation demonstrates efficacy after 1-, 2-, or 4-week treatment in patients with actinic keratosis. Cutis, 2002, Volume: 70, Issue:6 Topics: Administration, Topical; Adult; Antimetabolites, Antineoplastic; Female; Fluorouracil; Humans; Kerat	2002
Short incubation PDT versus 5-FU in treating actinic keratoses. Journal of drugs in dermatology : JDD, 2003, Volume: 2, Issue:6 Topics: Administration, Cutaneous; Aminolevulinic Acid; Antimetabolites, Antineoplastic; Face; Female; Fluor	2003
Effect of a 1-week treatment with 0.5% topical fluorouracil on occurrence of actinic keratosis after cryosurgery: a randomized, vehicle-controlled clinical trial. Archives of dermatology, 2004, Volume: 140, Issue:7 Topics: Administration, Cutaneous; Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Combined	2004
A randomized trial of topical 5% 5-fluorouracil (Efudix cream) in the treatment of actinic keratoses comparing daily with weekly treatment. The British journal of dermatology, 2005, Volume: 153, Issue:4 Topics: Aged; Aged, 80 and over; Antimetabolites; Drug Administration Schedule; Facial Dermatoses; Female; F	2005
One-week treatment with 0.5% fluorouracil cream prior to cryosurgery in patients with actinic keratoses: a double-blind, vehicle-controlled, long-term study. Journal of drugs in dermatology : JDD, 2006, Volume: 5, Issue:2 Topics: Antimetabolites, Antineoplastic; Cryosurgery; Double-Blind Method; Female; Fluorouracil; Humans; Ker	2006
Bilateral comparison of the efficacy and tolerability of 3% diclofenac sodium gel and 5% 5-fluorouracil cream in the treatment of actinic keratoses of the face and scalp. Journal of drugs in dermatology : JDD, 2006, Volume: 5, Issue:2 Topics: Anti-Inflammatory Agents, Non-Steroidal; Antimetabolites, Antineoplastic; Diclofenac; Facial Dermato	2006
Twice daily vs. four times daily 5-fluorouracil therapy for actinic keratoses: a split face study. The British journal of dermatology, 2006, Volume: 154, Issue:4 Topics: Aged; Antimetabolites; Drug Administration Schedule; Facial Dermatoses; Female; Fluorouracil; Humans	2006
A clinical comparison and long-term follow-up of topical 5-fluorouracil versus laser resurfacing in the treatment of widespread actinic keratoses. Lasers in surgery and medicine, 2006, Volume: 38, Issue:8 Topics: Administration, Topical; Aged; Aged, 80 and over; Chi-Square Distribution; Face; Female; Fluorouraci	2006
Facial resurfacing for nonmelanoma skin cancer prophylaxis. Archives of dermatology, 2006, Volume: 142, Issue:8 Topics: Aged; Aged, 80 and over; Carbon Dioxide; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Disease-Fr	2006
Treatment of post-transplant premalignant skin disease: a randomized intrapatient comparative study of 5-fluorouracil cream and topical photodynamic therapy. The British journal of dermatology, 2007, Volume: 156, Issue:2 Topics: Administration, Topical; Aged; Aminolevulinic Acid; Antimetabolites, Antineoplastic; Bowen's Disease	2007
Comparison of 5% 5-fluorouracil cream and 5% imiquimod cream in the management of actinic keratoses on the face and scalp. Journal of drugs in dermatology : JDD, 2007, Volume: 6, Issue:2 Topics: Administration, Topical; Adult; Aminoquinolines; Disease Management; Erythema; Facial Dermatoses; Fl	2007
The treatment of actinic keratoses with a combination of 5-fluorouracil and imiquimod creams. Journal of drugs in dermatology : JDD, 2007, Volume: 6, Issue:8 Topics: Adjuvants, Immunologic; Administration, Cutaneous; Aged; Aged, 80 and over; Aminoquinolines; Drug Ad	2007
A randomised study of topical 5% imiquimod vs. topical 5-fluorouracil vs. cryosurgery in immunocompetent patients with actinic keratoses: a comparison of clinical and histological outcomes including 1-year follow-up. The British journal of dermatology, 2007, Volume: 157 Suppl 2 Topics: Aged; Aged, 80 and over; Aminoquinolines; Antineoplastic Agents; Carcinoma, Squamous Cell; Cryosurge	2007
Selective cytotoxic effect of topical 5-fluorouracil. Archives of dermatology, 1983, Volume: 119, Issue:9 Topics: Administration, Topical; Adult; Aged; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Double-Blind	1983
A comparison of the efficacy and safety of Jessner's solution and 35% trichloroacetic acid vs 5% fluorouracil in the treatment of widespread facial actinic keratoses. Archives of dermatology, 1995, Volume: 131, Issue:2 Topics: Drug Combinations; Ethanol; Facial Dermatoses; Fluorouracil; Follow-Up Studies; Humans; Keratosis; L	1995
The new fluor-hydroxy pulse peel. A combination of 5-fluorouracil and glycolic acid. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 1998, Volume: 24, Issue:9 Topics: Administration, Cutaneous; Adult; Aged; Chemexfoliation; Drug Administration Schedule; Drug Synergis	1998
Patient survey of trichloroacetic acid treatment of facial actinic keratoses. Archives of dermatology, 1999, Volume: 135, Issue:3 Topics: Caustics; Facial Dermatoses; Fluorouracil; Humans; Keratosis; Patient Satisfaction; Sunlight; Trichl	1999
A randomized paired comparison of photodynamic therapy and topical 5-fluorouracil in the treatment of actinic keratoses. Journal of the American Academy of Dermatology, 1999, Volume: 41, Issue:3 Pt 1 Topics: Administration, Topical; Aged; Antimetabolites; Female; Fluorouracil; Forearm; Hand Dermatoses; Huma	1999
A pharmacokinetic evaluation of 0.5% and 5% fluorouracil topical cream in patients with actinic keratosis. Clinical therapeutics, 2001, Volume: 23, Issue:6 Topics: Administration, Topical; Aged; Antimetabolites, Antineoplastic; Area Under Curve; Female; Fluorourac	2001
Management of actinic keratoses with topical 5-fluorouracil. Cutis, 1976, Volume: 18, Issue:2 Topics: Administration, Topical; Adult; Aged; Clinical Trials as Topic; Female; Fluorouracil; Humans; Kerato	1976
Noninflammatory destruction of actinic keratoses by fluorouracil. Archives of dermatology, 1976, Volume: 112, Issue:9 Topics: Aged; Drug Combinations; Facial Dermatoses; Female; Fluorouracil; Humans; Keratosis; Male; Middle Ag	1976
Use of pyruvic acid in the treatment of actinic keratoses: a clinical and histopathologic study. Cutis, 1991, Volume: 47, Issue:5 Topics: Administration, Cutaneous; Drug Therapy, Combination; Erythema; Fluorouracil; Humans; Keratosis; Pyr	1991
Topical chemotherapy of actinic keratoses of the upper extremity with tretinoin and 5-fluorouracil: a double-blind controlled study. The British journal of dermatology, 1987, Volume: 116, Issue:4 Topics: Arm; Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Combination; Fluorouracil; Humans;	1987
The use of topical 5-fluorouracil in the treatment of skin tumours--preliminary report. Journal of the Irish Medical Association, 1969, Volume: 62, Issue:380 Topics: Aged; Carcinoma; Carcinoma, Basal Cell; Clinical Trials as Topic; Female; Fluorouracil; Humans; Kera	1969
[Therapeutic trial with 5-fluorouracil ointment]. Hospital (Rio de Janeiro, Brazil), 1970, Volume: 77, Issue:4 Topics: Adult; Aged; Carcinoma, Basal Cell; Clinical Trials as Topic; Evaluation Studies as Topic; Facial Ne	1970

Article	Year
A dog's life: an unfamiliar and lethal side effect of topical 5-fluorouracil. Clinical and experimental dermatology, 2018, Volume: 43, Issue:6 Topics: Administration, Topical; Animals; Antimetabolites, Antineoplastic; Dogs; Eating; Euthanasia, Animal;	2018
Usage and patient experience of 5% fluorouracil cream. Clinical and experimental dermatology, 2015, Volume: 40, Issue:1 Topics: Antimetabolites, Antineoplastic; Bowen's Disease; Carcinoma, Basal Cell; Cost Control; Fluorouracil;	2015
Optimized permeation enhancer for topical delivery of 5-fluorouracil-loaded elastic liposome using Design Expert: part II. Drug delivery, 2016, Volume: 23, Issue:4 Topics: Animals; Chemistry, Pharmaceutical; Drug Delivery Systems; Elasticity; Fluorouracil; Gels; Keratosis	2016
Chemowraps as an adjuvant to surgery for patients with diffuse squamous cell carcinoma of the extremities. Journal of drugs in dermatology : JDD, 2008, Volume: 7, Issue:7 Topics: Administration, Cutaneous; Aged; Antineoplastic Agents; Bandages; Carcinoma, Squamous Cell; Chemothe	2008
New treatments for actinic keratoses. Connecticut medicine, 2002, Volume: 66, Issue:10 Topics: Administration, Topical; Aminolevulinic Acid; Aminoquinolines; Dermatologic Agents; Diclofenac; Fluo	2002
Cutaneous recall reactions with systemic fluorouracil. Dermatology (Basel, Switzerland), 2003, Volume: 206, Issue:2 Topics: Administration, Topical; Aged; Antimetabolites, Antineoplastic; Drug Eruptions; Esophageal Neoplasms	2003
Pulse therapy with 5-FU. Journal of drugs in dermatology : JDD, 2002, Volume: 1, Issue:2 Topics: Antimetabolites, Antineoplastic; Fluorouracil; Humans; Keratosis; Patient Satisfaction; Pulse Therap	2002
Pulse therapy with 5-FU in eradicating actinic keratoses with less than recommended dosage. Journal of drugs in dermatology : JDD, 2002, Volume: 1, Issue:1 Topics: Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Clinical Trials as Topic; Dose-Response Re	2002
Photodynamic therapy for actinic keratosis followed by 5-fluorouracil reaction. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2003, Volume: 29, Issue:10 Topics: Aminolevulinic Acid; Antimetabolites, Antineoplastic; Emollients; Female; Fluorouracil; Humans; Kera	2003
Successful treatment of multiple premalignant and malignant lesions in arsenical keratosis with a combination of acitretin and intralesional 5-fluorouracil. The Journal of dermatology, 2003, Volume: 30, Issue:10 Topics: Acitretin; Arsenic; Biopsy, Needle; Bowen's Disease; Carcinoma, Squamous Cell; Drug Therapy, Combina	2003
Inflammation of actinic keratoses during capecitabine therapy. Archives of dermatology, 2004, Volume: 140, Issue:3 Topics: Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Capecitabine; Colorectal Neoplasms; Deoxyc	2004
Intermittent topical 5-fluorouracil is effective without significant irritation in the treatment of actinic keratoses but prolongs treatment duration. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2004, Volume: 30, Issue:4 Pt 1 Topics: Administration, Topical; Adult; Aged; Drug Administration Schedule; Drug Eruptions; Fluorouracil; Hu	2004
'Watering-can penis' in pseudoepitheliomatous, keratotic and micaceous balanitis. Acta dermato-venereologica, 2004, Volume: 84, Issue:4 Topics: Administration, Topical; Balanitis; Biopsy, Needle; Carcinoma, Verrucous; Diagnosis, Differential; F	2004
Actinic keratosis and capecitabine therapy. Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners, 2005, Volume: 11, Issue:4 Topics: Aged; Antimetabolites, Antineoplastic; Breast Neoplasms; Capecitabine; Carcinoma, Ductal, Breast; De	2005
Inflammation of actinic keratoses and acral erythrodysesthesia during capecitabine treatment. Journal of the American Academy of Dermatology, 2006, Volume: 55, Issue:5 Suppl Topics: Adenocarcinoma; Aged; Antimetabolites, Antineoplastic; Capecitabine; Colonic Neoplasms; Deoxycytidin	2006
[Onycholysis with hyponychium exudate secondary to chemotherapy with paclitaxel and capecitabine]. Actas dermo-sifiliograficas, 2006, Volume: 97, Issue:8 Topics: Adult; Anti-Bacterial Agents; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; As	2006
Allergic contact dermatitis because of topical use of 5-fluorouracil (Efudix cream). Contact dermatitis, 2007, Volume: 57, Issue:1 Topics: Administration, Topical; Aged; Aged, 80 and over; Dermatitis, Allergic Contact; Female; Fluorouracil	2007
Pharmacoeconomic analysis of the treatment of multiple actinic keratoses. Journal of drugs in dermatology : JDD, 2008, Volume: 7, Issue:1 Topics: Aminolevulinic Acid; Aminoquinolines; Clinical Trials, Phase III as Topic; Combined Modality Therapy	2008
Capecitabine induced inflammation of actinic keratoses. Dermatology online journal, 2007, Oct-13, Volume: 13, Issue:4 Topics: Aged; Antimetabolites, Antineoplastic; Breast Neoplasms; Capecitabine; Deoxycytidine; Female; Fluoro	2007
Actinic keratosis: from the skin to the lip. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 2008, Volume: 66, Issue:6 Topics: Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Biopsy; Chemexfoliation; Cryosurgery; Elec	2008
[Experience on topical 5-fluoruracil- (5-FU) in cutaneous carcinomatosis. I. Test on the efficiency of topical 5-FU]. Anales de la Facultad de Medicina, Universidad de la Republica, Montevideo, Uruguay, 1966, Volume: 51, Issue:1 Topics: Carcinoma, Basal Cell; Cheilitis; Facial Dermatoses; Female; Fluorouracil; Hand Dermatoses; Humans;	1966
Management of common skin tumours. The Medical journal of Australia, 1980, Sep-06, Volume: 2, Issue:5 Topics: Bowen's Disease; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Cryosurgery; Dermatitis, Seborrhei	1980
Bilateral cicatricial ectropion following topical administration of 5-fluorouracil. Annals of ophthalmology, 1981, Volume: 13, Issue:5 Topics: Administration, Topical; Aged; Cicatrix; Drug Eruptions; Ectropion; Facial Dermatoses; Fluorouracil;	1981
Actinic keratoses. American family physician, 1984, Volume: 30, Issue:1 Topics: Combined Modality Therapy; Cryosurgery; Fluorouracil; Humans; Keratosis; Ultraviolet Rays	1984
Commentary: use of topical fluorouracil. Archives of dermatology, 1983, Volume: 119, Issue:9 Topics: Administration, Topical; Fluorouracil; Humans; Keratosis	1983
Disseminated superficial porokeratosis: rapid therapeutic response to 5-fluorouracil. Cutis, 1983, Volume: 32, Issue:2 Topics: Administration, Topical; Fluorouracil; Humans; Keratosis; Male; Middle Aged; Ointments	1983
Porokeratosis (Mibelli): treatment with topical 5-fluorouracil. Journal of the American Academy of Dermatology, 1983, Volume: 8, Issue:1 Topics: Administration, Topical; Adult; Fluorouracil; Hand Dermatoses; Humans; Keratosis; Male; Skin; Syndro	1983
Combination of topical 5-fluorouracil with cryotherapy for treatment of actinic keratoses. The Journal of dermatologic surgery and oncology, 1983, Volume: 9, Issue:5 Topics: Administration, Topical; Cryosurgery; Fluorouracil; Humans; Keratosis	1983
A modified topical therapy for the treatment of solar keratoses. The Medical journal of Australia, 1983, May-14, Volume: 1, Issue:10 Topics: Adult; Aged; Fluorouracil; Humans; Keratosis; Middle Aged; Sunlight	1983
Porokeratosis associated with basal cell carcinoma. Cutis, 1982, Volume: 29, Issue:5 Topics: Aged; Carcinoma, Basal Cell; Female; Fluorouracil; Humans; Keratosis; Skin Neoplasms	1982
[Retinoic acid and 5-FU mixture in the topical treatment of several skin diseases (author's transl)]. L'Ateneo parmense. Acta bio-medica : organo della Societa di medicina e scienze naturali di Parma, 1980, Volume: 51, Issue:3 Topics: Drug Combinations; Fluorouracil; Humans; Keratosis; Ointments; Radiation Injuries; Skin Diseases; Sy	1980
Dysplastic epidermal keratosis in a black woman. Archives of dermatology, 1981, Volume: 117, Issue:12 Topics: Aged; Black People; Bowen's Disease; Carcinoma, Squamous Cell; Female; Fluorouracil; Humans; Keratos	1981
Treatment of hyperkeratosis lenticularis perstans (Flegel) with topical fluorouracil. Dermatologica, 1980, Volume: 160, Issue:5 Topics: Administration, Topical; Female; Fluorouracil; Humans; Keratosis; Middle Aged	1980
Cycloheximide as an alternative to the use of fluorouracil for actinic keratosis. Archives of dermatology, 1980, Volume: 116, Issue:6 Topics: Cycloheximide; Fluorouracil; Humans; Keratosis	1980
Mental depression secondary to fluorouracil therapy for actinic keratoses. Archives of dermatology, 1980, Volume: 116, Issue:10 Topics: Depression; Female; Fluorouracil; Humans; Keratosis; Middle Aged	1980
Treatment of actinic keratoses. "Life in the fast lane". Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 1995, Volume: 21, Issue:2 Topics: Carcinoma, Squamous Cell; Fluorouracil; Humans; Keratosis; Neoplasms, Radiation-Induced; Recurrence;	1995
Short-term intensive 5-fluorouracil treatment of actinic keratoses. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 1995, Volume: 21, Issue:2 Topics: Administration, Topical; Drug Evaluation; Drug Therapy, Combination; Fluorouracil; Humans; Keratosis	1995
An oncology patient with an erythematous papulosquamous eruption in sun-exposed areas. Inflamed actinic keratoses due to systemic chemotherapy (fluorouracil and, possibly, interferon alfa). Archives of dermatology, 1994, Volume: 130, Issue:9 Topics: Colonic Neoplasms; Erythema; Fluorouracil; Humans; Interferon-alpha; Keratosis; Male; Middle Aged; S	1994
Temporary ectropion due to topical fluorouracil. Cutis, 1994, Volume: 53, Issue:3 Topics: Administration, Cutaneous; Aged; Ectropion; Facial Dermatoses; Fluorouracil; Humans; Keratosis; Male	1994
Combination chemotherapy with 5-fluorouracil, folinic acid, and alpha-interferon producing histologic features of graft-versus-host disease. Journal of the American Academy of Dermatology, 1993, Volume: 29, Issue:2 Pt 2 Topics: Antineoplastic Combined Chemotherapy Protocols; Drug Eruptions; Erythema; Female; Fluorouracil; Graf	1993
Inflammation of solar keratoses following systemic 5-fluorouracil. The British journal of dermatology, 1996, Volume: 135, Issue:3 Topics: Aged; Antimetabolites, Antineoplastic; Erythema; Female; Fluorouracil; Humans; Keratosis; Male	1996
Skin lesion removal rationed in Florida. BMJ (Clinical research ed.), 1996, Dec-14, Volume: 313, Issue:7071 Topics: Florida; Fluorouracil; Health Care Rationing; Health Services for the Aged; Humans; Keratosis; Medic	1996
Temporary ectropion due to topical fluorouracil. International journal of dermatology, 1997, Volume: 36, Issue:1 Topics: Administration, Topical; Aged; Ectropion; Fluorouracil; Humans; Keratosis; Male	1997
Long-term efficacy and safety of Jessner's solution and 35% trichloroacetic acid vs 5% fluorouracil in the treatment of widespread facial actinic keratoses. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 1997, Volume: 23, Issue:3 Topics: Administration, Topical; Chemexfoliation; Drug Combinations; Ethanol; Facial Dermatoses; Fluorouraci	1997
Does intermittent "pulse" topical 5-fluorouracil therapy allow destruction of actinic keratoses without significant inflammation? Journal of the American Academy of Dermatology, 1998, Volume: 38, Issue:1 Topics: Administration, Cutaneous; Antimetabolites; Dermatitis; Drug Administration Schedule; Drug Eruptions	1998
Managing actinic keratoses with retinoids. Journal of the American Academy of Dermatology, 1998, Volume: 39, Issue:2 Pt 3 Topics: Antimetabolites, Antineoplastic; Drug Therapy, Combination; Etretinate; Fluorouracil; Humans; Kerato	1998
Destructive procedures are the standard of care for treatment of actinic keratoses. Journal of the American Academy of Dermatology, 1999, Volume: 40, Issue:1 Topics: Antimetabolites, Antineoplastic; Florida; Fluorouracil; Health Care Surveys; Humans; Keratosis; Medi	1999
Selective inflammatory effect of systemic fluorouracil in actinic keratosis. Cutis, 1999, Volume: 64, Issue:1 Topics: Adenocarcinoma; Administration, Topical; Aged; Antimetabolites, Antineoplastic; Colonic Neoplasms; F	1999
The treatment of actinic keratoses. Journal of the American Academy of Dermatology, 2000, Volume: 42, Issue:1 Pt 2 Topics: Administration, Topical; Antimetabolites; Cryosurgery; Curettage; Electrosurgery; Fluorouracil; Huma	2000
Fluorouracil cream: don't forget to wash your hands. The Annals of pharmacotherapy, 2000, Volume: 34, Issue:6 Topics: Aged; Aged, 80 and over; Antimetabolites; Fluorouracil; Hand Disinfection; Humans; Keratosis; Male;	2000
Actinic keratosis: time to call a spade a spade. Southern medical journal, 2000, Volume: 93, Issue:7 Topics: Antimetabolites, Antineoplastic; Carcinoma, Squamous Cell; Epidermis; Fluorouracil; Humans; Keratino	2000
Cryopeeling (extensive cryosurgery) for treatment of actinic keratoses: an update and comparison. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2000, Volume: 26, Issue:8 Topics: Carcinoma, Squamous Cell; Chemexfoliation; Cryosurgery; Facial Dermatoses; Female; Fluorouracil; Fol	2000
Bazex syndrome. Dermatology (Basel, Switzerland), 2001, Volume: 202, Issue:4 Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Ear, External;	2001
Allergic contact dermatitis from stearyl alcohol in Efudix cream. Contact dermatitis, 2001, Volume: 45, Issue:5 Topics: Aged; Bowen's Disease; Dermatitis, Allergic Contact; Fatty Alcohols; Female; Fluorouracil; Humans; K	2001
[Topical chemotherapy for carcinoma of the skin (author's transl)]. The Japanese journal of antibiotics, 1975, Volume: 28, Issue:1 Topics: Administration, Topical; Adolescent; Aged; Bleomycin; Bowen's Disease; Carcinoma, Basal Cell; Carcin	1975
Therapeutic challenge of premalignant and malignant skin lesions. Geriatrics, 1975, Volume: 30, Issue:3 Topics: Acetates; Adrenal Cortex Hormones; Adult; Aged; Balanitis; Bowen's Disease; Clioquinol; Cryosurgery;	1975
Topical fluorouracil therapy for precancers and cancers of the skin. Journal of the American Geriatrics Society, 1979, Volume: 27, Issue:12 Topics: Administration, Topical; Drug Eruptions; Fluorouracil; Humans; Keratosis; Precancerous Conditions; S	1979
[Non hereditary porokeratosis of Mibelli]. Medicina cutanea ibero-latino-americana, 1978, Volume: 6, Issue:1 Topics: Adolescent; Adult; Aged; Child; Facial Dermatoses; Female; Fluorouracil; Humans; Keratosis; Lip Dise	1978
Squamous cell carcinoma. Case report of an unusually aggressive skin cancer. Cutis, 1979, Volume: 23, Issue:3 Topics: Aged; Carcinoma, Squamous Cell; Chin; Facial Neoplasms; Female; Fluorouracil; Humans; Keratosis; Ski	1979
Actinic keratoses treated with a combination of topical 5-fluorouracil and dinitrochlorobenzene. Dermatologica, 1979, Volume: 158, Issue:4 Topics: Administration, Topical; Arm; Dermatitis, Contact; Dinitrochlorobenzene; Drug Evaluation; Drug Thera	1979
Male pattern alopecia regrowth following topical fluorouracil therapy. JAMA, 1977, Sep-12, Volume: 238, Issue:11 Topics: Alopecia; Alopecia Areata; Fluorouracil; Humans; Keratosis; Male; Middle Aged	1977
A short survey on the use and efficacy of 5-fluorouracil in Australia. The Journal of dermatologic surgery and oncology, 1978, Volume: 4, Issue:3 Topics: Aged; Australia; Carcinoma, Basal Cell; Fluorouracil; Humans; Keratosis; Skin Diseases; Skin Neoplas	1978
[Vitamin A acid for the topical management of epithelial neoplasms. Combination with 5-fluorouracil]. Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 1978, Volume: 29, Issue:6 Topics: Aged; Carcinoma, Basal Cell; Drug Therapy, Combination; Female; Fluorouracil; Humans; Keratosis; Leu	1978
Systemic fluorouracil photosensitivity. Cutis, 1978, Volume: 22, Issue:5 Topics: Aged; Colonic Neoplasms; Female; Fluorouracil; Humans; Keratosis; Photosensitivity Disorders	1978
Allergic contact dermatitis from topical fluorouracil. Archives of dermatology, 1977, Volume: 113, Issue:2 Topics: Administration, Topical; Dermatitis, Atopic; Dermatitis, Contact; Female; Fluorouracil; Humans; Kera	1977
[Topical use of antineoplastic agents in precancerous conditions of the skin]. Zeitschrift fur Hautkrankheiten, 1977, Apr-15, Volume: 52, Issue:8 Topics: Administration, Topical; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Fluorouracil; Humans; Kera	1977
Management of skin blemishes. Medical times, 1977, Volume: 105, Issue:6 Topics: Aged; Electrosurgery; Fluorouracil; Humans; Keratosis; Male; Middle Aged; Skin; Skin Diseases	1977
Treatment of lip keratoses (actinic cheilitis) with topical fluorouracil. Archives of dermatology, 1977, Volume: 113, Issue:7 Topics: Administration, Topical; Adult; Aged; Cheilitis; Female; Fluorouracil; Humans; Keratosis; Lip Neopla	1977
Allergic contact dermatitis to topical fluorouracil. Archives of dermatology, 1977, Volume: 113, Issue:8 Topics: California; Dermatitis, Atopic; Dermatitis, Contact; Fluorouracil; Keratosis; Prospective Studies; R	1977
Practical therapy for hyperkeratotic skin lesions. Geriatrics, 1975, Volume: 30, Issue:3 Topics: Acetates; Aged; Bandages; Callosities; Electrosurgery; Female; Fluorouracil; Foot; Humans; Keratoaca	1975
Letter: Two unusual complications of topical fluorouracil therapy. Archives of dermatology, 1975, Volume: 111, Issue:3 Topics: Administration, Topical; Adult; Female; Fluorouracil; Herpes Labialis; Humans; Keratosis; Male; Midd	1975
Delayed hypersensitivity in xeroderma pigmentosum. Archiv fur dermatologische Forschung, 1975, Volume: 251, Issue:4 Topics: Carcinoma, Squamous Cell; Child; Child, Preschool; Eye Diseases; Female; Fluorouracil; Humans; Hyper	1975
Treatment of solar keratoses with a 5-fluorouracil and salicylic acid varnish. The British journal of dermatology, 1975, Volume: 92, Issue:1 Topics: Administration, Topical; Adult; Aged; Collodion; Drug Combinations; Female; Fluorouracil; Hand; Huma	1975
Treatment of solar keratoses of the extremities with retinoic acid and 5-fluorouracil. The British journal of dermatology, 1975, Volume: 92, Issue:6 Topics: Adult; Aged; Drug Therapy, Combination; Female; Fluorouracil; Humans; Keratosis; Male; Middle Aged;	1975
Contact sensitivity to the stearyl alcohol in Efudix cream (5-fluorouracil). Contact dermatitis, 1992, Volume: 26, Issue:2 Topics: Aged; Dermatitis, Contact; Drug Eruptions; Fatty Alcohols; Female; Fluorouracil; Humans; Keratosis	1992
Hyperkeratosis lenticularis perstans (Flegel's disease). Ultrastructural study of lesional and perilesional skin and therapeutic trial of topical tretinoin versus 5-fluorouracil. Journal of the American Academy of Dermatology, 1992, Volume: 27, Issue:5 Pt 2 Topics: Administration, Cutaneous; Fluorouracil; Foot Dermatoses; Humans; Keratosis; Leg Dermatoses; Male; M	1992
Weekly pulse dosing: effective and comfortable topical 5-fluorouracil treatment of multiple facial actinic keratoses. Journal of the American Academy of Dermatology, 1991, Volume: 25, Issue:4 Topics: Administration, Cutaneous; Drug Administration Schedule; Erythema; Facial Dermatoses; Fluorouracil;	1991
Porokeratosis: a report of three clinical variants. The Medical journal of Malaysia, 1991, Volume: 46, Issue:1 Topics: Adolescent; Adult; Female; Fluorouracil; Humans; Keratosis	1991
Striate melanokeratosis. Archives of ophthalmology (Chicago, Ill. : 1960), 1991, Volume: 109, Issue:7 Topics: Corneal Diseases; Fluorouracil; Humans; Keratosis; Melanosis	1991
Striate melanokeratosis following trabeculectomy with 5-fluorouracil. Archives of ophthalmology (Chicago, Ill. : 1960), 1990, Volume: 108, Issue:9 Topics: Corneal Diseases; Fluorouracil; Glaucoma, Open-Angle; Humans; Keratosis; Male; Melanosis; Middle Age	1990
Toxic response to topical fluorouracil in two rheumatoid arthritis patients receiving low-dose, weekly methotrexate. Arthritis and rheumatism, 1990, Volume: 33, Issue:2 Topics: Aged; Arthritis, Rheumatoid; Drug Eruptions; Drug Synergism; Fluorouracil; Humans; Keratosis; Male;	1990
Subconjunctival 5-fluorouracil-induced transient striate melanokeratosis. Archives of ophthalmology (Chicago, Ill. : 1960), 1990, Volume: 108, Issue:9 Topics: Adult; Aged; Corneal Diseases; Fluorouracil; Humans; Keratosis; Melanosis; Middle Aged	1990
[The importance of local administration of 5% 5-fluorouracil in the therapy of senile keratoses and basocellular carcinoma]. Medicinski pregled, 1989, Volume: 42, Issue:3-4 Topics: Administration, Topical; Aged; Carcinoma, Basal Cell; Female; Fluorouracil; Humans; Keratosis; Male;	1989
Scrotal dermatitis caused by 5-fluorouracil (Efudex). Journal of the American Academy of Dermatology, 1988, Volume: 19, Issue:5 Pt 2 Topics: Adolescent; Adult; Condylomata Acuminata; Dermatitis, Contact; Drug Eruptions; Fluorouracil; Genital	1988
Treatment of solar keratoses. The Australasian journal of dermatology, 1988, Volume: 29, Issue:3 Topics: Fluorouracil; Humans; Keratosis; Sunlight	1988
Topical application of 5-fluorouracil in premalignant lesions of cornea, conjunctiva and eyelid. Documenta ophthalmologica. Advances in ophthalmology, 1986, Dec-30, Volume: 64, Issue:1 Topics: Aged; Carcinoma in Situ; Conjunctival Diseases; Corneal Diseases; Drug Administration Schedule; Eyel	1986
Hyperkeratosis lenticularis perstans (Flegel's disease). Case report and literature review. Journal of the American Academy of Dermatology, 1987, Volume: 16, Issue:1 Pt 2 Topics: Administration, Cutaneous; Diabetes Complications; Fluorouracil; Humans; Keratosis; Male; Middle Age	1987
Dermabrasion of the scalp as a treatment for actinic damage. Journal of the American Academy of Dermatology, 1986, Volume: 14, Issue:4 Topics: Aged; Alopecia; Dermabrasion; Fluorouracil; Humans; Keratosis; Male; Middle Aged; Scalp Dermatoses;	1986
[Comparative topic treatments of basal cell carcinomas and senile keratoses with 5-FU, retinoic acid and DNCB sensitization (author's transl)]. Dermatologica, 1974, Volume: 148, Issue:2 Topics: Administration, Topical; Carcinoma, Basal Cell; Chlorobenzenes; Fluorouracil; Humans; Immunotherapy;	1974
Treatment of skin cancers and keratoses with 5-fluorouracil. Acta chirurgiae plasticae, 1968, Volume: 10, Issue:3 Topics: Carcinoma, Basal Cell; Fluorouracil; Humans; Keratosis; Male; Ointments; Skin Neoplasms	1968
Actinic keratoses in Bantu albinos. Clinical experiences with the topical use of 5-fluoro-uracil. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1973, Nov-17, Volume: 47, Issue:45 Topics: Adult; Albinism; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Catechol Oxidase; Child; Female; F	1973
Untoward response with topical fluorouracil. Archives of dermatology, 1968, Volume: 97, Issue:1 Topics: Aged; Carcinoma, Basal Cell; Drug Eruptions; Female; Fluorouracil; Humans; Keratosis; Male; Middle A	1968
The treatment of premalignant and malignant skin lesions with 5-fluorouracil. Le Journal medical libanais. The Lebanese medical journal, 1971, Volume: 24, Issue:1 Topics: Drug Eruptions; Female; Fluorouracil; Humans; Keratosis; Male; Precancerous Conditions; Skin; Skin N	1971
Minor surgery for benign and malignant facial lesions. American family physician, 1974, Volume: 10, Issue:5 Topics: Acne Vulgaris; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Cicatrix; Cortisone; Curettage; Cyst	1974
Topical fluorouracil treatment of senile keratosis and mycosis fungoides. A clinical and ultrastructural study, with special reference to nucleolar structure. Archiv fur Geschwulstforschung, 1972, Volume: 39, Issue:2 Topics: Biopsy; Cell Nucleolus; Fluorouracil; Humans; Inclusion Bodies; Keratosis; Microscopy, Electron; Myc	1972
Epithelial neoplasms. Clinical pharmacology and therapeutics, 1974, Volume: 16, Issue:5 Part 2 Topics: Administration, Topical; Antineoplastic Agents; Erythema; Fluorouracil; Humans; Keratosis; Prostagla	1974
Tumors of the skin. Premalignment and malignant. Minnesota medicine, 1974, Volume: 57, Issue:10 Topics: Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Diagnosis, Differential; Fluorouracil; Humans; Kera	1974
Effect of topical 5-fluorouracil treatment on actinic keratosis: a light and electron microscopic study. Journal of cutaneous pathology, 1974, Volume: 1, Issue:6 Topics: Actinin; Administration, Topical; Aged; Basement Membrane; Cell Survival; Fluorouracil; Humans; Inte	1974
[Indications for fluorouracil in dermatology]. Medicina cutanea ibero-latino-americana, 1974, Issue:2 Topics: DNA; DNA Replication; Drug Evaluation; Fluorouracil; Humans; Keratoacanthoma; Keratosis; Neoplasms;	1974
Multiple cutaneous squamous cell carcinomas during immunosuppressive therapy. Archives of dermatology, 1973, Volume: 107, Issue:6 Topics: Adult; Azathioprine; Carcinoma, Squamous Cell; Fluorouracil; Humans; Hyperplasia; Immunosuppressive	1973
The clinical application of 5-fluorouracil in the treatment of skin lesions. Comment. Plastic and reconstructive surgery, 1973, Volume: 52, Issue:3 Topics: Carcinoma, Basal Cell; Fluorouracil; Humans; Keratosis; Skin Neoplasms	1973
Actinic keratosis--the advent of fluorouracil. The Journal of the Kansas Medical Society, 1973, Volume: 74, Issue:8 Topics: Fluorouracil; Humans; Keratosis; Photosensitivity Disorders; Sunlight	1973
Use of topical 5-fluorouracil in the treatment of solar keratoses. The Journal of the Louisiana State Medical Society : official organ of the Louisiana State Medical Society, 1973, Volume: 124, Issue:2 Topics: Female; Fluorouracil; Follow-Up Studies; Humans; Keratosis; Middle Aged	1973
Fluorouracil ointment treatment of porokeratosis of Mibelli. Archives of dermatology, 1973, Volume: 108, Issue:1 Topics: Adult; Dermatitis, Contact; Female; Fluorouracil; Humans; Keratosis; Male; Middle Aged; Ointments; R	1973
Letter: 5-Fluoro-uracil 5 per cent (Efudix). South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1973, Sep-01, Volume: 47, Issue:34 Topics: Carcinoma, Squamous Cell; Female; Fluorouracil; Humans; Keratosis; Skin Neoplasms	1973
Topical use of 5-fluorouracil. The Medical journal of Australia, 1973, Jul-14, Volume: 2, Issue:2 Topics: Carcinoma, Squamous Cell; Fluorouracil; Humans; Keratosis; Skin Neoplasms	1973
Letter: Multiple actinic keratoses of the forehead. Archives of dermatology, 1973, Volume: 108, Issue:4 Topics: Administration, Topical; Dermatomyositis; Fluorouracil; Humans; Inflammation; Keratosis; Male; Middl	1973
Proceedings: Chemotherapy and immunotherapy for cancer involving the skin. Proceedings. National Cancer Conference, 1972, Volume: 7 Topics: Administration, Topical; Antigens, Bacterial; Antineoplastic Agents; Carcinoma, Basal Cell; Carcinom	1972
Fluorouracil cream (Efudix) in dermatology. Drug and therapeutics bulletin, 1973, Nov-23, Volume: 11, Issue:24 Topics: Fluorouracil; Humans; Keratosis; Psoriasis; Skin Diseases; Skin Neoplasms; Xeroderma Pigmentosum	1973
[External treatment with 5-fluorouracil]. Nederlands tijdschrift voor geneeskunde, 1973, Jul-28, Volume: 117, Issue:30 Topics: Carcinoma, Squamous Cell; Fluorouracil; Humans; Keratoacanthoma; Keratosis; Ointments; Xeroderma Pig	1973
Effect of topical tubercidin on basal cell carcinomas and actinic keratoses. Cancer, 1974, Volume: 34, Issue:2 Topics: Adenosine; Administration, Topical; Aged; Carcinoma, Basal Cell; Female; Fluorouracil; Humans; Kerat	1974
The clinical application of 5-fluorouracil in the treatment of skin lesions. Plastic and reconstructive surgery, 1968, Volume: 41, Issue:6 Topics: Adolescent; Adult; Carcinoma, Basal Cell; Child; Child, Preschool; Dermatologic Agents; Fluorouracil	1968
Selectivity of fluorouracil in treatment of actinic keratoses. Archives of dermatology, 1968, Volume: 98, Issue:2 Topics: Aged; Fluorouracil; Humans; Keratosis; Male; Photosensitivity Disorders; Skin Transplantation; Sunbu	1968
Bullous pemphigoid following the topical use of fluorouracil. Archives of dermatology, 1970, Volume: 102, Issue:4 Topics: Aged; Autoantibodies; Fluorescent Antibody Technique; Fluorouracil; Humans; Keratosis; Male; Skin Di	1970
[Topical use of 5-fluorouracil ointment]. Dermatologische Monatschrift, 1972, Volume: 158, Issue:8 Topics: Female; Fluorouracil; Humans; Keratosis; Middle Aged; Ointments; Skin Tests	1972
Topical therapy with 5-Fluorouracil. Journal of surgical oncology, 1971, Volume: 3, Issue:3 Topics: DNA; Fluorouracil; Humans; Keratosis; Pharmaceutical Vehicles; Precancerous Conditions; Propylene Gl	1971
Review of a 3-year experience with topical chemotherapy and immunotherapy of superficial cutaneous neoplasms. Journal of surgical oncology, 1971, Volume: 3, Issue:3 Topics: Antineoplastic Agents; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Chlorine; Facial Neoplasms;	1971
Tumors of the skin. XII. Topical 5-Fluorouracil for epidermal neoplasms. Journal of surgical oncology, 1971, Volume: 3, Issue:3 Topics: Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Dermatitis; Esthetics; Female; Fluorouracil; Humans	1971
A comparison of chemical peeling, dermabrasion, and 5-fluourouracil in cancer prophylaxis. Journal of surgical oncology, 1971, Volume: 3, Issue:3 Topics: Cautery; Dermabrasion; Fluorouracil; Humans; Keratosis; Neoplasm Recurrence, Local; Phenols; Sunscre	1971
Porokeratosis plantaris, palmaris, et disseminata. A third type of porokeratosis. Archives of dermatology, 1971, Volume: 104, Issue:4 Topics: Adolescent; Adult; Age Factors; Aged; Biopsy; Carcinoma, Squamous Cell; Child; Female; Fluorouracil;	1971
[Topical therapy of superficial basalioma and senile keratoma with 5-fluorouracil]. Ceskoslovenska dermatologie, 1971, Volume: 46, Issue:5 Topics: Aged; Carcinoma, Basal Cell; Fluorouracil; Humans; Keratosis; Precancerous Conditions; Skin Neoplasm	1971
[Trials using local 5-FU therapy in precancerous states and cancer of the skin]. Dermatologica, 1971, Volume: 142, Issue:5 Topics: Carcinoma, Basal Cell; Fluorouracil; Follow-Up Studies; Humans; Keratosis; Ointments; Precancerous C	1971
Use of 5-fluorouracil 5 percent ointment (Efudix) in treatment of senile keratoses. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1971, Dec-04, Volume: 45, Issue:46 Topics: Age Factors; Aged; Female; Fluorouracil; Humans; Keratosis; Male	1971
[5-Fluorouracil in local therapy of precancerous conditions and carcinoma of the skin]. Schweizerische medizinische Wochenschrift, 1971, Aug-28, Volume: 101, Issue:34 Topics: Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Fluorouracil; Humans; Keratosis; Neoplasm Recurrenc	1971
[Treatment of cutaneous tumors with fluorouracil ointment]. Harefuah, 1971, Nov-01, Volume: 81, Issue:9 Topics: Adult; Aged; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Female; Fluorouracil; Humans; Keratosi	1971
The use of topical 5-fluorouracil in actinic keratoses. Canadian Medical Association journal, 1971, Dec-18, Volume: 105, Issue:12 Topics: Adult; Aged; Aging; Biopsy; Carcinoma, Squamous Cell; Fluorouracil; Humans; Keratosis; Middle Aged;	1971
Topical 5-fluorouracil: variability of effective dosage and duration of reaction. Journal of the American Geriatrics Society, 1971, Volume: 19, Issue:12 Topics: Carcinoma, Basal Cell; Fluorouracil; Humans; Keratosis; Skin Neoplasms	1971
Topical fluorouracil (5-FU) for premalignant keratoses. The Medical letter on drugs and therapeutics, 1971, May-28, Volume: 13, Issue:11 Topics: Fluorouracil; Humans; Keratosis; Precancerous Conditions	1971
Albinism. Birth defects original article series, 1971, Volume: 7, Issue:8 Topics: Adult; Albinism; Black People; Female; Fluorouracil; Humans; Keratosis; Light; Middle Aged; Nystagmu	1971
The topical use of Fluorouracil in the treatment of cancers and precancers. Journal of the South Carolina Medical Association (1975), 1967, Volume: 63, Issue:7 Topics: Fluorouracil; Humans; Keratosis; Skin Neoplasms	1967
Treatment of precancerous dermatoses with topical 5-Fluorouracil. Asthetische Medizin, 1969, Jul-20, Volume: 18, Issue:7 Topics: Fluorouracil; Humans; Keratosis; Ointments; Precancerous Conditions; Skin Diseases; Solutions	1969
Topical fluorouracil therapy. Southern medical journal, 1969, Volume: 62, Issue:10 Topics: Fluorouracil; Humans; Keratosis; Photosensitivity Disorders; Sunlight	1969
Resistance to fluorouracil. Archives of dermatology, 1969, Volume: 100, Issue:5 Topics: Fluorouracil; Humans; Keratosis; Male; Middle Aged; Photosensitivity Disorders	1969
Topical cytotoxic therapy of solar keratoses with 5-fluorouracil. The Medical journal of Australia, 1969, Dec-06, Volume: 2, Issue:23 Topics: Antineoplastic Agents; Dermatologic Agents; Erythema; Fluorouracil; Humans; Keratosis; Male; Ointmen	1969
Fluorouracil: mechanism of action in human skin and actinic keratoses. I. Effect on DNA synthesis in vivo. Archives of dermatology, 1970, Volume: 101, Issue:2 Topics: Chemical Phenomena; Chemistry; Deoxyuridine; DNA; Fluorouracil; Humans; Injections, Intradermal; Inj	1970
Experiences with local chemotherapy and immunotherapy in premalignant and malignant skin lesions. Cancer, 1970, Volume: 25, Issue:2 Topics: Antigen-Antibody Reactions; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Dermatitis; Dermatitis,	1970
[Treatment of carcinoma and precancerosis using 5-fluorouracil]. Archiv fur klinische und experimentelle Dermatologie, 1970, Volume: 237, Issue:1 Topics: Aged; Carcinoma; Carcinoma, Basal Cell; Female; Fluorouracil; Humans; Keratosis; Occlusive Dressings	1970
[Use of 5-fluorouracil ointment. Indications and limitations]. Bulletin de la Societe francaise de dermatologie et de syphiligraphie, 1970, Volume: 77, Issue:1 Topics: Carcinoma, Squamous Cell; Erythema; Fluorouracil; Humans; Keratosis; Ointments; Photosensitivity Dis	1970
Clinical comparison of chemical peeling dermabrasion, and 5-fu for senile keratoses. Plastic and reconstructive surgery, 1970, Volume: 46, Issue:1 Topics: Aged; Dermabrasion; Fluorouracil; Humans; Keratosis; Male	1970
The aging skin: problems and their causes. Geriatrics, 1970, Volume: 25, Issue:4 Topics: Aged; Aging; Arsenicals; Balanitis; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Female; Fluorou	1970
Treatment of actinic keratosis. Archives of dermatology, 1970, Volume: 102, Issue:3 Topics: Fluorouracil; Humans; Keratosis; Photosensitivity Disorders; Ultraviolet Therapy	1970
[Therapy of multiple actinic keratosis with a 5-percent fluorouracil ointment]. Giornale italiano di dermatolotia. Minerva dermatologica, 1970, Volume: 45, Issue:2 Topics: Adrenal Cortex Hormones; Fluorouracil; Humans; Keratosis; Ointments	1970
Occurrence of squamous carcinoma in hyperkeratoses and Bowenoid lesions treated with 5-fluorouracil. The Australasian journal of dermatology, 1970, Volume: 11, Issue:2 Topics: Aged; Carcinoma, Squamous Cell; Fluorouracil; Humans; Keratosis; Male; Middle Aged	1970
Summary of our trial with 5-fluorouracil (5-FU) ointment on the treatment of basal cell epithelioma and senile keratosis. Dermatologica, 1970, Volume: 140 Topics: Carcinoma, Basal Cell; Fluorouracil; Humans; Keratosis; Ointments; Skin Neoplasms; Time Factors	1970
Comparison of the clinical and histological effects of 5-fluorouracil (5-FU) alone and of 5-FU preceded by dimethyl-sulphoxide (DMSO) on senile keratosis. Dermatologica, 1970, Volume: 140 Topics: Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Dimethyl Sulfoxide; Fluorouracil; Humans; Keratosis	1970
5-fluorouracil ointment in tumors of the skin. Dermatologica, 1970, Volume: 140 Topics: Aged; Carcinoma, Basal Cell; Female; Fluorouracil; Humans; Keratoacanthoma; Keratosis; Male; Middle	1970
5-fluorouracil (5-FU) ointment in the treatment of benign and malignant skin lesions. Dermatologica, 1970, Volume: 140 Topics: Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Fluorouracil; Humans; Keratoacanthoma; Keratosis; L	1970
5-fluouracil (5-FU) ointment in the treatment of skin tumours and keratoses. Dermatologica, 1970, Volume: 140 Topics: Aged; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Female; Fluorouracil; Humans; Keratoacanthoma	1970
[Several cases treated topically with 5-fluorouracil]. Dermatologica, 1970, Volume: 141, Issue:2 Topics: Fluorouracil; Humans; Keratosis	1970
Topical 5-FU--a new approach to skin cancer. Annals of surgery, 1971, Volume: 173, Issue:6 Topics: Fluorouracil; Humans; Keratosis; Skin Neoplasms	1971
[Case of Mibelli's porokeratosis]. Archives belges de dermatologie et de syphiligraphie, 1967, Volume: 23, Issue:4 Topics: Child; Female; Fluorouracil; Humans; Keratosis; Sweat Glands	1967
Treatment of actinic keratoses with topical 5-fluorouracil. Journal of the Medical Association of Georgia, 1968, Volume: 57, Issue:5 Topics: Female; Fluorouracil; Humans; Keratosis	1968
Inflammation of actinic keratosis secondary to systemic 5-fluorouracil. Archives of dermatology, 1968, Volume: 98, Issue:1 Topics: Aged; Female; Fluorouracil; Humans; Inflammation; Keratosis	1968
Topical 5-fluorouracil for actinic keratoses. Geriatrics, 1968, Volume: 23, Issue:7 Topics: Fluorouracil; Humans; Keratosis; Photosensitivity Disorders; Propylene Glycols; Skin Absorption; Ski	1968
Topical chemotherapy of precancerous dermatoses. Texas medicine, 1968, Volume: 64, Issue:8 Topics: Fluorouracil; Humans; Keratosis; Precancerous Conditions	1968
Xeroderma pigmentosum. Treatment with topically applied fluorouracil. Archives of dermatology, 1968, Volume: 98, Issue:5 Topics: Adolescent; Adult; Carcinoma, Squamous Cell; Female; Fluorouracil; Humans; Keratosis; Skin Neoplasms	1968
Topical 5-fluorouracil in the treatment of actinic keratoses. Missouri medicine, 1968, Volume: 65, Issue:12 Topics: Aged; Fluorouracil; Humans; Keratosis; Male; Neoplasms, Radiation-Induced; Precancerous Conditions;	1968
Topical chemotherapy of cutaneous malignancy of the head and neck. Southern medical journal, 1969, Volume: 62, Issue:5 Topics: Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Fluorouracil; Head and Neck Neoplasms; Humans; Kera	1969
Fluorouracil topically for skin cancer. JAMA, 1969, Feb-03, Volume: 207, Issue:5 Topics: Aged; Carcinoma, Basal Cell; Fluorouracil; Humans; Keratosis; Male; Ointments; Propylene Glycols; Sk	1969
Inflammation of actinic keratoses due to systemic fluorouracil therapy. JAMA, 1969, Apr-07, Volume: 208, Issue:1 Topics: Aged; Breast Neoplasms; Female; Fluorouracil; Humans; Inflammation; Keratosis	1969
Preliminary studies in the use of 5-fluoro-uracil cream in the treatment of malignant and premalignant skin tumours. The Medical journal of Australia, 1969, Aug-23, Volume: 2, Issue:8 Topics: Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Fluorouracil; Humans; Keratoacanthoma; Keratosis; O	1969
Further studies with topical 5-fluorouracil. Archives of dermatology, 1965, Volume: 92, Issue:4 Topics: Adolescent; Adult; Aged; Carbon Isotopes; Fluorouracil; Humans; Keratosis; Middle Aged; Ointments; S	1965
Prevention of skin cancer with topical 5-fluorouracil. Rocky Mountain medical journal, 1966, Volume: 63, Issue:11 Topics: Adult; Aged; Female; Fluorouracil; Humans; Keratosis; Male; Middle Aged; Skin Neoplasms	1966

fluorouracil and Keratoderma Blennorrhagicum

Research Excerpts

Research

Studies (215)

Authors

Clinical Trials (2)

Trial Overview

Reviews

Trials

Other Studies

Authors	Studies
Khoo, AA	1
Mulgrew, S	1
Norton, S	1
Gibbs, S	1
Davis, T	1
Piotrowski, MJ	1
Gunn, H	1
Kirby, J	1
Ali, L	1
Helm, K	1
Hussain, A	1
Haque, MW	1
Singh, SK	1
Ahmed, FJ	1
Mann, M	1
Berk, DR	1
Petersen, J	1
Menter, A	2
Vamvakias, G	2
Jorizzo, J	4
Loven, K	1
Stein, L	1
Furst, K	5
Levy, S	4
Weiss, J	3
Hevia, O	1
Jones, T	1
Ling, M	1
Rist, T	1
Roberts, J	1
Shavin, JS	1
Sklar, J	1
Webster, G	1
Connolly, M	2
Stewart, D	1
Bucko, A	1
Davis, SA	1
Espy, P	1
Hino, P	1
Rodriguez, D	1
Savin, R	1
Stough, D	1
Kirkup, ME	1
Narayan, S	1
Kennedy, CT	1
Tutrone, WD	1
Saini, R	1
Caglar, S	1
Weinberg, JM	2
Crespo, J	1
Burkhart, CN	1
Burkhart, CG	1
Robins, P	2
Marcus, L	1
Dummer, R	1
Beyeler, M	1
Morcinek, J	1
Burg, G	1
Silapunt, S	1
Goldberg, LH	2
Alam, M	1
Khandpur, S	1
Sharma, VK	1
Smith, S	1
Piacquadio, D	1
Morhenn, V	1
Atkin, D	1
Fitzpatrick, R	1
Lewis, KG	1
Lewis, MD	1
Robinson-Bostom, L	1
Pan, TD	1
Labandeira, J	1
Pereiro, M	1
Valdés, F	1
Toribio, J	1
VandePol, C	1
Levy, SF	1
Zawar, V	1
Kirloskar, M	1
Chuh, A	1
McGillis, ST	1
Fein, H	1
Jorizzo, JL	4
Lober, BA	1
Fenske, NA	1
Carney, PS	1
Ko, WT	1
Weinkle, SH	1
Werschler, WP	1
Jury, CS	1
Ramraka-Jones, VS	1
Gudi, V	1
Herd, RM	1
Smith, SR	1
Morhenn, VB	1
Piacquadio, DJ	1
Berman, B	2
Villa, AM	1
Ramirez, CC	1
Gupta, AK	2
Davey, V	1
Mcphail, H	1
Epstein, E	5
Higa, GM	1
Kovach, RF	1
Abraham, J	1
Bienstock, L	1
Kuritzky, L	1
Mayeaux, EJ	1
Tyring, SK	1
Dissemond, J	1
Grabbe, S	1
Ostertag, JU	1
Quaedvlieg, PJ	1
van der Geer, S	1
Nelemans, P	1
Christianen, ME	1
Neumann, MH	1
Krekels, GA	1
Hantash, BM	1
Stewart, DB	1
Cooper, ZA	1
Rehmus, WE	1
Koch, RJ	1
Swetter, SM	1
Peramiquel, L	1
Dalmau, J	1
Puig, L	1
Roé, E	1
Fernández-Figueras, MT	1
Alomar, A	1
Tejera, A	1
Bosch, RJ	1
López, N	1
Herrera, E	1
Perrett, CM	1
McGregor, JM	1
Warwick, J	1
Karran, P	1
Leigh, IM	1
Proby, CM	1
Harwood, CA	1
Tanghetti, E	1
Werschler, P	1
Meijer, BU	1
de Waard-van der Spek, FB	1
Price, NM	2
McIntyre, WJ	1
Downs, MR	1
Bedwell, SA	1
Krawtchenko, N	1
Roewert-Huber, J	1
Ulrich, M	1
Mann, I	1
Sterry, W	1
Stockfleth, E	1
Gold, MH	1
Krathen, M	1
Treat, J	1
James, WD	1
Zide, MF	1
Chiaffitelli, C	1
Suarez Halty, L	1
Carter, DM	1
Balin, AK	1
Rogers, M	1
Galentine, P	1
Sloas, H	1
Hargett, N	1
Cupples, HP	1
Wilkerson, MG	1
Rapini, RP	1
Dillaha, CJ	2
Jansen, GT	5
Honeycutt, WM	2
Bradford, AC	1
Shelley, WB	2
Shelley, ED	2
McDonald, SG	1
Peterka, ES	1
Abadir, DM	1
Czarnecki, D	1
Apted, JH	1
Glickman, FS	1
Benoldi, D	1
Pezzarossa, E	1
Alinovi, A	1
Labrini, G	1
Marcheselli, W	1
de Panfilis, G	1
Manfredi, G	1
Weaver, SM	1
Kelly, AP	1
Lopansri, S	1
Wilson, PD	1
Ive, FA	1
Milstein, HG	2
Lawrence, N	2
Cox, SE	2
Cockerell, CJ	4
Freeman, RG	1
Cruz, PD	1
Dzubow, LM	1
Unis, ME	1
Sollitto, RB	1
Frank, W	1
Palko, MJ	1
Rogers, GS	1
Hecker, D	1
Hacker, SM	1
Ramos-Caro, FA	1
Flowers, FP	1
Beard, JS	1
Smith, KJ	1
Skelton, HG	1
Schwartz, RA	1
Bataille, V	1
Cunningham, D	1
Mansi, J	1
Mortimer, P	1
Charatan, FB	1
Lewis, JE	1
Witheiler, DD	1
Cruz, C	1
Freemen, RG	1
Barnaby, JW	1
Styles, AR	1
Odom, R	1
Marrero, GM	1
Katz, BE	1
Feldman, SR	1
Fleischer, AB	1
Williford, PM	1
Janmeja, M	1
Licata, A	1
Nabai, H	1
Mohindra, R	1
Mehregan, D	1
Kurwa, HA	1
Yong-Gee, SA	1
Seed, PT	1
Markey, AC	1
Barlow, RJ	1
Dinehart, SM	1
Leung, WY	1
Critchley, JA	1
Evans, C	1
Chiarello, SE	1
de Berker, D	2
Chern, W	1
Buxtorf, K	1
Hübscher, E	1
Panizzon, R	1
Weiss, JS	1
Yesudian, PD	1
King, CM	1
Miki, Y	1
Kawatsu, T	1
Matsuda, H	1
Yamada, T	1
Kahata, A	1
Katz, H	1
Redding, KG	1
Rees, RB	1
Cullen, SI	1
De Ascensão, AC	1
Biro, L	1
Price, E	1
Rietschel, RL	1
Madorsky, DD	1
Lewis, MB	1
Kurka, M	1
Orfanos, CE	1
Pullmann, H	1
Schreiber, MM	1
Simmonds, WL	1
Goette, DK	2
Odom, RB	2
Owens, R	1
Gartmann, H	1
Perry, HO	1
Breza, T	1
Taylor, R	1
Eaglstein, WH	2
Burnett, JW	1
Salamon, T	1
Stojaković, M	1
Bogdanović, B	1
Goncalves, JC	2
Robinson, TA	1
Kligman, AM	1
Marren, P	1
Powell, SM	1
Ryan, TJ	1
Langer, K	1
Zonzits, E	1
Konrad, K	1
Pearlman, DL	1
Singh, R	1
Ghazali, W	1
Nor, M	1
Lemp, MA	1
Griffin, TD	1
Van Scott, EJ	1
Peterson, MR	1
Skuta, GL	1
Phelan, MJ	1
Stanley, SA	1
Blackburn, WD	1
Alarcón, GS	1
Stank, TM	1
Krupin, T	1
Feitl, ME	1
Poljacki, M	1
Stojanović, S	1
Svilar, V	1
Sillman, FH	1
Sedlis, A	1
Boyce, JG	1
White, AD	1
Bercovitch, L	1
de Keizer, RJ	1
de Wolff-Rouendaal, D	1
van Delft, JL	1
Pearson, LH	1
Smith, JG	1
Chalker, DK	1
Winton, GB	1
Salasche, SJ	1
Remy, W	1
Stüttgen, G	1
Snyderman, RK	3
Starzynski, TE	2
Dogliotti, M	1
Sams, WM	1
Farah, FS	1
Shbaklo, Z	1
Dickinson, JT	1
Rooker, DW	1
Leonard, JR	1
Stenram, U	1
Lidén, S	1
Weinstein, GD	3
Lynch, PJ	1
Hodge, SJ	1
Schrodt, GR	1
Owen, LG	1
Padilla, H	1
Westburg, SP	1
Stone, OJ	1
Anderson, L	1
Litwin, MS	2
Leeming, JA	1
Belisario, JC	3
Vail, JT	1
Klein, E	5
Swart-Bruinsma, WA	1
Herrmann, WA	1
Burgess, GH	1
Bloch, A	1
Stoll, H	1
Milgrom, H	2
Helm, F	2
Saltzer, EI	1
Soderquist, NA	1
Wilson, JW	1
Healy, JB	1
Ashton, H	1
Beveridge, GW	1
Stevenson, CJ	1
Zackheim, HS	1
Farber, EM	1
Bart, BJ	1
Bean, SF	1
Lopes, CF	1
Armond, S	1
Czernielewski, A	1
Karpińska, A	1
Cavins, JA	1
Stoll, HL	1
Walker, MJ	1
Spira, M	2
Freeman, RF	1
Arfai, P	2
Gerow, FJ	1
Hardy, SB	2
Guss, SB	1
Osbourn, RA	1
Lutzner, MA	1
Trnka, J	1
Ott, F	2
Hansen, DA	1
Storck, H	1
Avrach, W	1
Ziprkowski, L	1
Richards, RN	1
Sykes, MP	1
Salem, P	1
Joffe, B	1
Shepard, MK	1
Ward, WQ	1
Hambrick, GW	1
Allison, JR	1
Rossman, RE	2
Frost, P	1
Williams, AC	2
Landes, E	1
Thivolet, J	1
Chabanon, M	1
Perrot, H	1
Freeman, R	1
Gero, FJ	1
Spencer, SK	1
Kierland, RR	1
Kestel, J	1
Hill, BH	1
Scarpa, C	1
Garcia-Perez, A	1
Aparicio, M	1
Carapeto, FJ	1
De Moragas, JM	1
Gimenez-Camarasa, JM	1
Midana, A	1
Leigheb, G	1
Almeida Gonçalves, JC	1
De Noronha, T	1
Schmid, U	1
Carpentier, E	1
Sturm, HM	1
Scott, H	1
Torre, D	2
Arnold, HL	1
Williams, RM	1
Kim, R	1
Carter, VH	1
Smith, KW	1
Noojin, RO	1
Hueser, JN	1
Strand, ME	1
Pugh, RP	1
Ryan, RF	1
Reed, RJ	1
Krementz, ET	1
Omura, EF	1
Anderson, FE	1
Johnson, AM	1
Havyatt, MT	1
Holt, GA	1
Neldner, KH	1