fluorouracil has been researched along with Keratitis, Ulcerative in 2 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We studied four patients who, having received postoperative 5-fluorouracil after glaucoma filtering operations, developed serious corneal complications." | 7.67 | Serious corneal complications of glaucoma filtering surgery with postoperative 5-fluorouracil. ( Driebe, WT; Heuer, DK; Knapp, A; Stern, GA, 1987) |
| "We studied four patients who, having received postoperative 5-fluorouracil after glaucoma filtering operations, developed serious corneal complications." | 3.67 | Serious corneal complications of glaucoma filtering surgery with postoperative 5-fluorouracil. ( Driebe, WT; Heuer, DK; Knapp, A; Stern, GA, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hickey-Dwyer, M | 1 |
| Wishart, PK | 1 |
| Knapp, A | 1 |
| Heuer, DK | 1 |
| Stern, GA | 1 |
| Driebe, WT | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Intermediate Term Outcomes of Intraoperative 5-Fluorouracil Versus Mitomycin c in Trabeculectomy Surgery.[NCT00346489] | Phase 4 | 70 participants | Interventional | 2004-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 other studies available for fluorouracil and Keratitis, Ulcerative
| Article | Year |
|---|---|
Serious corneal complication of 5-fluorouracil.
Topics: Abscess; Aged; Aged, 80 and over; Corneal Ulcer; Fluorouracil; Humans; Male; Postoperative Complicat | 1993 |
Serious corneal complications of glaucoma filtering surgery with postoperative 5-fluorouracil.
Topics: Aged; Corneal Diseases; Corneal Ulcer; Female; Fluorouracil; Glaucoma; Humans; Male; Middle Aged; Po | 1987 |