Page last updated: 2024-10-27

fluorouracil and Keratitis, Ulcerative

fluorouracil has been researched along with Keratitis, Ulcerative in 2 studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Research Excerpts

ExcerptRelevanceReference
"We studied four patients who, having received postoperative 5-fluorouracil after glaucoma filtering operations, developed serious corneal complications."7.67Serious corneal complications of glaucoma filtering surgery with postoperative 5-fluorouracil. ( Driebe, WT; Heuer, DK; Knapp, A; Stern, GA, 1987)
"We studied four patients who, having received postoperative 5-fluorouracil after glaucoma filtering operations, developed serious corneal complications."3.67Serious corneal complications of glaucoma filtering surgery with postoperative 5-fluorouracil. ( Driebe, WT; Heuer, DK; Knapp, A; Stern, GA, 1987)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19901 (50.00)18.7374
1990's1 (50.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Hickey-Dwyer, M1
Wishart, PK1
Knapp, A1
Heuer, DK1
Stern, GA1
Driebe, WT1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Intermediate Term Outcomes of Intraoperative 5-Fluorouracil Versus Mitomycin c in Trabeculectomy Surgery.[NCT00346489]Phase 470 participants Interventional2004-09-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

2 other studies available for fluorouracil and Keratitis, Ulcerative

ArticleYear
Serious corneal complication of 5-fluorouracil.
    The British journal of ophthalmology, 1993, Volume: 77, Issue:4

    Topics: Abscess; Aged; Aged, 80 and over; Corneal Ulcer; Fluorouracil; Humans; Male; Postoperative Complicat

1993
Serious corneal complications of glaucoma filtering surgery with postoperative 5-fluorouracil.
    American journal of ophthalmology, 1987, Feb-15, Volume: 103, Issue:2

    Topics: Aged; Corneal Diseases; Corneal Ulcer; Female; Fluorouracil; Glaucoma; Humans; Male; Middle Aged; Po

1987