fluorouracil has been researched along with Jejunal Diseases in 5 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Jejunal Diseases: Pathological development in the JEJUNUM region of the SMALL INTESTINE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Although 5-fluorouracil (5-FU) is a widely used as chemotherapy agent, severe mucositis develops in approximately 80% of patients." | 7.79 | Increased expression of 5-HT3 and NK 1 receptors in 5-fluorouracil-induced mucositis in mouse jejunum. ( Arakawa, K; Horie, S; Kato, S; Matsumoto, K; Nakajima, T; Narita, M; Sagara, A; Sakai, H; Tashima, K, 2013) |
| "Although 5-fluorouracil (5-FU) is a widely used as chemotherapy agent, severe mucositis develops in approximately 80% of patients." | 3.79 | Increased expression of 5-HT3 and NK 1 receptors in 5-fluorouracil-induced mucositis in mouse jejunum. ( Arakawa, K; Horie, S; Kato, S; Matsumoto, K; Nakajima, T; Narita, M; Sagara, A; Sakai, H; Tashima, K, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 4 (80.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Matsumoto, K | 1 |
| Nakajima, T | 1 |
| Sakai, H | 1 |
| Kato, S | 1 |
| Sagara, A | 1 |
| Arakawa, K | 1 |
| Tashima, K | 1 |
| Narita, M | 1 |
| Horie, S | 1 |
| Callaghan, B | 1 |
| Furness, JB | 1 |
| Satheeshkumar, PS | 2 |
| Mohan, MP | 2 |
| Moriyama, K | 1 |
| Kouchi, Y | 1 |
| Morinaga, H | 1 |
| Irimura, K | 1 |
| Hayashi, T | 1 |
| Ohuchida, A | 1 |
| Goto, T | 1 |
| Yoshizawa, Y | 1 |
5 other studies available for fluorouracil and Jejunal Diseases
| Article | Year |
|---|---|
Increased expression of 5-HT3 and NK 1 receptors in 5-fluorouracil-induced mucositis in mouse jejunum.
Topics: Animals; Autocrine Communication; Disease Models, Animal; Fluorouracil; Jejunal Diseases; Macrophage | 2013 |
New roles of serotonin and tachykinins in intestinal mucositis?
Topics: Animals; Fluorouracil; Jejunal Diseases; Male; Mucositis; Receptors, Neurokinin-1; Receptors, Seroto | 2013 |
Aprepitant, a NK-1R antagonist could be employed for cytotoxic therapy induced alimentary tract mucosal inflammation.
Topics: Animals; Fluorouracil; Jejunal Diseases; Male; Mucositis; Receptors, Neurokinin-1; Receptors, Seroto | 2014 |
Tachykinin Peptide, substance p, and its receptor have a significant role in tissue reactions induced by cytotoxic therapy.
Topics: Animals; Fluorouracil; Jejunal Diseases; Male; Mucositis; Receptors, Neurokinin-1; Receptors, Seroto | 2014 |
Diamine oxidase, a plasma biomarker in rats to GI tract toxicity of oral fluorouracil anti-cancer drugs.
Topics: Administration, Oral; Amine Oxidase (Copper-Containing); Animals; Antimetabolites, Antineoplastic; A | 2006 |