Page last updated: 2024-10-27

fluorouracil and Islet Cell Tumor, Malignant

fluorouracil has been researched along with Islet Cell Tumor, Malignant in 10 studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Research Excerpts

ExcerptRelevanceReference
"In patients with carcinoid tumor, a combination of cisplatin (150 mg) and doxorubicin (50 mg) was used."2.69Selective hepatic arterial chemoembolization for liver metastases in patients with carcinoid tumor or islet cell carcinoma. ( Ajani, JA; Carrasco, CH; Chuang, V; Dumas, P; Kim, YH; Lawrence, D; Richli, W; Wallace, S, 1999)
"Temozolomide is an active agent in metastatic pancreatic endocrine carcinomas."1.37First-line chemotherapy with capecitabine and temozolomide in patients with metastatic pancreatic endocrine carcinomas. ( Chen, DT; Choi, J; Coppola, D; Fine, RL; Helm, J; Kvols, L; Nasir, A; Strosberg, JR, 2011)
"Nonfunctioning islet cell tumor of the pancreas is frequently found in young female."1.34[Management of nonfunctioning islet cell tumors of the pancreas]. ( Ding, XW; Hao, XS; Liang, H; Pan, Y; Wang, BG; Wang, XN, 2007)
"Islet cell carcinomas have an incidence of 5 per million per year; 50 per cent of these are nonfunctioning islet cell tumors."1.31Nonfunctioning islet cell carcinoma of the pancreas: case report. ( Elster, E; Golocovsky, M; Pearl, J, 2002)

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (30.00)18.2507
2000's4 (40.00)29.6817
2010's3 (30.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Yoshioka, M1
Shibata, S1
Uchinami, H1
Watanabe, G1
Miyazawa, H1
Iida, M1
Yoshida, M1
Yoshioka, T1
Nanjo, H1
Yamamoto, Y1
Sugimoto, M1
Hines, OJ1
Dawson, DW1
Muthusamy, VR1
Reber, HA1
Donahue, TR1
Strosberg, JR1
Fine, RL1
Choi, J1
Nasir, A1
Coppola, D1
Chen, DT1
Helm, J1
Kvols, L1
Pearl, J1
Elster, E1
Golocovsky, M1
Arakawa, Y1
Mizunuma, N1
Aiba, K1
Ito, Y1
Takahashi, S1
Irie, T1
Watanabe, J1
Tada, K1
Okudaira, T1
Seki, M1
Yamaguchi, T1
Muto, T1
Hatake, K1
Kouvaraki, MA1
Ajani, JA3
Hoff, P1
Wolff, R1
Evans, DB1
Lozano, R1
Yao, JC1
Liang, H1
Wang, XN1
Wang, BG1
Pan, Y1
Ding, XW1
Hao, XS1
Lai, DT1
Chu, KM1
Thompson, JF1
Gallagher, JP1
Waugh, R1
Storey, DW1
Stephen, MS1
Rivera, E1
Kim, YH1
Carrasco, CH1
Dumas, P1
Richli, W1
Lawrence, D1
Chuang, V1
Wallace, S1

Clinical Trials (4)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Phase 2 Study of Temozolomide Plus Capecitabine in Patients With Grade 3 and Low Ki-67 Gastroenteropancreatic Neuroendocrine Tumors[NCT03079440]Phase 231 participants (Actual)Interventional2017-05-15Completed
Clinical Study of Radiopeptide 177Lu-DOTATOC in Combination With Capecitabine and Temozolomide in Advanced, Non-resectable and Progressive Neuroendocrine Tumors With Somatostatin Receptor Overexpression[NCT04194125]Phase 225 participants (Anticipated)Interventional2019-02-01Recruiting
UPCC 04219 Phase 2 Study of Capecitabine-Temozolomide(CapTem) With Yttrium-90 Radioembolization in the Treatment of Patients With Unresectable Metastatic Grade 2 Neuroendocrine Tumors[NCT04339036]Phase 250 participants (Anticipated)Interventional2021-10-07Recruiting
Peptide Receptor Radionuclide Therapy (PRRT) in Tumors With High Expression of Somatostatin Receptors[NCT04790708]250 participants (Anticipated)Interventional2018-07-02Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

2 trials available for fluorouracil and Islet Cell Tumor, Malignant

ArticleYear
Doxorubicin, streptozocin, and 5-fluorouracil chemotherapy for patients with metastatic islet-cell carcinoma.
    American journal of clinical oncology, 1998, Volume: 21, Issue:1

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Islet Cell; Doxo

1998
Selective hepatic arterial chemoembolization for liver metastases in patients with carcinoid tumor or islet cell carcinoma.
    Cancer investigation, 1999, Volume: 17, Issue:7

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoid Tumor; Carcinoma, Islet Cell;

1999

Other Studies

8 other studies available for fluorouracil and Islet Cell Tumor, Malignant

ArticleYear
The transformation of a nonfunctioning islet cell tumor of the pancreas into a proinsulinoma under conditions of lung metastasis.
    Internal medicine (Tokyo, Japan), 2015, Volume: 54, Issue:7

    Topics: Aged; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Is

2015
Preoperative Treatment With FOLFIRINOX and Successful Resection for a Patient With Mixed Acinar-Endocrine Carcinoma of the Pancreas.
    Pancreas, 2017, Volume: 46, Issue:4

    Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Carcinoma, Acinar Cell; Carcinoma, Isl

2017
First-line chemotherapy with capecitabine and temozolomide in patients with metastatic pancreatic endocrine carcinomas.
    Cancer, 2011, Jan-15, Volume: 117, Issue:2

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Carcinoma, Islet Cell; Da

2011
First-line chemotherapy with capecitabine and temozolomide in patients with metastatic pancreatic endocrine carcinomas.
    Cancer, 2011, Jan-15, Volume: 117, Issue:2

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Carcinoma, Islet Cell; Da

2011
First-line chemotherapy with capecitabine and temozolomide in patients with metastatic pancreatic endocrine carcinomas.
    Cancer, 2011, Jan-15, Volume: 117, Issue:2

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Carcinoma, Islet Cell; Da

2011
First-line chemotherapy with capecitabine and temozolomide in patients with metastatic pancreatic endocrine carcinomas.
    Cancer, 2011, Jan-15, Volume: 117, Issue:2

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Carcinoma, Islet Cell; Da

2011
First-line chemotherapy with capecitabine and temozolomide in patients with metastatic pancreatic endocrine carcinomas.
    Cancer, 2011, Jan-15, Volume: 117, Issue:2

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Carcinoma, Islet Cell; Da

2011
First-line chemotherapy with capecitabine and temozolomide in patients with metastatic pancreatic endocrine carcinomas.
    Cancer, 2011, Jan-15, Volume: 117, Issue:2

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Carcinoma, Islet Cell; Da

2011
First-line chemotherapy with capecitabine and temozolomide in patients with metastatic pancreatic endocrine carcinomas.
    Cancer, 2011, Jan-15, Volume: 117, Issue:2

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Carcinoma, Islet Cell; Da

2011
First-line chemotherapy with capecitabine and temozolomide in patients with metastatic pancreatic endocrine carcinomas.
    Cancer, 2011, Jan-15, Volume: 117, Issue:2

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Carcinoma, Islet Cell; Da

2011
First-line chemotherapy with capecitabine and temozolomide in patients with metastatic pancreatic endocrine carcinomas.
    Cancer, 2011, Jan-15, Volume: 117, Issue:2

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Carcinoma, Islet Cell; Da

2011
Nonfunctioning islet cell carcinoma of the pancreas: case report.
    The American surgeon, 2002, Volume: 68, Issue:10

    Topics: Adult; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Carcinoma, Islet Cell; Diagnosi

2002
[Pancreatic islet cell carcinoma with multiple hepatic metastases successfully treated with a streptozocin/5-FU regimen--a case report].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2002, Volume: 29, Issue:13

    Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Islet Cell; Drug Administration Schedule;

2002
Fluorouracil, doxorubicin, and streptozocin in the treatment of patients with locally advanced and metastatic pancreatic endocrine carcinomas.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2004, Dec-01, Volume: 22, Issue:23

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Islet Cell; Dose-Response Re

2004
[Management of nonfunctioning islet cell tumors of the pancreas].
    Zhonghua zhong liu za zhi [Chinese journal of oncology], 2007, Volume: 29, Issue:6

    Topics: Adenoma, Islet Cell; Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcin

2007
Islet cell carcinoma treated by induction regional chemotherapy and radical total pancreatectomy with liver revascularization and small bowel autotransplantation.
    Surgery, 1996, Volume: 119, Issue:1

    Topics: Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy P

1996