fluorouracil has been researched along with Island Cell Tumor in 40 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The results of combination chemotherapy with intermittent courses of 5-fluorouracil and streptozotocin in ten patients with metastatic carcinoid tumors and in eight patients with islet cell carcinoma are reported." | 7.66 | Combination chemotherapy for islet cell carcinoma and metastatic carcinoid tumors with 5-fluorouracil and streptozotocin. ( Bukowski, RM; Chernicoff, D; Groppe, CW; Hewlett, JS, 1979) |
| "The results of combination chemotherapy with intermittent courses of 5-fluorouracil and streptozotocin in ten patients with metastatic carcinoid tumors and in eight patients with islet cell carcinoma are reported." | 3.66 | Combination chemotherapy for islet cell carcinoma and metastatic carcinoid tumors with 5-fluorouracil and streptozotocin. ( Bukowski, RM; Chernicoff, D; Groppe, CW; Hewlett, JS, 1979) |
| "From May 1972 until May 1976, 105 patients were entered on Central Oncology Group protocol 7230 to compare the combination of streptozotocin, tubercidin, and 5-fluorouracil (5-FU) versus 5-FU alone in the treatment of adenocarcinoma and islet cell carcinoma of the pancreas." | 3.66 | 5-FU versus combination therapy with tubercidin, streptozotocin, and 5-FU in the treatment of pancreatic carcinomas: COG protocol 7230. ( Aust, JB; Awrich, A; Fletcher, WS; Grage, TB; Hill, GJ; Klotz, JH; Minton, JP; Multhauf, PM, 1979) |
| "5-Fluorouracil was administered by intravenous bolus injection at an initial dose of 400 mg/m2/day for 5 consecutive days." | 2.67 | A phase II trial of alpha-interferon and 5-fluorouracil in patients with advanced carcinoid and islet cell tumors. ( Kelsen, D; Kemeny, N; Saltz, L; Schwartz, G, 1994) |
| "A phase II trial of chemotherapy in carcinoid and islet cell pancreatic tumours has been conducted with the FAP protocol: 5-fluorouracil 400 mg/m2 per day (5-FU) for 3 days, 50 mg/m2 doxorubicin on day 2, and 90 mg/m2 cisplatin on day 2, repeated every 4 weeks." | 2.67 | Metastatic carcinoid and islet cell tumours of the pancreas: a phase II trial of the efficacy of combination chemotherapy with 5-fluorouracil, doxorubicin and cisplatin. ( Droz, JP; Ducreux, M; Kac, J; Oliveira, J; Rougier, P; Theodore, C, 1991) |
| "Nonfunctioning islet cell tumor of the pancreas is frequently found in young female." | 1.34 | [Management of nonfunctioning islet cell tumors of the pancreas]. ( Ding, XW; Hao, XS; Liang, H; Pan, Y; Wang, BG; Wang, XN, 2007) |
| "Uric acid nephrolithiasis developed in a 75-year-old man who had received a large cumulative dose of streptozotocin for treatment of metastatic islet cell carcinoma of the pancreas." | 1.27 | Uric acid nephrolithiasis and acute renal failure secondary to streptozotocin nephrotoxicity. ( Goldsmith, GH; Hricik, DE, 1988) |
| "Four patients with metastatic glucagonoma are described." | 1.26 | Glucagonoma and its angiographic diagnosis. ( Keller, FS; Lieberman, DA; Rösch, J; Wawrukiewicz, AS, 1982) |
| "Although advanced gastrointestinal cancer is the most commonplace problem encountered by the medical oncologist, this group of diseases has proved exceedingly resistant to past chemotherapy efforts." | 1.25 | Clinical management of advanced gastrointestinal cancer. ( Moertel, CG, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 27 (67.50) | 18.7374 |
| 1990's | 8 (20.00) | 18.2507 |
| 2000's | 4 (10.00) | 29.6817 |
| 2010's | 1 (2.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Christante, D | 1 |
| Pommier, S | 1 |
| Givi, B | 1 |
| Pommier, R | 1 |
| Naidoo, J | 1 |
| O'Toole, D | 1 |
| Kennedy, MJ | 1 |
| Reynolds, JV | 1 |
| O'Connor, M | 1 |
| O'Byrne, K | 1 |
| Strosberg, J | 1 |
| Hoffe, S | 1 |
| Gardner, N | 1 |
| Choi, J | 1 |
| Kvols, L | 1 |
| Liang, H | 1 |
| Wang, XN | 1 |
| Wang, BG | 1 |
| Pan, Y | 1 |
| Ding, XW | 1 |
| Hao, XS | 1 |
| Moertel, CG | 4 |
| Hanley, JA | 1 |
| Johnson, LA | 1 |
| Sordillo, PP | 1 |
| Magill, GB | 1 |
| Aabo, K | 1 |
| Romond, E | 1 |
| Dimitrov, NV | 1 |
| Denny, TN | 1 |
| Suhrland, LG | 1 |
| Wawrukiewicz, AS | 1 |
| Rösch, J | 1 |
| Keller, FS | 1 |
| Lieberman, DA | 1 |
| Hallengren, B | 1 |
| Dymling, JF | 1 |
| Manhem, P | 1 |
| Tennvall, L | 1 |
| Tibblin, S | 1 |
| Saltz, L | 2 |
| Kemeny, N | 1 |
| Schwartz, G | 1 |
| Kelsen, D | 1 |
| Eriksson, B | 1 |
| Oberg, K | 1 |
| Shimoike, T | 1 |
| Goto, M | 1 |
| Nakano, I | 1 |
| Sato, T | 1 |
| Migita, Y | 1 |
| Ito, T | 1 |
| Yanase, T | 1 |
| Sezai, S | 1 |
| Suzuki, T | 1 |
| Nawata, H | 1 |
| Brentjens, R | 1 |
| Cubilla, AL | 1 |
| Hajdu, SI | 1 |
| Kraybill, WG | 1 |
| Anderson, DD | 1 |
| Lindell, TD | 1 |
| Fletcher, WS | 3 |
| Eastman, RC | 1 |
| Come, SE | 1 |
| Strewler, GJ | 1 |
| Gorden, P | 1 |
| Kahn, CR | 1 |
| Zollinger, RM | 2 |
| Martin, EW | 1 |
| Carey, LC | 1 |
| Sparks, J | 1 |
| Minton, JP | 2 |
| Seligman, M | 1 |
| Bukowski, RM | 3 |
| Groppe, CW | 2 |
| Weick, JK | 1 |
| Hewlett, JS | 2 |
| Greenstreet, RL | 1 |
| Chernicoff, D | 1 |
| Awrich, A | 1 |
| Klotz, JH | 1 |
| Hill, GJ | 1 |
| Aust, JB | 1 |
| Grage, TB | 1 |
| Multhauf, PM | 1 |
| Khandekar, JD | 1 |
| Oyer, D | 1 |
| Miller, HJ | 1 |
| Vick, NA | 1 |
| Lefkopoulo, M | 1 |
| Lipsitz, S | 1 |
| Hahn, RG | 1 |
| Klaassen, D | 1 |
| Chabner, BA | 1 |
| Friedman, MA | 1 |
| Tangen, C | 1 |
| Lee, R | 1 |
| Macdonald, JS | 1 |
| Einstein, AB | 1 |
| Peterson, R | 1 |
| Fleming, TR | 1 |
| Rougier, P | 1 |
| Oliveira, J | 1 |
| Ducreux, M | 1 |
| Theodore, C | 1 |
| Kac, J | 1 |
| Droz, JP | 1 |
| Bresler, L | 1 |
| Boissel, P | 1 |
| Conroy, T | 1 |
| Grosdidier, J | 1 |
| Hricik, DE | 1 |
| Goldsmith, GH | 1 |
| Lee, SM | 1 |
| Forbes, A | 1 |
| Williams, R | 1 |
| Hansen, R | 1 |
| Helm, J | 1 |
| Wilson, JF | 1 |
| Wilson, S | 1 |
| Zimmermann, K | 1 |
| Rapp, T | 1 |
| Binder, J | 1 |
| Frölich, J | 1 |
| Bode, JC | 1 |
| Altimari, AF | 1 |
| Bhoopalam, N | 1 |
| O'Dorsio, T | 1 |
| Lange, CL | 1 |
| Sandberg, L | 1 |
| Prinz, RA | 1 |
| Vasen, HF | 1 |
| Sitsen, JM | 1 |
| Nortier, JW | 1 |
| Lips, CJ | 1 |
| Barragry, TP | 1 |
| Wick, MR | 1 |
| Delaney, JP | 1 |
| Massey, WH | 1 |
| Judkins, MP | 1 |
| Dennis, DL | 1 |
| Earle, E | 1 |
| Butts, D | 1 |
| Hoaglin, LL | 1 |
| Barclay, GA | 1 |
| al-Rais, SH | 1 |
| Patrassi, N | 1 |
| Basoli, A | 1 |
| Mineo, TC | 1 |
| Carboni, M | 1 |
1 review available for fluorouracil and Island Cell Tumor
| Article | Year |
|---|---|
Islet cell tumors of the pancreas: the medical oncologist's perspective.
Topics: Adenoma, Islet Cell; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Ag | 2001 |
5 trials available for fluorouracil and Island Cell Tumor
| Article | Year |
|---|---|
Streptozocin alone compared with streptozocin plus fluorouracil in the treatment of advanced islet-cell carcinoma.
Topics: Adenoma, Islet Cell; Adolescent; Adult; Aged; Clinical Trials as Topic; Drug Administration Schedule | 1980 |
A phase II trial of alpha-interferon and 5-fluorouracil in patients with advanced carcinoid and islet cell tumors.
Topics: Adenoma, Islet Cell; Adult; Aged; Carcinoid Tumor; Drug Administration Schedule; Drug Therapy, Combi | 1994 |
Streptozocin-doxorubicin, streptozocin-fluorouracil or chlorozotocin in the treatment of advanced islet-cell carcinoma.
Topics: Adenoma, Islet Cell; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Antineoplastic Combined | 1992 |
Phase II trial of chlorozotocin and fluorouracil in islet cell carcinoma: a Southwest Oncology Group study.
Topics: Adenoma, Islet Cell; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Drug Administratio | 1992 |
Metastatic carcinoid and islet cell tumours of the pancreas: a phase II trial of the efficacy of combination chemotherapy with 5-fluorouracil, doxorubicin and cisplatin.
Topics: Adenoma, Islet Cell; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoid Tumor; C | 1991 |
34 other studies available for fluorouracil and Island Cell Tumor
| Article | Year |
|---|---|
Hepatic artery chemoinfusion with chemoembolization for neuroendocrine cancer with progressive hepatic metastases despite octreotide therapy.
Topics: Adenoma, Islet Cell; Adult; Aged; Antineoplastic Agents; Carcinoid Tumor; Chemoembolization, Therape | 2008 |
A single institution experience of streptozocin/fluorouracil combination chemotherapy: a case series.
Topics: Adenoma, Islet Cell; Adult; Aged; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Carc | 2012 |
Effective treatment of locally advanced endocrine tumors of the pancreas with chemoradiotherapy.
Topics: Adenoma, Islet Cell; Adult; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Combined M | 2007 |
[Management of nonfunctioning islet cell tumors of the pancreas].
Topics: Adenoma, Islet Cell; Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcin | 2007 |
Phase II trial of methyl-CCNU, vincristine, 5-fluorouracil, and streptozotocin (MOF-Strep) in patients with disseminated pancreatic carcinoma.
Topics: Adenocarcinoma; Adenoma, Islet Cell; Adult; Aged; Drug Evaluation; Drug Therapy, Combination; Female | 1982 |
Pancreatic islet cell carcinoma associated with multiple hormone secretion and pancytopenia. Evidence of a serum factor suppressing hematopoiesis.
Topics: Adenoma, Islet Cell; Aged; Androgens; Animals; Female; Fluorouracil; Hematopoiesis; Hormones; Humans | 1983 |
Glucagonoma and its angiographic diagnosis.
Topics: Adenoma, Islet Cell; Adult; Aged; Angiography; Antineoplastic Agents; Dacarbazine; Drug Therapy, Com | 1982 |
Unsuccessful DTIC treatment of a patient with glucagonoma syndrome.
Topics: Adenoma, Islet Cell; Dacarbazine; Drug Therapy, Combination; Fluorouracil; Glucagonoma; Humans; Live | 1983 |
An update of the medical treatment of malignant endocrine pancreatic tumors.
Topics: Adenoma, Islet Cell; Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherap | 1993 |
Acinar-islet cell carcinoma presenting as insulinoma.
Topics: Adenoma, Islet Cell; Adult; alpha-Fetoproteins; Antineoplastic Agents; Carcinoma, Acinar Cell; Diagn | 1997 |
Islet cell carcinoma of the pancreas.
Topics: Adenoma, Islet Cell; Adolescent; Adult; Aged; Child; Cyclophosphamide; Dactinomycin; Female; Fluorou | 1975 |
Clinical management of advanced gastrointestinal cancer.
Topics: Adenoma, Islet Cell; Carcinoma, Hepatocellular; Carmustine; Colonic Neoplasms; Cytarabine; Drug Ther | 1975 |
Islet cell carcinoma of the pancreas: effective therapy with 5-fluorouracil, streptozotocin, and tubercidin.
Topics: Adenoma, Islet Cell; Adult; Diazoxide; Doxorubicin; Drug Administration Schedule; Drug Therapy, Comb | 1976 |
Walter Hubert lecture Chemotherapy of upper gastrointestinal carcinoma.
Topics: Adenoma, Islet Cell; Antineoplastic Agents; Carcinoid Tumor; Carcinoma, Hepatocellular; Carcinoma, S | 1976 |
Adriamycin therapy for advanced insulinoma.
Topics: Adenoma, Islet Cell; Adult; Blood Glucose; Diazoxide; Doxorubicin; Drug Therapy, Combination; Female | 1977 |
Observations on the postoperative tumor growth behavior of certain islet cell tumors.
Topics: Adenoma, Islet Cell; Fasting; Fluorouracil; Gastrins; Humans; Liver Neoplasms; Neoplasm Metastasis; | 1976 |
Chemotherapy of metastatic gastrointestinal neoplasms with 5-fluorouracil and streptozotocin.
Topics: Adenocarcinoma; Adenoma, Bile Duct; Adenoma, Islet Cell; Adult; Aged; Bile Duct Neoplasms; Carcinoid | 1977 |
Combination chemotherapy for islet cell carcinoma and metastatic carcinoid tumors with 5-fluorouracil and streptozotocin.
Topics: Adenoma, Islet Cell; Carcinoid Tumor; Drug Therapy, Combination; Fluorouracil; Humans; Intestinal Ne | 1979 |
5-FU versus combination therapy with tubercidin, streptozotocin, and 5-FU in the treatment of pancreatic carcinomas: COG protocol 7230.
Topics: Adenocarcinoma; Adenoma, Islet Cell; Antineoplastic Agents; Drug Therapy, Combination; Fluorouracil; | 1979 |
Neurologic involvement in glucagonoma syndrome: response to combination chemotherapy with 5-fluorouracil and streptozotocin.
Topics: Adenoma, Islet Cell; Adult; Central Nervous System Diseases; Drug Therapy, Combination; Fluorouracil | 1979 |
Progress against rare and not-so-rare cancers.
Topics: Adenoma, Islet Cell; Adrenal Gland Neoplasms; Antineoplastic Combined Chemotherapy Protocols; Carcin | 1992 |
Pancreatic islet cell carcinoma with hypercalcemia: complete remission 5 years after surgical excision and chemotherapy.
Topics: Adenoma, Islet Cell; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Fluo | 1991 |
Uric acid nephrolithiasis and acute renal failure secondary to streptozotocin nephrotoxicity.
Topics: Acute Kidney Injury; Adenoma, Islet Cell; Aged; Fluorouracil; Humans; Kidney Calculi; Male; Pancreat | 1988 |
Metastatic islet cell tumour with clinical manifestations of insulin and glucagon excess: successful treatment by hepatic artery embolization and chemotherapy.
Topics: Adenoma, Islet Cell; Combined Modality Therapy; Embolization, Therapeutic; Female; Fluorouracil; Glu | 1988 |
Nonfunctioning islet cell carcinoma of the pancreas. Complete response to continuous 5-fluorouracil infusion.
Topics: Adenoma, Islet Cell; Catheters, Indwelling; Fluorouracil; Humans; Infusions, Intravenous; Male; Midd | 1988 |
[Vipoma. 9-year observations using currently available therapy methods].
Topics: Adenoma, Islet Cell; Antineoplastic Combined Chemotherapy Protocols; Drug Therapy, Combination; Fluo | 1986 |
Use of a somatostatin analog (SMS 201-995) in the glucagonoma syndrome.
Topics: Adenoma, Islet Cell; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Dacarbaz | 1986 |
Chemotherapy of metastatic islet cell carcinoma. Report of 4 cases and review of the literature.
Topics: Adenoma, Islet Cell; Female; Fluorouracil; Humans; Liver Neoplasms; Male; Middle Aged; Pancreatic Ne | 1985 |
Pancreatic islet cell carcinoma with gastrin and vasoactive intestinal polypeptide production.
Topics: Adenoma, Islet Cell; Antineoplastic Combined Chemotherapy Protocols; Female; Fluorouracil; Gastrins; | 1985 |
Hepatic artery infusion for metastatic malignancy using percutaneously placed catheters.
Topics: Adenoma, Islet Cell; Adult; Aged; Bile Duct Neoplasms; Breast Neoplasms; Carcinoid Tumor; Carcinoma, | 1971 |
Metabolically active liver metastases treated by 5-fluorouracil hepatic artery infusion.
Topics: Adenoma, Islet Cell; Carcinoma, Squamous Cell; Female; Fluorouracil; Hepatic Artery; Hormones, Ectop | 1970 |
Malignant insulinoma with hepatic secondaries treated with hepatic artery ligation.
Topics: Adenoma, Islet Cell; Aged; Fluorouracil; Hepatic Artery; Humans; Ligation; Liver Neoplasms; Male; Ne | 1973 |
Proceedings: Islets of Langerhans.
Topics: Adenoma, Islet Cell; Diarrhea; Fluorouracil; Follow-Up Studies; Gastrectomy; Gastrins; Glucagon; Hum | 1972 |
[Indications and medical therapy of hypoglycemic beta-insular].
Topics: Adenoma, Islet Cell; Adrenal Cortex Hormones; Antineoplastic Agents; Carcinoma; Diazoxide; Diuretics | 1973 |