Page last updated: 2024-10-27

fluorouracil and Intraocular Pressure

fluorouracil has been researched along with Intraocular Pressure in 310 studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Intraocular Pressure: The pressure of the fluids in the eye.

Research Excerpts

ExcerptRelevanceReference
"To demonstrate that preoperative treatment for 28 days with topical dorzolamide/timolol is non-inferior (Δ = 4 mm Hg) to oral acetazolamide and topical dexamethasone (standard therapy) in terms of intraocular pressure (IOP) reduction 3 and 6 months after trabeculectomy in glaucoma patients."9.24Efficacy and safety of preoperative IOP reduction using a preservative-free fixed combination of dorzolamide/timolol eye drops versus oral acetazolamide and dexamethasone eye drops and assessment of the clinical outcome of trabeculectomy in glaucoma. ( Bell, K; Keicher, A; Lorenz, K; Pfeiffer, N; Renieri, G; Ruckes, C; Thieme, H; Wasielica-Poslednik, J, 2017)
"To compare the efficacy of transconjunctival needling revision with 5-fluorouracil versus medical treatment in glaucomatous eyes with uncontrolled intraocular pressure due to encapsulated bleb after trabeculectomy."9.17Early transconjunctival needling revision with 5-fluorouracil versus medical treatment in encapsulated blebs: a 12-month prospective study. ( Susanna, R; Suzuki, R, 2013)
"To compare the effectiveness of trabeculectomy with adjunctive, low-dose, subconjunctival 5-fluorouracil (5-FU) to trabeculectomy alone in patients with uncomplicated glaucoma undergoing their first incisional surgical procedure."9.09Low-dose 5-fluorouracil trabeculectomy as initial surgery in uncomplicated glaucoma: long-term followup. ( Liebmann, JM; Ritch, R; Rothman, RF, 2000)
"In a randomized clinical trial, the authors compared the use of postoperative subconjunctival injections of 5-fluorouracil (5-FU) in 19 eyes with a single intraoperative application of subconjunctival mitomycin (MMC) at the filtering site in 20 eyes at high risk for failure of glaucoma filtering surgery."9.07Intraoperative mitomycin versus postoperative 5-fluorouracil in high-risk glaucoma filtering surgery. ( Beeson, CC; Bergstrom, TJ; Falck, FY; Higginbotham, EJ; Klein, TB; Lichter, PR; Musch, DC; Skuta, GL, 1992)
" We concluded mitomycin C might be more effective in reducing intraocular pressure and increasing qualified success compared to 5-fluorouracil."8.98Is mytomicyn better than 5-fluorouracil as antimetabolite in trabeculectomy for glaucoma? ( Pimentel, E; Schmidt, J, 2018)
"To report the effectiveness and safety of 5-fluorouracil (5-FU)-augmented Xen45 implantation in primary open-angle glaucoma (POAG) and pseudoexfoliation glaucoma (PEXG)."8.02Results of fluorouracil-augmented Xen45 implantation in primary open-angle and pseudoexfoliation glaucoma. ( Başer, EF; Seymenoğlu, RG, 2021)
"To investigate the outcomes of trabeculectomy with 5-fluorouracil (5-FU) with or without subconjunctival bevacizumab in the surgical management of pseudoexfoliation glaucoma (PXG)."7.91Initial trabeculectomy with 5-fluorouracil with or without subconjunctival bevacizumab in the management of pseudoexfoliation glaucoma. ( Çolak, S; Elgin, U; Sen, E; Yılmazbas, P, 2019)
"To report our experience on treatment of primary congenital glaucoma with trabeculectomy in combination with biological amniotic membranes soaked with 5-fluorouracil."7.88Retrospective observation on trabeculectomy of primary congenital glaucoma by applying biological amniotic membranes soaked with 5-fluorouracil. ( Gao, H; Guo, B; Liu, C; Liu, W; Wang, J; Wang, X; Wu, M; Zhang, C, 2018)
"To examine the effect of mitomycin c and 5-flurouracil on treatment outcomes following Ahmed glaucoma valve implantation."7.85Effect of mitomycin c and 5-flurouracil adjuvant therapy on the outcomes of Ahmed glaucoma valve implantation. ( Cui, QN; Han, Y; Hsia, YC; Lin, SC; Mehta, N; Naseri, A; Porco, TC; Rose-Nussbaumer, J; Stamper, RL, 2017)
"This study was designed to investigate whether 5-fluorouracil (5-Fu)-polycaprolactone sustained-release film in Ahmed glaucoma valve implantation inhibits postoperative bleb scarring in rabbit eyes."7.81Application of 5-Fluorouracil-Polycaprolactone Sustained-Release Film in Ahmed Glaucoma Valve Implantation Inhibits Postoperative Bleb Scarring in Rabbit Eyes. ( Bi, XZ; Li, CH; Nan, KH; Pan, WH; Ren, ZJ; Song, ZM; Sun, M; Yu, XP, 2015)
"To evaluate the antimitotic and toxic effects of 5-chlorouracil (5-CU) and 5-fluorouracil (5-FU) and study their potential to delay filtering bleb closure in the rabbit eye when released by poly(ortho esters) (POE)."7.74Controlled delivery of 5-chlorouracil using poly(ortho esters) in filtering surgery for glaucoma. ( Behar-Cohen, F; BenEzra, D; Bourges, JL; Felt, O; Gurny, R; Jeanny, JC; Polak, MB; Rat, P; Thomas-Doyle, A; Torriglia, A; Valamanesh, F, 2008)
"Although adjunctive postoperative 5-fluorouracil (5-FU) injections are known to improve the success rate of glaucoma surgery, it is still unknown what dose, timing and frequency of application will give the best results with respect to the inhibition of postoperative scarring and intraocular pressure regulation."7.74Dose, timing and frequency of subconjunctival 5-fluorouracil injections after glaucoma filtering surgery. ( Bartz-Schmidt, KU; Besch, D; Denk, PO; Grüb, M; Reinthal, EK, 2007)
"To prospectively study the evolution of possible high risk features of conjunctival filtration blebs like avascularity, transconjunctival oozing (TCO), and leaks after mitomycin C (MMC) enhanced glaucoma surgery."7.73Mitomycin C augmented glaucoma surgery: evolution of filtering bleb avascularity, transconjunctival oozing, and leaks. ( Anand, N; Arora, S; Clowes, M, 2006)
"To report the outcome of 5-fluorouracil (5-FU)-augmented bleb needling revision of failed and failing filtration blebs and to identify risk factors for failure, indicators for success, and any complications of the procedure."7.72Needle revision of failing and failed trabeculectomy blebs with adjunctive 5-fluorouracil: survival analysis. ( Bloom, PA; Broadway, DC; Bunce, C; Khaw, PT; Thiagarajan, M, 2004)
"To investigate the changes of tear film functions due to the use of postoperative 5-fluourouracil (5-Fu) and intraoperative mitomycin C (MMC) in glaucoma filtration surgery."7.71[Influence on tear film of postoperative 5-fluourouracil and intraoperative mitomycin C in glaucoma filtration surgery]. ( Li, J; Pang, L, 2001)
"The authors evaluate the results of preoperative 5-minute administration of 5-fluorouracil (5-FU), 50 mg/ml, during trabeculectomy on 11 high risk eyes of children with primary and secondary glaucoma."7.70[Peroperative administration of 5-fluorouracil during trabeculectomy in complicated glaucoma in children]. ( Burdová, M; Filous, A, 1998)
"To determine the effect of intraoperative application of 5-fluorouracil (5-FU) on the long-term outcome of trabeculectomy in uveitis-related glaucoma."7.70Long-term follow-up of trabeculectomy with intraoperative 5-fluorouracil for uveitis-related glaucoma. ( Lightman, S; McCluskey, P; Shaer, B; Towler, HM, 2000)
"Patients with both cataract and glaucoma underwent combined mitomycin C trabeculectomy, extracapsular cataract extraction, and intraocular lens implantation."7.69One-year follow-up results of combined mitomycin C trabeculectomy and extracapsular cataract extraction. ( Bueche, MJ; Feuer, WJ; Grajewski, AL; Joos, KM; Palmberg, PF, 1995)
"Between 2/1991 and 1/1993 twenty-nine eyes of 11 female and 16 male patients with high-risk glaucoma (unsuccessful previous filtering surgery and a high risk of scarring) were treated with subconjunctival injections of 5-Fluorouracil after filtering surgery in the University Eye Hospital Düsseldorf."7.68[5-fluorouracil injection treatment after fistulating glaucoma operations]. ( Klüppel, M; Reinhard, T; Sundmacher, R, 1993)
"We studied 105 patients (105 eyes) operated on for glaucoma with adjunctive fluorouracil, who were followed up for 12 to 48 months (mean, 34."7.68Late complications after glaucoma filtering surgery with adjunctive 5-fluorouracil. ( Ophir, A; Ticho, U, 1993)
"Twenty-one eyes of 18 patients with uncontrolled glaucoma and intraocular inflammatory disease had glaucoma filtering surgery with postoperative subconjunctival 5-fluorouracil (5-FU)."7.68Glaucoma filtering surgery with postoperative 5-fluorouracil in patients with intraocular inflammatory disease. ( Lowder, CY; Meisler, DM; Patitsas, CJ; Rockwood, EJ, 1992)
"Trabeculectomy and subsequent subconjunctival injections of 5-fluorouracil (5-FU) were performed in four eyes (two children) with congenital glaucoma."7.68Subconjunctival injection of 5-fluorouracil following trabeculectomy for congenital and infantile glaucoma. ( Leiba, H; Oliver, M; Zalish, M, 1992)
"The effectiveness of trabeculectomy with adjunctive low-dose 5-fluorouracil (5-FU) as the initial surgical procedure in uncomplicated glaucoma was evaluated retrospectively in a consecutive series of 52 patients (mean follow-up, 18."7.68Initial 5-fluorouracil trabeculectomy in uncomplicated glaucoma. ( Liebmann, JM; Marmor, M; Nunez, J; Ritch, R; Wolner, B, 1991)
"The incidence of late-onset bleb-related endophthalmitis was evaluated retrospectively in 229 consecutive trabeculectomies performed with adjunctive 5-fluorouracil (5-FU) therapy."7.68Late bleb-related endophthalmitis after trabeculectomy with adjunctive 5-fluorouracil. ( Liebmann, JM; Marmor, M; Ritch, R; Sassani, JW; Speaker, M; Wolner, B, 1991)
"Nine patients (nine eyes) with iridocorneal endothelial (ICE) syndrome underwent trabeculectomy and received postoperative subconjunctival injections of 5-fluorouracil (5-FU) to enhance bleb formation (total 5-FU dose, 30-105 mg; mean, 53."7.685-Fluorouracil after trabeculectomy and the iridocorneal endothelial syndrome. ( Cristol, SM; Grajewski, AL; Parrish, RK; Wright, MM, 1991)
"We reviewed the records of 12 eyes of ten adult patients with inflammatory glaucoma who underwent trabeculectomy with the adjuvant use of 5-fluorouracil between January 1986 and January 1989."7.68Trabeculectomy with 5-fluorouracil for adult inflammatory glaucoma. ( Jabs, DA; Jampel, HD; Quigley, HA, 1990)
"5-Fluorouracil (5-FU) was injected subconjunctivally after glaucoma filtering surgery in a pilot study of eyes with poor surgical prognoses."7.675-fluorouracil and glaucoma filtering surgery. II. A pilot study. ( Anderson, DR; Gressel, MG; Heuer, DK; Hodapp, E; Palmberg, PF; Parrish, RK, 1984)
"We show that a 40-mg total dose of subconjunctival 5-fluorouracil after glaucoma filtering surgery can provide a success rate comparable to that demonstrated in prior studies employing a higher dose."7.67Low-dose 5-fluorouracil and glaucoma filtration surgery. ( Rabowsky, JH; Ruderman, JM, 1989)
"A prospective, randomized, double-masked, and placebo-controlled study was performed to examine the effect of a localized and sustained delivery of 5-fluorouracil (5-FU) on the success of glaucoma filtration surgery in 18 rabbits."7.67Glaucoma filtration surgery in rabbits using bioerodible polymers and 5-fluorouracil. ( Anderson, PJ; de Kater, AW; Flores, RA; Hertzmark, E; Lee, DA; Leong, KW; Teekhasaenee, C, 1987)
"The effect of 5-fluorouracil (5-FU) subconjunctival injection on the bleb formation and intraocular pressure (IOP) following trabeculectomy was studied in 18 glaucoma patients (20 eyes) with poor surgical prognosis."7.675-Fluorouracil for trabeculectomy in glaucoma. ( Kitazawa, Y; Nakano, Y; Shirato, S; Taniguchi, T; Yamamoto, T, 1987)
"Last controlled intraocular pressure is lower in C group patients (13."6.68[Intra- and postoperative use of 5-fluorouracil in the surgical treatment of refractory glaucoma]. ( Apatachioaie, I; Brănişteanu, D; Chiseliţă, D; Poiata, I; Rusu, V; Tătăruş, C, 1997)
"Late postoperative complications are similar with the exception of an increased incidence of Tenon cyst formation in the MMC-treated eyes."6.68Mitomycin C versus 5-fluorouracil in high-risk glaucoma filtering surgery. Extended follow-up. ( Bergstrom, TJ; Higginbotham, EJ; Johnson, AT; Katz, GJ; Lichter, PR; Musch, DC; Skuta, GL, 1995)
"Intraocular pressure was 20 mm Hg or lower in 24 eyes (96%) in the treatment group after mean follow-up of 17."6.67A randomized study of trabeculectomy and subconjunctival administration of fluorouracil in primary glaucomas. ( Ophir, A; Ticho, U, 1992)
"Raised intraocular pressure is a risk factor for glaucoma."6.52Mitomycin C versus 5-Fluorouracil for wound healing in glaucoma surgery. ( Cabourne, E; Clarke, JC; Evans, JR; Schlottmann, PG, 2015)
"Mitomycin C seems to be a better treatment than 5 fluorouracil."6.38[Mitomycin C in glaucoma surgery]. ( Collignon-Brach, J, 1993)
"5-Fluorouracil (5-FU) has been well described for a failing trabeculectomy bleb, but not for aqueous shunts."5.46Use of subconjunctival injections of 5-fluorouracil to rescue and prolong intraocular pressure reduction for a failing Ahmed glaucoma implant. ( Kaplowitz, K; Khodadadeh, S; Lee, D; Tsai, JC; Wang, S, 2017)
" In this study, 5-Fluorouracil (5-FU), a halogenated pyrimidine analogue and a potent anti-mitotic agent, was applied for seven days after trabeculectomy in eighteen complicated and unsuccessful filtering glaucomas, at a daily dosage of 5 mg in the form of 0."5.29The role of 5-fluorouracil in complicated glaucomas. ( Das, S; Jilani, FA; Khan, AM, 1993)
"The objective of this article was to study longitudinal changes in bleb morphology (presence of microcysts and bleb height and vascularity) in subjects enrolled in the Singapore 5-Fluorouracil (5-FU) trabeculectomy study."5.27Longitudinal Changes in Bleb Height, Vascularity, and Conjunctival Microcysts After Trabeculectomy. ( Aung, T; Htoon, HM; Husain, R; Kumaran, A, 2018)
"5-fluorouracil is an antimetabolite capable of inhibiting fibroblast proliferation."5.275-fluorouracil and glaucoma filtering surgery: I. An animal model. ( Folberg, R; Gressel, MG; Parrish, RK, 1984)
"To demonstrate that preoperative treatment for 28 days with topical dorzolamide/timolol is non-inferior (Δ = 4 mm Hg) to oral acetazolamide and topical dexamethasone (standard therapy) in terms of intraocular pressure (IOP) reduction 3 and 6 months after trabeculectomy in glaucoma patients."5.24Efficacy and safety of preoperative IOP reduction using a preservative-free fixed combination of dorzolamide/timolol eye drops versus oral acetazolamide and dexamethasone eye drops and assessment of the clinical outcome of trabeculectomy in glaucoma. ( Bell, K; Keicher, A; Lorenz, K; Pfeiffer, N; Renieri, G; Ruckes, C; Thieme, H; Wasielica-Poslednik, J, 2017)
"To compare the efficacy of transconjunctival needling revision with 5-fluorouracil versus medical treatment in glaucomatous eyes with uncontrolled intraocular pressure due to encapsulated bleb after trabeculectomy."5.17Early transconjunctival needling revision with 5-fluorouracil versus medical treatment in encapsulated blebs: a 12-month prospective study. ( Susanna, R; Suzuki, R, 2013)
"Primary outcome was bleb vascularity with secondary endpoints including visual acuity, intraocular pressure, bleb morphology, complications and total numbers of 5-fluorouracil injections were recorded at baseline, week 12 and 18 months."5.16Bleb vascularity following post-trabeculectomy subconjunctival bevacizumab: a pilot study. ( Chua, BE; Coote, MA; Crowston, JG; Gupta, V; Nguyen, DQ; Niyadurupola, N; Qin, Q; Ruddle, JB; Wells, AP; Wong, TT, 2012)
"Patients aged ≥ 30 years newly diagnosed with glaucoma were randomized to trabeculectomy with 5-fluorouracil or medical therapy."5.16A study of initial therapy for glaucoma in southern India: India Glaucoma Outcomes and Treatment (INGOT) Study. ( Congdon, NG; Friedman, DS; Gilbert, D; Goggins, W; Kader, MA; Krishnadas, R; Quigley, HA; Ramakrishnan, R; Tielsch, J, 2012)
"The perioperative use of oral prednisone did not alter the surgical outcome of filtering procedures associated with antifibrosis agents in this population of glaucoma patients."5.09Oral prednisone in guarded filtration procedures supplemented with antimetabolites. ( Augsburger, JJ; Azuara-Blanco, A; Spaeth, GL, 1999)
"To compare the effectiveness of trabeculectomy with adjunctive, low-dose, subconjunctival 5-fluorouracil (5-FU) to trabeculectomy alone in patients with uncomplicated glaucoma undergoing their first incisional surgical procedure."5.09Low-dose 5-fluorouracil trabeculectomy as initial surgery in uncomplicated glaucoma: long-term followup. ( Liebmann, JM; Ritch, R; Rothman, RF, 2000)
"Mean (+/-SD) preoperative and 1-year postoperative intraocular pressures in the 5-fluorouracil group were 26."5.09Randomized, controlled study of low-dose 5-fluorouracil in primary trabeculectomy. ( Caprioli, J; Chaudhry, IA; O'Connor, DJ; Pasha, MA; Weitzman, ML, 2000)
"Trabeculectomy is the procedure of choice for the surgical control of glaucoma, and is often augmented by intraoperative 5-fluorouracil application to reduce scarring."5.09Single intraoperative application of 5-Fluorouracil versus placebo in low-risk trabeculectomy surgery: a randomized trial. ( Bloom, P; Leyland, M; McAlister, J; Migdal, C; Rassam, S; Zinicola, E, 2001)
"To determine the efficacy and safety of subconjunctival 5- fluorouracil injections after trabeculectomy in patients with poor prognoses, to determine risk factors for surgical failure and to examine the relationship of intraocular pressure and visual function."5.08Five-year follow-up of the Fluorouracil Filtering Surgery Study. The Fluorouracil Filtering Surgery Study Group. ( , 1996)
"To study the effect of 5-Fluorouracil (5-FU) in glaucoma filtration surgery, 13 eyes of 12 patients with glaucoma were subjected to trabeculectomy with intraoperative one minute exposure of 50 mg/ml 5-FU."5.08Results of intraoperative 5-fluorouracil in patients undergoing trabeculectomy--pilot trial. ( Garg, D; Rao, BS; Revathi, B; Shelat, B; Vijaya, L, 1996)
"We examined the safety and efficacy of 5-fluorouracil in eyes with open-angle glaucoma undergoing combined cataract removal and filtration surgery."5.075-Fluorouracil after primary combined filtration surgery. ( Gieser, DK; Goldenfeld, M; Krupin, T; Liebmann, JM; Ritch, R; Rosenberg, LF; Ruderman, JM; Shields, MB; Wong, PC, 1994)
"The effects of postoperative subconjunctival 5-fluorouracil (5-FU) injections on the surgical outcomes of trabeculectomy were studied after a 5-year follow-up in 263 eyes of glaucoma patients by the life table analysis."5.07[A five-year follow-up of the effect of postoperative 5-fluorouracil subconjunctival injections on the surgical outcome of trabeculectomy]. ( Araie, M; Nakano, Y; Shirato, S; Shoji, N, 1993)
"Eighteen eyes of 15 patients with uncontrolled glaucoma (neovascular, intracapsular aphakia, uveitic, previous filtration failure) at high risk for failure of standard filtration underwent trabeculectomy with implantation of a purified collagen sponge containing 100 micrograms of antimetabolite (5-fluorouracil or bleomycin)."5.07Long-term results of trabeculectomy with collagen sponge implant containing low-dose antimetabolite. ( Herschler, J, 1992)
"In a randomized clinical trial, the authors compared the use of postoperative subconjunctival injections of 5-fluorouracil (5-FU) in 19 eyes with a single intraoperative application of subconjunctival mitomycin (MMC) at the filtering site in 20 eyes at high risk for failure of glaucoma filtering surgery."5.07Intraoperative mitomycin versus postoperative 5-fluorouracil in high-risk glaucoma filtering surgery. ( Beeson, CC; Bergstrom, TJ; Falck, FY; Higginbotham, EJ; Klein, TB; Lichter, PR; Musch, DC; Skuta, GL, 1992)
"We conducted a prospective, randomized study to compare mitomycin with fluorouracil for efficacy and safety as an adjunct to trabeculectomy in eyes with glaucoma with poor surgical prognosis."5.07Trabeculectomy with mitomycin. A comparative study with fluorouracil. ( Kawase, K; Kitazawa, Y; Matsushita, H; Minobe, M, 1991)
" We concluded mitomycin C might be more effective in reducing intraocular pressure and increasing qualified success compared to 5-fluorouracil."4.98Is mytomicyn better than 5-fluorouracil as antimetabolite in trabeculectomy for glaucoma? ( Pimentel, E; Schmidt, J, 2018)
"The preponderance of evidence from the literature suggests a small (2-4 mmHg) benefit from the use of mitomycin-C (MMC), but not 5-fluorouracil (5-FU), in combined cataract and glaucoma surgery (evidence grade B)."4.81Effect of technique on intraocular pressure after combined cataract and glaucoma surgery: An evidence-based review. ( Bass, EB; Congdon, N; Friedman, DS; Jampel, HD; Kempen, JH; Levkovitch-Verbin, H; Lubomski, LH; Quigley, H; Robinson, KA, 2002)
"To examine why most ophthalmologists routinely use mitomycin C or 5-fluorouracil (antimetabolites) in association with filtering surgery for glaucoma."4.81The use of antimetabolites with trabeculectomy: a critical appraisal. ( Mutlukan, E; Spaeth, GL, 2001)
"To report the effectiveness and safety of 5-fluorouracil (5-FU)-augmented Xen45 implantation in primary open-angle glaucoma (POAG) and pseudoexfoliation glaucoma (PEXG)."4.02Results of fluorouracil-augmented Xen45 implantation in primary open-angle and pseudoexfoliation glaucoma. ( Başer, EF; Seymenoğlu, RG, 2021)
"To investigate the outcomes of trabeculectomy with 5-fluorouracil (5-FU) with or without subconjunctival bevacizumab in the surgical management of pseudoexfoliation glaucoma (PXG)."3.91Initial trabeculectomy with 5-fluorouracil with or without subconjunctival bevacizumab in the management of pseudoexfoliation glaucoma. ( Çolak, S; Elgin, U; Sen, E; Yılmazbas, P, 2019)
"Rabbit model studies suggested better morphology blebs with equal intraocular pressure (IOP) efficacy as a standard mitomycin C (MMC) trabeculectomy using a novel slow-release drug delivery antifibrotic system delivering small quantities of MMC and 5-fluorouracil (5-FU)."3.91Effect of 2 Novel Sustained-release Drug Release Systems on Bleb Fibrosis: An In Vivo Trabeculectomy Study in a Rabbit Model. ( Ayyala, RS; Blake, D; Fullerton, M; Greenberg, E; John, V; Le, C; Mancera, N; Margo, C; Muddasani, N; Satija, C; Singh, S; Swann, FB; Wall, J; Zhang, Z; Zurakowski, D, 2019)
"To report our experience on treatment of primary congenital glaucoma with trabeculectomy in combination with biological amniotic membranes soaked with 5-fluorouracil."3.88Retrospective observation on trabeculectomy of primary congenital glaucoma by applying biological amniotic membranes soaked with 5-fluorouracil. ( Gao, H; Guo, B; Liu, C; Liu, W; Wang, J; Wang, X; Wu, M; Zhang, C, 2018)
"To evaluate the long-term outcome of trabeculectomy with intra- and postoperative 5-fluorouracil (5-FU) application in glaucoma."3.85Three-Year Follow-Up of Trabeculectomy with 5-Fluorouracil. ( Koutsonas, A; Kuerten, D; Lindemann, F; Plange, N; Schimitzek, H, 2017)
"To examine the effect of mitomycin c and 5-flurouracil on treatment outcomes following Ahmed glaucoma valve implantation."3.85Effect of mitomycin c and 5-flurouracil adjuvant therapy on the outcomes of Ahmed glaucoma valve implantation. ( Cui, QN; Han, Y; Hsia, YC; Lin, SC; Mehta, N; Naseri, A; Porco, TC; Rose-Nussbaumer, J; Stamper, RL, 2017)
"To determine the outcome of needling with adjunctive 5-fluorouracil (5-FU) in patients with a failing Ahmed glaucoma valve (AGV) implant, and to identify predictors of long-term intraocular pressure (IOP) control."3.83Needle Revision With 5-fluorouracil for the Treatment of Ahmed Glaucoma Valve Filtering Blebs: 5-Fluoruracil Needling Revision can be a Useful and Safe Tool in the Management of Failing Ahmed Glaucoma Valve Filtering Blebs. ( Floriani, I; Hollander, L; Katsanos, A; Konstas, AG; Poli, D; Quaranta, L, 2016)
"To compare the complication rate and effectiveness of mitomycin C (MMC), Ologen alone, and Ologen with 5-fluorouracil (5-FU) as adjunctives with Ex-PRESS mini shunt for medically uncontrolled glaucoma."3.81Ex-PRESS outcomes using mitomycin-C, Ologen alone, Ologen with 5-fluorouracil. ( Han, Y; Lowry, EA; Menda, SA; Porco, TC; Rubin, MR; Stamper, RL, 2015)
"This study was designed to investigate whether 5-fluorouracil (5-Fu)-polycaprolactone sustained-release film in Ahmed glaucoma valve implantation inhibits postoperative bleb scarring in rabbit eyes."3.81Application of 5-Fluorouracil-Polycaprolactone Sustained-Release Film in Ahmed Glaucoma Valve Implantation Inhibits Postoperative Bleb Scarring in Rabbit Eyes. ( Bi, XZ; Li, CH; Nan, KH; Pan, WH; Ren, ZJ; Song, ZM; Sun, M; Yu, XP, 2015)
"To investigate the safety and efficacy of Nd:YAG laser goniopuncture (LGP) in lowering intraocular pressure (IOP) in eyes having late bleb failure following trabeculectomy with mitomycin C administration."3.80Nd:YAG laser goniopuncture for late bleb failure after trabeculectomy with adjunctive mitomycin C. ( Alencar, LM; De Moraes, CG; Ritch, R; Susanna, R, 2014)
"To determine whether primary trabeculectomies performed in a UK district general hospital, specifically without making use of mitomycin-C augmentation but with selective use of the low potency anti-metabolite 5-fluorouracil, produce an acceptable long-term intraocular pressure (IOP)-lowering effect for an unselected patient group."3.79Enhanced trabeculectomy in a UK district general hospital setting: is selective use of 5-fluorouracil all that is required? ( Chaudhry, N; de Klerk, TA; Moriarty, AP, 2013)
"to investigate the ability of drug-loaded N,O-carboxymethyl chitosan (CMCS) hydrogels to modulate wound healing after glaucoma filtration surgery."3.76Ophthalmic drug-loaded N,O-carboxymethyl chitosan hydrogels: synthesis, in vitro and in vivo evaluation. ( CAI, X; CHEN, RF; CHENG, LZ; FAN, JZ; GUO, H; LAN, YQ; YANG, LQ; ZHANG, LM; ZHOU, HS, 2010)
" Intraocular pressure, visual acuity, complications and numbers of injections of 5-fluorouracil, suture removal, needling procedures and visits to ophthalmologists were recorded for 2 years."3.75Trabeculectomy with an active postoperative regimen: results and resource utilization. ( Alm, A; Niemelä, P; Taube, AB, 2009)
"To evaluate long-term outcomes after Ahmed valve implantation in patients with glaucoma when using adjunctive intraoperative mitomycin C (MMC) and postoperative 5-fluorouracil (5-FU)."3.74Ahmed valve implantation with adjunctive mitomycin C and 5-fluorouracil: long-term outcomes. ( Alvarado, JA; Hollander, DA; Juster, RP; Lee, LC, 2008)
"To evaluate the antimitotic and toxic effects of 5-chlorouracil (5-CU) and 5-fluorouracil (5-FU) and study their potential to delay filtering bleb closure in the rabbit eye when released by poly(ortho esters) (POE)."3.74Controlled delivery of 5-chlorouracil using poly(ortho esters) in filtering surgery for glaucoma. ( Behar-Cohen, F; BenEzra, D; Bourges, JL; Felt, O; Gurny, R; Jeanny, JC; Polak, MB; Rat, P; Thomas-Doyle, A; Torriglia, A; Valamanesh, F, 2008)
"Although adjunctive postoperative 5-fluorouracil (5-FU) injections are known to improve the success rate of glaucoma surgery, it is still unknown what dose, timing and frequency of application will give the best results with respect to the inhibition of postoperative scarring and intraocular pressure regulation."3.74Dose, timing and frequency of subconjunctival 5-fluorouracil injections after glaucoma filtering surgery. ( Bartz-Schmidt, KU; Besch, D; Denk, PO; Grüb, M; Reinthal, EK, 2007)
"To report the experience with trabeculectomy augmented with mitomycin C and 5-fluorouracil for the treatment of paediatric glaucoma."3.73Augmented trabeculectomy in paediatric glaucoma. ( Ehrlich, R; Friling, R; Gaton, DD; Lusky, M; Snir, M; Weinberger, D, 2005)
"In this study we compared the two groups of glaucoma patients who had underwent trabeculectomy, with or without intraoperative application of antimetabolite 5-Fluorouracile (5 FU)."3.73[Visual acuty after trabeculectomy]. ( Buzarovska, KB; Dzajkovska, E; Jordanova, VD; Vukosavljević, M, 2005)
"To prospectively study the evolution of possible high risk features of conjunctival filtration blebs like avascularity, transconjunctival oozing (TCO), and leaks after mitomycin C (MMC) enhanced glaucoma surgery."3.73Mitomycin C augmented glaucoma surgery: evolution of filtering bleb avascularity, transconjunctival oozing, and leaks. ( Anand, N; Arora, S; Clowes, M, 2006)
"To investigate the effect on intraocular pressure (IOP) of intraoperative 5-fluorouracil (5-FU) application during primary trabeculectomy in a West African population."3.72Intraoperative 5-fluorouracil application during primary trabeculectomy in Nigeria: a comparative study. ( Anand, N; Dawda, VK; Mielke, C, 2003)
"To report the outcome of 5-fluorouracil (5-FU)-augmented bleb needling revision of failed and failing filtration blebs and to identify risk factors for failure, indicators for success, and any complications of the procedure."3.72Needle revision of failing and failed trabeculectomy blebs with adjunctive 5-fluorouracil: survival analysis. ( Bloom, PA; Broadway, DC; Bunce, C; Khaw, PT; Thiagarajan, M, 2004)
"To evaluate the effect of temporal corneal phacoemulsification on intraocular pressure (IOP) in eyes after primary trabeculectomy with intraoperative fluorouracil (5-FU) or mitomycin C (MMC)."3.72Effect of temporal corneal phacoemulsification on intraocular pressure in eyes with prior trabeculectomy with an antimetabolite. ( Cantor, LB; Capistrano, AP; Swamynathan, K; WuDunn, D, 2004)
"A retrospective chart review of 44 eyes of 44 patients with uveitic glaucoma who underwent trabeculectomy with mitomycin C or 5-fluorouracil."3.71Trabeculectomy with antiproliferative agents in uveitic glaucoma. ( Beck, AD; Ceballos, EM; Lynn, MJ, 2002)
"To investigate the changes of tear film functions due to the use of postoperative 5-fluourouracil (5-Fu) and intraoperative mitomycin C (MMC) in glaucoma filtration surgery."3.71[Influence on tear film of postoperative 5-fluourouracil and intraoperative mitomycin C in glaucoma filtration surgery]. ( Li, J; Pang, L, 2001)
"To assess the outcome of trabeculectomy supplemented with intraoperative 5-Fluorouracil (5 FU) application in glaucoma patients."3.70Modification of trabeculectomy with single-dose intraoperative 5-Fluorouracil application. ( Anand, N; Menage, MJ; Sahni, K, 1998)
"The authors evaluate the results of preoperative 5-minute administration of 5-fluorouracil (5-FU), 50 mg/ml, during trabeculectomy on 11 high risk eyes of children with primary and secondary glaucoma."3.70[Peroperative administration of 5-fluorouracil during trabeculectomy in complicated glaucoma in children]. ( Burdová, M; Filous, A, 1998)
"This retrospective study was undertaken to evaluate if a "low dose" intraoperative sponge 5-fluorouracil application may improve the quality of the postoperative IOP control without increasing the incidence of postoperative complications following a first trabeculectomy in low-risk and/or severe field defects glaucomatous patients comparatively with a control group."3.70[Use of "low dose" 5-fluorouracil during trabeculectomy]. ( Detry-Morel, M; Kolanowski, C, 1999)
"To determine and compare the intraocular pressure (IOP) lowering effects of single-incision combined phacoemulsification and trabeculectomy with phacoemulsification done after previous trabeculectomy, both with an intraoperative dose of 5-fluorouracil (5-FU)."3.70Combined versus sequential phacotrabeculectomy with intraoperative 5-fluorouracil. ( Donoso, R; Rodríguez, A, 2000)
"To determine the effect of intraoperative application of 5-fluorouracil (5-FU) on the long-term outcome of trabeculectomy in uveitis-related glaucoma."3.70Long-term follow-up of trabeculectomy with intraoperative 5-fluorouracil for uveitis-related glaucoma. ( Lightman, S; McCluskey, P; Shaer, B; Towler, HM, 2000)
"To study the association between after-cataract and secondary glaucoma after lensectomy and 5-fluorouracil treatment in an experimental infant rabbit model."3.70After-cataract and secondary glaucoma in the aphakic infant rabbit. ( Holmén, JB; Kugelberg, U; Lundgren, B; Lundvall, A; Zetterström, C, 2000)
"A concurrent series (from January 1, 1987, to October 1, 1997) of one surgeon's consecutive 585 (456 patients) combined cataract extraction, intraocular lens implantation, and trabeculectomy surgeries, some with intraoperative mitomycin C and/or postoperative subconjunctival 5-fluorouracil."3.70Outcomes of combined cataract extraction, lens implantation, and trabeculectomy surgeries. ( Hahn, J; Larive, B; Rockwood, EJ, 2000)
"The cytostatic 5-fluorouracil (5-FU) is used at present in the postoperative treatment of glaucoma."3.70[Use of 5-fluorouracil in trabeculectomy]. ( Hovorková, M; Kvasnicka, J; Lochman, J; Novák, J; Rozsíval, P, 2000)
" In the 56 eyes where 5-fluorouracil was not used, the mean intraocular pressure (IOP) on diagnosis was 33."3.69Intraocular pressure control following microtrabeculectomy. ( Spencer, AF; Vernon, SA, 1995)
"Patients with both cataract and glaucoma underwent combined mitomycin C trabeculectomy, extracapsular cataract extraction, and intraocular lens implantation."3.69One-year follow-up results of combined mitomycin C trabeculectomy and extracapsular cataract extraction. ( Bueche, MJ; Feuer, WJ; Grajewski, AL; Joos, KM; Palmberg, PF, 1995)
"To evaluate intraocular pressure (IOP) control and surgical complications following trabeculectomy with 5-fluorouracil (5-FU) or mitomycin at the inferior limbus."3.69Trabeculectomy at the inferior limbus. ( Caronia, RM; Cohen, H; Friedman, R; Liebmann, JM; Ritch, R, 1996)
"A 2-month-old female infant with intractable congenital glaucoma and diffuse corneal opacification underwent trabeculectomy with 5-fluorouracil (5-FU) injection in both eyes followed by penetrating keratoplasty (PKP) combined with partial cyclocryotherapy in the right eye."3.69Ultrasonographic findings of the optic disc in congenital glaucoma. ( Barash, D; Kremer, I; Lusky, M; Snir, M; Yassur, Y, 1996)
"Forty consecutive case patients who underwent temporal corneal phacoemulsification combined with superior trabeculectomy plus low-dose 5-fluorouracil (case [combined surgery] group) and 40 control patients, matched for age race, preoperative intraocular pressure (IOP), number of preoperative antiglaucoma medications, and number of 5-fluorouracil injections, who underwent trabeculectomy alone plus low-dose 5-fluorouracil (control [trabeculectomy] group)."3.69Temporal corneal phacoemulsification combined with superior trabeculectomy. A retrospective case-control study. ( Caprioli, J; Park, HJ; Weitzman, M, 1997)
"The revision of a failed filtering bleb using mitomycin C was performed in 40 eyes (28 eyes with primary open angle glaucoma and 12 eyes with secondary open angle glaucoma) in which the previous trabeculectomy using 5-fluorouracil had failed to control intraocular pressure (IOP)."3.69[Surgical revision of failed filtering bleb with mitomycin C]. ( Hara, T; Shirato, S, 1997)
" Forty patients (controls; TRAB group) who had trabeculectomy alone were matched to the cases for length of follow-up, age, IOP, number of anti-glaucoma medications, number of 5-fluorouracil (5-FU) injections, race, sex and diagnosis."3.69Temporal corneal phacoemulsification in filtered glaucoma patients. ( Caprioli, J; Kwon, YH; Park, HJ; Weitzman, M, 1997)
"To investigate the incidence of complications reportedly caused by the use of 5-fluorouracil (5-FU) in glaucoma filtering surgery, we performed trabeculectomy with 5-FU on 57 eyes of 56 patients with advanced glaucoma."3.68Incidence of complications following 5-fluorouracil with trabeculectomies. ( Gieser, SC; Jacob, A; Raju, R; Sen, S; Thomas, R, 1993)
"Between 2/1991 and 1/1993 twenty-nine eyes of 11 female and 16 male patients with high-risk glaucoma (unsuccessful previous filtering surgery and a high risk of scarring) were treated with subconjunctival injections of 5-Fluorouracil after filtering surgery in the University Eye Hospital Düsseldorf."3.68[5-fluorouracil injection treatment after fistulating glaucoma operations]. ( Klüppel, M; Reinhard, T; Sundmacher, R, 1993)
"We measured aqueous flare in 16 glaucomatous eyes after trabeculectomy in which 5-fluorouracil (5-FU) or mitomycin C (MMC) had been used as an adjunctive therapy."3.68Anterior chamber reaction after mitomycin and 5-fluorouracil trabeculectomy: a comparative study. ( Jikihara, S; Kawase, K; Kitazawa, Y; Nishimura, K; Yamamoto, T, 1993)
"We studied 105 patients (105 eyes) operated on for glaucoma with adjunctive fluorouracil, who were followed up for 12 to 48 months (mean, 34."3.68Late complications after glaucoma filtering surgery with adjunctive 5-fluorouracil. ( Ophir, A; Ticho, U, 1993)
" These observations have lead to the widespread clinical use in humans of 5-fluorouracil and more recently mitomycin-C in glaucoma filtering surgery."3.68Antimetabolites in the surgical treatment of glaucomas. ( Van Caelenberghe, E; Van Oye, R, 1992)
"Twenty-one eyes of 18 patients with uncontrolled glaucoma and intraocular inflammatory disease had glaucoma filtering surgery with postoperative subconjunctival 5-fluorouracil (5-FU)."3.68Glaucoma filtering surgery with postoperative 5-fluorouracil in patients with intraocular inflammatory disease. ( Lowder, CY; Meisler, DM; Patitsas, CJ; Rockwood, EJ, 1992)
"Six patients, each with one eye that had previously undergone circular buckling surgery for the repair of retinal detachment before or followed by cataract extraction with or without intraocular lens implantation, underwent trabeculectomy with 5-fluorouracil (5-FU) for intractable glaucoma."3.68Trabeculectomy with 5-fluorouracil subsequent to circular buckling operation and cataract extraction. ( Ophir, A; Ticho, U, 1992)
"Trabeculectomy and subsequent subconjunctival injections of 5-fluorouracil (5-FU) were performed in four eyes (two children) with congenital glaucoma."3.68Subconjunctival injection of 5-fluorouracil following trabeculectomy for congenital and infantile glaucoma. ( Leiba, H; Oliver, M; Zalish, M, 1992)
"Repeated doses of 5mg of 5-fluorouracil (5-FU) were injected subconjunctivally in 25 poor-prognosis glaucomatous eyes after filtering surgery to prevent filtering bleb scarring."3.68Regulating the dose of 5-fluorouracil to prevent filtering bleb scarring. ( Ophir, A; Ticho, U, 1991)
"The effectiveness of trabeculectomy with adjunctive low-dose 5-fluorouracil (5-FU) as the initial surgical procedure in uncomplicated glaucoma was evaluated retrospectively in a consecutive series of 52 patients (mean follow-up, 18."3.68Initial 5-fluorouracil trabeculectomy in uncomplicated glaucoma. ( Liebmann, JM; Marmor, M; Nunez, J; Ritch, R; Wolner, B, 1991)
"The incidence of late-onset bleb-related endophthalmitis was evaluated retrospectively in 229 consecutive trabeculectomies performed with adjunctive 5-fluorouracil (5-FU) therapy."3.68Late bleb-related endophthalmitis after trabeculectomy with adjunctive 5-fluorouracil. ( Liebmann, JM; Marmor, M; Ritch, R; Sassani, JW; Speaker, M; Wolner, B, 1991)
"Nine patients (nine eyes) with iridocorneal endothelial (ICE) syndrome underwent trabeculectomy and received postoperative subconjunctival injections of 5-fluorouracil (5-FU) to enhance bleb formation (total 5-FU dose, 30-105 mg; mean, 53."3.685-Fluorouracil after trabeculectomy and the iridocorneal endothelial syndrome. ( Cristol, SM; Grajewski, AL; Parrish, RK; Wright, MM, 1991)
"We reviewed the records of 12 eyes of ten adult patients with inflammatory glaucoma who underwent trabeculectomy with the adjuvant use of 5-fluorouracil between January 1986 and January 1989."3.68Trabeculectomy with 5-fluorouracil for adult inflammatory glaucoma. ( Jabs, DA; Jampel, HD; Quigley, HA, 1990)
"5-Fluorouracil (5-FU) was injected subconjunctivally after glaucoma filtering surgery in a pilot study of eyes with poor surgical prognoses."3.675-fluorouracil and glaucoma filtering surgery. II. A pilot study. ( Anderson, DR; Gressel, MG; Heuer, DK; Hodapp, E; Palmberg, PF; Parrish, RK, 1984)
"The antimetabolite 5-fluorouracil (5-FU) was used as adjunctive treatment in glaucomatous eyes with poor prognoses undergoing filtering surgery."3.67Adjusting the dose of 5-fluorouracil after filtration surgery to minimize side effects. ( Weinreb, RN, 1987)
"We show that a 40-mg total dose of subconjunctival 5-fluorouracil after glaucoma filtering surgery can provide a success rate comparable to that demonstrated in prior studies employing a higher dose."3.67Low-dose 5-fluorouracil and glaucoma filtration surgery. ( Rabowsky, JH; Ruderman, JM, 1989)
"The effect of 5-fluorouracil (5-FU) subconjunctival injection on the bleb formation and intraocular pressure (IOP) following trabeculectomy was studied in 27 primary open-angle glaucoma patients (33 eyes) who had never been operated upon (25 eyes) or had undergone single trabeculectomy that failed to reduce IOP (8 eyes)."3.67Long-term results of 5-fluorouracil trabeculectomy for primary open-angle glaucoma. ( Kitazawa, Y; Shimizu, U; Taniguchi, T, 1989)
"A prospective, randomized, double-masked, and placebo-controlled study was performed to examine the effect of a localized and sustained delivery of 5-fluorouracil (5-FU) on the success of glaucoma filtration surgery in 18 rabbits."3.67Glaucoma filtration surgery in rabbits using bioerodible polymers and 5-fluorouracil. ( Anderson, PJ; de Kater, AW; Flores, RA; Hertzmark, E; Lee, DA; Leong, KW; Teekhasaenee, C, 1987)
"The effect of 5-fluorouracil (5-FU) subconjunctival injection on the bleb formation and intraocular pressure (IOP) following trabeculectomy was studied in 18 glaucoma patients (20 eyes) with poor surgical prognosis."3.675-Fluorouracil for trabeculectomy in glaucoma. ( Kitazawa, Y; Nakano, Y; Shirato, S; Taniguchi, T; Yamamoto, T, 1987)
" Although the success of trabeculectomy in lowering IOP is reduced when combined with phacoemulsification compared with trabeculectomy alone, this finding has to be set against the possible need for subsequent cataract surgery following trabeculectomy alone, which represents a second trip and expense for the patient and results in 10-61% failure of the trabeculectomy at one year post-cataract surgery."2.82Is Beta Radiation Better than 5 Flurouracil as an Adjunct for Trabeculectomy Surgery When Combined with Cataract Surgery? A Randomised Controlled Trial. ( Bowman, R; Cousens, S; Dhalla, K; Murdoch, I; Wood, M, 2016)
"68 eyes with chronic open angle glaucoma were included in a randomised trial of intraoperative 5-FU versus placebo."2.70A randomised trial of the effect of intraoperative 5-FU on the outcome of trabeculectomy in east Africa. ( Khaw, PT; Yorston, D, 2001)
"The use of low-dose subconjunctival 5-FU (mean dosage of 24."2.69Long-term outcome of primary glaucoma triple procedure with adjunctive 5-fluorouracil. ( Glover, BK; Hughes, BA; Juzych, MS; Kim, C; Kim, YY; O'Grady, JM; Ren, J; Shin, DH, 1998)
"Forty-two open angle glaucoma patients with uncontrolled intra-ocular pressure and with no risk factor of bleb fibrosis, underwent a NPDS."2.69[Deep nonpenetrating sclerectomy and open angle glaucoma. Intermediate results from the first operated patients]. ( Hamard, H; Hamard, P; Kopel, J; Plaza, L; Quesnot, S, 1999)
"5-Fluorouracil and MMC were found to be equally safe and effective adjuncts to primary trabeculectomy in the short- and medium-term postoperative periods."2.69Trabeculectomy with intraoperative mitomycin C versus 5-fluorouracil. Prospective randomized clinical trial. ( Baerveldt, GS; Budenz, DL; Chen, PP; Cohen, JS; Greenfield, DS; Mehta, K; Moster, MR; Shaikh, NM; Shaikh, S; Singh, K; Tsai, JC, 2000)
"Last controlled intraocular pressure is lower in C group patients (13."2.68[Intra- and postoperative use of 5-fluorouracil in the surgical treatment of refractory glaucoma]. ( Apatachioaie, I; Brănişteanu, D; Chiseliţă, D; Poiata, I; Rusu, V; Tătăruş, C, 1997)
"Late postoperative complications are similar with the exception of an increased incidence of Tenon cyst formation in the MMC-treated eyes."2.68Mitomycin C versus 5-fluorouracil in high-risk glaucoma filtering surgery. Extended follow-up. ( Bergstrom, TJ; Higginbotham, EJ; Johnson, AT; Katz, GJ; Lichter, PR; Musch, DC; Skuta, GL, 1995)
"Intraocular pressure was 20 mmHg or lower in 94% of 5-FU eyes and in 73% of control eyes (P < 0."2.675-Fluorouracil in initial trabeculectomy. A prospective, randomized, multicenter study. ( Gieser, DK; Goldenfeld, M; Krupin, T; Liebmann, JM; Ritch, R; Rosenberg, LF; Ruderman, JM; Wong, PC, 1994)
"Intraocular pressure was 20 mm Hg or lower in 24 eyes (96%) in the treatment group after mean follow-up of 17."2.67A randomized study of trabeculectomy and subconjunctival administration of fluorouracil in primary glaucomas. ( Ophir, A; Ticho, U, 1992)
"The risk of suprachoroidal hemorrhage was strongly associated with the level of the preoperative intraocular pressure."2.67Risk factors for suprachoroidal hemorrhage after filtering surgery. The Fluorouracil Filtering Surgery Study Group. ( , 1992)
"Raised intraocular pressure is a risk factor for glaucoma."2.52Mitomycin C versus 5-Fluorouracil for wound healing in glaucoma surgery. ( Cabourne, E; Clarke, JC; Evans, JR; Schlottmann, PG, 2015)
"In cases where such treatment fails, glaucoma-filtering surgery is considered, most commonly trabeculectomy surgery with variations in technique, for example, the type of conjunctival flap (fornix- or limbal-based)."2.52Fornix-based versus limbal-based conjunctival trabeculectomy flaps for glaucoma. ( Abdulaal, M; Al-Haddad, C; Al-Moujahed, A; Ervin, AM, 2015)
"The mean follow-up time after treatment for endophthalmitis was 6."2.41Delayed-onset bleb-associated endophthalmitis: clinical features and visual acuity outcomes. ( Budenz, DL; Flynn, HW; Scott, IU; Song, A, 2002)
"The use of antiscarring agents, particularly the antimetabolites 5-fluorouracil and mitomycin C, have revolutionized glaucoma surgery over the past decade."2.39Current techniques in wound healing modulation in glaucoma surgery. ( Khaw, PT; Migdal, CS, 1996)
"Mitomycin C seems to be a better treatment than 5 fluorouracil."2.38[Mitomycin C in glaucoma surgery]. ( Collignon-Brach, J, 1993)
" There was no significant adverse event for either group and no significant IOP difference in any of the observational periods between them (P=0."1.51Comparison of Efficacy and Safety of Bleb Needle Revision With and Without 5-Fluorouracil for Failing Trabeculectomy Bleb. ( Jeoung, JW; Kim, HJ; Kim, JS; Kim, YK; Na, KI; Park, KH, 2019)
"5-Fluorouracil (5-FU) has been well described for a failing trabeculectomy bleb, but not for aqueous shunts."1.46Use of subconjunctival injections of 5-fluorouracil to rescue and prolong intraocular pressure reduction for a failing Ahmed glaucoma implant. ( Kaplowitz, K; Khodadadeh, S; Lee, D; Tsai, JC; Wang, S, 2017)
"Intraocular pressure was 16 mmHg in the right and 36 mmHg in the left eye."1.40Iridocorneal endothelial syndrome. ( Akhtar, F; Ali, M; Saleem, AA, 2014)
"the Wuerzburg bleb classification score (WBCS) aims at an objective and standardized assessment of the developing filtering bleb after trabeculectomy, in order to detect and treat bleb scarring at the earliest possible stage of development."1.37The prognostic value of the wuerzburg bleb classification score for the outcome of trabeculectomy. ( Ellinger, P; Grehn, F; Guthoff, R; Kann, G; Klink, J; Klink, T, 2011)
" Based on the Wuerzburg bleb classification score (WBCS) for postoperative wound healing evaluation, 30 of these operations of group A (group B: n = 26) did not receive 5 FU postoperatively (controls), 67 (93) received up to 7 postoperative injections of 5 mg 5 FU (normal dosage group), and 72 (93) received more than 7 injections (high dosage group)."1.36[Corneal epitheliopathy following trabeculectomy with postoperative adjunctive 5-fluorouracil]. ( Geerling, G; Grehn, F; Klink, T; Reiter, C; Schultheiss, A; Wimmer, S, 2010)
"The area and the height of the bleb in the conjunctivae with radial incision (Ain and Hin, respectively) were compared with the area and the height of the bleb in the conjunctivae without radial incision (Ano and Hno, respectively)."1.35Restricted post-trabeculectomy bleb formation by conjunctival scarring. ( Inatani, M; Iwao, K; Ogata-Iwao, M; Takihara, Y; Tanihara, H, 2009)
"Juvenile-onset Open Angle Glaucoma (JOAG) has been proposed to be a small subset of Primary Open Angle Glaucoma (POAG) and on a continual spectrum of Primary Open Angle Glaucoma."1.35Bilateral ocular hypertension with rapidly progressive optic neuropathy in a teen. ( Byrne, E; Hua, LV; Yudcovitch, L, 2009)
"Others were encapsulated bleb 7."1.35Post-operative complication of trabeculectomy in Ibadan, Nigeria: outcome of 1-year follow-up. ( Ashaye, AO; Komolafe, OO, 2009)
"5-Fluorouracil (5-FU) has been used in patients with a pre-existing bleb, undergoing cataract surgery, but there are no published reports for or against its use in such cases."1.34Phacoemulsification in patients with previous trabeculectomy: role of 5-fluorouracil. ( Arora, S; Corridan, PG; Sharma, TK, 2007)
"Almost 49% of blebs underwent massage and a similar number required at least one suture removal, 31."1.34Frequency of bleb manipulations after trabeculectomy surgery. ( Alwitry, A; King, AJ; Moodie, J; Rotchford, AP, 2007)
" This study ascertained whether repeated injection of 5-FU has toxic effects on intraocular structures."1.33Do injections of 5-fluorouracil after trabeculectomy have toxic effects on the anterior segment? ( Allen, RC; Baynham, S; Lattanzio, FA; Samudre, S; Samuel, P; Sheppard, JD, 2005)
"Within this group, blebs were classified into three different categories according to their optical coherence tomography pattern: type A (featuring a thick wall and a single large fluid-filled space), type B (featuring a thin wall and multiple large fluid-filled spaces) and type C (featuring multiple, irregular and flattened fluid-filled spaces)."1.33Filtering blebs imaging by optical coherence tomography. ( Barboni, P; Savini, G; Zanini, M, 2005)
"5-Fluorouracil was safe and improved trabeculectomy survival."1.31The efficacy and safety of intraoperative and/or postoperative 5-fluorouracil in trabeculectomy and phacotrabeculectomy. ( Goldberg, I; Mohsin, M; Singh, RP, 2001)
"Intraocular pressure was significantly lower and an avascular area was more frequent in eyes with oozing or leak than in eyes without (P <."1.31Late-onset transconjunctival oozing and point leak of aqueous humor from filtering bleb after trabeculectomy. ( Araie, M; Matsuo, H; Shirato, S; Suzuki, Y; Tomidokoro, A, 2002)
"Mitomycin C was administered intraoperatively in the dose of 0."1.31[Antimetabolites in glaucoma surgery--long-term results]. ( Ferková, S; Jakabovicová, E; Michalíková, L; Strmen, P, 2002)
"Intraocular pressures were lower in the group that received MMC compared to the 5-FU group, but not in the group that did not receive antimetabolites, at all time intervals measured (P < ."1.30Comparison of phacotrabeculectomy with 5-fluorouracil, mitomycin-C, and without antifibrotic agents. ( Budenz, DL; Gordon, J; Keates, EU; Piltz-Seymour, J; Pyfer, M; Singh, K, 1999)
"A 71-year-old white woman with primary open angle glaucoma received trabeculectomy with antimetabolite."1.29Profound long-term hypotony without maculopathy after trabeculectomy with antimetabolite. ( Kaufman, PL; Kee, C, 1994)
"14 eyes of 14 patients with medically untreatable glaucoma and extremely bad surgical prognosis because of young age, secondary glaucomas or following previous surgery were treated by means of goniotrephination with a scleral flap and a fornix-based conjunctival flap."1.29[5-fluorouracil in goniotrepanation with poor prognosis. Results of 1-year follow-up]. ( Grehn, F; Pfeiffer, N, 1993)
" In this study, 5-Fluorouracil (5-FU), a halogenated pyrimidine analogue and a potent anti-mitotic agent, was applied for seven days after trabeculectomy in eighteen complicated and unsuccessful filtering glaucomas, at a daily dosage of 5 mg in the form of 0."1.29The role of 5-fluorouracil in complicated glaucomas. ( Das, S; Jilani, FA; Khan, AM, 1993)
"Complications included suprachoroidal hemorrhage in 7 (14%) of 49 eyes and intraoperative vitreous hemorrhage in 2."1.29Holmium laser sclerectomy. Success and complications. ( Bellows, AR; Hutchinson, BT; Lytle, R; Puliafito, CA; Schuman, JS; Stinson, WG, 1993)
"5-Fluorouracil (5-FU) has been used to improve the outcome of trabeculectomy in high-risk cases, employing a postoperative regimen of subconjunctival injections."1.29Low-dose perioperative 5-fluorouracil in trabeculectomy. ( Hugkulstone, CE; Vernon, SA, 1996)
" Our study may provide data on the appropriate dosage and indications for the use of this drug after glaucoma surgery."1.28Trabeculectomy with 5-fluorouracil. ( Iwata, K; Nanba, K; Sawaguchi, S; Watanabe, J, 1991)
"5-fluorouracil was injected subconjunctivally as an antiproliferative agent to prevent or decrease cell proliferation and scar formation."1.28External limbal sclerostomy with contact Nd:YAG laser versus surgical knife. ( Khoobehi, B; Oncel, M; Peyman, GA; Tawakol, ME, 1989)
"5-fluorouracil is an antimetabolite capable of inhibiting fibroblast proliferation."1.275-fluorouracil and glaucoma filtering surgery: I. An animal model. ( Folberg, R; Gressel, MG; Parrish, RK, 1984)
"Ater eight days, a hypertrophic scar formed, with the corneal endothelium extending over the scarred surface."1.27Q-switched neodymium-YAG laser trabeculopuncture in monkeys. ( Epstein, DL; Melamed, S; Pei, J; Puliafito, CA, 1985)

Research

Studies (310)

TimeframeStudies, this research(%)All Research%
pre-199015 (4.84)18.7374
1990's136 (43.87)18.2507
2000's91 (29.35)29.6817
2010's57 (18.39)24.3611
2020's11 (3.55)2.80

Authors

AuthorsStudies
Kandarakis, S1
Kontaxakis, A1
Doumazos, L1
Petrou, P1
Droutsas, K1
Papaconstantinou, D1
Georgalas, I1
Al-Mugheiry, TS1
Clark, A1
Broadway, DC2
Lee, JY1
Wu, J1
Liu, Y1
Saraswathy, S1
Zhou, L1
Bu, Q1
Su, Y1
Choi, D1
Park, E1
Strohmaier, CA1
Weinreb, RN3
Hong, YK1
Pan, X1
Huang, AS1
Wałek, E1
Przeździecka-Dołyk, J1
Helemejko, I1
Misiuk-Hojło, M1
Ang, BCH1
Seen, S1
Kumaran, A2
De Leon, JMS1
Seah, SKL1
Foster, PJ6
Gazzard, G7
Htoon, HM4
Khaw, PT16
Aung, T9
Husain, R7
Halili, A1
Kessel, L1
Subhi, Y1
Bach-Holm, D1
Chen, X1
Hong, Y1
Zhang, C3
Başer, EF1
Seymenoğlu, RG1
Kawashima, R1
Matsushita, K1
Kawasaki, R1
Nishida, K1
Zhao, X1
Liu, S1
Han, Y3
Wang, Y2
Lin, Q1
Kaplowitz, K2
Khodadadeh, S1
Wang, S1
Lee, D1
Tsai, JC3
Lindemann, F1
Plange, N2
Kuerten, D1
Schimitzek, H1
Koutsonas, A2
Shihadeh, W1
Massad, I1
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Clinical Trials (12)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Evaluation of Macular Thickness in Patients With Glaucoma in Use of Topical Prostaglandin Analogue Undergoing Trabeculectomy With Mitomycin C[NCT06000280]37 participants (Actual)Interventional2021-01-04Completed
Early Transconjunctival Needling Revision With 5-fluorouracil Versus Medical Treatment in Encapsulated Blebs: a 12-month Prospective Study[NCT01887223]Phase 240 participants (Actual)Interventional2010-05-31Completed
Clinical Efficacy and Safety of Minimally Invasive Glaucoma Surgery on Chinese Primary Angle Closure Glaucoma[NCT02964676]246 participants (Anticipated)Interventional2017-01-31Not yet recruiting
Efficacy and Safety of Trabeculectomy With Subconjunctival Bevacizumab Versus Trabeculectomy With Mitomycin C.[NCT01310764]36 participants (Actual)Interventional2009-04-30Completed
Intermediate Term Outcomes of Intraoperative 5-Fluorouracil Versus Mitomycin c in Trabeculectomy Surgery.[NCT00346489]Phase 470 participants Interventional2004-09-30Completed
Comparison of Combined Phacotrabeculectomy and Trabeculectomy Only in the Treatment of Primary Angle-closure Glaucoma[NCT01298635]31 participants (Actual)Interventional2005-01-31Completed
Anterior Segment Optical Coherence Tomography Findings in Patients With Ahmed Glaucoma Drainage Implants With Either a Pericardial Patch Graft and Fibrin Tissue Glue or a Partial-Thickness Scleral Flap and Conventional Sutures[NCT00453024]Phase 240 participants (Anticipated)Interventional2007-02-28Recruiting
Intraocular Pressure Control Following One Site Versus Two Site Combined Phacoemulsification/IOL And Trabeculectomy[NCT00695747]95 participants (Actual)Interventional1998-01-31Completed
[NCT00000122]Phase 30 participants Interventional1985-09-30Completed
[NCT00000149]Phase 30 participants Interventional1993-10-31Active, not recruiting
Phacoemulsification Combined With Trabeculectomy Versus Phacoemulsification Combined With Trabeculotomy for Treatment of Chronic Angle Closure Glaucoma[NCT04683055]50 participants (Actual)Interventional2020-10-28Completed
Glaucoma Eye Drop Instillation: Impact of Education[NCT01416415]119 participants (Actual)Interventional2011-08-31Terminated (stopped due to Not practical to continue due interim results)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

19 reviews available for fluorouracil and Intraocular Pressure

ArticleYear
Needling after trabeculectomy - does augmentation by anti-metabolites provide better outcomes and is Mitomycin C better than 5-Fluoruracil? A systematic review with network meta-analyses.
    Acta ophthalmologica, 2020, Volume: 98, Issue:7

    Topics: Fluorouracil; Glaucoma; Humans; Immunosuppressive Agents; Intraocular Pressure; Mitomycin; Network M

2020
Is mytomicyn better than 5-fluorouracil as antimetabolite in trabeculectomy for glaucoma?
    Medwave, 2018, Jan-18, Volume: 18, Issue:1

    Topics: Antimetabolites; Cicatrix; Fluorouracil; Glaucoma; Humans; Intraocular Pressure; Mitomycin; Randomiz

2018
Trabeculectomy: A Brief History and Review of Current Trends.
    International ophthalmology clinics, 2018,Summer, Volume: 58, Issue:3

    Topics: Angiogenesis Inhibitors; Fluorouracil; Glaucoma; History, 20th Century; History, 21st Century; Human

2018
Mitomycin C versus 5-fluorouracil as an adjunctive treatment for trabeculectomy: a meta-analysis of randomized clinical trials.
    Clinical & experimental ophthalmology, 2013, Volume: 41, Issue:8

    Topics: Alkylating Agents; Antimetabolites; Chemotherapy, Adjuvant; Epithelium, Corneal; Fluorouracil; Glauc

2013
Mitomycin C versus 5-Fluorouracil for wound healing in glaucoma surgery.
    The Cochrane database of systematic reviews, 2015, Nov-06, Issue:11

    Topics: Antimetabolites; Chemotherapy, Adjuvant; Cicatrix; Fluorouracil; Glaucoma; Humans; Intraocular Press

2015
Fornix-based versus limbal-based conjunctival trabeculectomy flaps for glaucoma.
    The Cochrane database of systematic reviews, 2015, Nov-25, Issue:11

    Topics: Antihypertensive Agents; Fluorouracil; Glaucoma; Humans; Intraocular Pressure; Limbus Corneae; Mitom

2015
Intraoperative mitomycin C versus intraoperative 5-fluorouracil for trabeculectomy: a systematic review and meta-analysis.
    Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2012, Volume: 28, Issue:2

    Topics: Controlled Clinical Trials as Topic; Fluorouracil; Humans; Intraocular Pressure; Intraoperative Care

2012
Current variations of glaucoma filtration surgery.
    Current opinion in ophthalmology, 2012, Volume: 23, Issue:2

    Topics: Alkylating Agents; Fluorouracil; Glaucoma; Humans; Intraocular Pressure; Mitomycin; Surgical Flaps;

2012
Deep sclerectomy.
    Developments in ophthalmology, 2012, Volume: 50

    Topics: Conjunctiva; Fibrosis; Fluorouracil; Follow-Up Studies; Glaucoma; Humans; Immunosuppressive Agents;

2012
Effect of technique on intraocular pressure after combined cataract and glaucoma surgery: An evidence-based review.
    Ophthalmology, 2002, Volume: 109, Issue:12

    Topics: Antimetabolites, Antineoplastic; Cataract; Cataract Extraction; Evidence-Based Medicine; Fluorouraci

2002
[Modulation of wound healing in filtration surgery for glaucoma].
    Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft, 2003, Volume: 100, Issue:4

    Topics: Adolescent; Adult; Age Factors; Alkylating Agents; Animals; Antimetabolites; Child; Filtering Surger

2003
[Mitomycin C in glaucoma surgery].
    Bulletin de la Societe belge d'ophtalmologie, 1993, Volume: 247, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Cicatrix; Fluorouracil; Glaucoma; Humans; Intraocular Pressure; Midd

1993
Wound healing modulation in glaucoma filtration surgery.
    Ophthalmic surgery, 1993, Volume: 24, Issue:3

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Aqueous Humor; Fluorouracil; Glaucoma; Humans; Intraocular

1993
Trabeculectomy with intraoperative sponge 5-fluorouracil.
    Ophthalmology, 1996, Volume: 103, Issue:6

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antimetabolites; Chemotherapy, Adjuvant; Child; Child, P

1996
Trabeculectomy with intraoperative sponge 5-fluorouracil in Afro-Caribbeans.
    The British journal of ophthalmology, 1997, Volume: 81, Issue:7

    Topics: Administration, Topical; Antimetabolites; Black People; Case-Control Studies; Female; Fluorouracil;

1997
Surgical consequences in coexisting cataract and glaucoma.
    Current opinion in ophthalmology, 1995, Volume: 6, Issue:2

    Topics: Cataract; Cataract Extraction; Fluorouracil; Glaucoma; Humans; Intraocular Pressure; Lenses, Intraoc

1995
Current techniques in wound healing modulation in glaucoma surgery.
    Current opinion in ophthalmology, 1996, Volume: 7, Issue:2

    Topics: Animals; Antimetabolites; Cataract Extraction; Cicatrix; Filtering Surgery; Fluorouracil; Glaucoma;

1996
The use of antimetabolites with trabeculectomy: a critical appraisal.
    Journal of glaucoma, 2001, Volume: 10, Issue:3

    Topics: Antimetabolites; Combined Modality Therapy; Delivery of Health Care; Fluorouracil; Glaucoma; Humans;

2001
Delayed-onset bleb-associated endophthalmitis: clinical features and visual acuity outcomes.
    Ophthalmology, 2002, Volume: 109, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Anterior Chamber; Bacteria; Endophthalmitis; Eye Infections, Bacteri

2002

Trials

72 trials available for fluorouracil and Intraocular Pressure

ArticleYear
Assessing safety and success after using bevacizumab, 5-fluorouracil or placebo in primary trabeculectomy. A prospective randomized placebo controlled 1-year follow-up study.
    Cutaneous and ocular toxicology, 2022, Volume: 41, Issue:1

    Topics: Angiogenesis Inhibitors; Bevacizumab; Fluorouracil; Follow-Up Studies; Humans; Intraocular Pressure;

2022
Fluorouracil Filtering Surgery Study One-Year Follow-up.
    American journal of ophthalmology, 2018, Volume: 186

    Topics: Aged; Conjunctiva; Dose-Response Relationship, Drug; Female; Filtering Surgery; Fluorouracil; Follow

2018
Longitudinal Changes in Bleb Height, Vascularity, and Conjunctival Microcysts After Trabeculectomy.
    Journal of glaucoma, 2018, Volume: 27, Issue:7

    Topics: Aged; Blister; Combined Modality Therapy; Conjunctiva; Conjunctival Diseases; Cysts; Female; Fluorou

2018
The Singapore 5-fluorouracil trial: intraocular pressure outcomes at 8 years.
    Ophthalmology, 2013, Volume: 120, Issue:6

    Topics: Antihypertensive Agents; Antimetabolites; Combined Modality Therapy; Double-Blind Method; Fluorourac

2013
The effect of bevacizumab on the outcome of trabeculectomy with 5-Fluorouracil.
    Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2013, Volume: 29, Issue:7

    Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Antimetabolites, Antineoplastic; Bevaciz

2013
Early transconjunctival needling revision with 5-fluorouracil versus medical treatment in encapsulated blebs: a 12-month prospective study.
    Clinics (Sao Paulo, Brazil), 2013, Volume: 68, Issue:10

    Topics: Adult; Aged; Aged, 80 and over; Antimetabolites; Blister; Conjunctiva; Female; Fluorouracil; Glaucom

2013
Is Beta Radiation Better than 5 Flurouracil as an Adjunct for Trabeculectomy Surgery When Combined with Cataract Surgery? A Randomised Controlled Trial.
    PloS one, 2016, Volume: 11, Issue:9

    Topics: Aged; Beta Particles; Cataract Extraction; Female; Fluorouracil; Follow-Up Studies; Humans; Intraocu

2016
Efficacy and safety of preoperative IOP reduction using a preservative-free fixed combination of dorzolamide/timolol eye drops versus oral acetazolamide and dexamethasone eye drops and assessment of the clinical outcome of trabeculectomy in glaucoma.
    PloS one, 2017, Volume: 12, Issue:2

    Topics: Acetazolamide; Aged; Antihypertensive Agents; Dexamethasone; Drug Combinations; Female; Fluorouracil

2017
Long-term outcomes of intraoperative 5-fluorouracil versus intraoperative mitomycin C in primary trabeculectomy surgery.
    Ophthalmology, 2009, Volume: 116, Issue:2

    Topics: Administration, Topical; Alkylating Agents; Antihypertensive Agents; Antimetabolites; Combined Modal

2009
The singapore 5-Fluorouracil trabeculectomy study: effects on intraocular pressure control and disease progression at 3 years.
    Ophthalmology, 2009, Volume: 116, Issue:2

    Topics: Adult; Aged; Antimetabolites, Antineoplastic; Combined Modality Therapy; Disease Progression; Double

2009
Optic disc and visual field changes after trabeculectomy.
    Investigative ophthalmology & visual science, 2009, Volume: 50, Issue:10

    Topics: Adult; Aged; Aged, 80 and over; Antimetabolites; Combined Modality Therapy; Disease Progression; Dou

2009
Central corneal thickness and glaucoma in East Asian people.
    Investigative ophthalmology & visual science, 2011, Oct-28, Volume: 52, Issue:11

    Topics: Adult; Aged; Aged, 80 and over; Aging; Alkylating Agents; Asian People; Case-Control Studies; Cornea

2011
Cataract surgery after trabeculectomy: the effect on trabeculectomy function.
    Archives of ophthalmology (Chicago, Ill. : 1960), 2012, Volume: 130, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Alkylating Agents; Female; Fluorouracil; Follow-Up Studies; Glaucoma

2012
Randomized, controlled trial of a sustained delivery formulation of 5-fluorouracil for the treatment of failing blebs.
    Ophthalmology, 2012, Volume: 119, Issue:2

    Topics: Aged; Aqueous Humor; Conjunctiva; Delayed-Action Preparations; Female; Fluorouracil; Glaucoma; Human

2012
Bleb vascularity following post-trabeculectomy subconjunctival bevacizumab: a pilot study.
    Clinical & experimental ophthalmology, 2012, Volume: 40, Issue:8

    Topics: Aged; Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Antimetabolites; Bevacizumab; Conj

2012
A study of initial therapy for glaucoma in southern India: India Glaucoma Outcomes and Treatment (INGOT) Study.
    Ophthalmic epidemiology, 2012, Volume: 19, Issue:3

    Topics: Aged; Antihypertensive Agents; Antimetabolites, Antineoplastic; Brimonidine Tartrate; Drug Combinati

2012
Comparison of needle revision with subconjunctival bevacizumab and 5-fluorouracil injection of failed trabeculectomy blebs.
    Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2012, Volume: 28, Issue:5

    Topics: Antibodies, Monoclonal, Humanized; Bevacizumab; Conjunctiva; Female; Fluorouracil; Glaucoma; Humans;

2012
Risk of endophthalmitis and other long-term complications of trabeculectomy in the Collaborative Initial Glaucoma Treatment Study (CIGTS).
    American journal of ophthalmology, 2013, Volume: 155, Issue:4

    Topics: Antimetabolites; Cataract Extraction; Endophthalmitis; Fluorouracil; Follow-Up Studies; Glaucoma, Op

2013
A prospective randomized trial comparing intraoperative 5-fluorouracil vs mitomycin C in primary trabeculectomy.
    American journal of ophthalmology, 2002, Volume: 134, Issue:4

    Topics: Antimetabolites; Double-Blind Method; Fluorouracil; Glaucoma; Humans; Intraocular Pressure; Intraope

2002
Viscocanalostomy versus trabeculectomy in white adults affected by open-angle glaucoma: a 2-year randomized, controlled trial.
    Ophthalmology, 2003, Volume: 110, Issue:5

    Topics: Aged; Anterior Eye Segment; Conjunctiva; Exfoliation Syndrome; Female; Fluorouracil; Glaucoma, Open-

2003
Intraocular pressure and visual field loss in primary angle closure and primary open angle glaucomas.
    The British journal of ophthalmology, 2003, Volume: 87, Issue:6

    Topics: Antimetabolites; Cross-Sectional Studies; Female; Fluorouracil; Glaucoma, Angle-Closure; Glaucoma, O

2003
A randomised, prospective study comparing trabeculectomy with viscocanalostomy with adjunctive antimetabolite usage for the management of open angle glaucoma uncontrolled by medical therapy.
    The British journal of ophthalmology, 2004, Volume: 88, Issue:8

    Topics: Adult; Aged; Aged, 80 and over; Antimetabolites; Blister; Cataract; Female; Filtering Surgery; Fluor

2004
[Intra- and postoperative use of 5-fluorouracil in the surgical treatment of refractory glaucoma].
    Oftalmologia (Bucharest, Romania : 1990), 1997, Volume: 41, Issue:2

    Topics: Antimetabolites; Conjunctiva; Fluorouracil; Follow-Up Studies; Glaucoma; Humans; Injections; Intraoc

1997
Comparison of 1-site versus 2-site phacotrabeculectomy.
    Journal of cataract and refractive surgery, 2006, Volume: 32, Issue:5

    Topics: Antihypertensive Agents; Case-Control Studies; Cataract; Fluorouracil; Follow-Up Studies; Glaucoma;

2006
The role of antimetabolites in filtration surgery for neovascular glaucoma: intermediate-term follow-up.
    Acta ophthalmologica Scandinavica, 2007, Volume: 85, Issue:3

    Topics: Adult; Aged; Antimetabolites; Combined Modality Therapy; Female; Fluorouracil; Follow-Up Studies; Gl

2007
5-Fluorouracil in initial trabeculectomy. A prospective, randomized, multicenter study.
    Ophthalmology, 1994, Volume: 101, Issue:6

    Topics: Aged; Aged, 80 and over; Combined Modality Therapy; Exfoliation Syndrome; Female; Fluorouracil; Foll

1994
5-Fluorouracil after primary combined filtration surgery.
    American journal of ophthalmology, 1994, Feb-15, Volume: 117, Issue:2

    Topics: Aged; Cataract; Cataract Extraction; Combined Modality Therapy; Female; Fluorouracil; Glaucoma, Open

1994
Update of the subconjunctival THC:YAG (holmium) laser sclerostomy ab externo clinical trial: 30-month report.
    Ophthalmic surgery, 1994, Volume: 25, Issue:1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Female; Fluorouracil; Follow-Up Studies; Glaucoma

1994
Risk factors for the development of encapsulated filtering blebs. The role of surgical glove powder and 5-fluorouracil.
    Ophthalmology, 1994, Volume: 101, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Female; Fluorouracil; Follow-Up Studies; Glaucoma; Gloves, Surgical;

1994
Trabeculectomy, phacoemulsification, and posterior chamber lens implantation with and without 5-fluorouracil.
    American journal of ophthalmology, 1993, Nov-15, Volume: 116, Issue:5

    Topics: Aged; Cataract Extraction; Chronic Disease; Conjunctiva; Fluorouracil; Follow-Up Studies; Glaucoma,

1993
A prospective trial of intraoperative fluorouracil during trabeculectomy in a black population.
    American journal of ophthalmology, 1993, Nov-15, Volume: 116, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Black People; Female; Fluorouracil; Follow-Up Studies; Ghana; Glauco

1993
Three-year follow-up of the Fluorouracil Filtering Surgery Study.
    American journal of ophthalmology, 1993, Volume: 115, Issue:1

    Topics: Fluorouracil; Follow-Up Studies; Glaucoma; Humans; Intraocular Pressure; Postoperative Care; Surviva

1993
[A five-year follow-up of the effect of postoperative 5-fluorouracil subconjunctival injections on the surgical outcome of trabeculectomy].
    Nippon Ganka Gakkai zasshi, 1993, Volume: 97, Issue:2

    Topics: Adult; Conjunctiva; Female; Fluorouracil; Follow-Up Studies; Glaucoma; Humans; Injections; Intraocul

1993
Five-year follow-up of the Fluorouracil Filtering Surgery Study. The Fluorouracil Filtering Surgery Study Group.
    American journal of ophthalmology, 1996, Volume: 121, Issue:4

    Topics: Cataract Extraction; Chemotherapy, Adjuvant; Fluorouracil; Follow-Up Studies; Glaucoma; Humans; Immu

1996
Results of intraoperative 5-fluorouracil in patients undergoing trabeculectomy--pilot trial.
    Indian journal of ophthalmology, 1996, Volume: 44, Issue:2

    Topics: Adolescent; Adult; Aged; Antimetabolites; Chemotherapy, Adjuvant; Conjunctiva; Female; Fluorouracil;

1996
Temporal corneal phacoemulsification combined with superior trabeculectomy: a controlled study.
    Transactions of the American Ophthalmological Society, 1996, Volume: 94

    Topics: Aged; Aged, 80 and over; Case-Control Studies; Cataract; Cornea; Female; Fluorouracil; Glaucoma; Hum

1996
Short-term results of initial trabeculectomy with intraoperative or postoperative 5-fluorouracil for primary glaucomas.
    Indian journal of ophthalmology, 1996, Volume: 44, Issue:3

    Topics: Antimetabolites; Chemotherapy, Adjuvant; Conjunctiva; Female; Fluorouracil; Glaucoma, Angle-Closure;

1996
5-fluorouracil in combined trabeculectomy and clear-cornea phacoemulsification with posterior chamber intraocular lens implantation. A one-year randomized, controlled clinical trial.
    Ophthalmology, 1997, Volume: 104, Issue:2

    Topics: Antimetabolites; Cataract; Cornea; Fluorouracil; Follow-Up Studies; Glaucoma, Open-Angle; Humans; In

1997
Mitomycin C versus 5-fluorouracil in high-risk glaucoma filtering surgery. Extended follow-up.
    Ophthalmology, 1995, Volume: 102, Issue:9

    Topics: Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Chemotherapy, Adjuvant; Female; Filter

1995
Trabeculectomy with intraoperative 5-fluorouracil vs mitomycin C.
    American journal of ophthalmology, 1997, Volume: 123, Issue:1

    Topics: Antimetabolites; Female; Fluorouracil; Glaucoma; Humans; Intraocular Pressure; Intraoperative Care;

1997
Short-term results of initial trabeculectomy with intraoperative or postoperative 5-fluorouracil for primary glaucomas.
    Indian journal of ophthalmology, 1997, Volume: 45, Issue:3

    Topics: Administration, Topical; Antimetabolites; Female; Fluorouracil; Follow-Up Studies; Glaucoma, Angle-C

1997
Risk of hypotony after primary trabeculectomy with antifibrotic agents in a black west African population.
    Journal of glaucoma, 1998, Volume: 7, Issue:2

    Topics: Fluorouracil; Follow-Up Studies; Ghana; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Intraope

1998
Delayed postoperative use of 5-fluorouracil in primary open angle glaucoma.
    Acta ophthalmologica Scandinavica. Supplement, 1997, Issue:224

    Topics: Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Fluorouracil; Follow-Up Studies; Glauc

1997
Long-term outcome of primary glaucoma triple procedure with adjunctive 5-fluorouracil.
    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 1998, Volume: 236, Issue:7

    Topics: Aged; Chemotherapy, Adjuvant; Female; Fluorouracil; Follow-Up Studies; Glaucoma, Open-Angle; Humans;

1998
Delayed post-operative use of 5-fluorouracil as an adjunct in medically uncontrolled open angle glaucoma.
    Eye (London, England), 1998, Volume: 12 ( Pt 4)

    Topics: Aged; Aged, 80 and over; Antimetabolites; Chemotherapy, Adjuvant; Drug Administration Schedule; Fema

1998
Oral prednisone in guarded filtration procedures supplemented with antimetabolites.
    Ophthalmic surgery and lasers, 1999, Volume: 30, Issue:2

    Topics: Administration, Oral; Aged; Chemotherapy, Adjuvant; Double-Blind Method; Female; Filtering Surgery;

1999
A randomized phase II trial of interferon-alpha2b versus 5-fluorouracil after trabeculectomy.
    Australian and New Zealand journal of ophthalmology, 1999, Volume: 27, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Cataract; Cataract Extraction; Connective Tissue; Double-Blind Metho

1999
Fornix-based versus limbal-based conjunctival flaps in initial trabeculectomy with postoperative 5-fluorouracil: four-year follow-up findings.
    Journal of glaucoma, 1999, Volume: 8, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Antimetabolites; Conjunctiva; Fluorouracil; Follow-Up Studies; Glauc

1999
[Deep nonpenetrating sclerectomy and open angle glaucoma. Intermediate results from the first operated patients].
    Journal francais d'ophtalmologie, 1999, Volume: 22, Issue:1

    Topics: Administration, Topical; Aged; Collagen; Female; Fluorouracil; Follow-Up Studies; Glaucoma, Open-Ang

1999
Combined cataract and glaucoma surgery: trabeculectomy versus endoscopic laser cycloablation.
    Journal of cataract and refractive surgery, 1999, Volume: 25, Issue:9

    Topics: Cataract; Ciliary Body; Endoscopy; Female; Fluorouracil; Follow-Up Studies; Glaucoma; Humans; Intrao

1999
Low-dose 5-fluorouracil trabeculectomy as initial surgery in uncomplicated glaucoma: long-term followup.
    Ophthalmology, 2000, Volume: 107, Issue:6

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Chemotherapy, Adjuvant; Female; Fluorouracil; Follow-Up

2000
Trabeculectomy with intraoperative mitomycin C versus 5-fluorouracil. Prospective randomized clinical trial.
    Ophthalmology, 2000, Volume: 107, Issue:12

    Topics: Aged; Antimetabolites, Antineoplastic; Chemotherapy, Adjuvant; Drug Evaluation; Female; Fluorouracil

2000
Randomized, controlled study of low-dose 5-fluorouracil in primary trabeculectomy.
    American journal of ophthalmology, 2000, Volume: 130, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Antimetabolites; Chemotherapy, Adjuvant; Conjunctiva; Drug Evaluatio

2000
Efficacy of sulodexide as adjunct in trabeculectomy. A two-year randomized clinical study.
    Acta ophthalmologica Scandinavica. Supplement, 2000, Issue:232

    Topics: Chemotherapy, Adjuvant; Fibrinolytic Agents; Fluorouracil; Follow-Up Studies; Glaucoma, Open-Angle;

2000
A randomised trial of the effect of intraoperative 5-FU on the outcome of trabeculectomy in east Africa.
    The British journal of ophthalmology, 2001, Volume: 85, Issue:9

    Topics: Antimetabolites; Chronic Disease; Fluorouracil; Follow-Up Studies; Glaucoma, Open-Angle; Humans; Int

2001
Prognosis and risk factors for early postoperative wound leaks after trabeculectomy with and without 5-fluorouracil.
    American journal of ophthalmology, 2001, Volume: 132, Issue:5

    Topics: Antimetabolites; Conjunctiva; Female; Fluorouracil; Follow-Up Studies; Glaucoma; Humans; Injections;

2001
Interim clinical outcomes in the Collaborative Initial Glaucoma Treatment Study comparing initial treatment randomized to medications or surgery.
    Ophthalmology, 2001, Volume: 108, Issue:11

    Topics: Adrenergic beta-Antagonists; Adult; Aged; Cataract; Female; Fluorouracil; Follow-Up Studies; Glaucom

2001
Interim clinical outcomes in the Collaborative Initial Glaucoma Treatment Study comparing initial treatment randomized to medications or surgery.
    Ophthalmology, 2001, Volume: 108, Issue:11

    Topics: Adrenergic beta-Antagonists; Adult; Aged; Cataract; Female; Fluorouracil; Follow-Up Studies; Glaucom

2001
Interim clinical outcomes in the Collaborative Initial Glaucoma Treatment Study comparing initial treatment randomized to medications or surgery.
    Ophthalmology, 2001, Volume: 108, Issue:11

    Topics: Adrenergic beta-Antagonists; Adult; Aged; Cataract; Female; Fluorouracil; Follow-Up Studies; Glaucom

2001
Interim clinical outcomes in the Collaborative Initial Glaucoma Treatment Study comparing initial treatment randomized to medications or surgery.
    Ophthalmology, 2001, Volume: 108, Issue:11

    Topics: Adrenergic beta-Antagonists; Adult; Aged; Cataract; Female; Fluorouracil; Follow-Up Studies; Glaucom

2001
Interim clinical outcomes in the Collaborative Initial Glaucoma Treatment Study comparing initial treatment randomized to medications or surgery.
    Ophthalmology, 2001, Volume: 108, Issue:11

    Topics: Adrenergic beta-Antagonists; Adult; Aged; Cataract; Female; Fluorouracil; Follow-Up Studies; Glaucom

2001
Interim clinical outcomes in the Collaborative Initial Glaucoma Treatment Study comparing initial treatment randomized to medications or surgery.
    Ophthalmology, 2001, Volume: 108, Issue:11

    Topics: Adrenergic beta-Antagonists; Adult; Aged; Cataract; Female; Fluorouracil; Follow-Up Studies; Glaucom

2001
Interim clinical outcomes in the Collaborative Initial Glaucoma Treatment Study comparing initial treatment randomized to medications or surgery.
    Ophthalmology, 2001, Volume: 108, Issue:11

    Topics: Adrenergic beta-Antagonists; Adult; Aged; Cataract; Female; Fluorouracil; Follow-Up Studies; Glaucom

2001
Interim clinical outcomes in the Collaborative Initial Glaucoma Treatment Study comparing initial treatment randomized to medications or surgery.
    Ophthalmology, 2001, Volume: 108, Issue:11

    Topics: Adrenergic beta-Antagonists; Adult; Aged; Cataract; Female; Fluorouracil; Follow-Up Studies; Glaucom

2001
Interim clinical outcomes in the Collaborative Initial Glaucoma Treatment Study comparing initial treatment randomized to medications or surgery.
    Ophthalmology, 2001, Volume: 108, Issue:11

    Topics: Adrenergic beta-Antagonists; Adult; Aged; Cataract; Female; Fluorouracil; Follow-Up Studies; Glaucom

2001
Single intraoperative application of 5-Fluorouracil versus placebo in low-risk trabeculectomy surgery: a randomized trial.
    Journal of glaucoma, 2001, Volume: 10, Issue:6

    Topics: Aged; Antimetabolites; Chemotherapy, Adjuvant; Conjunctiva; Double-Blind Method; Female; Fluorouraci

2001
A randomised, prospective study comparing trabeculectomy augmented with antimetabolites with a viscocanalostomy technique for the management of open angle glaucoma uncontrolled by medical therapy.
    The British journal of ophthalmology, 2002, Volume: 86, Issue:7

    Topics: Adult; Aged; Aged, 80 and over; Antimetabolites; Combined Modality Therapy; Female; Fluorouracil; Fo

2002
Long-term results of trabeculectomy with collagen sponge implant containing low-dose antimetabolite.
    Ophthalmology, 1992, Volume: 99, Issue:5

    Topics: Adult; Aged; Biological Dressings; Bleomycin; Collagen; Drug Implants; Female; Fluorouracil; Glaucom

1992
Daunorubicin versus 5-fluoro-uracil in surgical treatment of primary open angle glaucoma: a prospective study.
    International ophthalmology, 1992, Volume: 16, Issue:4-5

    Topics: Aged; Daunorubicin; Female; Fluorouracil; Follow-Up Studies; Glaucoma, Open-Angle; Humans; Injection

1992
A randomized study of trabeculectomy and subconjunctival administration of fluorouracil in primary glaucomas.
    Archives of ophthalmology (Chicago, Ill. : 1960), 1992, Volume: 110, Issue:8

    Topics: Aged; Aged, 80 and over; Conjunctiva; Female; Fluorouracil; Glaucoma; Humans; Injections; Intraocula

1992
Intraoperative mitomycin versus postoperative 5-fluorouracil in high-risk glaucoma filtering surgery.
    Ophthalmology, 1992, Volume: 99, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Corneal Diseases; Epithelium; Female; Fluorouracil; Glaucoma; Humans

1992
Risk factors for suprachoroidal hemorrhage after filtering surgery. The Fluorouracil Filtering Surgery Study Group.
    American journal of ophthalmology, 1992, May-15, Volume: 113, Issue:5

    Topics: Aged; Cataract Extraction; Choroid Hemorrhage; Fluorouracil; Glaucoma; Humans; Incidence; Intraocula

1992
Encapsulated filtering bleb and subconjunctival 5-fluorouracil.
    Ophthalmic surgery, 1992, Volume: 23, Issue:5

    Topics: Aged; Aged, 80 and over; Fibroblasts; Fluorouracil; Follow-Up Studies; Glaucoma, Open-Angle; Humans;

1992
Trabeculectomy with mitomycin. A comparative study with fluorouracil.
    Archives of ophthalmology (Chicago, Ill. : 1960), 1991, Volume: 109, Issue:12

    Topics: Adult; Aged; Cicatrix; Combined Modality Therapy; Female; Fluorouracil; Glaucoma; Humans; Intraocula

1991
Use of trabeculectomy with postoperative 5-fluorouracil in patients requiring extremely low intraocular pressure levels to limit further glaucoma progression.
    Ophthalmology, 1991, Volume: 98, Issue:7

    Topics: Aged; Aged, 80 and over; Chronic Disease; Female; Fluorouracil; Follow-Up Studies; Glaucoma, Open-An

1991
The use of 5-fluorouracil in patients following combined trabeculectomy and cataract extraction.
    Ophthalmic surgery, 1991, Volume: 22, Issue:8

    Topics: Aged; Aged, 80 and over; Cataract Extraction; Combined Modality Therapy; Female; Fluorouracil; Glauc

1991
Fluorouracil Filtering Surgery Study one-year follow-up. The Fluorouracil Filtering Surgery Study Group.
    American journal of ophthalmology, 1989, Dec-15, Volume: 108, Issue:6

    Topics: Adult; Aged; Bias; Chi-Square Distribution; Data Interpretation, Statistical; Female; Fluorouracil;

1989
Fluorouracil Filtering Surgery Study one-year follow-up. The Fluorouracil Filtering Surgery Study Group.
    American journal of ophthalmology, 1989, Dec-15, Volume: 108, Issue:6

    Topics: Adult; Aged; Bias; Chi-Square Distribution; Data Interpretation, Statistical; Female; Fluorouracil;

1989
Fluorouracil Filtering Surgery Study one-year follow-up. The Fluorouracil Filtering Surgery Study Group.
    American journal of ophthalmology, 1989, Dec-15, Volume: 108, Issue:6

    Topics: Adult; Aged; Bias; Chi-Square Distribution; Data Interpretation, Statistical; Female; Fluorouracil;

1989
Fluorouracil Filtering Surgery Study one-year follow-up. The Fluorouracil Filtering Surgery Study Group.
    American journal of ophthalmology, 1989, Dec-15, Volume: 108, Issue:6

    Topics: Adult; Aged; Bias; Chi-Square Distribution; Data Interpretation, Statistical; Female; Fluorouracil;

1989
Effect of postoperative subconjunctival 5-fluorouracil injections on the surgical outcome of trabeculectomy in the Japanese.
    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 1989, Volume: 227, Issue:6

    Topics: Adolescent; Adult; Aged; Child; Clinical Trials as Topic; Conjunctiva; Fluorouracil; Follow-Up Studi

1989
A prospective, randomized study of 5-fluorouracil and filtration surgery.
    Transactions of the American Ophthalmological Society, 1987, Volume: 85

    Topics: Adolescent; Adult; Aged; Child; Female; Fluorouracil; Glaucoma; Humans; Intraocular Pressure; Male;

1987
A randomized study of 5-fluorouracil and filtration surgery.
    American journal of ophthalmology, 1987, Sep-15, Volume: 104, Issue:3

    Topics: Female; Fluorouracil; Glaucoma; Humans; Intraocular Pressure; Male; Middle Aged; Postoperative Compl

1987

Other Studies

219 other studies available for fluorouracil and Intraocular Pressure

ArticleYear
The Norwich trabeculectomy study: risk factor analysis for the development of adverse, thin cystic blebs.
    Acta ophthalmologica, 2022, Volume: 100, Issue:7

    Topics: Antimetabolites; Conjunctiva; Factor Analysis, Statistical; Fluorouracil; Glaucoma; Humans; Intraocu

2022
Subconjunctival Lymphatics Respond to VEGFC and Anti-Metabolites in Rabbit and Mouse Eyes.
    Investigative ophthalmology & visual science, 2022, 09-01, Volume: 63, Issue:10

    Topics: Animals; Antimetabolites; Conjunctiva; Dextrans; Fluorouracil; Glaucoma; Intraocular Pressure; Mice;

2022
Efficacy of postoperative management with 5-fluorouracil injections after XEN Gel Stent implantation.
    International ophthalmology, 2020, Volume: 40, Issue:1

    Topics: Aged; Conjunctiva; Female; Fluorouracil; Follow-Up Studies; Glaucoma Drainage Implants; Glaucoma, Op

2020
Visual field progression 8 years after trabeculectomy in Asian eyes: results from The Singapore 5-Fluorouracil Study.
    The British journal of ophthalmology, 2020, Volume: 104, Issue:12

    Topics: Adult; Aged; Disease Progression; Female; Fluorouracil; Follow-Up Studies; Glaucoma, Open-Angle; Hum

2020
Does bleb needling augmented by mitomycin C or 5-fluorouracil share similar efficacy with no antimetabolites?
    Acta ophthalmologica, 2021, Volume: 99, Issue:5

    Topics: Antimetabolites; Fluorouracil; Humans; Intraocular Pressure; Mitomycin; Nucleic Acid Synthesis Inhib

2021
Results of fluorouracil-augmented Xen45 implantation in primary open-angle and pseudoexfoliation glaucoma.
    International ophthalmology, 2021, Volume: 41, Issue:3

    Topics: Aged; Fluorouracil; Glaucoma; Glaucoma Drainage Implants; Glaucoma, Open-Angle; Humans; Intraocular

2021
Efficacy and safety of 5-fluorouracil in infrared monitor guided bleb revision.
    BMC ophthalmology, 2021, Feb-08, Volume: 21, Issue:1

    Topics: Fluorouracil; Follow-Up Studies; Humans; Intraocular Pressure; Postoperative Complications; Reoperat

2021
Preparation of 5-fluorouracil loaded chitosan microtube via in situ precipitation for glaucoma drainage device application: in vitro and in vivo investigation.
    Journal of biomaterials science. Polymer edition, 2021, Volume: 32, Issue:14

    Topics: Chitosan; Fluorouracil; Glaucoma; Glaucoma Drainage Implants; Humans; Intraocular Pressure

2021
Use of subconjunctival injections of 5-fluorouracil to rescue and prolong intraocular pressure reduction for a failing Ahmed glaucoma implant.
    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2017, Volume: 255, Issue:6

    Topics: Aged; Conjunctiva; Female; Fluorouracil; Follow-Up Studies; Glaucoma; Glaucoma Drainage Implants; Hu

2017
Three-Year Follow-Up of Trabeculectomy with 5-Fluorouracil.
    Ophthalmic research, 2017, Volume: 58, Issue:2

    Topics: Adult; Aged; Conjunctiva; Female; Fluorouracil; Follow-Up Studies; Germany; Glaucoma; Humans; Immuno

2017
Comparison of the Outcomes of Trabeculectomy with 5-Fluorouracil versus Ologen Implant in Primary Open-Angle Glaucoma.
    Ophthalmic research, 2017, Volume: 58, Issue:2

    Topics: Collagen; Drug Implants; Female; Fluorouracil; Follow-Up Studies; Glaucoma, Open-Angle; Glycosaminog

2017
Practice Preferences for Glaucoma Surgery: A Survey of the American Glaucoma Society.
    Journal of glaucoma, 2017, Volume: 26, Issue:8

    Topics: Alkylating Agents; Cataract; Female; Filtering Surgery; Fluorouracil; Glaucoma Drainage Implants; Gl

2017
Subconjunctival injections of 5-fluorouracil for failing Ahmed glaucoma implants.
    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2017, Volume: 255, Issue:11

    Topics: Conjunctiva; Fluorouracil; Glaucoma; Glaucoma Drainage Implants; Humans; Injections; Intraocular Pre

2017
Use of subconjunctival injections of 5-fluorouracil to rescue and prolong intraocular pressure reduction for a failing Ahmed glaucoma implant.
    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2017, Volume: 255, Issue:11

    Topics: Fluorouracil; Glaucoma; Glaucoma Drainage Implants; Humans; Injections; Intraocular Pressure; Ocular

2017
Retrospective observation on trabeculectomy of primary congenital glaucoma by applying biological amniotic membranes soaked with 5-fluorouracil.
    International ophthalmology, 2018, Volume: 38, Issue:5

    Topics: Adolescent; Amnion; Antimetabolites, Antineoplastic; Biological Dressings; Child; Child, Preschool;

2018
Bilateral Scheie's procedure with Ophthalmic Viscoelastic Device and 5-Fluorouracil.
    International ophthalmology, 2019, Volume: 39, Issue:1

    Topics: Female; Fluorouracil; Glaucoma; Glaucoma Drainage Implants; Humans; Immunosuppressive Agents; Inject

2019
Initial trabeculectomy with 5-fluorouracil with or without subconjunctival bevacizumab in the management of pseudoexfoliation glaucoma.
    International ophthalmology, 2019, Volume: 39, Issue:6

    Topics: Aged; Angiogenesis Inhibitors; Antihypertensive Agents; Bevacizumab; Exfoliation Syndrome; Female; F

2019
Needling With 5-Fluorouracil (5-FU) After XEN Gel Stent Implantation: 6-Month Outcomes.
    Journal of glaucoma, 2018, Volume: 27, Issue:10

    Topics: Aged; Aged, 80 and over; Exfoliation Syndrome; Female; Fluorouracil; Gels; Glaucoma; Glaucoma Draina

2018
Needle revision outcomes after glaucoma filtering surgery: survival analysis and predictive factors.
    European journal of ophthalmology, 2020, Volume: 30, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Antimetabolites; Combined Modality Therapy; Female; Fluorouracil; Gl

2020
Effect of 2 Novel Sustained-release Drug Release Systems on Bleb Fibrosis: An In Vivo Trabeculectomy Study in a Rabbit Model.
    Journal of glaucoma, 2019, Volume: 28, Issue:6

    Topics: Absorbable Implants; Animals; Drug Delivery Systems; Drug Implants; Drug Liberation; Endophthalmitis

2019
Comparison of Efficacy and Safety of Bleb Needle Revision With and Without 5-Fluorouracil for Failing Trabeculectomy Bleb.
    Journal of glaucoma, 2019, Volume: 28, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Antimetabolites; Conjunctiva; Female; Fluorouracil; Glaucoma; Humans

2019
Outcomes of Combined Ahmed Glaucoma Valve and Trabeculectomy Revision With Adjunctive Antimetabolite.
    Journal of glaucoma, 2019, Volume: 28, Issue:5

    Topics: Aged; Aged, 80 and over; Antimetabolites; Case-Control Studies; Chemotherapy, Adjuvant; Combined Mod

2019
5-Fluorouracil augmented needle revision of trabeculectomy: does the location of outflow resistance make a difference?
    Journal of glaucoma, 2013, Volume: 22, Issue:6

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Child; Conjunctiva; Fem

2013
Impact of application of bio-amniotic membrane immersed in 5-fluorouracil solution in trabeculectomy on rabbit retina.
    Indian journal of ophthalmology, 2013, Volume: 61, Issue:12

    Topics: Amnion; Animals; Chromatography, High Pressure Liquid; Female; Fluorouracil; Glaucoma; Immunosuppres

2013
[Long-term results after trabeculectomy with 5-fluorouracil].
    Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft, 2014, Volume: 111, Issue:8

    Topics: Aged; Combined Modality Therapy; Female; Fluorouracil; Glaucoma; Humans; Immunosuppressive Agents; I

2014
Nd:YAG laser goniopuncture for late bleb failure after trabeculectomy with adjunctive mitomycin C.
    JAMA ophthalmology, 2014, Volume: 132, Issue:3

    Topics: Aged; Alkylating Agents; Female; Fluorouracil; Glaucoma; Gonioscopy; Humans; Intraocular Pressure; L

2014
Iridocorneal endothelial syndrome.
    Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, 2014, Volume: 24 Suppl 2

    Topics: Adult; Fluorouracil; Glaucoma; Glaucoma, Angle-Closure; Gonioscopy; Humans; Intraocular Pressure; Ir

2014
Ex-PRESS outcomes using mitomycin-C, Ologen alone, Ologen with 5-fluorouracil.
    International ophthalmology, 2015, Volume: 35, Issue:3

    Topics: Aged; Alkylating Agents; Anthracenes; Antihypertensive Agents; Collagen; Combined Modality Therapy;

2015
Outcomes: Trabeculectomy Bleb Needle Revision With 5-Fluorouracil.
    Journal of glaucoma, 2016, Volume: 25, Issue:3

    Topics: Aged; Antihypertensive Agents; Antimetabolites; Combined Modality Therapy; Female; Fluorouracil; Fol

2016
Application of 5-Fluorouracil-Polycaprolactone Sustained-Release Film in Ahmed Glaucoma Valve Implantation Inhibits Postoperative Bleb Scarring in Rabbit Eyes.
    PloS one, 2015, Volume: 10, Issue:11

    Topics: Animals; Anterior Eye Segment; Cicatrix; Delayed-Action Preparations; Fluorouracil; Glaucoma; Glauco

2015
Needle Revision With 5-fluorouracil for the Treatment of Ahmed Glaucoma Valve Filtering Blebs: 5-Fluoruracil Needling Revision can be a Useful and Safe Tool in the Management of Failing Ahmed Glaucoma Valve Filtering Blebs.
    Journal of glaucoma, 2016, Volume: 25, Issue:4

    Topics: Aged; Antimetabolites; Combined Modality Therapy; Female; Filtering Surgery; Fluorouracil; Follow-Up

2016
Transconjunctival Revision With Mitomycin-C Following Failed Trabeculectomy.
    Journal of glaucoma, 2016, Volume: 25, Issue:7

    Topics: Aged; Aged, 80 and over; Alkylating Agents; Combined Modality Therapy; Conjunctiva; Female; Fluorour

2016
Effect of mitomycin c and 5-flurouracil adjuvant therapy on the outcomes of Ahmed glaucoma valve implantation.
    Clinical & experimental ophthalmology, 2017, Volume: 45, Issue:2

    Topics: Administration, Topical; Aged; Antibiotics, Antineoplastic; Dose-Response Relationship, Drug; Drug T

2017
Results From a Modified Bleb Needling Procedure With Continuous Infusion Performed in the Operating Room.
    Journal of glaucoma, 2016, Volume: 25, Issue:9

    Topics: Aged; Conjunctiva; Female; Fluorouracil; Glaucoma, Open-Angle; Humans; Injections; Intraocular Press

2016
Aqueous shunts in glaucoma: a report by the American Academy of Ophthalmology.
    Ophthalmology, 2008, Volume: 115, Issue:6

    Topics: Academies and Institutes; Alkylating Agents; Anti-Inflammatory Agents, Non-Steroidal; Aqueous Humor;

2008
Ahmed valve implantation with adjunctive mitomycin C and 5-fluorouracil: long-term outcomes.
    American journal of ophthalmology, 2008, Volume: 146, Issue:2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alkylating Agents; Cataract Extraction; Combined Modalit

2008
Controlled delivery of 5-chlorouracil using poly(ortho esters) in filtering surgery for glaucoma.
    Investigative ophthalmology & visual science, 2008, Volume: 49, Issue:7

    Topics: Animals; Antimitotic Agents; Apoptosis; Blister; Cell Death; Cell Proliferation; Cell Survival; Cell

2008
Trabeculectomy with an active postoperative regimen: results and resource utilization.
    Acta ophthalmologica, 2009, Volume: 87, Issue:5

    Topics: Aged; Conjunctiva; Female; Fluorouracil; Glaucoma; Glaucoma, Open-Angle; Humans; Injections; Intraoc

2009
Subconjunctival sustained release 5-fluorouracil for glaucoma filtration surgery.
    Acta pharmacologica Sinica, 2008, Volume: 29, Issue:9

    Topics: Animals; Antimetabolites; Aqueous Humor; Chromatography, High Pressure Liquid; Conjunctiva; Delayed-

2008
Comparison of 90-s versus 5-min intraoperative 5-fluorouracil in trabeculectomy.
    International ophthalmology, 2010, Volume: 30, Issue:1

    Topics: Aged; Antihypertensive Agents; Antimetabolites; Blister; Cicatrix; Female; Fluorouracil; Follow-Up S

2010
Postoperative use of bevacizumab as an antifibrotic agent in glaucoma filtration surgery in the rabbit.
    Investigative ophthalmology & visual science, 2009, Volume: 50, Issue:7

    Topics: Angiogenesis Inhibitors; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antimet

2009
Restricted post-trabeculectomy bleb formation by conjunctival scarring.
    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2009, Volume: 247, Issue:8

    Topics: Antimetabolites; Blister; Cicatrix; Combined Modality Therapy; Conjunctiva; Conjunctival Diseases; C

2009
Long-term outcomes of needle revision of trabeculectomy blebs with mitomycin C and 5-fluorouracil: a comparative safety and efficacy report.
    Journal of glaucoma, 2009, Volume: 18, Issue:7

    Topics: Aged; Alkylating Agents; Antihypertensive Agents; Combined Modality Therapy; Female; Fluorouracil; F

2009
Bilateral ocular hypertension with rapidly progressive optic neuropathy in a teen.
    Optometry and vision science : official publication of the American Academy of Optometry, 2009, Volume: 86, Issue:9

    Topics: Adolescent; Antimetabolites; Disease Progression; Female; Fluorouracil; Fundus Oculi; Glaucoma, Open

2009
The prognostic value of the wuerzburg bleb classification score for the outcome of trabeculectomy.
    Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde, 2011, Volume: 225, Issue:1

    Topics: Antimetabolites; Blister; Combined Modality Therapy; Conjunctiva; Female; Fluorouracil; Follow-Up St

2011
Combined trabeculotomy-trabeculectomy augmented with 5-fluorouracil in paediatric glaucoma.
    Clinical & experimental ophthalmology, 2011, Volume: 39, Issue:3

    Topics: Alkylating Agents; Child; Child, Preschool; Combined Modality Therapy; Female; Fluorouracil; Humans;

2011
Ophthalmic drug-loaded N,O-carboxymethyl chitosan hydrogels: synthesis, in vitro and in vivo evaluation.
    Acta pharmacologica Sinica, 2010, Volume: 31, Issue:12

    Topics: Administration, Topical; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Bevaciz

2010
[Corneal epitheliopathy following trabeculectomy with postoperative adjunctive 5-fluorouracil].
    Klinische Monatsblatter fur Augenheilkunde, 2010, Volume: 227, Issue:11

    Topics: Aged; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Combined Modality Therapy; Corne

2010
Postoperative complications after glaucoma surgery for primary angle-closure glaucoma vs primary open-angle glaucoma.
    Archives of ophthalmology (Chicago, Ill. : 1960), 2011, Volume: 129, Issue:8

    Topics: Aged; Female; Fluorouracil; Glaucoma, Angle-Closure; Glaucoma, Open-Angle; Gonioscopy; Humans; Incid

2011
Paediatric glaucoma: baby-steps to improved control.
    Clinical & experimental ophthalmology, 2011, Volume: 39, Issue:3

    Topics: Adolescent; Antimetabolites; Child; Child, Preschool; Combined Modality Therapy; Fluorouracil; Human

2011
Bleb needling with subconjunctival injection of sodium hyaluronate 1.4%: 1-year outcomes.
    Canadian journal of ophthalmology. Journal canadien d'ophtalmologie, 2011, Volume: 46, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Alkylating Agents; Conjunctiva; Drug Therapy, Combination; Female; F

2011
Snailtrack corneal changes following subconjunctival injection of 5-fluorouracil.
    Eye (London, England), 2012, Volume: 26, Issue:11

    Topics: Antimetabolites; Conjunctiva; Corneal Diseases; Endothelium, Corneal; Fluorouracil; Glaucoma; Humans

2012
Enhanced trabeculectomy in a UK district general hospital setting: is selective use of 5-fluorouracil all that is required?
    International ophthalmology, 2013, Volume: 33, Issue:4

    Topics: Aged; Aged, 80 and over; Antimetabolites; Female; Fluorouracil; Follow-Up Studies; Glaucoma; Hospita

2013
Trabeculectomy with antiproliferative agents in uveitic glaucoma.
    Journal of glaucoma, 2002, Volume: 11, Issue:3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antibiotics, Antineoplastic; Antimetabolites, Antineopla

2002
Long-term follow-up of initially successful trabeculectomy with 5-fluorouracil injections.
    Ophthalmology, 2002, Volume: 109, Issue:10

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antimetabolites; Child; Child, Preschool; Conjunctiva; F

2002
The role of needle revision and 5-fluorouracil application over the filtration site in the management of bleb failure after trabeculectomy: a prospective study.
    Documenta ophthalmologica. Advances in ophthalmology, 2003, Volume: 106, Issue:2

    Topics: Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Combined Modality Therapy; Female; Fluorou

2003
[Assessment of nonpenetrating deep sclerectomy with reticulated hyaluronic acid implant SKGEL and/or preoperative application of 5-luorouracil: results of 2 and a half years].
    Bulletin de la Societe belge d'ophtalmologie, 2003, Issue:287

    Topics: Adult; Aged; Female; Fluorouracil; Follow-Up Studies; Glaucoma, Open-Angle; Humans; Hyaluronic Acid;

2003
Postoperative 5-fluorouracil versus intraoperative mitomycin C in high-risk glaucoma filtering surgery: extended follow up.
    Clinical & experimental ophthalmology, 2003, Volume: 31, Issue:3

    Topics: Adult; Aged; Female; Filtering Surgery; Fluorouracil; Glaucoma; Humans; Intraocular Pressure; Intrao

2003
Optical coherence tomography assessment of retinal nerve fiber layer thickness changes after glaucoma surgery.
    Ophthalmology, 2003, Volume: 110, Issue:8

    Topics: Chemotherapy, Adjuvant; Female; Fluorouracil; Glaucoma, Open-Angle; Humans; Interferometry; Intraocu

2003
Intraoperative 5-fluorouracil application during primary trabeculectomy in Nigeria: a comparative study.
    Eye (London, England), 2003, Volume: 17, Issue:7

    Topics: Aged; Antimetabolites; Developing Countries; Female; Fluorouracil; Follow-Up Studies; Glaucoma; Huma

2003
Needling revision of failed filtering blebs after trabeculectomy: a retrospective study.
    Acta ophthalmologica Scandinavica, 2003, Volume: 81, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Child, Preschool; Conjunctiva; Female; Fluorouracil; Follow-Up Studi

2003
Intensified postoperative care versus conventional follow-up: a retrospective long-term analysis of 177 trabeculectomies.
    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2004, Volume: 242, Issue:2

    Topics: Aged; Female; Fluorouracil; Follow-Up Studies; Glaucoma; Humans; Intraocular Pressure; Male; Middle

2004
Outcome of consecutive trabeculectomy.
    Clinical & experimental ophthalmology, 2004, Volume: 32, Issue:1

    Topics: Adolescent; Adult; Aged; Antimetabolites; Female; Fluorouracil; Glaucoma, Open-Angle; Humans; Intrao

2004
Needle revision of failing and failed trabeculectomy blebs with adjunctive 5-fluorouracil: survival analysis.
    Ophthalmology, 2004, Volume: 111, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Blister; Chemotherapy, Adjuvant; Conjunctiva; Female; Fibrosis; Fluo

2004
Effect of temporal corneal phacoemulsification on intraocular pressure in eyes with prior trabeculectomy with an antimetabolite.
    Ophthalmology, 2004, Volume: 111, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Antimetabolites; Case-Control Studies; Cornea; Female; Fluorouracil;

2004
Viscocanalostomy versus trabeculectomy.
    Ophthalmology, 2004, Volume: 111, Issue:5

    Topics: Anterior Eye Segment; Antimetabolites, Antineoplastic; Conjunctiva; Fluorouracil; Glaucoma, Open-Ang

2004
Operative revision of non-functioning filtering blebs with 5-fluorouracil to regain intraocular pressure control.
    Clinical & experimental ophthalmology, 2004, Volume: 32, Issue:4

    Topics: Adult; Aged; Antimetabolites; Conjunctiva; Female; Filtering Surgery; Fluorouracil; Glaucoma, Open-A

2004
Needle revision of failed filtering blebs using 5-Fluorouracil and a combined ab-externo and ab-interno approach.
    Journal of glaucoma, 2005, Volume: 14, Issue:1

    Topics: Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Combined Modality Therapy; Conjunctiva; Fe

2005
Augmented trabeculectomy in paediatric glaucoma.
    The British journal of ophthalmology, 2005, Volume: 89, Issue:2

    Topics: Antimetabolites; Child; Child, Preschool; Combined Modality Therapy; Female; Fluorouracil; Glaucoma;

2005
Use of surodex in phacotrabeculectomy surgery.
    American journal of ophthalmology, 2005, Volume: 139, Issue:5

    Topics: Anterior Eye Segment; Dexamethasone; Drug Delivery Systems; Fluorouracil; Follow-Up Studies; Glaucom

2005
Ahmed valve drainage implant surgery in the management of paediatric aphakic glaucoma.
    The British journal of ophthalmology, 2005, Volume: 89, Issue:7

    Topics: Adolescent; Antihypertensive Agents; Aphakia, Postcataract; Child; Child, Preschool; Female; Fluorou

2005
Do injections of 5-fluorouracil after trabeculectomy have toxic effects on the anterior segment?
    Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2005, Volume: 21, Issue:3

    Topics: Animals; Anterior Eye Segment; Antimetabolites; Aqueous Humor; Female; Fluorouracil; Injections, Int

2005
Loss of vision after phacotrabeculectomy.
    Journal of glaucoma, 2005, Volume: 14, Issue:4

    Topics: Antimetabolites; Blindness; Chemotherapy, Adjuvant; Conjunctival Diseases; Cysts; Diabetes Complicat

2005
Short term experience with "modern" trabeculectomy augmented with intraoperative antimetabolites.
    Bulletin de la Societe belge d'ophtalmologie, 2005, Issue:296

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antimetabolites; Fluorouracil; Follow-Up Studies; Glauco

2005
Filtering blebs imaging by optical coherence tomography.
    Clinical & experimental ophthalmology, 2005, Volume: 33, Issue:5

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antimetabolites; Blister; Child; Combined Modality Thera

2005
Audit of trabeculectomy at a tertiary referral hospital in East Africa.
    Journal of glaucoma, 2005, Volume: 14, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Antimetabolites; Female; Fluorouracil; Glau

2005
Is intraocular pressure in the early postoperative period predictive of antimetabolite-augmented filtration surgery success?
    Journal of glaucoma, 2005, Volume: 14, Issue:6

    Topics: Aged; Antimetabolites; Combined Modality Therapy; Female; Fluorouracil; Glaucoma; Humans; Intraocula

2005
Failed trabeculectomy.
    Journal of glaucoma, 2005, Volume: 14, Issue:6

    Topics: Antimetabolites; Conjunctiva; Fistula; Fluorouracil; Glaucoma Drainage Implants; Glaucoma, Open-Angl

2005
[Visual acuty after trabeculectomy].
    Vojnosanitetski pregled, 2005, Volume: 62, Issue:11

    Topics: Antimetabolites; Female; Fluorouracil; Glaucoma; Humans; Intraocular Pressure; Male; Middle Aged; Tr

2005
[Clinical observation of needle revision and 5-fluorouracil subconjunctival injection on the dysfunctional filtering blebs].
    [Zhonghua yan ke za zhi] Chinese journal of ophthalmology, 2005, Volume: 41, Issue:12

    Topics: Adult; Aged; Combined Modality Therapy; Conjunctiva; Female; Fluorouracil; Follow-Up Studies; Glauco

2005
Mitomycin C augmented glaucoma surgery: evolution of filtering bleb avascularity, transconjunctival oozing, and leaks.
    The British journal of ophthalmology, 2006, Volume: 90, Issue:2

    Topics: Aged; Blister; Conjunctiva; Conjunctival Diseases; Female; Fluorouracil; Glaucoma; Humans; Intraocul

2006
Phacoemulsification in patients with previous trabeculectomy: role of 5-fluorouracil.
    Eye (London, England), 2007, Volume: 21, Issue:6

    Topics: Aged; Aged, 80 and over; Antihypertensive Agents; Antimetabolites; Drug Administration Schedule; Dru

2007
Review of consecutive phacotrabeculectomies supplemented with early needle revision and antimetabolites.
    Canadian journal of ophthalmology. Journal canadien d'ophtalmologie, 2006, Volume: 41, Issue:4

    Topics: Aged; Aged, 80 and over; Antimetabolites; Cataract; Female; Fluorouracil; Glaucoma; Humans; Intraocu

2006
[Needle revision of late failing filtering blebs after glaucoma surgery].
    Archivos de la Sociedad Espanola de Oftalmologia, 2006, Volume: 81, Issue:9

    Topics: Aged; Aged, 80 and over; Female; Filtering Surgery; Fluorouracil; Glaucoma; Humans; Immunosuppressiv

2006
Dose, timing and frequency of subconjunctival 5-fluorouracil injections after glaucoma filtering surgery.
    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2007, Volume: 245, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Conjunctiva; Female; Fluorouracil; Glaucoma; Humans; Immunosuppressi

2007
Immediate postoperative intraocular pressure measurements after trabeculectomy with releasable sutures.
    Clinical & experimental ophthalmology, 2006, Volume: 34, Issue:8

    Topics: Adult; Aged; Aged, 80 and over; Combined Modality Therapy; False Negative Reactions; Female; Fluorou

2006
Intraocular pressure outcome in primary 5FU phacotrabeculectomies compared with 5FU trabeculectomies.
    Journal of glaucoma, 2006, Volume: 15, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Cataract; Combined Modality Therapy

2006
Frequency of bleb manipulations after trabeculectomy surgery.
    The British journal of ophthalmology, 2007, Volume: 91, Issue:7

    Topics: Adult; Aged; Aged, 80 and over; Antimetabolites; Blister; Female; Fluorouracil; Follow-Up Studies; H

2007
Phacotrabeculectomy study.
    Journal of cataract and refractive surgery, 2007, Volume: 33, Issue:2

    Topics: Alkylating Agents; Antihypertensive Agents; Cataract; Fluorouracil; Glaucoma; Humans; Intraocular Pr

2007
[Late needling with 5-fluorouracil when scarring of filtering bleb seems imminent].
    Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft, 2007, Volume: 104, Issue:4

    Topics: Blister; Cicatrix; Cicatrix, Hypertrophic; Drug Administration Schedule; Filtering Surgery; Fluorour

2007
Post-operative complication of trabeculectomy in Ibadan, Nigeria: outcome of 1-year follow-up.
    Eye (London, England), 2009, Volume: 23, Issue:2

    Topics: Adult; Aged; Anterior Chamber; Antimetabolites; Blister; Epidemiologic Methods; Female; Fluorouracil

2009
Needling revision of trabeculectomies bleb morphology and long-term survival.
    Ophthalmology, 2008, Volume: 115, Issue:7

    Topics: Adult; Aged; Aged, 80 and over; Antimetabolites; Conjunctiva; Female; Fluorouracil; Glaucoma; Humans

2008
5-fluorouracil and glaucoma filtering surgery. II. A pilot study.
    Ophthalmology, 1984, Volume: 91, Issue:4

    Topics: Adolescent; Adult; Aged; Cataract Extraction; Child; Cicatrix; Combined Modality Therapy; Dose-Respo

1984
5-fluorouracil and glaucoma filtering surgery: I. An animal model.
    Ophthalmology, 1984, Volume: 91, Issue:4

    Topics: Animals; Aotus trivirgatus; Cicatrix; Combined Modality Therapy; Fibroblasts; Fluorouracil; Glaucoma

1984
Intraocular pressure control following microtrabeculectomy.
    Eye (London, England), 1995, Volume: 9 ( Pt 3)

    Topics: Adult; Aged; Aged, 80 and over; Female; Fluorouracil; Glaucoma, Open-Angle; Humans; Intraocular Pres

1995
[Experiences with sclerostomy with the Holmium laser].
    Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft, 1994, Volume: 91, Issue:5

    Topics: Aged; Aged, 80 and over; Combined Modality Therapy; Female; Fluorouracil; Follow-Up Studies; Glaucom

1994
Removable sutures in glaucoma surgery.
    Australian and New Zealand journal of ophthalmology, 1994, Volume: 22, Issue:3

    Topics: Fluorouracil; Glaucoma; Humans; Intraocular Pressure; Mitomycin; Suture Techniques; Time Factors; Tr

1994
One-year follow-up results of combined mitomycin C trabeculectomy and extracapsular cataract extraction.
    Ophthalmology, 1995, Volume: 102, Issue:1

    Topics: Adult; Aged; Astigmatism; Cataract; Cataract Extraction; Female; Fluorouracil; Follow-Up Studies; Gl

1995
Profound long-term hypotony without maculopathy after trabeculectomy with antimetabolite.
    Acta ophthalmologica, 1994, Volume: 72, Issue:3

    Topics: Aged; Female; Fluorescein Angiography; Fluorouracil; Fundus Oculi; Glaucoma, Open-Angle; Humans; Int

1994
Incidence of complications following 5-fluorouracil with trabeculectomies.
    Indian journal of ophthalmology, 1993, Volume: 41, Issue:4

    Topics: Combined Modality Therapy; Corneal Diseases; Fluorouracil; Follow-Up Studies; Glaucoma; Humans; Inci

1993
[Hydrodynamics of the rabbit eye after general administration of cytostatics].
    Klinika oczna, 1994, Volume: 96, Issue:1

    Topics: Animals; Biological Transport, Active; Ciliary Body; Fluorouracil; Intraocular Pressure; Methotrexat

1994
Single intraoperative applications of 5-fluorouracil during filtration surgery: early results.
    The British journal of ophthalmology, 1994, Volume: 78, Issue:1

    Topics: Adolescent; Adult; Aged; Child, Preschool; Female; Filtration; Fluorouracil; Glaucoma; Humans; Intra

1994
[5-fluorouracil injection treatment after fistulating glaucoma operations].
    Klinische Monatsblatter fur Augenheilkunde, 1993, Volume: 203, Issue:5

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Combined Modality Therapy; Female; Fluorouracil;

1993
[5-fluorouracil in goniotrepanation with poor prognosis. Results of 1-year follow-up].
    Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft, 1993, Volume: 90, Issue:6

    Topics: Adult; Aged; Combined Modality Therapy; Female; Fluorouracil; Follow-Up Studies; Glaucoma; Humans; I

1993
Intra-operative use of 5-fluorouracil in glaucoma filtering surgery.
    Acta ophthalmologica, 1993, Volume: 71, Issue:6

    Topics: Adult; Aged; Combined Modality Therapy; Fluorouracil; Follow-Up Studies; Glaucoma; Humans; Infant; I

1993
Intraoperative 5-fluorouracil for filtration surgery in the rabbit.
    Investigative ophthalmology & visual science, 1993, Volume: 34, Issue:12

    Topics: Animals; Conjunctiva; Double-Blind Method; Fluorouracil; Glaucoma; Injections; Intraocular Pressure;

1993
Trabeculectomy with 5-fluorouracil vs single-plate Molteno implantation.
    Ophthalmic surgery, 1993, Volume: 24, Issue:10

    Topics: Adult; Aged; Combined Modality Therapy; Female; Fluorouracil; Glaucoma; Humans; Intraocular Pressure

1993
5-FU-supplemented phacoemulsification, posterior chamber intraocular lens implantation, and trabeculectomy.
    Ophthalmic surgery, 1993, Volume: 24, Issue:10

    Topics: Aged; Cataract Extraction; Fluorouracil; Follow-Up Studies; Glaucoma; Humans; Intraocular Pressure;

1993
The role of 5-fluorouracil in complicated glaucomas.
    Indian journal of ophthalmology, 1993, Volume: 41, Issue:2

    Topics: Adult; Aphakia; Female; Fluorouracil; Follow-Up Studies; Glaucoma; Glaucoma, Neovascular; Humans; In

1993
Filtering surgery with 5-fluorouracil subsequent to Molteno implant.
    Israel journal of medical sciences, 1993, Volume: 29, Issue:11

    Topics: Adolescent; Adult; Female; Fluorouracil; Follow-Up Studies; Glaucoma; Humans; Injections; Intraocula

1993
Needling revision of failed filtering blebs with adjunctive 5-fluorouracil.
    Ophthalmic surgery, 1993, Volume: 24, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Chronic Disease; Female; Fluorouracil; Follow-Up Studies; Glaucoma,

1993
Holmium laser sclerectomy. Success and complications.
    Ophthalmology, 1993, Volume: 100, Issue:7

    Topics: Aged; Choroid Hemorrhage; Chronic Disease; Fluorouracil; Follow-Up Studies; Glaucoma; Humans; Intrao

1993
Sturge-Weber syndrome: management of glaucoma with combined trabeculotomy-trabeculectomy.
    Ophthalmic surgery, 1993, Volume: 24, Issue:6

    Topics: Child; Child, Preschool; Female; Fluorouracil; Follow-Up Studies; Glaucoma; Humans; Infant; Infant,

1993
[Combined posterior chamber intraocular lens implantation and trabeculectomy--a life-table analysis of postoperative clinical course].
    Nippon Ganka Gakkai zasshi, 1993, Volume: 97, Issue:1

    Topics: Aged; Female; Fluorouracil; Humans; Intraocular Pressure; Lenses, Intraocular; Life Tables; Male; Pr

1993
Anterior chamber reaction after mitomycin and 5-fluorouracil trabeculectomy: a comparative study.
    Ophthalmic surgery, 1993, Volume: 24, Issue:1

    Topics: Anterior Chamber; Aqueous Humor; Biological Transport, Active; Blood; Chemotherapy, Adjuvant; Eye Pr

1993
Subconjunctival THC:YAG ("holmium") laser thermal sclerostomy ab externo. A one-year report.
    Ophthalmology, 1993, Volume: 100, Issue:3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Cohort Studies; Conjunctiva; Female; Fluorouracil

1993
Effects of intraoperative 5-fluorouracil or mitomycin C on glaucoma filtration surgery in the rabbit.
    Ophthalmology, 1993, Volume: 100, Issue:3

    Topics: Animals; Double-Blind Method; Drug Evaluation, Preclinical; Fluorouracil; Glaucoma; Intraocular Pres

1993
Late complications after glaucoma filtering surgery with adjunctive 5-fluorouracil.
    American journal of ophthalmology, 1993, Apr-15, Volume: 115, Issue:4

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Chemotherapy, Adjuvant; Child; Child, Preschool; Eye Dis

1993
Hypotonous maculopathy after trabeculectomy with subconjunctival 5-fluorouracil.
    American journal of ophthalmology, 1993, Apr-15, Volume: 115, Issue:4

    Topics: Adult; Fluorouracil; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Macula Lutea; Male; Ocular

1993
Pump shunt success underscored.
    Ophthalmic surgery, 1993, Volume: 24, Issue:3

    Topics: Fluorouracil; Glaucoma, Neovascular; Humans; Intraocular Pressure; Prostheses and Implants; Treatmen

1993
Surgical management of post-traumatic angle recession glaucoma.
    Ophthalmology, 1993, Volume: 100, Issue:5

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anterior Chamber; Child; Combined Modality Therapy; Drai

1993
Treatment of failing glaucoma filtering cystic blebs with tissue plasminogen activator (tPA).
    Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 1995,Fall, Volume: 11, Issue:3

    Topics: Aged; Aged, 80 and over; Chemotherapy, Adjuvant; Drug Therapy, Combination; Female; Filtering Surger

1995
Trabeculectomy at the inferior limbus.
    Archives of ophthalmology (Chicago, Ill. : 1960), 1996, Volume: 114, Issue:4

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anterior Eye Segment; Chemotherapy, Adjuvant; Child; Chi

1996
Use of oversized bandage soft contact lenses in the management of early hypotony following filtration surgery.
    Ophthalmic surgery and lasers, 1996, Volume: 27, Issue:6

    Topics: Aged; Aged, 80 and over; Antimetabolites; Contact Lenses, Hydrophilic; Female; Fluorouracil; Follow-

1996
Sustained-release subconjunctival 5-fluorouracil.
    Ophthalmic surgery and lasers, 1996, Volume: 27, Issue:9

    Topics: Aged; Antimetabolites; Conjunctiva; Delayed-Action Preparations; Drug Implants; Female; Fluorouracil

1996
Late bleb leakage after trabeculectomy with 5-fluorouracil or mitomycin C.
    Canadian journal of ophthalmology. Journal canadien d'ophtalmologie, 1996, Volume: 31, Issue:6

    Topics: Adult; Aged; Chemotherapy, Adjuvant; Female; Fluorouracil; Glaucoma, Open-Angle; Humans; Intraocular

1996
Low-dose perioperative 5-fluorouracil in trabeculectomy.
    Ophthalmic surgery and lasers, 1996, Volume: 27, Issue:11

    Topics: Antimetabolites; Drug Administration Routes; Female; Fluorouracil; Follow-Up Studies; Glaucoma; Huma

1996
Ultrasonographic findings of the optic disc in congenital glaucoma.
    Ophthalmic surgery and lasers, 1996, Volume: 27, Issue:12

    Topics: Antimetabolites; Corneal Opacity; Cryotherapy; Female; Fluorouracil; Follow-Up Studies; Glaucoma; Hu

1996
[Single dose intraoperative administration of 5-fluorouracil (5-FU) in trabeculectomy. Long-term results of a pilot study].
    Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft, 1996, Volume: 93, Issue:5

    Topics: Aged; Antimetabolites; Cell Division; Exfoliation Syndrome; Female; Fluorouracil; Glaucoma, Open-Ang

1996
[Antiproliferative therapy with 5-fluorouracil in erbium:YAG laser sclerostomy ab externo].
    Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft, 1996, Volume: 93, Issue:5

    Topics: Antimetabolites; Cell Division; Cicatrix; Combined Modality Therapy; Female; Fluorouracil; Glaucoma;

1996
Temporal corneal phacoemulsification combined with superior trabeculectomy. A retrospective case-control study.
    Archives of ophthalmology (Chicago, Ill. : 1960), 1997, Volume: 115, Issue:3

    Topics: Aged; Aged, 80 and over; Antimetabolites; Case-Control Studies; Cornea; Female; Fluorouracil; Glauco

1997
Pseudotumor cerebri appearing with unilateral papilledema after trabeculectomy.
    Archives of ophthalmology (Chicago, Ill. : 1960), 1997, Volume: 115, Issue:3

    Topics: Acetazolamide; Adult; Antimetabolites; Carbonic Anhydrase Inhibitors; Female; Fluorouracil; Fundus O

1997
Results of intraoperative 5-fluorouracil or lower dose mitomycin-C administration on initial trabeculectomy surgery.
    Journal of glaucoma, 1997, Volume: 6, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Antibiotics, Antineoplastic; Antimetabolites; Chemotherapy, Adjuvant

1997
Needling revision of glaucoma drainage device filtering blebs.
    Ophthalmology, 1997, Volume: 104, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Antimetabolites; Chemotherapy, Adjuvant; Drainage; Female; Fluoroura

1997
Risk factors for unsatisfactory intraocular pressure control in combined trabeculectomy and cataract surgery.
    Ophthalmic surgery and lasers, 1997, Volume: 28, Issue:6

    Topics: Aged; Aged, 80 and over; Antimetabolites; Cataract; Cataract Extraction; Female; Fluorouracil; Follo

1997
[Surgical revision of failed filtering bleb with mitomycin C].
    Nippon Ganka Gakkai zasshi, 1997, Volume: 101, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Female; Filtering Surgery; Fluorouracil; Follow-Up Studies; Glaucoma

1997
Small incision trabeculectomy avoiding Tenon's capsule. A new procedure for glaucoma surgery.
    Ophthalmology, 1997, Volume: 104, Issue:8

    Topics: Adult; Aged; Aged, 80 and over; Conjunctiva; Connective Tissue; Fluorouracil; Follow-Up Studies; Gla

1997
5-Fluorouracil in primary combined glaucoma surgery.
    Ophthalmology, 1997, Volume: 104, Issue:10

    Topics: Antimetabolites; Cornea; Fluorouracil; Glaucoma; Humans; Intraocular Pressure; Lenses, Intraocular;

1997
Temporal corneal phacoemulsification in filtered glaucoma patients.
    Transactions of the American Ophthalmological Society, 1997, Volume: 95

    Topics: Aged; Aged, 80 and over; Case-Control Studies; Cornea; Female; Fluorouracil; Follow-Up Studies; Glau

1997
Long-term results and complications after trabeculectomy with a single per-operative application of 5-fluorouracil.
    Eye (London, England), 1997, Volume: 11 ( Pt 5)

    Topics: Adult; Aged; Antimetabolites; Eye Diseases; Female; Fluorouracil; Follow-Up Studies; Glaucoma; Human

1997
Management of coexisting pseudophakic bullous keratopathy and open-angle glaucoma.
    Journal of glaucoma, 1998, Volume: 7, Issue:1

    Topics: Administration, Topical; Aged; Cataract Extraction; Corneal Diseases; Female; Fluorouracil; Follow-U

1998
Modification of trabeculectomy with single-dose intraoperative 5-Fluorouracil application.
    Acta ophthalmologica Scandinavica, 1998, Volume: 76, Issue:1

    Topics: Antimetabolites; Chemotherapy, Adjuvant; Female; Fluorouracil; Follow-Up Studies; Glaucoma; Humans;

1998
Late removal of releasable sutures after trabeculectomy or combined trabeculectomy with cataract extraction supplemented with antifibrotics.
    Journal of glaucoma, 1998, Volume: 7, Issue:2

    Topics: Aged; Cataract Extraction; Female; Fluorouracil; Follow-Up Studies; Glaucoma; Humans; Intraocular Pr

1998
Antimetabolites in glaucoma surgery: our experiences and results.
    Acta ophthalmologica Scandinavica. Supplement, 1997, Issue:224

    Topics: Antimetabolites; Fluorouracil; Follow-Up Studies; Glaucoma; Humans; Intraocular Pressure; Intraopera

1997
The treatment of encapsulated trabeculectomy blebs in an out-patient setting using a needling technique and subconjunctival 5-fluorouracil injection.
    Eye (London, England), 1998, Volume: 12 ( Pt 1)

    Topics: Adult; Aged; Aged, 80 and over; Antimetabolites; Combined Modality Therapy; Cysts; Eye Diseases; Fem

1998
[Peroperative administration of 5-fluorouracil during trabeculectomy in complicated glaucoma in children].
    Ceska a slovenska oftalmologie : casopis Ceske oftalmologicke spolecnosti a Slovenske oftalmologicke spolecnosti, 1998, Volume: 54, Issue:2

    Topics: Adolescent; Antimetabolites; Child; Child, Preschool; Female; Fluorouracil; Glaucoma; Humans; Intrao

1998
Management of large, leaking, and inadvertent filtering blebs with the neodymium:YAG laser.
    Ophthalmology, 1998, Volume: 105, Issue:6

    Topics: Aged; Aqueous Humor; Female; Filtering Surgery; Fluorouracil; Glaucoma; Humans; Intraocular Pressure

1998
Needling revision of glaucoma drainage device filtering blebs.
    Ophthalmology, 1998, Volume: 105, Issue:7

    Topics: Chemotherapy, Adjuvant; Drainage; Filtering Surgery; Fluorouracil; Glaucoma; Humans; Intraocular Pre

1998
Trabeculectomy with intraoperative 5-fluorouracil.
    Ophthalmic surgery and lasers, 1998, Volume: 29, Issue:7

    Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Fluorouracil; Glaucoma; Humans; Int

1998
Trabeculectomy survival with and without intra-operative 5-fluorouracil application in an Asian population.
    Australian and New Zealand journal of ophthalmology, 1998, Volume: 26, Issue:4

    Topics: Administration, Topical; Antimetabolites; Female; Fluorouracil; Follow-Up Studies; Glaucoma; Humans;

1998
Occlusive ligature and standardized fenestration of a Baerveldt tube with and without antimetabolites for early postoperative intraocular pressure control.
    Ophthalmology, 1998, Volume: 105, Issue:12

    Topics: Aged; Antimetabolites; Aqueous Humor; Female; Fluorouracil; Glaucoma; Glaucoma Drainage Implants; Hu

1998
Comparison of deep sclerectomy with collagen implant and trabeculectomy in open-angle glaucoma.
    Journal of cataract and refractive surgery, 1999, Volume: 25, Issue:3

    Topics: Aged; Collagen; Female; Fluorouracil; Follow-Up Studies; Glaucoma Drainage Implants; Glaucoma, Open-

1999
Malignant glaucoma.
    Journal of glaucoma, 1999, Volume: 8, Issue:2

    Topics: Anterior Chamber; Chronic Disease; Female; Fluorouracil; Follow-Up Studies; Glaucoma, Angle-Closure;

1999
Mitomycin C-augumented trabeculectomy with postoperative wound modulation in pediatric glaucoma.
    Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus, 1999, Volume: 3, Issue:2

    Topics: Adolescent; Chemotherapy, Adjuvant; Child; Child, Preschool; Female; Fluorouracil; Follow-Up Studies

1999
Comparison of phacotrabeculectomy with 5-fluorouracil, mitomycin-C, and without antifibrotic agents.
    Ophthalmic surgery and lasers, 1999, Volume: 30, Issue:5

    Topics: Aged; Cataract; Chemotherapy, Adjuvant; Fibrosis; Fluorouracil; Glaucoma; Humans; Intraocular Pressu

1999
[Use of "low dose" 5-fluorouracil during trabeculectomy].
    Bulletin de la Societe belge d'ophtalmologie, 1999, Volume: 272

    Topics: Adult; Aged; Aged, 80 and over; Antimetabolites; Female; Fluorouracil; Follow-Up Studies; Glaucoma;

1999
Combined versus sequential phacotrabeculectomy with intraoperative 5-fluorouracil.
    Journal of cataract and refractive surgery, 2000, Volume: 26, Issue:1

    Topics: Aged; Antimetabolites; Cataract; Conjunctiva; Fluorouracil; Glaucoma, Open-Angle; Humans; Injections

2000
Amniotic membrane transplantation or conjunctival limbal autograft for limbal stem cell deficiency induced by 5-fluorouracil in glaucoma surgeries.
    Cornea, 2000, Volume: 19, Issue:3

    Topics: Aged; Amnion; Cell Transplantation; Conjunctiva; Corneal Diseases; Epithelial Cells; Epithelium, Cor

2000
Glaucoma surgery with or without adjunctive antiproliferatives in normal tension glaucoma: 1 intraocular pressure control and complications.
    The British journal of ophthalmology, 2000, Volume: 84, Issue:6

    Topics: Aged; Antimetabolites; Chemotherapy, Adjuvant; Female; Fluorouracil; Glaucoma, Open-Angle; Humans; I

2000
Long-term follow-up of trabeculectomy with intraoperative 5-fluorouracil for uveitis-related glaucoma.
    Ophthalmology, 2000, Volume: 107, Issue:10

    Topics: Adolescent; Adult; Aged; Antimetabolites; Child; Female; Fluorouracil; Follow-Up Studies; Glaucoma;

2000
After-cataract and secondary glaucoma in the aphakic infant rabbit.
    Journal of cataract and refractive surgery, 2000, Volume: 26, Issue:9

    Topics: Animals; Animals, Newborn; Anterior Chamber; Aphakia, Postcataract; Cataract; Fluorouracil; Glaucoma

2000
Outcomes of combined cataract extraction, lens implantation, and trabeculectomy surgeries.
    American journal of ophthalmology, 2000, Volume: 130, Issue:6

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antimetabolites; Cataract; Cataract Extraction; Female;

2000
Wound modulation after trabeculectomy by different formulations of antimetabolites in rabbits.
    Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2000, Volume: 16, Issue:6

    Topics: Animals; Antimetabolites; Biocompatible Materials; Conjunctiva; Dose-Response Relationship, Drug; Dr

2000
Success criteria and success rates in trabeculectomy with and without intraoperative antimetabolites using intensified postoperative care (IPC).
    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2000, Volume: 238, Issue:11

    Topics: Adult; Aged; Aged, 80 and over; Antimetabolites; Female; Fluorouracil; Glaucoma; Humans; Intraocular

2000
A new poly(ortho ester)-based drug delivery system as an adjunct treatment in filtering surgery.
    Investigative ophthalmology & visual science, 2001, Volume: 42, Issue:3

    Topics: Animals; Anterior Eye Segment; Aqueous Humor; Biocompatible Materials; Chemotherapy, Adjuvant; Drug

2001
[Use of 5-fluorouracil in trabeculectomy].
    Ceska a slovenska oftalmologie : casopis Ceske oftalmologicke spolecnosti a Slovenske oftalmologicke spolecnosti, 2000, Volume: 56, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Female; Fluorouracil; Glaucoma; Humans; Intraocular Pressure; Male;

2000
Should antiproliferatives be used in filtering surgery of normal tension glaucoma?
    The British journal of ophthalmology, 2001, Volume: 85, Issue:6

    Topics: Antineoplastic Agents; Filtering Surgery; Fluorouracil; Glaucoma; Humans; Intraocular Pressure; Mito

2001
Glaucoma surgery with or without adjunctive antiproliferatives in normal tension glaucoma: 2 Visual field progression.
    The British journal of ophthalmology, 2001, Volume: 85, Issue:6

    Topics: Aged; Antimetabolites; Chemotherapy, Adjuvant; Female; Fluorouracil; Glaucoma, Open-Angle; Humans; I

2001
Long-term surgical outcomes of patients with glaucoma secondary to the iridocorneal endothelial syndrome.
    Ophthalmology, 2001, Volume: 108, Issue:10

    Topics: Adult; Antihypertensive Agents; Corneal Diseases; Endothelium, Corneal; Fluorouracil; Follow-Up Stud

2001
Slow release of the antimetabolite 5-fluorouracil (5-FU) from modified Baerveldt glaucoma drains to prolong drain function.
    Biomaterials, 2001, Volume: 22, Issue:24

    Topics: Animals; Antimetabolites; Biocompatible Materials; Collagen; Delayed-Action Preparations; Drug Impla

2001
The efficacy and safety of intraoperative and/or postoperative 5-fluorouracil in trabeculectomy and phacotrabeculectomy.
    Clinical & experimental ophthalmology, 2001, Volume: 29, Issue:5

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antimetabolites; Cataract; Female; Fluorouracil; Glaucom

2001
Risk factors for failure of 5-fluorouracil needling revision for failed conjunctival filtration blebs.
    American journal of ophthalmology, 2001, Volume: 132, Issue:6

    Topics: Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Cataract Extraction; Conjunctiva; Female;

2001
Long-term follow-up of initial 5-fluorouracil trabeculectomy in primary open-angle glaucoma in Japanese patients.
    Journal of glaucoma, 2001, Volume: 10, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Antimetabolites; Conjunctiva; Female; Fluorouracil; Follow-Up Studie

2001
[Influence on tear film of postoperative 5-fluourouracil and intraoperative mitomycin C in glaucoma filtration surgery].
    [Zhonghua yan ke za zhi] Chinese journal of ophthalmology, 2001, Volume: 37, Issue:1

    Topics: Adult; Aged; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Conjunctiva; Dry Eye Synd

2001
Predictors for success of needle revision of failing filtration blebs.
    Ophthalmology, 2002, Volume: 109, Issue:4

    Topics: Aged; Antimetabolites; Conjunctiva; Female; Fluorouracil; Glaucoma; Humans; Intraocular Pressure; Ma

2002
Late-onset transconjunctival oozing and point leak of aqueous humor from filtering bleb after trabeculectomy.
    American journal of ophthalmology, 2002, Volume: 133, Issue:4

    Topics: Antimetabolites; Aqueous Humor; Chemotherapy, Adjuvant; Conjunctiva; Cross-Sectional Studies; Female

2002
[Antimetabolites in glaucoma surgery--long-term results].
    Ceska a slovenska oftalmologie : casopis Ceske oftalmologicke spolecnosti a Slovenske oftalmologicke spolecnosti, 2002, Volume: 58, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Antimetabolites; Fluorouracil; Glaucoma; Humans; Intraocular Pressur

2002
Antimetabolites in the surgical treatment of glaucomas.
    Bulletin de la Societe belge d'ophtalmologie, 1992, Volume: 244

    Topics: Animals; Aotidae; Cell Division; Fibroblasts; Fluorouracil; Glaucoma; Humans; Intraocular Pressure;

1992
Glaucoma filtering surgery with postoperative 5-fluorouracil in patients with intraocular inflammatory disease.
    Ophthalmology, 1992, Volume: 99, Issue:4

    Topics: Adolescent; Adult; Aged; Cataract Extraction; Conjunctiva; Female; Fluorouracil; Follow-Up Studies;

1992
Outcome of White pump shunt surgery for neovascular glaucoma in Asians.
    Ophthalmic surgery, 1992, Volume: 23, Issue:10

    Topics: Adult; Aged; Cell Count; Drainage; Endothelium, Corneal; Female; Fluorouracil; Glaucoma, Neovascular

1992
Treatment of encapsulated blebs with 30-gauge needling and injection of low-dose 5-fluorouracil.
    Canadian journal of ophthalmology. Journal canadien d'ophtalmologie, 1992, Volume: 27, Issue:5

    Topics: Adult; Aged; Conjunctival Diseases; Cysts; Female; Fluorouracil; Glaucoma, Angle-Closure; Glaucoma,

1992
Intraoperative application of 5-fluorouracil during trabeculectomy.
    Ophthalmic surgery, 1992, Volume: 23, Issue:10

    Topics: Adult; Aged; Aged, 80 and over; Cicatrix; Female; Fluorouracil; Follow-Up Studies; Glaucoma; Humans;

1992
Trabeculectomy with 5-fluorouracil subsequent to circular buckling operation and cataract extraction.
    Annals of ophthalmology, 1992, Volume: 24, Issue:10

    Topics: Adult; Aged; Atropine; Cataract Extraction; Female; Fluorouracil; Follow-Up Studies; Glaucoma, Open-

1992
Results of intraoperative 5-fluorouracil supplementation on trabeculectomy for open-angle glaucoma.
    American journal of ophthalmology, 1992, Dec-15, Volume: 114, Issue:6

    Topics: Administration, Topical; Adult; Aged; Female; Fluorouracil; Follow-Up Studies; Glaucoma, Open-Angle;

1992
Combined cataract extraction and filtering surgery.
    The CLAO journal : official publication of the Contact Lens Association of Ophthalmologists, Inc, 1992, Volume: 18, Issue:3

    Topics: Cataract Extraction; Fluorouracil; Glaucoma; Humans; Intraocular Pressure; Laser Therapy; Lenses, In

1992
Postoperative subconjunctival 5-fluorouracil injections and success probability of trabeculectomy in Japanese: results of 5-year follow-up.
    Japanese journal of ophthalmology, 1992, Volume: 36, Issue:2

    Topics: Adult; Conjunctiva; Fluorouracil; Follow-Up Studies; Glaucoma, Open-Angle; Humans; Injections; Intra

1992
Subconjunctival injection of 5-fluorouracil following trabeculectomy for congenital and infantile glaucoma.
    Ophthalmic surgery, 1992, Volume: 23, Issue:3

    Topics: Child; Conjunctiva; Female; Fluorouracil; Follow-Up Studies; Glaucoma; Humans; Injections; Intraocul

1992
Combined no-stitch phacoemulsification cataract extraction with foldable silicone intraocular implant and holmium laser sclerostomy followed by 5-FU injections.
    Ophthalmic surgery, 1992, Volume: 23, Issue:3

    Topics: Aged; Cataract Extraction; Fluorouracil; Glaucoma, Open-Angle; Humans; Injections; Intraocular Press

1992
Design and results of trabeculectomy operation for use with 5-fluorouracil.
    Ophthalmic surgery, 1992, Volume: 23, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Female; Fluorouracil; Glaucoma; Humans; Intraocular Pressure; Male;

1992
5-fluorouracil in trabeculectomy for patients under the age of 40 years.
    Ophthalmic surgery, 1992, Volume: 23, Issue:4

    Topics: Adolescent; Adult; Age Factors; Child; Female; Fluorouracil; Follow-Up Studies; Glaucoma, Open-Angle

1992
Reversible corneal keratinization following trabeculectomy and treatment with 5-fluorouracil.
    Ophthalmic surgery, 1990, Volume: 21, Issue:4

    Topics: Aged; Conjunctiva; Corneal Diseases; Fluorouracil; Glaucoma, Open-Angle; Humans; Intraocular Pressur

1990
Effects of subconjunctival 5-fluorouracil injections on the corneal endothelium and ciliary epithelium.
    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 1990, Volume: 228, Issue:6

    Topics: Animals; Aqueous Humor; Ciliary Body; Conjunctiva; Dextrans; Endothelium, Corneal; Epithelium; Femal

1990
5-FU trabeculectomy.
    Ophthalmology, 1992, Volume: 99, Issue:1

    Topics: Fluorouracil; Glaucoma; Humans; Intraocular Pressure; Trabeculectomy

1992
Initial 5-fluorouracil trabeculectomy in young patients.
    Ophthalmology, 1992, Volume: 99, Issue:1

    Topics: Adolescent; Adult; Combined Modality Therapy; Evaluation Studies as Topic; Female; Fluorouracil; Fol

1992
Regulating the dose of 5-fluorouracil to prevent filtering bleb scarring.
    Annals of ophthalmology, 1991, Volume: 23, Issue:6

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anterior Chamber; Child; Cicatrix; Conjunctiva; Dosage F

1991
Trabeculectomy with 5-fluorouracil.
    Acta ophthalmologica, 1991, Volume: 69, Issue:4

    Topics: Aged; Aged, 80 and over; Combined Modality Therapy; Fluorouracil; Follow-Up Studies; Glaucoma, Angle

1991
[5-Fu as remedy for unsuccessful glaucoma filtration surgery].
    [Zhonghua yan ke za zhi] Chinese journal of ophthalmology, 1991, Volume: 27, Issue:6

    Topics: Adolescent; Adult; Child; Female; Fluorouracil; Glaucoma; Humans; Injections; Intraocular Pressure;

1991
Initial 5-fluorouracil trabeculectomy in uncomplicated glaucoma.
    Ophthalmology, 1991, Volume: 98, Issue:7

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Evaluation Studies as Topic; Female; Fluorouracil; Follo

1991
Late bleb-related endophthalmitis after trabeculectomy with adjunctive 5-fluorouracil.
    Ophthalmology, 1991, Volume: 98, Issue:7

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Child; Child, Preschool; Endophth

1991
Subconjunctival THC:YAG laser thermal sclerostomy.
    Ophthalmology, 1991, Volume: 98, Issue:9

    Topics: Adult; Aged; Aged, 80 and over; Child; Conjunctiva; Female; Fluorouracil; Follow-Up Studies; Glaucom

1991
Reducing corneal toxicity of 5-fluorouracil in the early postoperative period following glaucoma filtering surgery.
    Australian and New Zealand journal of ophthalmology, 1991, Volume: 19, Issue:3

    Topics: Aged; Aged, 80 and over; Aphakia; Corneal Diseases; Female; Fluorouracil; Glaucoma, Open-Angle; Huma

1991
Bandage contact lens augmentation of 5-fluorouracil treatment in glaucoma filtration surgery.
    Ophthalmic surgery, 1991, Volume: 22, Issue:10

    Topics: Aged; Cataract Extraction; Contact Lenses; Female; Fluorouracil; Glaucoma, Open-Angle; Humans; Intra

1991
Remission of anterior uveitis by subconjunctival fluorouracil.
    Archives of ophthalmology (Chicago, Ill. : 1960), 1991, Volume: 109, Issue:1

    Topics: Aged; Conjunctiva; Fluorouracil; Follow-Up Studies; Glaucoma; Humans; Intraocular Pressure; Middle A

1991
5-Fluorouracil after trabeculectomy and the iridocorneal endothelial syndrome.
    Ophthalmology, 1991, Volume: 98, Issue:3

    Topics: Adult; Cataract Extraction; Conjunctiva; Corneal Diseases; Endothelium, Corneal; Fluorouracil; Follo

1991
Restoring the function of the failed bleb.
    Australian and New Zealand journal of ophthalmology, 1991, Volume: 19, Issue:1

    Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Drainage; Female; Fluorouracil; Glaucoma; Humans;

1991
Internal sclerostomy with argon contact laser--animal experiment using 5-fluorouracil.
    Japanese journal of ophthalmology, 1990, Volume: 34, Issue:3

    Topics: Animals; Anterior Chamber; Conjunctiva; Fluorouracil; Intraocular Pressure; Laser Therapy; Macaca mu

1990
Primate trabeculectomies with 5-fluorouracil collagen implants.
    American journal of ophthalmology, 1990, Jun-15, Volume: 109, Issue:6

    Topics: Animals; Anterior Chamber; Biological Dressings; Double-Blind Method; Drug Implants; Fibroblasts; Fl

1990
Trabeculectomy with 5-fluorouracil for adult inflammatory glaucoma.
    American journal of ophthalmology, 1990, Feb-15, Volume: 109, Issue:2

    Topics: Adult; Aged; Female; Fluorometholone; Fluorouracil; Follow-Up Studies; Glaucoma; Humans; Inflammatio

1990
Adjunctive use of delayed and adjustable low-dose 5-fluorouracil in refractory glaucoma.
    American journal of ophthalmology, 1990, Apr-15, Volume: 109, Issue:4

    Topics: Adolescent; Adult; Aged; Conjunctiva; Dose-Response Relationship, Drug; Drug Administration Schedule

1990
Combined cataract implant and filtering surgery with 5-fluorouracil.
    Ophthalmic surgery, 1990, Volume: 21, Issue:3

    Topics: Aged; Cataract Extraction; Contrast Sensitivity; Female; Fluorouracil; Glaucoma, Angle-Closure; Glau

1990
Delivery of antifibroblast agents as adjuncts to filtration surgery--Part II: Delivery of 5-fluorouracil and bleomycin in a collagen implant: pilot study in the rabbit.
    Ophthalmic surgery, 1986, Volume: 17, Issue:12

    Topics: Animals; Bleomycin; Cell Division; Collagen; Drug Implants; Eye; Female; Fibroblasts; Fluorouracil;

1986
Adjusting the dose of 5-fluorouracil after filtration surgery to minimize side effects.
    Ophthalmology, 1987, Volume: 94, Issue:5

    Topics: Adult; Aged; Female; Fluorouracil; Glaucoma; Humans; Inflammation; Intraocular Pressure; Iris; Male;

1987
Low-dose 5-fluorouracil and glaucoma filtration surgery.
    Ophthalmic surgery, 1989, Volume: 20, Issue:5

    Topics: Adolescent; Adult; Aged; Child; Cornea; Epithelial Cells; Fluorouracil; Follow-Up Studies; Glaucoma;

1989
Long-term results of 5-fluorouracil trabeculectomy for primary open-angle glaucoma.
    International ophthalmology, 1989, Volume: 13, Issue:1-2

    Topics: Adult; Aged; Epinephrine; Female; Fluorouracil; Glaucoma, Open-Angle; Humans; Injections; Intraocula

1989
External limbal sclerostomy with contact Nd:YAG laser versus surgical knife.
    International ophthalmology, 1989, Volume: 13, Issue:3

    Topics: Animals; Anterior Chamber; Cell Division; Conjunctiva; Fluorouracil; Glaucoma; Intraocular Pressure;

1989
Glaucoma filtration surgery in rabbits using bioerodible polymers and 5-fluorouracil.
    Ophthalmology, 1987, Volume: 94, Issue:12

    Topics: Animals; Biodegradation, Environmental; Double-Blind Method; Drug Implants; Fluorouracil; Glaucoma;

1987
[Use of 5-fluorouracil in the surgery of glaucoma].
    Journal francais d'ophtalmologie, 1987, Volume: 10, Issue:10

    Topics: Conjunctiva; Female; Fibrosis; Fluorouracil; Follow-Up Studies; Glaucoma; Humans; Intraocular Pressu

1987
5-Fluorouracil for trabeculectomy in glaucoma.
    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 1987, Volume: 225, Issue:6

    Topics: Cicatrix; Female; Fluorouracil; Follow-Up Studies; Glaucoma; Humans; Intraocular Pressure; Male; Pos

1987
Q-switched neodymium-YAG laser trabeculopuncture in monkeys.
    Archives of ophthalmology (Chicago, Ill. : 1960), 1985, Volume: 103, Issue:1

    Topics: Animals; Cicatrix; Fluorouracil; Hyaluronic Acid; Injections; Intraocular Pressure; Laser Therapy; M

1985