fluorouracil has been researched along with Intestinal Neoplasms in 119 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Intestinal Neoplasms: Tumors or cancer of the INTESTINES.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The purpose of this study was to review the efficacy of a protracted venous infusion of 5-fluorouracil (PVI 5-FU)-based chemotherapy in advanced small bowel adenocarcinoma." | 9.08 | The Royal Marsden experience of a small bowel adenocarcinoma treated with protracted venous infusion 5-fluorouracil. ( Crawley, C; Cunningham, D; Hill, A; Norman, A; Ross, P, 1998) |
| "The results of combination chemotherapy with intermittent courses of 5-fluorouracil and streptozotocin in ten patients with metastatic carcinoid tumors and in eight patients with islet cell carcinoma are reported." | 7.66 | Combination chemotherapy for islet cell carcinoma and metastatic carcinoid tumors with 5-fluorouracil and streptozotocin. ( Bukowski, RM; Chernicoff, D; Groppe, CW; Hewlett, JS, 1979) |
| "Although hyperammonemia is a known side effect of 5-FU that can cause serious pathological conditions, only a few cases have been reported." | 5.42 | [Four cases of 5-fluorouracil-related hyperammonemia in patients with large intestinal cancer and multiple liver metastases, including a case of hyperammonemia treated using hemodialysis]. ( Iida, T; Isshiki, H; Kaneto, H; Murakami, K; Naganawa, Y; Sasaki, H; Satoh, S; Shimizu, H; Tani, M; Wagatsuma, K, 2015) |
| "5-Fluorouracil (5-FU) has been the foundation of advanced colorectal cancer treatment for over 40 years." | 5.31 | Response to 5-fluorouracil chemotherapy is modified by dietary folic acid deficiency in Apc(Min/+) mice. ( Berger, FG; Bunni, MA; Davis, C; Kitchens, ME; Priest, DG; Spencer, HT; Tucker, JM, 2002) |
| "Due to regular DNA histograms in the carcinoid tumors, it is suggested that reliable studies are permitted of the effect of cytotoxins on the different phases of the cell cycle in vivo." | 5.27 | Nuclear DNA in intestinal carcinoid tumors. A study before and after cytotoxin (streptozotocin and 5-fluorouracil) treatment. ( Bengtsson, A; Lindgren, PG; Lundqvist, M; Norheim, I; Oberg, K; Wilander, E, 1985) |
| "The purpose of this study was to review the efficacy of a protracted venous infusion of 5-fluorouracil (PVI 5-FU)-based chemotherapy in advanced small bowel adenocarcinoma." | 5.08 | The Royal Marsden experience of a small bowel adenocarcinoma treated with protracted venous infusion 5-fluorouracil. ( Crawley, C; Cunningham, D; Hill, A; Norman, A; Ross, P, 1998) |
| "In a prospective, multi-centre, randomized study of 109 patients with metastatic gastro-intestinal adenocarcinomas the response rate, survival time and side-effects of two drug combinations, carmustin +5-fluorouracil and carmustin + ftorafur, were compared (same carmustin dosage in both groups)." | 5.04 | [A prospective multi-centre study of the response of metastatic gastrointestinal tumours (author's transl)]. ( Arnold, H; Drings, P; Geldmacher, J; Hartwich, G; Kredel, L; Mayer, M; Neidhardt, B; Queisser, W; Rösch, W; Schaefer, J; von Oldershausen, HF; Wahrendorf, J, 1979) |
| "FOLFOX (5-Fluorouracile and oxaliplatin) exhibits promising activity in advanced well-differentiated neuroendocrine tumors (NETs)." | 4.02 | Efficacy of FOLFOX Chemotherapy in Metastatic Enteropancreatic Neuroendocrine Tumors. ( Cavaglione, G; Charrier, N; Mineur, L; Niccoli, P; Oziel-Taieb, S; Piana, G; Poizat, F; Raoul, JL; Zemmour, C, 2021) |
| "Capesitabine is a orally administered cytotoxic drug metabolized to 5-fluorouracil and is widely used in large intestine cancer and breast cancer therapy." | 3.75 | [Coronary artery disease attack caused by cytotoxic chemotherapy]. ( Eskola, M; Ilveskoski, E; Nikus, K; Tanner, M, 2009) |
| "To assess the efficacy of 5-fluorouracil (5-FU) and either platinum compounds or irinotecan in patients with advanced small bowel adenocarcinoma (SBA), for whom data on the efficacy of chemotherapy are scarce." | 3.73 | Combination chemotherapy in advanced small bowel adenocarcinoma. ( Boige, V; Ducreux, M; Elias, D; Lasser, P; Lebray, P; Locher, C; Malka, D, 2005) |
| " Programs including streptozotocin and 5-fluorouracil or doxorubicin are generally regarded as first line treatment for pancreatic endocrine tumors with liver metastases, whereas midgut carcinoid tumors often are resistant to systemic chemotherapy." | 3.71 | Nonsurgical treatment of advanced malignant neuroendocrine pancreatic tumors and midgut carcinoids. ( Skogseid, B, 2001) |
| "To determine the effect of combined treatment with 7-ethyl-10-hydroxycamptothecin (SN-38, the active metabolite of irinotecan) and 5-fluorouracil/ folinic acid (5FU/FA) in vitro using HCT-8 human intestinal adenocarcinoma cells." | 3.70 | Effect of adding the topoisomerase I poison 7-ethyl-10-hydroxycamptothecin (SN-38) to 5-fluorouracil and folinic acid in HCT-8 cells: elevated dTTP pools and enhanced cytotoxicity. ( Erlichman, C; Kaufmann, SH; Mullany, S; Svingen, PA, 1998) |
| "A case of poorly differentiated adenocarcinoma of the small bowel with extensive lymph node metastases is herein presented, which responded to methotrexate/5-fluorouracil (MTX/5-FU) sequential therapy." | 3.69 | Small intestinal cancer with extensive lymph node metastases showing complete remission by methotrexate/5-fluorouracil sequential therapy: report of a case. ( Imamura, M; Maetani, S; Nishitai, R; Onodera, H; Shimizu, K, 1997) |
| "The results of combination chemotherapy with intermittent courses of 5-fluorouracil and streptozotocin in ten patients with metastatic carcinoid tumors and in eight patients with islet cell carcinoma are reported." | 3.66 | Combination chemotherapy for islet cell carcinoma and metastatic carcinoid tumors with 5-fluorouracil and streptozotocin. ( Bukowski, RM; Chernicoff, D; Groppe, CW; Hewlett, JS, 1979) |
| "PRODIGE 41-BEVANEC is an academic randomized, phase II study designed to evaluate the efficacy of bevacizumab in combination with FOLFIRI after failure of CT1 in unknown primary NEC and GEP-NEC." | 2.87 | Evaluating bevacizumab in combination with FOLFIRI after the failure of platinum-etoposide regimen in patients with advanced poorly differentiated neuroendocrine carcinoma: The PRODIGE 41-BEVANEC randomized phase II study. ( Assenat, E; Bouarioua, N; Cadiot, G; Coriat, R; Dahan, L; Dubreuil, O; Elhajbi, F; Ferru, A; Gangloff, A; Granger, V; Hautefeuille, V; Hentic, O; Kurtz, JE; Le Malicot, K; Lepage, C; Lepere, C; Lievre, A; Lombard-Bohas, C; Malka, D; Roquin, G; Scoazec, JY; Smith, D; Walter, T, 2018) |
| "Fluorouracil has been used for a long time, remission rates reported range from 0% to 80%." | 2.36 | [Chemotherapy of gastrointestinal tumors (review of the literature)]. ( Mayr, AC, 1978) |
| "A 56-year-old woman was diagnosed with rectal cancer and liver metastases(Stage IV), and underwent low anterior resection and laparoscopic partial hepatectomy." | 1.48 | [Primary Small Bowel Tumor with Simultaneous Lung Metastases from Rectal Cancer - A Case Report]. ( Hayashi, H; Hyodo, M; Inoue, Y; Lefor, AK; Okada, M; Ota, G; Sato, H; Shinohara, S; Tsukahara, M; Yasuda, Y, 2018) |
| "Although hyperammonemia is a known side effect of 5-FU that can cause serious pathological conditions, only a few cases have been reported." | 1.42 | [Four cases of 5-fluorouracil-related hyperammonemia in patients with large intestinal cancer and multiple liver metastases, including a case of hyperammonemia treated using hemodialysis]. ( Iida, T; Isshiki, H; Kaneto, H; Murakami, K; Naganawa, Y; Sasaki, H; Satoh, S; Shimizu, H; Tani, M; Wagatsuma, K, 2015) |
| " DMH was given to fish by intraperitoneal injection in a dosage of 15 mg/kg body weight once a week for 6 weeks." | 1.37 | [Chemopreventive effects of 5-fluorouracil and lactoferrin on goldfish intestinal carcinogenesis induced by 1,2-dimethylhydrazine]. ( Kakuta, I; Takase, K, 2011) |
| "Microsatellite instability was observed in all VCMsh2 strains and limited to the intestinal mucosa." | 1.36 | An Msh2 conditional knockout mouse for studying intestinal cancer and testing anticancer agents. ( Bronson, RT; Clark, AB; Edelmann, W; Fan, K; Hou, H; Jelicks, L; Kucherlapati, MH; Kucherlapati, R; Kunkel, TA; Lee, K; Li, H; Lipkin, M; Nguyen, AA; Rosulek, A; Yang, K, 2010) |
| "One-hundred and sixteen patients with gastric cancer were treated with 5-FU-based adjuvant chemotherapy." | 1.35 | The polymorphisms of TS and MTHFR predict survival of gastric cancer patients treated with fluorouracil-based adjuvant chemotherapy in Chinese population. ( Hua, D; Huang, ZH; Li, LH, 2009) |
| "5-Fluorouracil (5-FU) has been the foundation of advanced colorectal cancer treatment for over 40 years." | 1.31 | Response to 5-fluorouracil chemotherapy is modified by dietary folic acid deficiency in Apc(Min/+) mice. ( Berger, FG; Bunni, MA; Davis, C; Kitchens, ME; Priest, DG; Spencer, HT; Tucker, JM, 2002) |
| " Depending on the location of the anastomosis and the route of 5-FU administration, even a period of 3 days between operation and first dosage seemed insufficient to prevent weakening of the anastomosis." | 1.30 | Is early post-operative treatment with 5-fluorouracil possible without affecting anastomotic strength in the intestine? ( de Man, BM; Hendriks, T; van der Kolk, BM; Wobbes, T, 1999) |
| "Due to regular DNA histograms in the carcinoid tumors, it is suggested that reliable studies are permitted of the effect of cytotoxins on the different phases of the cell cycle in vivo." | 1.27 | Nuclear DNA in intestinal carcinoid tumors. A study before and after cytotoxin (streptozotocin and 5-fluorouracil) treatment. ( Bengtsson, A; Lindgren, PG; Lundqvist, M; Norheim, I; Oberg, K; Wilander, E, 1985) |
| "Forty patients with gastric cancer and 30 patients with colon cancer were administered FT-207 prior to the operation." | 1.26 | [Tissue concentration of 5-FU following pre-operative administration of FT-207]. ( Fukao, K; Ishikawa, A; Iwasaki, Y; Nagoshi, K; Okamura, T; Orii, K; Ozaki, A; Sarashina, H; Takase, Y; Takeshima, T; Todoroki, T, 1982) |
| "The levels of anticancer drugs in tissue were measured by bioassay method in 28 patients with gastrointestinal cancer, who were treated with intravenous administration of 500 mg of 5-FU combined with ANG-II during surgery." | 1.26 | [Clinical studies of cancer chemotherapy combined with angiotensin-II (ANG-II)]. ( Kanno, H; Kikuchi, K; Kunii, Y; Takahashi, N, 1982) |
| " Twelve (33%) of the 36 patients reported adverse effects: gastrointestinal symptoms in 8, CNS symptoms in 3, and others in 1." | 1.26 | [TAC-278. A new 5-FU derivative, by the oral route for its efficacy and safety in 36 patients with advanced cancers]. ( Arimori, S; Furue, H; Ikenaga, M; Iketa, T; Komita, T; Nagao, T; Ohki, S; Satoh, H; Watanabe, K; Yamamoto, S, 1982) |
| " These results showed that the maximum tolerated dosage of the agents administered intrarectally suppressed the development of new tumors after start of the treatment and also the growth of tumors which were detected by endoscopy before the treatment." | 1.26 | Cancer chemotherapy model using autochthonous large bowel cancer in rats. ( Kono, K; Narisawa, T; Takahashi, T; Yamaguchi, T, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 67 (56.30) | 18.7374 |
| 1990's | 8 (6.72) | 18.2507 |
| 2000's | 18 (15.13) | 29.6817 |
| 2010's | 23 (19.33) | 24.3611 |
| 2020's | 3 (2.52) | 2.80 |
| Authors | Studies |
|---|---|
| Legué, LM | 1 |
| van Erning, FN | 1 |
| Bernards, N | 1 |
| Lemmens, VEPP | 1 |
| de Hingh, IHJT | 1 |
| Creemers, GJ | 1 |
| Nishikawa, Y | 1 |
| Hoshino, N | 1 |
| Horimatsu, T | 2 |
| Funakoshi, T | 1 |
| Hida, K | 1 |
| Sakai, Y | 1 |
| Muto, M | 2 |
| Nakayama, T | 1 |
| Oziel-Taieb, S | 1 |
| Zemmour, C | 1 |
| Raoul, JL | 1 |
| Mineur, L | 1 |
| Poizat, F | 1 |
| Charrier, N | 1 |
| Piana, G | 1 |
| Cavaglione, G | 1 |
| Niccoli, P | 1 |
| Hadoux, J | 1 |
| Afchain, P | 1 |
| Walter, T | 2 |
| Tougeron, D | 2 |
| Hautefeuille, V | 2 |
| Monterymard, C | 1 |
| Lorgis, V | 1 |
| Thuillier, F | 1 |
| Baudin, E | 1 |
| Scoazec, JY | 2 |
| Lepage, C | 2 |
| Desgrippes, R | 1 |
| Makino, S | 1 |
| Takahashi, H | 1 |
| Haraguchi, N | 1 |
| Nishimura, J | 1 |
| Hata, T | 2 |
| Matsuda, C | 1 |
| Ikenaga, M | 2 |
| Murata, K | 1 |
| Yamamoto, H | 1 |
| Doki, Y | 1 |
| Mori, M | 1 |
| Mizushima, T | 1 |
| Nakayama, N | 1 |
| Moriwaki, T | 1 |
| Hirashima, Y | 1 |
| Fujita, M | 1 |
| Asayama, M | 1 |
| Moriyama, I | 1 |
| Nakashima, K | 1 |
| Baba, E | 2 |
| Kitamura, H | 1 |
| Tamura, T | 1 |
| Hosokawa, A | 1 |
| Yoshimura, K | 1 |
| Takayoshi, K | 1 |
| Kusaba, H | 1 |
| Uenomachi, M | 1 |
| Mitsugi, K | 1 |
| Makiyama, C | 1 |
| Makiyama, A | 1 |
| Uchino, K | 1 |
| Shirakawa, T | 1 |
| Shibata, Y | 1 |
| Shinohara, Y | 1 |
| Inadomi, K | 1 |
| Tsuchihashi, K | 1 |
| Arita, S | 1 |
| Ariyama, H | 1 |
| Esaki, T | 1 |
| Akashi, K | 1 |
| Malka, D | 3 |
| Hentic, O | 1 |
| Lombard-Bohas, C | 1 |
| Le Malicot, K | 1 |
| Smith, D | 1 |
| Ferru, A | 1 |
| Assenat, E | 1 |
| Cadiot, G | 1 |
| Lievre, A | 1 |
| Kurtz, JE | 1 |
| Dahan, L | 1 |
| Dubreuil, O | 1 |
| Lepere, C | 1 |
| Gangloff, A | 1 |
| Elhajbi, F | 1 |
| Coriat, R | 1 |
| Roquin, G | 1 |
| Bouarioua, N | 1 |
| Granger, V | 1 |
| Shinohara, S | 1 |
| Hyodo, M | 1 |
| Ota, G | 1 |
| Hayashi, H | 1 |
| Inoue, Y | 1 |
| Sato, H | 1 |
| Tsukahara, M | 1 |
| Okada, M | 1 |
| Lefor, AK | 1 |
| Yasuda, Y | 1 |
| Huffman, BM | 1 |
| Jin, Z | 2 |
| Yadav, S | 1 |
| Patel, S | 2 |
| Nagorney, DM | 1 |
| Truty, MJ | 1 |
| McWilliams, RR | 1 |
| Halfdanarson, TR | 1 |
| Mahipal, A | 1 |
| Matoba, H | 1 |
| Hirakata, A | 1 |
| Yoshida, H | 2 |
| Seta, S | 1 |
| Makino, H | 1 |
| Yokoyama, T | 1 |
| Maruyama, H | 1 |
| Ueda, J | 1 |
| Takata, H | 1 |
| Kikuchi, Y | 1 |
| Ueda, K | 1 |
| Miyashita, T | 1 |
| Yoshioka, M | 1 |
| Kusakabe, M | 1 |
| Asami, K | 1 |
| Neely, D | 1 |
| Ong, J | 1 |
| Patterson, J | 1 |
| Kirkpatrick, D | 1 |
| Skelly, R | 1 |
| Costa, FP | 1 |
| Gumz, B | 1 |
| Pasche, B | 1 |
| Kesavan, M | 1 |
| Claringbold, PG | 1 |
| Turner, JH | 1 |
| Iida, T | 1 |
| Wagatsuma, K | 1 |
| Tani, M | 1 |
| Sasaki, H | 1 |
| Naganawa, Y | 1 |
| Isshiki, H | 1 |
| Murakami, K | 1 |
| Satoh, S | 1 |
| Shimizu, H | 1 |
| Kaneto, H | 1 |
| Aydin, D | 1 |
| Sendur, MA | 1 |
| Kefeli, U | 1 |
| Ustaalioglu, BB | 1 |
| Aydin, O | 1 |
| Yildirim, E | 1 |
| Isik, D | 1 |
| Ozcelik, M | 1 |
| Surmeli, H | 1 |
| Oyman, A | 1 |
| Isik, S | 1 |
| Sener, N | 1 |
| Ercelep, O | 1 |
| Odabas, H | 1 |
| Aliustaoglu, M | 1 |
| Gumus, M | 1 |
| Huang, ZH | 1 |
| Hua, D | 1 |
| Li, LH | 1 |
| Overman, MJ | 2 |
| Kopetz, S | 2 |
| Wen, S | 1 |
| Hoff, PM | 1 |
| Fogelman, D | 1 |
| Morris, J | 1 |
| Abbruzzese, JL | 2 |
| Ajani, JA | 1 |
| Wolff, RA | 2 |
| Sugae, T | 1 |
| Yaguchi, T | 1 |
| Kajikawa, M | 1 |
| Nakayama, S | 1 |
| Takase, T | 1 |
| Inokawa, Y | 1 |
| Tsushima, Y | 1 |
| Watanabe, T | 1 |
| Harada, A | 1 |
| Zhao, J | 1 |
| Aguilar, G | 1 |
| Palencia, S | 1 |
| Newton, E | 1 |
| Abo, A | 1 |
| Suenaga, M | 1 |
| Mizunuma, N | 1 |
| Chin, K | 1 |
| Matsusaka, S | 1 |
| Shinozaki, E | 1 |
| Oya, M | 1 |
| Ueno, M | 1 |
| Yamaguchi, T | 2 |
| Muto, T | 1 |
| Konishi, F | 1 |
| Hatake, K | 1 |
| Varadhachary, GR | 1 |
| Adinin, R | 1 |
| Lin, E | 1 |
| Morris, JS | 1 |
| Eng, C | 1 |
| Zouhairi, ME | 1 |
| Venner, A | 1 |
| Charabaty, A | 1 |
| Pishvaian, MJ | 1 |
| Ilveskoski, E | 1 |
| Nikus, K | 1 |
| Tanner, M | 1 |
| Eskola, M | 1 |
| Kucherlapati, MH | 1 |
| Lee, K | 1 |
| Nguyen, AA | 1 |
| Clark, AB | 1 |
| Hou, H | 1 |
| Rosulek, A | 1 |
| Li, H | 1 |
| Yang, K | 1 |
| Fan, K | 1 |
| Lipkin, M | 1 |
| Bronson, RT | 1 |
| Jelicks, L | 1 |
| Kunkel, TA | 1 |
| Kucherlapati, R | 1 |
| Edelmann, W | 1 |
| Orphanos, GS | 1 |
| Stavrou, NG | 1 |
| Picolos, MK | 1 |
| Trikudanathan, G | 1 |
| Dasanu, CA | 1 |
| Lorenzen, S | 1 |
| Panzram, B | 1 |
| Rosenberg, R | 1 |
| Nekarda, H | 1 |
| Becker, K | 1 |
| Schenk, U | 1 |
| Höfler, H | 1 |
| Siewert, JR | 1 |
| Jäger, D | 1 |
| Ott, K | 1 |
| Darsigny, M | 1 |
| Babeu, JP | 1 |
| Seidman, EG | 1 |
| Gendron, FP | 1 |
| Levy, E | 1 |
| Carrier, J | 1 |
| Perreault, N | 1 |
| Boudreau, F | 1 |
| Okubo, K | 1 |
| Yoshioka, S | 1 |
| Asukai, K | 1 |
| Nakanishi, M | 1 |
| Maekawa, T | 1 |
| Hama, N | 1 |
| Kashiwazaki, M | 1 |
| Taniguchi, M | 1 |
| Tsujie, M | 1 |
| Konishi, M | 1 |
| Yano, K | 1 |
| Fujimoto, T | 1 |
| Zaanan, A | 1 |
| Gauthier, M | 1 |
| Locher, C | 2 |
| Gornet, JM | 1 |
| Thirot-Bidault, A | 1 |
| Taïeb, J | 1 |
| Bonnetain, F | 1 |
| Aparicio, T | 1 |
| Takase, K | 1 |
| Kakuta, I | 1 |
| Guo, WJ | 1 |
| Wang, AY | 1 |
| Gardini, A | 1 |
| Saragoni, L | 1 |
| La Barba, G | 1 |
| Serra, L | 1 |
| Calistri, D | 1 |
| Ulivi, P | 1 |
| Casadei, A | 1 |
| Frassineti, GL | 1 |
| Garcea, D | 1 |
| Tucker, JM | 2 |
| Davis, C | 2 |
| Kitchens, ME | 1 |
| Bunni, MA | 1 |
| Priest, DG | 1 |
| Spencer, HT | 1 |
| Berger, FG | 2 |
| Sun, H | 1 |
| Li, PP | 1 |
| Chen, YZ | 1 |
| REITEMEIER, RJ | 3 |
| MOERTEL, CG | 3 |
| DOWD, JE | 1 |
| DIPAOLO, JA | 1 |
| WATNE, AL | 1 |
| FALKSON, G | 1 |
| SNYMAN, HJ | 1 |
| MCCAFFERY, JF | 1 |
| ROCHLIN, DB | 1 |
| SMART, CR | 1 |
| SILVA, A | 1 |
| Murphy, JT | 1 |
| Boige, V | 1 |
| Lebray, P | 1 |
| Elias, D | 1 |
| Lasser, P | 1 |
| Ducreux, M | 1 |
| Noronha, V | 1 |
| Burtness, B | 1 |
| Murren, J | 1 |
| Duffy, TP | 1 |
| Liu, D | 1 |
| Caron, P | 1 |
| Seiter, K | 1 |
| Cao, J | 1 |
| Zuo, Y | 1 |
| Lv, F | 1 |
| Chen, Z | 1 |
| Li, J | 1 |
| Habeshaw, T | 1 |
| Adam, JS | 1 |
| Kirk, J | 1 |
| Rasenack, U | 1 |
| Caspary, W | 1 |
| Davis, HL | 1 |
| Martin, F | 1 |
| Sarashina, H | 1 |
| Ozaki, A | 1 |
| Okamura, T | 1 |
| Fukao, K | 1 |
| Takase, Y | 1 |
| Takeshima, T | 1 |
| Todoroki, T | 1 |
| Ishikawa, A | 1 |
| Orii, K | 1 |
| Nagoshi, K | 1 |
| Iwasaki, Y | 1 |
| Okuda, M | 1 |
| Teramoto, T | 1 |
| Sato, K | 1 |
| Ushijima, Y | 1 |
| Uematsu, Y | 1 |
| Takahashi, N | 1 |
| Kunii, Y | 1 |
| Kanno, H | 1 |
| Kikuchi, K | 1 |
| Higgins, GA | 3 |
| Watanabe, K | 1 |
| Satoh, H | 1 |
| Ohki, S | 1 |
| Furue, H | 1 |
| Komita, T | 1 |
| Iketa, T | 1 |
| Arimori, S | 1 |
| Nagao, T | 1 |
| Yamamoto, S | 1 |
| Luporini, G | 1 |
| Labianca, R | 1 |
| Fraschini, P | 1 |
| Tedeschi, L | 1 |
| Scanni, A | 1 |
| Tomirotti, M | 1 |
| Biraghi, M | 1 |
| Annibali, E | 1 |
| Del Bianco, S | 1 |
| Stephens, JD | 1 |
| Golbus, MS | 1 |
| Miller, TR | 1 |
| Wilber, RR | 1 |
| Epstein, CJ | 1 |
| Manente, P | 1 |
| Buchberger, R | 1 |
| Valmachino, G | 1 |
| Fioretti, D | 1 |
| Lo Giudice, C | 1 |
| Gasparoni, P | 1 |
| Conte, N | 1 |
| Caravella, LP | 1 |
| Burns, JA | 1 |
| Zangmeister, M | 1 |
| Allen, BJ | 1 |
| Parker, D | 1 |
| Wright, AL | 1 |
| Weidmann, B | 1 |
| Teipel, A | 1 |
| Niederle, N | 1 |
| Onodera, H | 1 |
| Nishitai, R | 1 |
| Shimizu, K | 1 |
| Maetani, S | 1 |
| Imamura, M | 1 |
| Crawley, C | 1 |
| Ross, P | 1 |
| Norman, A | 1 |
| Hill, A | 1 |
| Cunningham, D | 1 |
| Mullany, S | 1 |
| Svingen, PA | 1 |
| Kaufmann, SH | 1 |
| Erlichman, C | 1 |
| van der Kolk, BM | 1 |
| de Man, BM | 1 |
| Wobbes, T | 1 |
| Hendriks, T | 1 |
| Swiatkowska-Freund, M | 1 |
| Preis, K | 1 |
| Emerich, J | 1 |
| Reeder, RE | 1 |
| Mika, RO | 1 |
| Skogseid, B | 1 |
| Mayr, AC | 1 |
| Pettavel, J | 1 |
| Morgenthaler, F | 1 |
| Maisin, H | 1 |
| Anckaert, MA | 1 |
| Van Evercoren, A | 1 |
| De Coster, BM | 1 |
| Chernicoff, D | 1 |
| Bukowski, RM | 1 |
| Groppe, CW | 1 |
| Hewlett, JS | 1 |
| Sokova, OI | 1 |
| Volgareva, GM | 1 |
| Sawai, K | 1 |
| Sonoda, Y | 1 |
| Ohkuma, S | 1 |
| Misawa, S | 1 |
| Takino, T | 1 |
| Queisser, W | 1 |
| Schaefer, J | 1 |
| Arnold, H | 1 |
| Drings, P | 1 |
| Geldmacher, J | 1 |
| Hartwich, G | 1 |
| Kredel, L | 1 |
| Mayer, M | 1 |
| Neidhardt, B | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase II Study of Capecitabine and Oxaliplatin (XELOX) in Adenocarcinoma of the Small Bowel and Ampulla of Vater[NCT00354887] | Phase 2 | 31 participants (Actual) | Interventional | 2004-11-30 | Completed | ||
| The ADAPTA Study: ADjuvant chemotherAPy After Curative Intent resecTion of Ampullary Cancer. A Pan-European Prospective Multicenter Double Single Arm Cohort Study.[NCT06068023] | 400 participants (Anticipated) | Observational | 2023-07-01 | Recruiting | |||
| TWICE-IRI: Optimization of Second-line Therapy With Aflibercept, Irinotecan (Day 1 or Day 1,3), 5-Fluorouracile and Folinic Acid in Patients With Metastatic Colorectal Cancer. A Randomized Phase III Study.[NCT04392479] | Phase 3 | 202 participants (Anticipated) | Interventional | 2020-09-02 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Overall response rate defined as Complete Response (CR), disappearance of all target lesions; or Partial Response (PR), at least a 30% decrease in sum of longest diameter (LD) of target lesions, taking as reference the baseline sum LD, assessed by Response Evaluation Criteria in Solid Tumors (RECIST) Committee [JNCI 92(3):205-216, 2000]. In addition to a baseline scan, confirmatory scans for those deemed to have achieved a PR or CR. (NCT00354887)
Timeframe: Every 9 weeks from treatment initiation and confirmatory images 6 weeks or more after initial responses
| Intervention | participants (Number) | |
|---|---|---|
| Participants with CR | Participants with PR | |
| Oxaliplatin + Capecitabine | 3 | 12 |
10 reviews available for fluorouracil and Intestinal Neoplasms
| Article | Year |
|---|---|
Chemotherapy for patients with unresectable or metastatic small bowel adenocarcinoma: a systematic review.
Topics: Adenocarcinoma; Albumins; Antineoplastic Combined Chemotherapy Protocols; Doxorubicin; Fluorouracil; | 2020 |
Small intestinal adenocarcinoma: rarely considered, often missed?
Topics: Adenocarcinoma; Aged; Capsule Endoscopy; Celiac Disease; Chemotherapy, Adjuvant; Cystic Fibrosis; Do | 2013 |
Selecting patients for cytotoxic therapies in gastroenteropancreatic neuroendocrine tumours.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Cell | 2012 |
Small bowel adenocarcinoma.
Topics: Adenocarcinoma; Age of Onset; Animals; Antimetabolites, Antineoplastic; Disease Models, Animal; Fema | 2008 |
Evolving pharmacotherapeutic strategies for small bowel adenocarcinoma.
Topics: Adenocarcinoma; Camptothecin; Clinical Trials as Topic; Fluorouracil; Humans; Intestinal Neoplasms; | 2010 |
Oxaliplatin induces a delayed immune-mediated hemolytic anemia: a case report and review of the literature.
Topics: Anemia, Hemolytic; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; | 2005 |
Large bowel cancer: an overview.
Topics: Antineoplastic Agents; Clinical Trials as Topic; Colonic Neoplasms; Drug Therapy, Combination; Femal | 1982 |
[Chemotherapy of gastrointestinal tumors (review of the literature)].
Topics: Ancitabine; Carcinoma, Hepatocellular; Colonic Neoplasms; Doxorubicin; Drug Therapy, Combination; Fl | 1978 |
[Adjuvant chemotherapy following radical operations for cancer of the large intestine].
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Com | 1985 |
The metabolism and pharmacology of 5-fluorouracil.
Topics: Adenocarcinoma; Alopecia; Animals; Breast Neoplasms; Carbon Isotopes; Cell Division; Chromosome Aber | 1971 |
13 trials available for fluorouracil and Intestinal Neoplasms
| Article | Year |
|---|---|
FOLFIRINEC: a randomized phase II trial of mFOLFIRINOX vs platinum-etoposide for metastatic neuroendocrine carcinoma of gastroenteropancreatic or unknown origin.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Biomarkers; Carcinoma, Neuroendocrine; Etopos | 2021 |
A phase II study of 5-fluorouracil/L-leucovorin/oxaliplatin (mFOLFOX6) in Japanese patients with metastatic or unresectable small bowel adenocarcinoma.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Asian People; Disease-F | 2017 |
Evaluating bevacizumab in combination with FOLFIRI after the failure of platinum-etoposide regimen in patients with advanced poorly differentiated neuroendocrine carcinoma: The PRODIGE 41-BEVANEC randomized phase II study.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Carcinoma, Neuroendocrine | 2018 |
Hematological toxicity of combined 177Lu-octreotate radiopeptide chemotherapy of gastroenteropancreatic neuroendocrine tumors in long-term follow-up.
Topics: Adult; Aged; Anemia; Antineoplastic Agents; Blood Platelets; Capecitabine; Dacarbazine; Deoxycytidin | 2014 |
Phase II study of capecitabine and oxaliplatin for advanced adenocarcinoma of the small bowel and ampulla of Vater.
Topics: Adenocarcinoma; Adult; Aged; Ampulla of Vater; Antineoplastic Combined Chemotherapy Protocols; Capec | 2009 |
Phase II study of capecitabine and oxaliplatin for advanced adenocarcinoma of the small bowel and ampulla of Vater.
Topics: Adenocarcinoma; Adult; Aged; Ampulla of Vater; Antineoplastic Combined Chemotherapy Protocols; Capec | 2009 |
Phase II study of capecitabine and oxaliplatin for advanced adenocarcinoma of the small bowel and ampulla of Vater.
Topics: Adenocarcinoma; Adult; Aged; Ampulla of Vater; Antineoplastic Combined Chemotherapy Protocols; Capec | 2009 |
Phase II study of capecitabine and oxaliplatin for advanced adenocarcinoma of the small bowel and ampulla of Vater.
Topics: Adenocarcinoma; Adult; Aged; Ampulla of Vater; Antineoplastic Combined Chemotherapy Protocols; Capec | 2009 |
Chemotherapy of large bowel cancer.
Topics: Antineoplastic Agents; Clinical Trials as Topic; Drug Therapy, Combination; Floxuridine; Fluorouraci | 1982 |
Large bowel cancer: an overview.
Topics: Antineoplastic Agents; Clinical Trials as Topic; Colonic Neoplasms; Drug Therapy, Combination; Femal | 1982 |
The Royal Marsden experience of a small bowel adenocarcinoma treated with protracted venous infusion 5-fluorouracil.
Topics: Adenocarcinoma; Adult; Antimetabolites, Antineoplastic; Female; Fluorouracil; Humans; Infusions, Int | 1998 |
[A prospective multi-centre study of the response of metastatic gastrointestinal tumours (author's transl)].
Topics: Adenocarcinoma; Carmustine; Fluorouracil; Gastrointestinal Neoplasms; Humans; Intestinal Neoplasms; | 1979 |
5-Fluorouracil as adjuvant chemotherapy for large bowel cancer. Is it appropriate for routine community use?
Topics: BCG Vaccine; Clinical Trials as Topic; Fluorouracil; Humans; Intestinal Neoplasms; Neoplasm Metastas | 1979 |
Adjuvant chemotherapy in the surgical treatment of large bowel cancer.
Topics: Clinical Trials as Topic; Drug Administration Schedule; Drug Therapy, Combination; Fluorouracil; Hum | 1976 |
[Adjuvant chemotherapy following radical operations for cancer of the large intestine].
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Com | 1985 |
A comparison of 5-fluorouracil administered by slow infusion and rapid injection.
Topics: Adenocarcinoma; Clinical Trials as Topic; Fluorouracil; Humans; Infusions, Parenteral; Injections, I | 1972 |
98 other studies available for fluorouracil and Intestinal Neoplasms
| Article | Year |
|---|---|
Addition of Bevacizumab to First-Line Palliative Chemotherapy in Patients with Metastatic Small Bowel Adenocarcinoma: A Population-Based Study.
Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Capecitabine; Fem | 2019 |
Efficacy of FOLFOX Chemotherapy in Metastatic Enteropancreatic Neuroendocrine Tumors.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Female; Fluorouracil | 2021 |
A Single Institutional Analysis of Systemic Therapy for Unresectable or Recurrent Small Bowel Adenocarcinoma.
Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Disease-Free Survival; Female; | 2017 |
Suggestion of added value by bevacizumab to chemotherapy in patients with unresectable or recurrent small bowel cancer.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Beva | 2017 |
[Primary Small Bowel Tumor with Simultaneous Lung Metastases from Rectal Cancer - A Case Report].
Topics: Antineoplastic Combined Chemotherapy Protocols; Female; Fluorouracil; Humans; Intestinal Neoplasms; | 2018 |
Novel Prognostic Factors in Resected Small Bowel Adenocarcinoma.
Topics: Adenocarcinoma; Adult; Age Factors; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Pr | 2019 |
[A Case of Survival Following Fourth-Line Outpatient Chemotherapy 19 Months after Surgery for Small Intestinal Cancer with Multiple Liver Metastases in a Patient with Good General Condition].
Topics: Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Female; Fluorouracil; Humans; Intestina | 2019 |
[Four cases of 5-fluorouracil-related hyperammonemia in patients with large intestinal cancer and multiple liver metastases, including a case of hyperammonemia treated using hemodialysis].
Topics: Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Fluorouracil; Humans; Hyperammonemia; Inte | 2015 |
Evaluation of Bevacizumab in Advanced Small Bowel Adenocarcinoma.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothec | 2017 |
The polymorphisms of TS and MTHFR predict survival of gastric cancer patients treated with fluorouracil-based adjuvant chemotherapy in Chinese population.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; China; Cohort Studies | 2009 |
Chemotherapy with 5-fluorouracil and a platinum compound improves outcomes in metastatic small bowel adenocarcinoma.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Disease-Free Survival; | 2008 |
[A case report of primary adenocarcinoma of small intestine successfully treated with FOLFOX].
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Carcinoembryonic Antigen; Fluorourac | 2008 |
rNAPc2 inhibits colorectal cancer in mice through tissue factor.
Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Bevacizumab; Cell Line, Tumor; C | 2009 |
Chemotherapy for small-bowel Adenocarcinoma at a single institution.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Disease P | 2009 |
[Coronary artery disease attack caused by cytotoxic chemotherapy].
Topics: Aged; Antimetabolites, Antineoplastic; Breast Neoplasms; Capecitabine; Chest Pain; Coronary Vasospas | 2009 |
An Msh2 conditional knockout mouse for studying intestinal cancer and testing anticancer agents.
Topics: Adenocarcinoma; Adenoma; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protoc | 2010 |
Hypertriglyceridemia: An underdiagnosed side effect of Capecitabine chemotherapy.
Topics: Adenocarcinoma; Antineoplastic Agents; Bezafibrate; Capecitabine; Cecum; Deoxycytidine; Fluorouracil | 2010 |
Prognostic significance of free peritoneal tumor cells in the peritoneal cavity before and after neoadjuvant chemotherapy in patients with gastric carcinoma undergoing potentially curative resection.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Combined Modality Therapy; F | 2010 |
Hepatocyte nuclear factor-4alpha promotes gut neoplasia in mice and protects against the production of reactive oxygen species.
Topics: Adenoma; Animals; Antimetabolites, Antineoplastic; Colonic Neoplasms; Female; Fluorouracil; Gene Exp | 2010 |
[A case report of primary adenocarcinoma of small intestine].
Topics: Adenocarcinoma; Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; | 2010 |
Second-line chemotherapy with fluorouracil, leucovorin, and irinotecan (FOLFIRI regimen) in patients with advanced small bowel adenocarcinoma after failure of first-line platinum-based chemotherapy: a multicenter AGEO study.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Female; F | 2011 |
[Chemopreventive effects of 5-fluorouracil and lactoferrin on goldfish intestinal carcinogenesis induced by 1,2-dimethylhydrazine].
Topics: 1,2-Dimethylhydrazine; Animals; Anti-Infective Agents; Antimetabolites, Antineoplastic; Blood Cell C | 2011 |
[Expression of Bcl-w protein in human small intestinal adenocarcinoma and effect of Bcl-w siRNA on apoptosis in intestinal adenocarcinoma HuTu-80 cells].
Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Apoptosis; Apoptosis Regulatory Proteins; Cell Line | 2012 |
Challenge in differential diagnosis of a liver mass histologically defined as a metastatic lesion from an occult primary intestinal tumour. The importance of clinical findings and the limitations of histology and molecular profiles. A case report.
Topics: Adenoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Bile Duct Neoplasms; Bile Ducts, Intr | 2012 |
Response to 5-fluorouracil chemotherapy is modified by dietary folic acid deficiency in Apc(Min/+) mice.
Topics: Animals; Antimetabolites, Antineoplastic; Diet; DNA Primers; Fluorouracil; Folic Acid; Folic Acid De | 2002 |
[Clinical observation of chemotherapy combined with yiqi xiaozheng granule in treating advanced malignant tumor].
Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Drug Therapy, Combination; Drugs, Chinese | 2003 |
Comparison of rapid and slow intravenous administration of 5-fluorouracil in treating patients with advanced carcinoma of the large intestine.
Topics: Adenocarcinoma; Administration, Intravenous; Colonic Diseases; Fluorouracil; Humans; Intestinal Neop | 1962 |
INDIVIDUALIZED CHEMOTHERAPY BY IN VITRO DRUG SELECTION.
Topics: Antineoplastic Agents; Bone Neoplasms; Dactinomycin; Female; Floxuridine; Fluorouracil; Genital Neop | 1964 |
EXPERIENCE WITH CHEMOTHERAPY OF CANCER AT THE UNIVERSITY OF PRETORIA.
Topics: Antineoplastic Agents; Aziridines; Breast Neoplasms; Cyclophosphamide; Dactinomycin; Fluorouracil; H | 1964 |
STUDIES IN THE TOXICITY AND CLINICAL APPLICATION OF 5-FLUOROURACIL.
Topics: Adenocarcinoma; Agranulocytosis; Biomedical Research; Diarrhea; Diverticulitis; Drug Eruptions; Fluo | 1964 |
CHEMOTHERAPY OF MALIGNANCIES OF THE GASTROINTESTINAL TRACT.
Topics: Antineoplastic Agents; Carcinoid Tumor; Colonic Neoplasms; Cyclophosphamide; Fluorouracil; Gastroint | 1965 |
Raltitrexed increases tumorigenesis as a single agent yet exhibits anti-tumor synergy with 5-fluorouracil in ApcMin/+ mice.
Topics: Adenoma; Adenomatous Polyposis Coli Protein; Animals; Antineoplastic Combined Chemotherapy Protocols | 2004 |
Combination chemotherapy in advanced small bowel adenocarcinoma.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Chemothera | 2005 |
Acute myelogenous leukemia following irinotecan-based chemotherapy for adenocarcinoma of the small intestine.
Topics: Adenocarcinoma; Adult; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Fluorouracil; H | 2007 |
Primary small intestinal malignant tumors: survival analysis of 48 postoperative patients.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Chemotherapy, Adjuvant; Female; Fluorouracil; Follow-U | 2008 |
Weekly large fraction radiotherapy and 5 fluorouracil as a palliative treatment for large bowel carcinoma: a pilot study.
Topics: Adenocarcinoma; Adult; Aged; Diarrhea; Fluorouracil; Humans; Intestinal Neoplasms; Intestine, Large; | 1982 |
[Therapy of carcinoid and the carcinoid syndrome].
Topics: Aminocaproic Acid; Aprotinin; Carcinoma, Squamous Cell; Cyproheptadine; Doxorubicin; Embolization, T | 1983 |
[Adjuvant chemotherapy in cancers of the stomach, pancreas and intestine].
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Combined M | 1984 |
[Tissue concentration of 5-FU following pre-operative administration of FT-207].
Topics: Female; Fluorouracil; Humans; Intestinal Neoplasms; Intestine, Large; Lymph Nodes; Male; Middle Aged | 1982 |
[Clinical study of serum and tissue concentrations of FT-207 and 5-FU in patients with cancer of the large intestine following preoperative application of FT-207 suppositories].
Topics: Adult; Aged; Biological Assay; Female; Fluorouracil; Humans; Intestinal Neoplasms; Intestine, Large; | 1982 |
[Clinical studies of cancer chemotherapy combined with angiotensin-II (ANG-II)].
Topics: Adult; Aged; Angiotensin II; Antibiotics, Antineoplastic; Antineoplastic Agents; Blood Pressure; Bre | 1982 |
[TAC-278. A new 5-FU derivative, by the oral route for its efficacy and safety in 36 patients with advanced cancers].
Topics: Adult; Aged; Blood Platelets; Drug Evaluation; Female; Fluorouracil; Humans; Intestinal Neoplasms; I | 1982 |
[Evaluation of the combination of BCNU, VCR and 5-FU in the treatment of disseminated neoplasms of the large intestine].
Topics: Adolescent; Adult; Aged; Carmustine; Drug Therapy, Combination; Female; Fluorouracil; Humans; Intest | 1980 |
[Cyclophosphamide, methotrexate and 5-fluorouracil (CMF), versus 5-fluorouracil, in carcinoma of the large intestine in an advanced stage].
Topics: Aged; Cyclophosphamide; Drug Therapy, Combination; Female; Fluorouracil; Humans; Intestinal Neoplasm | 1980 |
Multiple congenital anomalies in a fetus exposed to 5-fluorouracil during the first trimester.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Bone and Bones; Digestive System Abnorm | 1980 |
[Cardiotoxicity induced by 5-fluorouracil. A case report].
Topics: Adult; Coronary Disease; Fluorouracil; Humans; Intestinal Neoplasms | 1980 |
Punctal-canalicular stenosis related to systemic fluorouracil therapy.
Topics: Adenocarcinoma; Adult; Breast Neoplasms; Female; Fluorouracil; Humans; Intestinal Neoplasms; Lacrima | 1981 |
Reticulate pigmentation due to 5-fluorouracil.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Carcinoma; Erythema; Fluorouracil; Humans | 1995 |
The syndrome of 5-fluorouracil cardiotoxicity: an elusive cardiopathy.
Topics: Adenocarcinoma; Angina Pectoris; Electrocardiography; Female; Fluorouracil; Heart; Heart Diseases; H | 1994 |
Small intestinal cancer with extensive lymph node metastases showing complete remission by methotrexate/5-fluorouracil sequential therapy: report of a case.
Topics: Adenocarcinoma; Adult; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule; | 1997 |
Effect of adding the topoisomerase I poison 7-ethyl-10-hydroxycamptothecin (SN-38) to 5-fluorouracil and folinic acid in HCT-8 cells: elevated dTTP pools and enhanced cytotoxicity.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cell Cycle; Cell Survi | 1998 |
Is early post-operative treatment with 5-fluorouracil possible without affecting anastomotic strength in the intestine?
Topics: Anastomosis, Surgical; Animals; Antimetabolites, Antineoplastic; Colon; Fluorouracil; Ileum; Infusio | 1999 |
[Appendiceal mucinous carcinoma].
Topics: Adenocarcinoma, Mucinous; Adult; Antineoplastic Combined Chemotherapy Protocols; Appendiceal Neoplas | 2000 |
Ectropion secondary to bolus injection of 5-fluorouracil.
Topics: Aged; Diagnosis, Differential; Ectropion; Fluorouracil; Humans; Immunosuppressive Agents; Injections | 2001 |
Nonsurgical treatment of advanced malignant neuroendocrine pancreatic tumors and midgut carcinoids.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoid Tumor; Fluorouracil; Humans; Interferon-al | 2001 |
[Hepatic metastases of cancers of the large intestine. Results of arterial chemotherapeutic treatment].
Topics: Female; Floxuridine; Fluorouracil; Humans; Injections, Intra-Arterial; Intestinal Neoplasms; Intesti | 1976 |
[Combination of chemotherapy and radiotherapy. I. Differential effect on the intestinal syndrome of irradiation combined with the drug administered in fractional doses and at various times].
Topics: Animals; Drug Administration Schedule; Female; Fluorouracil; Intestinal Neoplasms; Lethal Dose 50; M | 1979 |
Combination chemotherapy for islet cell carcinoma and metastatic carcinoid tumors with 5-fluorouracil and streptozotocin.
Topics: Adenoma, Islet Cell; Carcinoid Tumor; Drug Therapy, Combination; Fluorouracil; Humans; Intestinal Ne | 1979 |
[Action of ftorafur and 5-fluorouracil on the chromosomes of normal and tumorous cells in vivo].
Topics: Animals; Bone Marrow; Bone Marrow Cells; Chromosomes; Cricetinae; Dose-Response Relationship, Drug; | 1977 |
[A combined immuno-chemotherapy with futraful and picibanil for advanced cancer (author's transl)].
Topics: Aged; Biological Products; Drug Therapy, Combination; Female; Fluorouracil; Humans; Intestinal Neopl | 1977 |
[Chemotherapy of intestinal carcinomas].
Topics: Cyclophosphamide; Fluorouracil; Humans; Intestinal Neoplasms; Peritoneal Neoplasms | 1979 |
The carcinoid syndrome: methods of treatment and recent experience with hepatic artery ligation and infusion.
Topics: Female; Fluorouracil; Heart Failure; Hepatic Artery; Humans; Hydroxyindoleacetic Acid; Ileum; Intest | 1977 |
Cancer chemotherapy model using autochthonous large bowel cancer in rats.
Topics: Administration, Topical; Animals; Drug Evaluation, Preclinical; Female; Fluorouracil; Intestinal Neo | 1978 |
Comparison of liquid- and gas-liquid chromatographic assays of 5-fluorouracil in plasma.
Topics: Chromatography, Gas; Chromatography, High Pressure Liquid; Fluorouracil; Humans; Intestinal Neoplasm | 1979 |
Primary adenocarcinoma of the small intestine.
Topics: Adenocarcinoma; Adult; Aged; BCG Vaccine; Female; Fluorouracil; Follow-Up Studies; Humans; Intestina | 1977 |
[Late results of the prophylactic treatment with 5-fluorouracil of cancer of the large intestine and rectum].
Topics: Adult; Aged; Female; Fluorouracil; Follow-Up Studies; Humans; Intestinal Neoplasms; Intestine, Large | 1976 |
Chemotherapy, adjuvant to surgery, for gastrointestinal cancer.
Topics: Female; Fluorouracil; Gastrointestinal Neoplasms; Humans; Intestinal Neoplasms; Male; Stomach Neopla | 1976 |
Hepatic artery ligation in treatment of carcinoid syndrome.
Topics: Aged; Angiography; Cyclophosphamide; Female; Fluorouracil; Hepatic Artery; Humans; Hydroxyindoleacet | 1975 |
[The action of 5-fluorouracil in DMH-induced carcinogenesis in rats].
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Dimethylhydrazines; Disease Models, Animal; Drug Evalua | 1992 |
Chemotherapy with 5-fluorouracil and streptozotocin in carcinoid tumors of gastrointestinal origin: experiences with 13 patients.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Appendiceal Neoplasms; Carcinoid Tumor; | 1991 |
Adenocarcinoma of the small intestine presenting as an ovarian mass. A case report.
Topics: Adenocarcinoma; Adult; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Doxorubicin; Femal | 1989 |
Interferon-induced nuclear DNA alterations in malignant carcinoid tumors in vivo.
Topics: Adult; Aged; Carcinoid Tumor; Cell Nucleus; DNA, Neoplasm; Female; Flow Cytometry; Fluorouracil; Hum | 1986 |
Nuclear DNA in intestinal carcinoid tumors. A study before and after cytotoxin (streptozotocin and 5-fluorouracil) treatment.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoid Tumor; Cell Nucleus; Diploidy; DNA; | 1985 |
In vitro biochemical and in vivo biological studies of the uridine 'rescue' of 5-fluorouracil.
Topics: Animals; Bone Marrow; Colonic Neoplasms; Drug Interactions; Female; Fluorouracil; Humans; Intestinal | 1988 |
[Mitomycin alone and in therapeutic association in the palliative treatment of solid tumors].
Topics: Antineoplastic Agents; Breast Neoplasms; Cobalt Isotopes; Cyclophosphamide; Drug Combinations; Femal | 1971 |
Possible approaches to the chemotherapy of gut cancer.
Topics: Animals; Azacitidine; Culture Techniques; Fluorouracil; Humans; Intestinal Neoplasms; Methods; Mice; | 1973 |
Development of carcinoma in regional enteritis.
Topics: Adenocarcinoma, Mucinous; Barium Sulfate; Cecum; Colon; Colonic Diseases; Crohn Disease; Enema; Fluo | 1974 |
[Therapy of advanced tumors with 5-fluoro-uracil].
Topics: Femoral Neoplasms; Fluorouracil; Humans; Injections, Intra-Arterial; Injections, Intravenous; Intest | 1969 |
Combination chemotherapy in gastrointestinal cancer.
Topics: Adenocarcinoma; Adult; Alopecia; Appendiceal Neoplasms; Diarrhea; Drug Eruptions; Fluorouracil; Gall | 1970 |
Enzymatic determinants of responsiveness of the LPC-1 plasma cell neoplasm to fluorouracil and fluorodeoxyuridine.
Topics: Animals; Cell Line; Disease Models, Animal; Floxuridine; Fluorouracil; Intestinal Neoplasms; Mice; N | 1970 |
Experience with hepatic arterial infusions.
Topics: Adult; Aged; Bile Duct Neoplasms; Carcinoma, Hepatocellular; Female; Floxuridine; Fluorouracil; Gall | 1971 |
Clinical management of advanced gastrointestinal cancer.
Topics: Adenocarcinoma; Alkylating Agents; Biliary Tract; Carcinoid Tumor; Carcinoma, Hepatocellular; Fluoro | 1973 |
Immunotherapy: its possible application in the management of large-bowel cancer.
Topics: BCG Vaccine; Carcinoembryonic Antigen; Chlorine; Evaluation Studies as Topic; Fluorouracil; Humans; | 1974 |
Prevention of recurrent cancer of the large bowel.
Topics: Animals; Antineoplastic Agents; Fluorouracil; Humans; Intestinal Neoplasms; Intestine, Large; Ligati | 1974 |
The administration of 5-fluorouracil by mouth.
Topics: Adenocarcinoma; Administration, Oral; Aged; Female; Fluorouracil; Gastrointestinal Neoplasms; Heart | 1974 |
[Drug therapy of cancer].
Topics: Antineoplastic Agents; Breast Neoplasms; Fluorouracil; Hospitals, Special; Humans; Intestinal Neopla | 1974 |
Cytotoxic agents in the treatment of malignant disease.
Topics: Antimetabolites; Antineoplastic Agents; Breast Neoplasms; Carcinoma; Chlorambucil; Choriocarcinoma; | 1968 |
Combined parenteral hyperalimentation and chemotherapy in the treatment of disseminated solid tumors.
Topics: Amino Acids; Analgesics; Appetite; Body Weight; Breast Neoplasms; Carcinoid Tumor; Colonic Neoplasms | 1971 |
Hepatic artery ligation and cytotoxic infusion in treatment of liver metastases.
Topics: Aged; Alkaline Phosphatase; Female; Fluorouracil; Gallbladder Neoplasms; Hepatic Artery; Humans; Inj | 1972 |
The phase II study: some reflections, particularly concerning disseminated breast cancer.
Topics: Antineoplastic Agents; Breast Neoplasms; Carmustine; Cyclohexanes; Cyclophosphamide; Female; Fluorou | 1972 |
[Systemic chemotherapy of cancer of the stomach and the intestine].
Topics: Antineoplastic Agents; Cyclophosphamide; Cytarabine; Fluorouracil; Humans; Intestinal Neoplasms; Mit | 1972 |
[Villous tumors of the jejunum and ileum].
Topics: Adenocarcinoma; Cell Transformation, Neoplastic; Female; Fluorouracil; Humans; Ileum; Intestinal Neo | 1971 |
Cytotoxic penetration and concentration in human malignant tumours.
Topics: Antineoplastic Agents; Breast Neoplasms; Colonic Neoplasms; Female; Fluorouracil; Humans; Injections | 1969 |
[Experience with the treatment of patients with malignant tumors with 5-fluorouracil].
Topics: Adenocarcinoma; Adult; Aged; Colonic Neoplasms; Duodenal Neoplasms; Female; Fluorouracil; Humans; In | 1967 |
Clinical evaluation of combined radiation and chemotherapy in gastrointestinal malignancies.
Topics: Bone Marrow; Bone Marrow Cells; Colonic Neoplasms; Fluorouracil; Gastrointestinal Neoplasms; Humans; | 1968 |
Fluorouracil toxicity following gastrointestinal surgery.
Topics: Adenocarcinoma; Colitis, Ulcerative; Colostomy; Fluorouracil; Humans; Intestinal Mucosa; Intestinal | 1965 |
[Use of 5-fluorouracil chemotherapy in malignant neoplasms of the large intestine].
Topics: Aged; Female; Fluorouracil; Humans; Intestinal Neoplasms; Intestine, Large; Male; Middle Aged | 1965 |
[The use of 5-fluorouracil in the therapy of some epithelial tumors].
Topics: Adenocarcinoma; Breast Neoplasms; Carcinosarcoma; Fluorouracil; Humans; Intestinal Neoplasms; Lung N | 1966 |