Page last updated: 2024-10-27

fluorouracil and Intestinal Diseases

fluorouracil has been researched along with Intestinal Diseases in 40 studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Intestinal Diseases: Pathological processes in any segment of the INTESTINE from DUODENUM to RECTUM.

Research Excerpts

ExcerptRelevanceReference
"Intestinal mucositis and diarrhea are common manifestations of anticancer regimens that include irinotecan, 5-fluorouracil (5-FU), and other cytotoxic drugs."8.93Irinotecan- and 5-fluorouracil-induced intestinal mucositis: insights into pathogenesis and therapeutic perspectives. ( Cunha, FQ; Leite, CA; Lima-Júnior, RC; Mota, JM; Ribeiro, RA; Souza, MH; Wanderley, CW; Wong, DV, 2016)
"This study aims to evaluate the effect of berberine-based carbon quantum dots (Ber-CDs) on improving 5-fluorouracil (5-FU)-induced intestinal mucositis in C57BL/6 mice, and explored the mechanisms behind this effect."8.31Berberine-Based Carbon Quantum Dots Improve Intestinal Barrier Injury and Alleviate Oxidative Stress in C57BL/6 Mice with 5-Fluorouracil-Induced Intestinal Mucositis by Enhancing Gut-Derived Short-Chain Fatty Acids Contents. ( He, J; Li, H; Sun, C; Tan, J; Wang, D; Wu, L; Xi, Y; Yan, M, 2023)
"FOLFOX (5-fluorouracil, leucovorin, and oxaliplatin), a 5-fluorouracil (5-FU)-based chemotherapy regimen, is one of most common therapeutic regimens for colorectal cancer."7.96Fecal Microbiota Transplantation Prevents Intestinal Injury, Upregulation of Toll-Like Receptors, and 5-Fluorouracil/Oxaliplatin-Induced Toxicity in Colorectal Cancer. ( Chang, CW; Chen, MJ; Chen, YJ; Chiang Chiau, JS; Chuang, WH; Lee, HC; Li, LH; Liu, CY; Shih, SC; Tsai, TH; Wang, HY; Wang, TE, 2020)
"The chemotherapeutic agent 5-fluorouracil (5-FU) causes intestinal mucositis with severe diarrhoea, but the pathogenesis is not fully understood."7.85Apoptosis, Dysbiosis and Expression of Inflammatory Cytokines are Sequential Events in the Development of 5-Fluorouracil-Induced Intestinal Mucositis in Mice. ( Amagase, K; Hamouda, N; Higuchi, K; Kato, S; Matsumoto, K; Oikawa, Y; Ozaki, T; Sano, T; Shimakawa, M, 2017)
" 5-Fluorouracil (5-FU), widely used for cancer chemotherapy, is known to frequently induce intestinal mucositis accompanied by severe diarrhoea."7.85Probiotic Bifidobacterium bifidum G9-1 attenuates 5-fluorouracil-induced intestinal mucositis in mice via suppression of dysbiosis-related secondary inflammatory responses. ( Amagase, K; Hamouda, N; Kano, Y; Kato, S; Matsumoto, K; Oikawa, Y; Shimakawa, M; Tanaka, Y, 2017)
"5-Fluorouracil (5-FU) has broadly been applied to treat colorectal cancer as one of the most effective chemotherapeutic agents."7.85Oral Administration of Polaprezinc Attenuates Fluorouracil-induced Intestinal Mucositis in a Mouse Model. ( Li, M; Liang, X; Liu, Z; Teng, N; Wang, X; Xie, W; Yang, Z; Zhang, Z, 2017)
"5-Fluorouracil is one of the most commonly used anticancer drugs for the treatment of various types of cancer but has potential adverse effects such as intestinal mucositis, renal, hepatic, and reproductive organ toxicity."7.83Taurine ameliorates 5-flourouracil-induced intestinal mucositis, hepatorenal and reproductive organ damage in Wistar rats: A biochemical and histological study. ( Al-Asmari, AK; Al-Shahrani, HM; Al-Zahrani, AM; Ali Al Amri, M; Khan, AQ, 2016)
"Our results bring support to the hUP1 inhibitor strategy as a novel possibility of prevention and treatment of mucositis during the 5-FU chemotherapy, based on the approach of uridine accumulation in plasma and tissues."7.80Human uridine phosphorylase-1 inhibitors: a new approach to ameliorate 5-fluorouracil-induced intestinal mucositis. ( Basso, LA; Campos, MM; Lopes, TG; Machado, P; Petersen, GO; Renck, D; Santos, AA; Santos, DS, 2014)
"To evaluate gastrointestinal motility during 5-fluorouracil (5-FU)-induced intestinal mucositis."7.74Gastrointestinal dysmotility in 5-fluorouracil-induced intestinal mucositis outlasts inflammatory process resolution. ( Assreuy, AM; Brito, GA; Gomes, AS; Mota, JM; Oliveira, RB; Ribeiro, RA; Santos, AA; Soares, PM; Souza, MH, 2008)
"In 16 advanced colorectal cancer patients with 5-fluorouracil-associated diarrhea, we evaluated the role of bacterial pathogens in the development of this adverse effect."7.69Have enteric infections a role in 5-fluorouracil-associated diarrhea? ( Cascinu, S; Catalano, G, 1995)
"5-Fluorouracil (5-FU) is a front-line cytotoxic therapy."5.72Thymol ameliorates 5-fluorouracil-induced intestinal mucositis: Evidence of down-regulatory effect on TGF-β/MAPK pathways through NF-κB. ( Al-Amin, MA; Al-Khrashi, LA; Badr, AM; Mahran, YF, 2022)
"Intestinal mucositis is one of the major troublesome side effects of anticancer chemotherapy leading to poor patient compliance."5.38Apolipoprotein E COG 133 mimetic peptide improves 5-fluorouracil-induced intestinal mucositis. ( Araújo, CV; Azevedo, OG; Costa, TB; Guerrant, RL; Lima, AÂ; Lima, RC; Lucena, HB; Oliveira, BC; Oliveira, RA; Oriá, RB; Ribeiro, RA; Vitek, MP; Warren, CA; Wong, DV; Zaja-Milatovic, S, 2012)
"Gastrointestinal mucositis is a common side effect of cancer chemotherapy."5.37Role of platelet-activating factor in the pathogenesis of 5-fluorouracil-induced intestinal mucositis in mice. ( Brito, GA; Cunha, FQ; Justino, PF; Lima-Junior, RC; Mota, JM; Ribeiro, RA; Soares, PM; Souza, MH, 2011)
"Intestinal mucositis and diarrhea are common manifestations of anticancer regimens that include irinotecan, 5-fluorouracil (5-FU), and other cytotoxic drugs."4.93Irinotecan- and 5-fluorouracil-induced intestinal mucositis: insights into pathogenesis and therapeutic perspectives. ( Cunha, FQ; Leite, CA; Lima-Júnior, RC; Mota, JM; Ribeiro, RA; Souza, MH; Wanderley, CW; Wong, DV, 2016)
"This study aims to evaluate the effect of berberine-based carbon quantum dots (Ber-CDs) on improving 5-fluorouracil (5-FU)-induced intestinal mucositis in C57BL/6 mice, and explored the mechanisms behind this effect."4.31Berberine-Based Carbon Quantum Dots Improve Intestinal Barrier Injury and Alleviate Oxidative Stress in C57BL/6 Mice with 5-Fluorouracil-Induced Intestinal Mucositis by Enhancing Gut-Derived Short-Chain Fatty Acids Contents. ( He, J; Li, H; Sun, C; Tan, J; Wang, D; Wu, L; Xi, Y; Yan, M, 2023)
"FOLFOX (5-fluorouracil, leucovorin, and oxaliplatin), a 5-fluorouracil (5-FU)-based chemotherapy regimen, is one of most common therapeutic regimens for colorectal cancer."3.96Fecal Microbiota Transplantation Prevents Intestinal Injury, Upregulation of Toll-Like Receptors, and 5-Fluorouracil/Oxaliplatin-Induced Toxicity in Colorectal Cancer. ( Chang, CW; Chen, MJ; Chen, YJ; Chiang Chiau, JS; Chuang, WH; Lee, HC; Li, LH; Liu, CY; Shih, SC; Tsai, TH; Wang, HY; Wang, TE, 2020)
"The chemotherapeutic agent 5-fluorouracil (5-FU) causes intestinal mucositis with severe diarrhoea, but the pathogenesis is not fully understood."3.85Apoptosis, Dysbiosis and Expression of Inflammatory Cytokines are Sequential Events in the Development of 5-Fluorouracil-Induced Intestinal Mucositis in Mice. ( Amagase, K; Hamouda, N; Higuchi, K; Kato, S; Matsumoto, K; Oikawa, Y; Ozaki, T; Sano, T; Shimakawa, M, 2017)
" 5-Fluorouracil (5-FU), widely used for cancer chemotherapy, is known to frequently induce intestinal mucositis accompanied by severe diarrhoea."3.85Probiotic Bifidobacterium bifidum G9-1 attenuates 5-fluorouracil-induced intestinal mucositis in mice via suppression of dysbiosis-related secondary inflammatory responses. ( Amagase, K; Hamouda, N; Kano, Y; Kato, S; Matsumoto, K; Oikawa, Y; Shimakawa, M; Tanaka, Y, 2017)
"5-Fluorouracil (5-FU) has broadly been applied to treat colorectal cancer as one of the most effective chemotherapeutic agents."3.85Oral Administration of Polaprezinc Attenuates Fluorouracil-induced Intestinal Mucositis in a Mouse Model. ( Li, M; Liang, X; Liu, Z; Teng, N; Wang, X; Xie, W; Yang, Z; Zhang, Z, 2017)
"5-Fluorouracil is one of the most commonly used anticancer drugs for the treatment of various types of cancer but has potential adverse effects such as intestinal mucositis, renal, hepatic, and reproductive organ toxicity."3.83Taurine ameliorates 5-flourouracil-induced intestinal mucositis, hepatorenal and reproductive organ damage in Wistar rats: A biochemical and histological study. ( Al-Asmari, AK; Al-Shahrani, HM; Al-Zahrani, AM; Ali Al Amri, M; Khan, AQ, 2016)
"Our results bring support to the hUP1 inhibitor strategy as a novel possibility of prevention and treatment of mucositis during the 5-FU chemotherapy, based on the approach of uridine accumulation in plasma and tissues."3.80Human uridine phosphorylase-1 inhibitors: a new approach to ameliorate 5-fluorouracil-induced intestinal mucositis. ( Basso, LA; Campos, MM; Lopes, TG; Machado, P; Petersen, GO; Renck, D; Santos, AA; Santos, DS, 2014)
"Mice were injected with 5-fluorouracil (5-FU) or saline to induce mucositis and were then treated with GLP-1, GLP-2, GLP-2 (3-33), exendin (9-39) or vehicle."3.79Glucagon-like peptide-1 as a treatment for chemotherapy-induced mucositis. ( Hartmann, B; Holst, JJ; Kissow, H; Poulsen, SS, 2013)
"To evaluate gastrointestinal motility during 5-fluorouracil (5-FU)-induced intestinal mucositis."3.74Gastrointestinal dysmotility in 5-fluorouracil-induced intestinal mucositis outlasts inflammatory process resolution. ( Assreuy, AM; Brito, GA; Gomes, AS; Mota, JM; Oliveira, RB; Ribeiro, RA; Santos, AA; Soares, PM; Souza, MH, 2008)
"In 16 advanced colorectal cancer patients with 5-fluorouracil-associated diarrhea, we evaluated the role of bacterial pathogens in the development of this adverse effect."3.69Have enteric infections a role in 5-fluorouracil-associated diarrhea? ( Cascinu, S; Catalano, G, 1995)
"One of the major complications that patients experience during pharmacological treatment is the occurrence of adverse drug reactions (ADRs)."2.61Drug-induced gene expression profile changes in relation to intestinal toxicity: State-of-the-art and new approaches. ( de Kok, TM; Jennen, DGJ; Kleinjans, JCS; Lemmens, L; Rodrigues, D; Souza, T, 2019)
"5-Fluorouracil (5-FU) is a front-line cytotoxic therapy."1.72Thymol ameliorates 5-fluorouracil-induced intestinal mucositis: Evidence of down-regulatory effect on TGF-β/MAPK pathways through NF-κB. ( Al-Amin, MA; Al-Khrashi, LA; Badr, AM; Mahran, YF, 2022)
"Cancer chemotherapy is frequently accompanied by adverse effects, such as diarrhoea and leukopenia, which lead to malnutrition and a decrease in the patients' quality of life."1.51Nutritional treatment with an immune-modulating enteral formula alleviates 5-fluorouracil-induced adverse effects in rats. ( Ashida, K; Nakamura, K; Sasayama, A; Tonouchi, H; Yamaji, T, 2019)
"Altogether, 11 components were identified or tentatively characterized in dosed plasma."1.51The protective effects of Aquilariae Lignum Resinatum extract on 5-Fuorouracil-induced intestinal mucositis in mice. ( Gao, J; Gao, W; Jin, Z; Man, S; Zhang, J; Zheng, H, 2019)
"Intestinal mucositis is one of the major troublesome side effects of anticancer chemotherapy leading to poor patient compliance."1.38Apolipoprotein E COG 133 mimetic peptide improves 5-fluorouracil-induced intestinal mucositis. ( Araújo, CV; Azevedo, OG; Costa, TB; Guerrant, RL; Lima, AÂ; Lima, RC; Lucena, HB; Oliveira, BC; Oliveira, RA; Oriá, RB; Ribeiro, RA; Vitek, MP; Warren, CA; Wong, DV; Zaja-Milatovic, S, 2012)
"Gastrointestinal mucositis is a common side effect of cancer chemotherapy."1.37Role of platelet-activating factor in the pathogenesis of 5-fluorouracil-induced intestinal mucositis in mice. ( Brito, GA; Cunha, FQ; Justino, PF; Lima-Junior, RC; Mota, JM; Ribeiro, RA; Soares, PM; Souza, MH, 2011)
" These and control animals were sacrificed and, using inverted sacs, the rate of absorption of either dimethylnitrosamine and benzo(a)pyrene determined."1.26Use of inverted intestinal sacs to assess the effect of gastrointestinal insult on carcinogen absorption. ( Capel, ID; Cosier, RS; Pinnock, MH; Williams, DC, 1981)

Research

Studies (40)

TimeframeStudies, this research(%)All Research%
pre-19908 (20.00)18.7374
1990's5 (12.50)18.2507
2000's4 (10.00)29.6817
2010's17 (42.50)24.3611
2020's6 (15.00)2.80

Authors

AuthorsStudies
Al-Khrashi, LA1
Badr, AM1
Al-Amin, MA1
Mahran, YF1
Chen, KJ1
Huang, YL1
Kuo, LM1
Chen, YT1
Hung, CF1
Hsieh, PW1
Wu, L1
Xi, Y1
Yan, M1
Sun, C1
Tan, J1
He, J1
Li, H1
Wang, D1
Nakamura, K1
Tonouchi, H1
Sasayama, A1
Yamaji, T1
Ashida, K1
Chang, CW1
Lee, HC1
Li, LH1
Chiang Chiau, JS1
Wang, TE1
Chuang, WH1
Chen, MJ1
Wang, HY1
Shih, SC1
Liu, CY1
Tsai, TH1
Chen, YJ1
Hu, M1
Wu, X1
Luo, M1
Wei, H1
Xu, D1
Xu, F1
Fideles, LS1
de Miranda, JAL1
Martins, CDS1
Barbosa, MLL1
Pimenta, HB1
Pimentel, PVS1
Teixeira, CS1
Scafuri, MAS1
Façanha, SO1
Barreto, JEF1
Carvalho, PMM1
Scafuri, AG1
Araújo, JL1
Rocha, JA1
Vieira, IGP1
Ricardo, NMPS1
da Silva Campelo, M1
Ribeiro, MENP1
de Castro Brito, GA1
Cerqueira, GS1
Hamouda, N2
Sano, T1
Oikawa, Y2
Ozaki, T1
Shimakawa, M2
Matsumoto, K2
Amagase, K2
Higuchi, K1
Kato, S2
Kano, Y1
Tanaka, Y1
Liu, Z1
Xie, W1
Li, M1
Teng, N1
Liang, X1
Zhang, Z1
Yang, Z2
Wang, X1
de Freitas-Blanco, VS1
Monteiro, KM1
de Oliveira, PR1
de Oliveira, ECS1
de Oliveira Braga, LE1
de Carvalho, JE1
Ferreira Rodrigues, RA1
Zheng, H1
Gao, J1
Man, S1
Zhang, J1
Jin, Z1
Gao, W1
Rodrigues, D1
Souza, T1
Jennen, DGJ1
Lemmens, L1
Kleinjans, JCS1
de Kok, TM1
Renck, D1
Santos, AA2
Machado, P1
Petersen, GO1
Lopes, TG1
Santos, DS1
Campos, MM1
Basso, LA1
Al-Asmari, AK1
Al-Zahrani, AM1
Khan, AQ1
Al-Shahrani, HM1
Ali Al Amri, M1
Chen, D1
Zhao, J1
Wang, H1
An, N1
Zhou, Y1
Fan, J1
Luo, J1
Su, W1
Liu, C1
Li, J1
Yoshida, Y1
Kawabata, R1
Yoshikawa, M1
Kameda, C1
Koga, C1
Murakami, M1
Hitora, T1
Hirota, M1
Ikenaga, M1
Shimizu, J1
Miwa, H1
Hasegawa, J1
Asahara, T1
Takahashi, A1
Yuki, N1
Kaji, R1
Takahashi, T1
Nomoto, K1
Ribeiro, RA4
Wanderley, CW1
Wong, DV2
Mota, JM3
Leite, CA1
Souza, MH3
Cunha, FQ2
Lima-Júnior, RC2
Soares, PM2
Justino, PF1
Brito, GA2
Azevedo, OG1
Oliveira, RA1
Oliveira, BC1
Zaja-Milatovic, S1
Araújo, CV1
Costa, TB1
Lucena, HB1
Lima, RC1
Warren, CA1
Lima, AÂ1
Vitek, MP1
Guerrant, RL1
Oriá, RB1
Prisciandaro, LD1
Geier, MS1
Chua, AE1
Butler, RN1
Cummins, AG1
Sander, GR1
Howarth, GS1
Kissow, H1
Hartmann, B1
Holst, JJ1
Poulsen, SS1
BALLERINI, G1
BOSI, L1
CASTOLDI, GL1
RICCI, N1
NASH, DT1
BRIN, M1
Zlotnik, Y1
Patya, M1
Vanichkin, A1
Novogrodsky, A1
Gomes, AS1
Oliveira, RB1
Assreuy, AM1
Maisin, H1
Anckaert, MA1
De Coster, BM1
Capel, ID1
Cosier, RS1
Pinnock, MH1
Williams, DC1
Chevreau, N1
Wang, Y1
Funk-Archuleta, M1
Cascinu, S1
Catalano, G1
Orazi, A1
Du, X1
Kashai, M1
Williams, DA1
Rakovitch, E1
Fyles, AW1
Pintilie, M1
Leung, PM1
Lokich, J1
Huang, FS1
Kemp, CJ1
Williams, JL1
Erwin, CR1
Warner, BW1
Bounous, G2
Maestracci, D1
Jehad Feddah, M1
Vázquez Gallego, JM1
Gómez Bosque, O1
Nakamura, J1
Katayama, M1
Nishida, K1
Sasaki, H1
Gentile, JM1
Hugon, J1
Gear, EV1

Reviews

3 reviews available for fluorouracil and Intestinal Diseases

ArticleYear
Drug-induced gene expression profile changes in relation to intestinal toxicity: State-of-the-art and new approaches.
    Cancer treatment reviews, 2019, Volume: 77

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Fluorouracil; Humans; Intestinal Diseases; Protein Kinase I

2019
Irinotecan- and 5-fluorouracil-induced intestinal mucositis: insights into pathogenesis and therapeutic perspectives.
    Cancer chemotherapy and pharmacology, 2016, Volume: 78, Issue:5

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Camptothecin; Cytokines; Fluorou

2016
Dobbins WO 3d,+DOBBINS WO III: Rectal biopsy. A review of its diagnostic usefulness.
    Gastroenterology, 1968, Volume: 55, Issue:4

    Topics: Amyloidosis; Biopsy; Colitis, Ulcerative; Crohn Disease; Cystic Fibrosis; Cysts; Deficiency Diseases

1968

Other Studies

37 other studies available for fluorouracil and Intestinal Diseases

ArticleYear
Thymol ameliorates 5-fluorouracil-induced intestinal mucositis: Evidence of down-regulatory effect on TGF-β/MAPK pathways through NF-κB.
    Journal of biochemical and molecular toxicology, 2022, Volume: 36, Issue:1

    Topics: Animals; Chymases; Fluorouracil; Intestinal Diseases; MAP Kinase Signaling System; Mucositis; NF-kap

2022
Protective role of casuarinin from Melastoma malabathricum against a mouse model of 5-fluorouracil-induced intestinal mucositis: Impact on inflammation and gut microbiota dysbiosis.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2022, Volume: 101

    Topics: Animals; Disease Models, Animal; Dysbiosis; Fluorouracil; Gastrointestinal Diseases; Gastrointestina

2022
Berberine-Based Carbon Quantum Dots Improve Intestinal Barrier Injury and Alleviate Oxidative Stress in C57BL/6 Mice with 5-Fluorouracil-Induced Intestinal Mucositis by Enhancing Gut-Derived Short-Chain Fatty Acids Contents.
    Molecules (Basel, Switzerland), 2023, Feb-24, Volume: 28, Issue:5

    Topics: Animals; Berberine; Fatty Acids, Volatile; Fluorouracil; Intestinal Diseases; Intestinal Mucosa; Mic

2023
Nutritional treatment with an immune-modulating enteral formula alleviates 5-fluorouracil-induced adverse effects in rats.
    PloS one, 2019, Volume: 14, Issue:11

    Topics: Animals; Body Weight; Cultured Milk Products; Dietary Supplements; Disease Models, Animal; Eating; E

2019
Fecal Microbiota Transplantation Prevents Intestinal Injury, Upregulation of Toll-Like Receptors, and 5-Fluorouracil/Oxaliplatin-Induced Toxicity in Colorectal Cancer.
    International journal of molecular sciences, 2020, Jan-08, Volume: 21, Issue:2

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Colorectal Neo

2020
Lactobacillus rhamnosus FLRH93 protects against intestinal damage in mice induced by 5-fluorouracil.
    Journal of dairy science, 2020, Volume: 103, Issue:6

    Topics: Animals; Disease Models, Animal; Female; Fluorouracil; Ileum; Interleukin-1beta; Intestinal Diseases

2020
Role of Rutin in 5-Fluorouracil-Induced Intestinal Mucositis: Prevention of Histological Damage and Reduction of Inflammation and Oxidative Stress.
    Molecules (Basel, Switzerland), 2020, Jun-17, Volume: 25, Issue:12

    Topics: Animals; Fluorouracil; Inflammation; Intestinal Diseases; Male; Mice; Mucositis; Oxidative Stress; R

2020
Apoptosis, Dysbiosis and Expression of Inflammatory Cytokines are Sequential Events in the Development of 5-Fluorouracil-Induced Intestinal Mucositis in Mice.
    Basic & clinical pharmacology & toxicology, 2017, Volume: 121, Issue:3

    Topics: Animals; Anti-Bacterial Agents; Antimetabolites, Antineoplastic; Apoptosis; Cell Proliferation; Cyto

2017
Probiotic Bifidobacterium bifidum G9-1 attenuates 5-fluorouracil-induced intestinal mucositis in mice via suppression of dysbiosis-related secondary inflammatory responses.
    Clinical and experimental pharmacology & physiology, 2017, Volume: 44, Issue:10

    Topics: Animals; Apoptosis; Bifidobacterium bifidum; Body Weight; Diarrhea; Dysbiosis; Fluorouracil; Inflamm

2017
Oral Administration of Polaprezinc Attenuates Fluorouracil-induced Intestinal Mucositis in a Mouse Model.
    Basic & clinical pharmacology & toxicology, 2017, Volume: 121, Issue:6

    Topics: Animals; Anti-Ulcer Agents; Antimetabolites, Antineoplastic; Carnosine; Cell Proliferation; Colorect

2017
Spilanthol, the Principal Alkylamide from Acmella oleracea, Attenuates 5-Fluorouracil-Induced Intestinal Mucositis in Mice.
    Planta medica, 2019, Volume: 85, Issue:3

    Topics: Animals; Asteraceae; Fluorouracil; Intestinal Diseases; Jejunum; Male; Mice; Mucositis; Polyunsatura

2019
The protective effects of Aquilariae Lignum Resinatum extract on 5-Fuorouracil-induced intestinal mucositis in mice.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2019, Feb-15, Volume: 54

    Topics: Animals; Antimetabolites, Antineoplastic; Diarrhea; Fluorouracil; Intestinal Diseases; Male; Medicin

2019
Human uridine phosphorylase-1 inhibitors: a new approach to ameliorate 5-fluorouracil-induced intestinal mucositis.
    Investigational new drugs, 2014, Volume: 32, Issue:6

    Topics: Animals; Antimetabolites, Antineoplastic; Enzyme Inhibitors; Female; Fluorouracil; Humans; Intestina

2014
Taurine ameliorates 5-flourouracil-induced intestinal mucositis, hepatorenal and reproductive organ damage in Wistar rats: A biochemical and histological study.
    Human & experimental toxicology, 2016, Volume: 35, Issue:1

    Topics: Animals; Dose-Response Relationship, Drug; Fluorouracil; Intestinal Diseases; Intestines; Kidney; Li

2016
Oxytocin evokes a pulsatile PGE2 release from ileum mucosa and is required for repair of intestinal epithelium after injury.
    Scientific reports, 2015, Jul-10, Volume: 5

    Topics: Animals; Antineoplastic Agents; Calcium; Cyclooxygenase 2; Dextran Sulfate; Dinoprostone; Disease Mo

2015
[A Case of Penetrating Diverticulum of the Small Intestine that Occurred during Chemotherapy for Esophageal Cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2015, Volume: 42, Issue:12

    Topics: Abdominal Abscess; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Biopsy; Carcin

2015
Protective Effect of a Synbiotic against Multidrug-Resistant Acinetobacter baumannii in a Murine Infection Model.
    Antimicrobial agents and chemotherapy, 2016, Volume: 60, Issue:5

    Topics: Acinetobacter baumannii; Acinetobacter Infections; Animals; Anti-Bacterial Agents; Bifidobacterium;

2016
Role of platelet-activating factor in the pathogenesis of 5-fluorouracil-induced intestinal mucositis in mice.
    Cancer chemotherapy and pharmacology, 2011, Volume: 68, Issue:3

    Topics: Animals; Antimetabolites, Antineoplastic; Cytokines; Duodenum; Fluorouracil; Ginkgolides; Intestinal

2011
Apolipoprotein E COG 133 mimetic peptide improves 5-fluorouracil-induced intestinal mucositis.
    BMC gastroenterology, 2012, Jul-13, Volume: 12

    Topics: Animals; Apolipoproteins E; Apoptosis; Biomimetic Materials; Cell Movement; Cell Proliferation; Cell

2012
Probiotic factors partially prevent changes to caspases 3 and 7 activation and transepithelial electrical resistance in a model of 5-fluorouracil-induced epithelial cell damage.
    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2012, Volume: 20, Issue:12

    Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Caspase 3; Caspase 7; Cells, Cultured; Electric

2012
Glucagon-like peptide-1 as a treatment for chemotherapy-induced mucositis.
    Gut, 2013, Volume: 62, Issue:12

    Topics: Animals; Antimetabolites, Antineoplastic; Female; Fluorouracil; Glucagon-Like Peptide 1; Glucagon-Li

2013
[Experimental enteropathy induced by 5-fluorouracil in the rat].
    Bollettino della Societa italiana di biologia sperimentale, 1961, Jun-30, Volume: 37

    Topics: Animals; Disease; Fluorouracil; Intestinal Diseases; Intestine, Small; Intestines; Rats; Uracil

1961
MALABSORPTION IN MALIGNANT CARCINOID WITH NORMAL 5 HIAA.
    New York state journal of medicine, 1964, May-01, Volume: 64

    Topics: Blood Chemical Analysis; Celiac Disease; Fluorouracil; Hydroxyindoleacetic Acid; Indoleacetic Acids;

1964
Tyrphostins reduce chemotherapy-induced intestinal injury in mice: assessment by a biochemical assay.
    British journal of cancer, 2005, Jan-31, Volume: 92, Issue:2

    Topics: Animals; Antineoplastic Agents; Cisplatin; Female; Fluorouracil; gamma-Glutamyltransferase; Intestin

2005
Gastrointestinal dysmotility in 5-fluorouracil-induced intestinal mucositis outlasts inflammatory process resolution.
    Cancer chemotherapy and pharmacology, 2008, Volume: 63, Issue:1

    Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Carbachol; Fluorouracil; Gastric Emptying; Gast

2008
[Combination chemotherapy and radiotherapy. Differential effect, on the intestinal syndrome, of fractionated irradiation with fractionated drug administration].
    Comptes rendus des seances de la Societe de biologie et de ses filiales, 1982, Volume: 176, Issue:1

    Topics: Animals; Disease Models, Animal; Drug Administration Schedule; Female; Fluorouracil; Intestinal Dise

1982
Use of inverted intestinal sacs to assess the effect of gastrointestinal insult on carcinogen absorption.
    Oncology, 1981, Volume: 38, Issue:4

    Topics: Animals; Aspirin; Benzopyrenes; Carcinogens; Cold Temperature; Dimethylnitrosamine; Dose-Response Re

1981
Effect of diets on 5-fluorouracil and cyclophosphamide toxicity.
    Nutrition and cancer, 1995, Volume: 23, Issue:2

    Topics: Animals; Caseins; Cyclophosphamide; Dietary Proteins; Fluorouracil; Intestinal Diseases; Intestines;

1995
Have enteric infections a role in 5-fluorouracil-associated diarrhea?
    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 1995, Volume: 3, Issue:5

    Topics: Adult; Aged; Antimetabolites, Antineoplastic; Bacterial Infections; Colorectal Neoplasms; Diarrhea;

1995
Interleukin-11 prevents apoptosis and accelerates recovery of small intestinal mucosa in mice treated with combined chemotherapy and radiation.
    Laboratory investigation; a journal of technical methods and pathology, 1996, Volume: 75, Issue:1

    Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Cell Division; Cytoplasm; Fluorouracil; Interle

1996
Role of mitomycin C in the development of late bowel toxicity following chemoradiation for locally advanced carcinoma of the cervix.
    International journal of radiation oncology, biology, physics, 1997, Jul-15, Volume: 38, Issue:5

    Topics: Adenocarcinoma; Adenocarcinoma, Clear Cell; Adult; Aged; Aged, 80 and over; Antibiotics, Antineoplas

1997
5-fluorouracil-induced small bowel toxicity in patients with colorectal carcinoma.
    Cancer, 2000, May-15, Volume: 88, Issue:10

    Topics: Antimetabolites, Antineoplastic; Colorectal Neoplasms; Diarrhea; Fluorouracil; Humans; Intestinal Di

2000
Role of epidermal growth factor and its receptor in chemotherapy-induced intestinal injury.
    American journal of physiology. Gastrointestinal and liver physiology, 2002, Volume: 282, Issue:3

    Topics: Animals; Antineoplastic Agents; Enteritis; Epidermal Growth Factor; ErbB Receptors; Fluorouracil; Ge

2002
Use of an elemental diet in animals during treatment with 5-fluorouracil (NSC-19893).
    Cancer treatment reports, 1976, Volume: 60, Issue:1

    Topics: Animals; Caseins; Diet; Drug Tolerance; Fluorouracil; gamma-Glutamyltransferase; Hydrolysis; Intesti

1976
[Morphological changes induced by 5-fluorouracil in the intestinal mucosa. I. Observations with the optical microscope].
    Revista espanola de las enfermedades del aparato digestivo, 1978, May-15, Volume: 53, Issue:4

    Topics: Animals; Fluorouracil; Intestinal Diseases; Intestinal Mucosa; Male; Rats

1978
An assessment of mucosal damage in vivo: effect of oral pretreatment with 5-fluorouracil on the intestinal first-pass metabolism of salicylamide in rabbits.
    Chemical & pharmaceutical bulletin, 1992, Volume: 40, Issue:4

    Topics: Administration, Oral; Animals; Fluorouracil; Intestinal Diseases; Intestinal Mucosa; Male; Rabbits;

1992
Elemental diet in the management of the intestinal lesion produced by 5-fluorouracil in man.
    Canadian journal of surgery. Journal canadien de chirurgie, 1971, Volume: 14, Issue:5

    Topics: Aged; Amino Acids; Animals; Biopsy; Diarrhea; Diet Therapy; Dietary Proteins; Female; Fluorouracil;

1971