fluorouracil has been researched along with Intellectual Disability in 1 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Intellectual Disability: Subnormal intellectual functioning which originates during the developmental period. This has multiple potential etiologies, including genetic defects and perinatal insults. Intelligence quotient (IQ) scores are commonly used to determine whether an individual has an intellectual disability. IQ scores between 70 and 79 are in the borderline range. Scores below 67 are in the disabled range. (from Joynt, Clinical Neurology, 1992, Ch55, p28)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| van Kuilenburg, AB | 1 |
| Dobritzsch, D | 1 |
| Meinsma, R | 1 |
| Haasjes, J | 1 |
| Waterham, HR | 1 |
| Nowaczyk, MJ | 1 |
| Maropoulos, GD | 1 |
| Hein, G | 1 |
| Kalhoff, H | 1 |
| Kirk, JM | 1 |
| Baaske, H | 1 |
| Aukett, A | 1 |
| Duley, JA | 1 |
| Ward, KP | 1 |
| Lindqvist, Y | 1 |
| van Gennip, AH | 1 |
1 other study available for fluorouracil and Intellectual Disability
| Article | Year |
|---|---|
Novel disease-causing mutations in the dihydropyrimidine dehydrogenase gene interpreted by analysis of the three-dimensional protein structure.
Topics: Age of Onset; Amino Acids; Animals; Cells, Cultured; Child, Preschool; Crystallography, X-Ray; Dihyd | 2002 |