Page last updated: 2024-10-27

fluorouracil and Inflammatory Bowel Diseases

fluorouracil has been researched along with Inflammatory Bowel Diseases in 8 studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Inflammatory Bowel Diseases: Chronic, non-specific inflammation of the GASTROINTESTINAL TRACT. Etiology may be genetic or environmental. This term includes CROHN DISEASE and ULCERATIVE COLITIS.

Research Excerpts

ExcerptRelevanceReference
"5-FU-induced mucositis affects 80% of patients undergoing oncological treatment causing mucosal gut dysfunctions and great discomfort."1.46Secretion of biologically active pancreatitis-associated protein I (PAP) by genetically modified dairy Lactococcus lactis NZ9000 in the prevention of intestinal mucositis. ( Azevedo, V; Bermúdez-Humarán, LG; Breyner, N; Carmona, D; Carvalho, RD; Chatel, JM; da Gloria Souza, D; de Azevedo, MS; de Faria, AM; Figueiredo, HC; Langella, P; Lemos, L; Maioli, TU; Menezes-Garcia, Z; Rodrigues, NM, 2017)
"Oral mucositis was induced in male Golden Syrian hamsters with 5-fluorouracil 60 mg/kg intraperitoneal, days 0 and 2."1.29IL-11, a pleiotropic cytokine: exciting new effects of IL-11 on gastrointestinal mucosal biology. ( Albert, L; Keith, JC; Pfeiffer, CJ; Schaub, RG; Sonis, ST, 1994)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's5 (62.50)18.2507
2000's0 (0.00)29.6817
2010's3 (37.50)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Zheng, JH1
Lin, SR1
Tseng, FJ1
Tsai, MJ1
Lue, SI1
Chia, YC1
Woon, M1
Fu, YS1
Weng, CF1
Carvalho, RD1
Breyner, N1
Menezes-Garcia, Z1
Rodrigues, NM1
Lemos, L1
Maioli, TU1
da Gloria Souza, D1
Carmona, D1
de Faria, AM1
Langella, P1
Chatel, JM1
Bermúdez-Humarán, LG1
Figueiredo, HC1
Azevedo, V1
de Azevedo, MS1
Dhawan, P1
Ahmad, R1
Chaturvedi, R1
Smith, JJ1
Midha, R1
Mittal, MK1
Krishnan, M1
Chen, X1
Eschrich, S1
Yeatman, TJ1
Harris, RC1
Washington, MK1
Wilson, KT1
Beauchamp, RD1
Singh, AB1
Keith, JC1
Albert, L1
Sonis, ST1
Pfeiffer, CJ1
Schaub, RG1
Lee, FD1
Atkins, CD1
Tiersten, A1
Saltz, LB1
Johnson, MR1
Hageboutros, A1
Wang, K1
High, L1
Smith, JB1
Diasio, RB1

Other Studies

8 other studies available for fluorouracil and Inflammatory Bowel Diseases

ArticleYear
Clerodane Diterpene Ameliorates Inflammatory Bowel Disease and Potentiates Cell Apoptosis of Colorectal Cancer.
    Biomolecules, 2019, 11-21, Volume: 9, Issue:12

    Topics: Animals; Apoptosis; Azoxymethane; Biomarkers, Tumor; Caco-2 Cells; Cell Cycle; Cell Proliferation; C

2019
Secretion of biologically active pancreatitis-associated protein I (PAP) by genetically modified dairy Lactococcus lactis NZ9000 in the prevention of intestinal mucositis.
    Microbial cell factories, 2017, Feb-13, Volume: 16, Issue:1

    Topics: Animals; Antibiosis; Antigens, Neoplasm; Biomarkers, Tumor; Disease Models, Animal; Enterococcus fae

2017
Claudin-2 expression increases tumorigenicity of colon cancer cells: role of epidermal growth factor receptor activation.
    Oncogene, 2011, Jul-21, Volume: 30, Issue:29

    Topics: Animals; Caco-2 Cells; Cell Division; Claudins; Colonic Neoplasms; Epidermal Growth Factor; ErbB Rec

2011
IL-11, a pleiotropic cytokine: exciting new effects of IL-11 on gastrointestinal mucosal biology.
    Stem cells (Dayton, Ohio), 1994, Volume: 12 Suppl 1

    Topics: Acetates; Acetic Acid; Animals; Animals, Genetically Modified; beta 2-Microglobulin; Colitis; Cricet

1994
Importance of apoptosis in the histopathology of drug related lesions in the large intestine.
    Journal of clinical pathology, 1993, Volume: 46, Issue:2

    Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Cell Count; Colitis; Colon; Female;

1993
Inflammatory bowel disease associated with levamisole and fluorouracil chemotherapy for colon cancer.
    Journal of the National Cancer Institute, 1996, Mar-06, Volume: 88, Issue:5

    Topics: Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Fluorouracil; Humans; Inflammator

1996
Influence of inflammatory bowel disease on the ability of patients to tolerate systemic fluorouracil-based chemotherapy.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1996, Volume: 14, Issue:7

    Topics: Adult; Aged; Antimetabolites, Antineoplastic; Diarrhea; Female; Fluorouracil; Gastrointestinal Neopl

1996
Life-threatening toxicity in a dihydropyrimidine dehydrogenase-deficient patient after treatment with topical 5-fluorouracil.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1999, Volume: 5, Issue:8

    Topics: Aged; Antimetabolites, Antineoplastic; Blotting, Western; Carcinoma, Basal Cell; Diarrhea; Dihydrour

1999