fluorouracil has been researched along with Inflammatory Bowel Diseases in 8 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Inflammatory Bowel Diseases: Chronic, non-specific inflammation of the GASTROINTESTINAL TRACT. Etiology may be genetic or environmental. This term includes CROHN DISEASE and ULCERATIVE COLITIS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "5-FU-induced mucositis affects 80% of patients undergoing oncological treatment causing mucosal gut dysfunctions and great discomfort." | 1.46 | Secretion of biologically active pancreatitis-associated protein I (PAP) by genetically modified dairy Lactococcus lactis NZ9000 in the prevention of intestinal mucositis. ( Azevedo, V; Bermúdez-Humarán, LG; Breyner, N; Carmona, D; Carvalho, RD; Chatel, JM; da Gloria Souza, D; de Azevedo, MS; de Faria, AM; Figueiredo, HC; Langella, P; Lemos, L; Maioli, TU; Menezes-Garcia, Z; Rodrigues, NM, 2017) |
| "Oral mucositis was induced in male Golden Syrian hamsters with 5-fluorouracil 60 mg/kg intraperitoneal, days 0 and 2." | 1.29 | IL-11, a pleiotropic cytokine: exciting new effects of IL-11 on gastrointestinal mucosal biology. ( Albert, L; Keith, JC; Pfeiffer, CJ; Schaub, RG; Sonis, ST, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (62.50) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (37.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zheng, JH | 1 |
| Lin, SR | 1 |
| Tseng, FJ | 1 |
| Tsai, MJ | 1 |
| Lue, SI | 1 |
| Chia, YC | 1 |
| Woon, M | 1 |
| Fu, YS | 1 |
| Weng, CF | 1 |
| Carvalho, RD | 1 |
| Breyner, N | 1 |
| Menezes-Garcia, Z | 1 |
| Rodrigues, NM | 1 |
| Lemos, L | 1 |
| Maioli, TU | 1 |
| da Gloria Souza, D | 1 |
| Carmona, D | 1 |
| de Faria, AM | 1 |
| Langella, P | 1 |
| Chatel, JM | 1 |
| Bermúdez-Humarán, LG | 1 |
| Figueiredo, HC | 1 |
| Azevedo, V | 1 |
| de Azevedo, MS | 1 |
| Dhawan, P | 1 |
| Ahmad, R | 1 |
| Chaturvedi, R | 1 |
| Smith, JJ | 1 |
| Midha, R | 1 |
| Mittal, MK | 1 |
| Krishnan, M | 1 |
| Chen, X | 1 |
| Eschrich, S | 1 |
| Yeatman, TJ | 1 |
| Harris, RC | 1 |
| Washington, MK | 1 |
| Wilson, KT | 1 |
| Beauchamp, RD | 1 |
| Singh, AB | 1 |
| Keith, JC | 1 |
| Albert, L | 1 |
| Sonis, ST | 1 |
| Pfeiffer, CJ | 1 |
| Schaub, RG | 1 |
| Lee, FD | 1 |
| Atkins, CD | 1 |
| Tiersten, A | 1 |
| Saltz, LB | 1 |
| Johnson, MR | 1 |
| Hageboutros, A | 1 |
| Wang, K | 1 |
| High, L | 1 |
| Smith, JB | 1 |
| Diasio, RB | 1 |
8 other studies available for fluorouracil and Inflammatory Bowel Diseases
| Article | Year |
|---|---|
Clerodane Diterpene Ameliorates Inflammatory Bowel Disease and Potentiates Cell Apoptosis of Colorectal Cancer.
Topics: Animals; Apoptosis; Azoxymethane; Biomarkers, Tumor; Caco-2 Cells; Cell Cycle; Cell Proliferation; C | 2019 |
Secretion of biologically active pancreatitis-associated protein I (PAP) by genetically modified dairy Lactococcus lactis NZ9000 in the prevention of intestinal mucositis.
Topics: Animals; Antibiosis; Antigens, Neoplasm; Biomarkers, Tumor; Disease Models, Animal; Enterococcus fae | 2017 |
Claudin-2 expression increases tumorigenicity of colon cancer cells: role of epidermal growth factor receptor activation.
Topics: Animals; Caco-2 Cells; Cell Division; Claudins; Colonic Neoplasms; Epidermal Growth Factor; ErbB Rec | 2011 |
IL-11, a pleiotropic cytokine: exciting new effects of IL-11 on gastrointestinal mucosal biology.
Topics: Acetates; Acetic Acid; Animals; Animals, Genetically Modified; beta 2-Microglobulin; Colitis; Cricet | 1994 |
Importance of apoptosis in the histopathology of drug related lesions in the large intestine.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Cell Count; Colitis; Colon; Female; | 1993 |
Inflammatory bowel disease associated with levamisole and fluorouracil chemotherapy for colon cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Fluorouracil; Humans; Inflammator | 1996 |
Influence of inflammatory bowel disease on the ability of patients to tolerate systemic fluorouracil-based chemotherapy.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Diarrhea; Female; Fluorouracil; Gastrointestinal Neopl | 1996 |
Life-threatening toxicity in a dihydropyrimidine dehydrogenase-deficient patient after treatment with topical 5-fluorouracil.
Topics: Aged; Antimetabolites, Antineoplastic; Blotting, Western; Carcinoma, Basal Cell; Diarrhea; Dihydrour | 1999 |