fluorouracil has been researched along with Infertility, Male in 1 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Infertility, Male: The inability of the male to effect FERTILIZATION of an OVUM after a specified period of unprotected intercourse. Male sterility is permanent infertility.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Rectal cancer is a common malignant disease and occurs not infrequently in younger men." | 1.32 | [Male gonadal dose in adjuvant 3-d-pelvic irradiation after anterior resection of rectal cancer. Influence to fertility]. ( Hensley, F; Piroth, MD; Wannenmacher, M; Zierhut, D, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Piroth, MD | 1 |
| Hensley, F | 1 |
| Wannenmacher, M | 1 |
| Zierhut, D | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Semen Analysis Following Definitive Treatment of Prostate Cancer With Proton Radiation Therapy Alone[NCT01072513] | 31 participants (Actual) | Interventional | 2010-03-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 other study available for fluorouracil and Infertility, Male
| Article | Year |
|---|---|
[Male gonadal dose in adjuvant 3-d-pelvic irradiation after anterior resection of rectal cancer. Influence to fertility].
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Combined Modality Therapy; Dose Fractionation, Radiati | 2003 |