fluorouracil has been researched along with Infertility, Female in 5 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Infertility, Female: Diminished or absent ability of a female to achieve conception.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Premenopausal patients with breast cancer are at high risk of premature ovarian failure induced by systemic treatments, but no standard strategies for preventing this adverse effect are yet available." | 2.76 | Effect of the gonadotropin-releasing hormone analogue triptorelin on the occurrence of chemotherapy-induced early menopause in premenopausal women with breast cancer: a randomized trial. ( Bighin, C; Boni, L; Cresti, N; Del Mastro, L; Gamucci, T; Garrone, O; Giordano, M; Giraudi, S; Gori, S; Levaggi, A; Magnolfi, E; Michelotti, A; Olmeo, N; Pronzato, P; Scotto, T; Vecchio, C; Venturini, M, 2011) |
| "There were 64 women with Stage II breast carcinoma and 36 women with UICC Stage III breast carcinoma." | 2.72 | Gonadotropin-releasing hormone analogues added to adjuvant chemotherapy protect ovarian function and improve clinical outcomes in young women with early breast carcinoma. ( Amiconi, G; Candeloro, G; Cesta, A; Di Blasio, A; Rea, S; Recchia, F; Saggio, G, 2006) |
| "Up to 6% of women with colorectal cancer are diagnosed in the reproductive age and are at risk for premature ovarian failure and infertility due to pelvic irradiation and chemotherapy." | 1.35 | Fertility preservation for young women with rectal cancer--a combined approach from one referral center. ( Elizur, SE; Huang, JY; Levin, D; Meterissian, S; Tan, SL; Tulandi, T, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (60.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Milgrom, SA | 1 |
| Vargas, HA | 1 |
| Sala, E | 1 |
| Kelvin, JF | 1 |
| Hricak, H | 1 |
| Goodman, KA | 1 |
| Elizur, SE | 1 |
| Tulandi, T | 1 |
| Meterissian, S | 1 |
| Huang, JY | 1 |
| Levin, D | 1 |
| Tan, SL | 1 |
| Del Mastro, L | 1 |
| Boni, L | 1 |
| Michelotti, A | 1 |
| Gamucci, T | 1 |
| Olmeo, N | 1 |
| Gori, S | 1 |
| Giordano, M | 1 |
| Garrone, O | 1 |
| Pronzato, P | 1 |
| Bighin, C | 1 |
| Levaggi, A | 1 |
| Giraudi, S | 1 |
| Cresti, N | 1 |
| Magnolfi, E | 1 |
| Scotto, T | 1 |
| Vecchio, C | 1 |
| Venturini, M | 1 |
| Markaki, M | 1 |
| Craig, RK | 1 |
| Savakis, C | 1 |
| Recchia, F | 1 |
| Saggio, G | 1 |
| Amiconi, G | 1 |
| Di Blasio, A | 1 |
| Cesta, A | 1 |
| Candeloro, G | 1 |
| Rea, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Prevention of Chemotherapy-induced Menopause by Temporary Ovarian Suppression With Triptorelin Vs. Control in Young Breast Cancer Patients. A Randomized Phase III Multicenter Study [PROMISE][NCT00311636] | Phase 3 | 280 participants (Anticipated) | Interventional | 2003-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for fluorouracil and Infertility, Female
| Article | Year |
|---|---|
Effect of the gonadotropin-releasing hormone analogue triptorelin on the occurrence of chemotherapy-induced early menopause in premenopausal women with breast cancer: a randomized trial.
Topics: Adult; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy | 2011 |
Gonadotropin-releasing hormone analogues added to adjuvant chemotherapy protect ovarian function and improve clinical outcomes in young women with early breast carcinoma.
Topics: Adult; Age of Onset; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carcinoma; Ch | 2006 |
3 other studies available for fluorouracil and Infertility, Female
| Article | Year |
|---|---|
Acute effects of pelvic irradiation on the adult uterus revealed by dynamic contrast-enhanced MRI.
Topics: Adult; Antimetabolites, Antineoplastic; Chemoradiotherapy; Contrast Media; Endometrium; Female; Fluo | 2013 |
Fertility preservation for young women with rectal cancer--a combined approach from one referral center.
Topics: Adult; Antimetabolites, Antineoplastic; Cryopreservation; Female; Fluorouracil; Humans; Infertility, | 2009 |
Insect population control using female specific pro-drug activation.
Topics: Animals; Animals, Genetically Modified; Cytosine Deaminase; DNA Transposable Elements; Drosophila me | 2004 |