Page last updated: 2024-10-27

fluorouracil and Infertility, Female

fluorouracil has been researched along with Infertility, Female in 5 studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Infertility, Female: Diminished or absent ability of a female to achieve conception.

Research Excerpts

ExcerptRelevanceReference
"Premenopausal patients with breast cancer are at high risk of premature ovarian failure induced by systemic treatments, but no standard strategies for preventing this adverse effect are yet available."2.76Effect of the gonadotropin-releasing hormone analogue triptorelin on the occurrence of chemotherapy-induced early menopause in premenopausal women with breast cancer: a randomized trial. ( Bighin, C; Boni, L; Cresti, N; Del Mastro, L; Gamucci, T; Garrone, O; Giordano, M; Giraudi, S; Gori, S; Levaggi, A; Magnolfi, E; Michelotti, A; Olmeo, N; Pronzato, P; Scotto, T; Vecchio, C; Venturini, M, 2011)
"There were 64 women with Stage II breast carcinoma and 36 women with UICC Stage III breast carcinoma."2.72Gonadotropin-releasing hormone analogues added to adjuvant chemotherapy protect ovarian function and improve clinical outcomes in young women with early breast carcinoma. ( Amiconi, G; Candeloro, G; Cesta, A; Di Blasio, A; Rea, S; Recchia, F; Saggio, G, 2006)
"Up to 6% of women with colorectal cancer are diagnosed in the reproductive age and are at risk for premature ovarian failure and infertility due to pelvic irradiation and chemotherapy."1.35Fertility preservation for young women with rectal cancer--a combined approach from one referral center. ( Elizur, SE; Huang, JY; Levin, D; Meterissian, S; Tan, SL; Tulandi, T, 2009)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (60.00)29.6817
2010's2 (40.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Milgrom, SA1
Vargas, HA1
Sala, E1
Kelvin, JF1
Hricak, H1
Goodman, KA1
Elizur, SE1
Tulandi, T1
Meterissian, S1
Huang, JY1
Levin, D1
Tan, SL1
Del Mastro, L1
Boni, L1
Michelotti, A1
Gamucci, T1
Olmeo, N1
Gori, S1
Giordano, M1
Garrone, O1
Pronzato, P1
Bighin, C1
Levaggi, A1
Giraudi, S1
Cresti, N1
Magnolfi, E1
Scotto, T1
Vecchio, C1
Venturini, M1
Markaki, M1
Craig, RK1
Savakis, C1
Recchia, F1
Saggio, G1
Amiconi, G1
Di Blasio, A1
Cesta, A1
Candeloro, G1
Rea, S1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Prevention of Chemotherapy-induced Menopause by Temporary Ovarian Suppression With Triptorelin Vs. Control in Young Breast Cancer Patients. A Randomized Phase III Multicenter Study [PROMISE][NCT00311636]Phase 3280 participants (Anticipated)Interventional2003-09-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

2 trials available for fluorouracil and Infertility, Female

ArticleYear
Effect of the gonadotropin-releasing hormone analogue triptorelin on the occurrence of chemotherapy-induced early menopause in premenopausal women with breast cancer: a randomized trial.
    JAMA, 2011, Jul-20, Volume: 306, Issue:3

    Topics: Adult; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy

2011
Gonadotropin-releasing hormone analogues added to adjuvant chemotherapy protect ovarian function and improve clinical outcomes in young women with early breast carcinoma.
    Cancer, 2006, Feb-01, Volume: 106, Issue:3

    Topics: Adult; Age of Onset; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carcinoma; Ch

2006

Other Studies

3 other studies available for fluorouracil and Infertility, Female

ArticleYear
Acute effects of pelvic irradiation on the adult uterus revealed by dynamic contrast-enhanced MRI.
    The British journal of radiology, 2013, Volume: 86, Issue:1031

    Topics: Adult; Antimetabolites, Antineoplastic; Chemoradiotherapy; Contrast Media; Endometrium; Female; Fluo

2013
Fertility preservation for young women with rectal cancer--a combined approach from one referral center.
    Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2009, Volume: 13, Issue:6

    Topics: Adult; Antimetabolites, Antineoplastic; Cryopreservation; Female; Fluorouracil; Humans; Infertility,

2009
Insect population control using female specific pro-drug activation.
    Insect biochemistry and molecular biology, 2004, Volume: 34, Issue:2

    Topics: Animals; Animals, Genetically Modified; Cytosine Deaminase; DNA Transposable Elements; Drosophila me

2004