fluorouracil has been researched along with Infections, Staphylococcal in 11 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (54.55) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (18.18) | 29.6817 |
| 2010's | 1 (9.09) | 24.3611 |
| 2020's | 2 (18.18) | 2.80 |
| Authors | Studies |
|---|---|
| Sedlmayer, F | 1 |
| Woischnig, AK | 1 |
| Unterreiner, V | 1 |
| Fuchs, F | 1 |
| Baeschlin, D | 1 |
| Khanna, N | 1 |
| Fussenegger, M | 1 |
| McLeod, JR | 1 |
| Harvey, PA | 1 |
| Detweiler, CS | 1 |
| Nakahara, S | 1 |
| Kitamura, K | 1 |
| Honma, K | 1 |
| Yamamoto, Y | 1 |
| Takenaka, Y | 1 |
| Yasui, T | 1 |
| Hanamoto, A | 1 |
| Morii, E | 1 |
| Inohara, H | 1 |
| ROGERS, HJ | 1 |
| PERKINS, HR | 1 |
| DEREPENTIGNY, J | 1 |
| SONEA, S | 1 |
| FRAPPIER, A | 1 |
| HIGNETT, RC | 2 |
| Alexandre, J | 1 |
| Nicco, C | 1 |
| Chéreau, C | 1 |
| Laurent, A | 1 |
| Weill, B | 1 |
| Goldwasser, F | 1 |
| Batteux, F | 1 |
| Nyhlén, A | 1 |
| Ljungberg, B | 1 |
| Nilsson-Ehle, I | 1 |
| Odenholt, I | 1 |
| Ottolenghi, F | 1 |
| Andreassi, L | 1 |
| Sbano, E | 1 |
| Fimiani, M | 1 |
| Badr el Din, A | 1 |
| Coibion, M | 1 |
| Guenier, C | 1 |
| Nogaret, JM | 1 |
| Lorent, I | 1 |
| Van Houtte, P | 1 |
| Tueni, E | 1 |
| Mattheiem, W | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Local Feasibility Study on Mangafodipir as an Adjunct to FOLFOX6 Chemotherapy in Patients Operated Upon Colon Cancer Stage Dukes' C[NCT00671996] | Phase 2 | 14 participants (Actual) | Interventional | 2008-06-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for fluorouracil and Infections, Staphylococcal
| Article | Year |
|---|---|
[A Case of Nasopharyngeal Cancer with Febrile Neutropenia Followed by Death during Adjuvant Chemotherapy].
Topics: Antineoplastic Combined Chemotherapy Protocols; Autopsy; Carcinoma, Squamous Cell; Chemoradiotherapy | 2015 |
10 other studies available for fluorouracil and Infections, Staphylococcal
| Article | Year |
|---|---|
5-Fluorouracil blocks quorum-sensing of biofilm-embedded methicillin-resistant Staphylococcus aureus in mice.
Topics: Animals; Bacterial Proteins; Biofilms; Carbon-Sulfur Lyases; Enzyme Inhibitors; Female; Fluorouracil | 2021 |
An Oral Fluorouracil Prodrug, Capecitabine, Mitigates a Gram-Positive Systemic Infection in Mice.
Topics: Administration, Oral; Animals; Anti-Bacterial Agents; Capecitabine; Female; Fluorouracil; Humans; Mi | 2021 |
5-Fluorouracil and mucopeptide biosynthesis by Staphylococcus aureus.
Topics: Fluorouracil; Mucoproteins; Peptides; Peptidoglycan; Staphylococcal Infections; Staphylococcus; Stap | 1960 |
[MACROMOLECULAR MODIFICATIONS IN A PATHOGENIC BACTERIUM BY MEANS OF ANTIMETABOLITES OF NUCLEIC ACIDS: COMPARATIVE EFFECTS OF 5-FLUOROURACIL AND ACRIDINE ORANGE ON VIRULENCE INDICATORS IN STAPHYLOCOCCUS AUREUS].
Topics: Acridine Orange; Acridines; Antigens; Antimetabolites; DNA; DNA, Bacterial; Fluorescence; Fluorourac | 1964 |
THE INCORPORATION OF 5-FLUOROURACIL BY STAPHYLOCOCCUS AUREUS (STRAIN DUNCAN). II.
Topics: Bacterial Proteins; Electrophoresis; Fluorouracil; Metabolism; Pharmacology; Proteins; Research; Rib | 1964 |
THE INCORPORATION OF 5-FLUOROURACIL BY STAPHYLOCOCCUS AUREUS (STRAIN DUNCAN). 3.
Topics: Deoxyribonucleases; DNA; Fluorouracil; Metabolism; Research; Ribonucleases; Staphylococcal Infection | 1965 |
Improvement of the therapeutic index of anticancer drugs by the superoxide dismutase mimic mangafodipir.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Catalase; Cell Line, Tumor; Cell Survival; | 2006 |
Bactericidal effect of combinations of antibiotic and antineoplastic agents against Staphylococcus aureus and Escherichia coli.
Topics: Anti-Bacterial Agents; Antineoplastic Agents; Ceftazidime; Cephalosporins; Doxorubicin; Drug Interac | 2002 |
[Diffuse chronic mucocutaneous candidiasis: Effects of antimycotics in vitro].
Topics: Amphotericin B; Antifungal Agents; Candida; Candidiasis, Cutaneous; Candidiasis, Oral; Child; Chroni | 1975 |
Local postoperative morbidity following pre-operative irradiation in locally advanced breast cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Combined Modality Therapy; Cycloph | 1989 |