Page last updated: 2024-10-27

fluorouracil and Infections, Staphylococcal

fluorouracil has been researched along with Infections, Staphylococcal in 11 studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19906 (54.55)18.7374
1990's0 (0.00)18.2507
2000's2 (18.18)29.6817
2010's1 (9.09)24.3611
2020's2 (18.18)2.80

Authors

AuthorsStudies
Sedlmayer, F1
Woischnig, AK1
Unterreiner, V1
Fuchs, F1
Baeschlin, D1
Khanna, N1
Fussenegger, M1
McLeod, JR1
Harvey, PA1
Detweiler, CS1
Nakahara, S1
Kitamura, K1
Honma, K1
Yamamoto, Y1
Takenaka, Y1
Yasui, T1
Hanamoto, A1
Morii, E1
Inohara, H1
ROGERS, HJ1
PERKINS, HR1
DEREPENTIGNY, J1
SONEA, S1
FRAPPIER, A1
HIGNETT, RC2
Alexandre, J1
Nicco, C1
Chéreau, C1
Laurent, A1
Weill, B1
Goldwasser, F1
Batteux, F1
Nyhlén, A1
Ljungberg, B1
Nilsson-Ehle, I1
Odenholt, I1
Ottolenghi, F1
Andreassi, L1
Sbano, E1
Fimiani, M1
Badr el Din, A1
Coibion, M1
Guenier, C1
Nogaret, JM1
Lorent, I1
Van Houtte, P1
Tueni, E1
Mattheiem, W1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Local Feasibility Study on Mangafodipir as an Adjunct to FOLFOX6 Chemotherapy in Patients Operated Upon Colon Cancer Stage Dukes' C[NCT00671996]Phase 214 participants (Actual)Interventional2008-06-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for fluorouracil and Infections, Staphylococcal

ArticleYear
[A Case of Nasopharyngeal Cancer with Febrile Neutropenia Followed by Death during Adjuvant Chemotherapy].
    Nihon Jibiinkoka Gakkai kaiho, 2015, Volume: 118, Issue:6

    Topics: Antineoplastic Combined Chemotherapy Protocols; Autopsy; Carcinoma, Squamous Cell; Chemoradiotherapy

2015

Other Studies

10 other studies available for fluorouracil and Infections, Staphylococcal

ArticleYear
5-Fluorouracil blocks quorum-sensing of biofilm-embedded methicillin-resistant Staphylococcus aureus in mice.
    Nucleic acids research, 2021, 07-21, Volume: 49, Issue:13

    Topics: Animals; Bacterial Proteins; Biofilms; Carbon-Sulfur Lyases; Enzyme Inhibitors; Female; Fluorouracil

2021
An Oral Fluorouracil Prodrug, Capecitabine, Mitigates a Gram-Positive Systemic Infection in Mice.
    Microbiology spectrum, 2021, 09-03, Volume: 9, Issue:1

    Topics: Administration, Oral; Animals; Anti-Bacterial Agents; Capecitabine; Female; Fluorouracil; Humans; Mi

2021
5-Fluorouracil and mucopeptide biosynthesis by Staphylococcus aureus.
    The Biochemical journal, 1960, Volume: 77

    Topics: Fluorouracil; Mucoproteins; Peptides; Peptidoglycan; Staphylococcal Infections; Staphylococcus; Stap

1960
[MACROMOLECULAR MODIFICATIONS IN A PATHOGENIC BACTERIUM BY MEANS OF ANTIMETABOLITES OF NUCLEIC ACIDS: COMPARATIVE EFFECTS OF 5-FLUOROURACIL AND ACRIDINE ORANGE ON VIRULENCE INDICATORS IN STAPHYLOCOCCUS AUREUS].
    Revue canadienne de biologie, 1964, Volume: 23

    Topics: Acridine Orange; Acridines; Antigens; Antimetabolites; DNA; DNA, Bacterial; Fluorescence; Fluorourac

1964
THE INCORPORATION OF 5-FLUOROURACIL BY STAPHYLOCOCCUS AUREUS (STRAIN DUNCAN). II.
    Biochimica et biophysica acta, 1964, Dec-16, Volume: 91

    Topics: Bacterial Proteins; Electrophoresis; Fluorouracil; Metabolism; Pharmacology; Proteins; Research; Rib

1964
THE INCORPORATION OF 5-FLUOROURACIL BY STAPHYLOCOCCUS AUREUS (STRAIN DUNCAN). 3.
    Biochimica et biophysica acta, 1965, Apr-19, Volume: 95

    Topics: Deoxyribonucleases; DNA; Fluorouracil; Metabolism; Research; Ribonucleases; Staphylococcal Infection

1965
Improvement of the therapeutic index of anticancer drugs by the superoxide dismutase mimic mangafodipir.
    Journal of the National Cancer Institute, 2006, Feb-15, Volume: 98, Issue:4

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Catalase; Cell Line, Tumor; Cell Survival;

2006
Bactericidal effect of combinations of antibiotic and antineoplastic agents against Staphylococcus aureus and Escherichia coli.
    Chemotherapy, 2002, Volume: 48, Issue:2

    Topics: Anti-Bacterial Agents; Antineoplastic Agents; Ceftazidime; Cephalosporins; Doxorubicin; Drug Interac

2002
[Diffuse chronic mucocutaneous candidiasis: Effects of antimycotics in vitro].
    Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 1975, Volume: 26, Issue:5

    Topics: Amphotericin B; Antifungal Agents; Candida; Candidiasis, Cutaneous; Candidiasis, Oral; Child; Chroni

1975
Local postoperative morbidity following pre-operative irradiation in locally advanced breast cancer.
    European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 1989, Volume: 15, Issue:6

    Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Combined Modality Therapy; Cycloph

1989