fluorouracil and Infections, Pseudomonas
fluorouracil has been researched along with Infections, Pseudomonas in 12 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Research Excerpts
Excerpt | Relevance | Reference |
---|---|---|
"A 61-year-old woman with metastatic breast cancer who was undergoing treatment with capecitabine developed erythema, fissuring, and erosions over both hands and feet, consistent with HFS." | 8.87 | Capecitabine-induced hand-foot syndrome complicated by pseudomonal superinfection resulting in bacterial sepsis and death: case report and review of the literature. ( Baker, SG; Cotliar, JA; Gunawardane, ND; Hoesly, FJ, 2011) |
"A 61-year-old woman with metastatic breast cancer who was undergoing treatment with capecitabine developed erythema, fissuring, and erosions over both hands and feet, consistent with HFS." | 4.87 | Capecitabine-induced hand-foot syndrome complicated by pseudomonal superinfection resulting in bacterial sepsis and death: case report and review of the literature. ( Baker, SG; Cotliar, JA; Gunawardane, ND; Hoesly, FJ, 2011) |
" Flucytosine administration at clinically meaningful dosing regimens suppressed P." | 1.39 | Repurposing the antimycotic drug flucytosine for suppression of Pseudomonas aeruginosa pathogenicity. ( Bragonzi, A; Facchini, M; Frangipani, E; Imperi, F; Leoni, L; Massai, F; Visaggio, D; Visca, P, 2013) |
" Subsequent dosing with 5-FU induced lethal septicaemia caused by the inoculated strains in most of these mice, whereas CY did not regularly induce septicaemia." | 1.29 | Experimental endogenous septicaemia caused by Klebsiella pneumoniae and Escherichia coli in mice. ( Furuya, N; Hirakata, Y; Matsumoto, T; Tateda, K; Yamaguchi, K, 1996) |
Research
Studies (12)
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 2 (16.67) | 18.7374 |
1990's | 3 (25.00) | 18.2507 |
2000's | 1 (8.33) | 29.6817 |
2010's | 3 (25.00) | 24.3611 |
2020's | 3 (25.00) | 2.80 |
Authors
Authors | Studies |
---|---|
Di Bonaventura, G | 2 |
Lupetti, V | 2 |
De Fabritiis, S | 1 |
Piccirilli, A | 2 |
Porreca, A | 1 |
Di Nicola, M | 1 |
Pompilio, A | 2 |
Santana, AB | 1 |
Souto, BS | 1 |
Santos, NCM | 1 |
Pereira, JA | 1 |
Tagliati, CA | 1 |
Novaes, RD | 1 |
Corsetti, PP | 1 |
de Almeida, LA | 1 |
Di Giulio, A | 1 |
Muzzi, M | 1 |
Cariani, L | 1 |
Imperi, F | 1 |
Massai, F | 1 |
Facchini, M | 1 |
Frangipani, E | 1 |
Visaggio, D | 1 |
Leoni, L | 1 |
Bragonzi, A | 1 |
Visca, P | 1 |
García-Contreras, R | 1 |
Martínez-Vázquez, M | 1 |
Velázquez Guadarrama, N | 1 |
Villegas Pañeda, AG | 1 |
Hashimoto, T | 1 |
Maeda, T | 1 |
Quezada, H | 1 |
Wood, TK | 1 |
Hoesly, FJ | 1 |
Baker, SG | 1 |
Gunawardane, ND | 1 |
Cotliar, JA | 1 |
Ishitsuka, H | 1 |
Umeda, Y | 1 |
Nakamura, J | 1 |
Yagi, Y | 1 |
Hirakata, Y | 2 |
Furuya, N | 2 |
Matsumoto, T | 2 |
Tateda, K | 2 |
Yamaguchi, K | 2 |
Lebowitz, D | 1 |
Gürses-Ozden, R | 1 |
Rothman, RF | 1 |
Liebmann, JM | 1 |
Tello, C | 1 |
Ritch, R | 1 |
Miura, S | 1 |
Takimoto, H | 1 |
Yoshikai, Y | 1 |
Kumazawa, Y | 1 |
Yamada, A | 1 |
Nomoto, K | 1 |
Rosenoff, SH | 1 |
Wolf, ML | 1 |
Chabner, BA | 1 |
Clinical Trials (1)
Trial Overview
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
A Phase II, Randomised Controlled Trial to Evaluate the Efficacy and Safety of Moisturising Creams With or Without Palm-oil-derived Vitamin E Concentrate in Addition to Urea-based Cream or Urea-based Cream Alone in Capecitabine-associated Palmar-Plantar E[NCT05939726] | 90 participants (Anticipated) | Interventional | 2023-05-16 | Recruiting | |||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
Reviews
1 review available for fluorouracil and Infections, Pseudomonas
Article | Year |
---|---|
Capecitabine-induced hand-foot syndrome complicated by pseudomonal superinfection resulting in bacterial sepsis and death: case report and review of the literature.
Topics: Antimetabolites, Antineoplastic; Bacteremia; Breast Neoplasms; Capecitabine; Deoxycytidine; Fatal Ou | 2011 |
Other Studies
11 other studies available for fluorouracil and Infections, Pseudomonas
Article | Year |
---|---|
Giving Drugs a Second Chance: Antibacterial and Antibiofilm Effects of Ciclopirox and Ribavirin against Cystic Fibrosis
Topics: Anti-Bacterial Agents; Biofilms; Ciclopirox; Cystic Fibrosis; Dactinomycin; Drug Repositioning; Extr | 2022 |
Murine response to the opportunistic bacterium Pseudomonas aeruginosa infection in gut dysbiosis caused by 5-fluorouracil chemotherapy-induced mucositis.
Topics: Animals; Antineoplastic Agents; Bacteria; Dysbiosis; Fluorouracil; Intestinal Mucosa; Mice; Mice, In | 2022 |
Repurposing High-Throughput Screening Identifies Unconventional Drugs with Antibacterial and Antibiofilm Activities against Pseudomonas aeruginosa under Experimental Conditions Relevant to Cystic Fibrosis.
Topics: Anti-Bacterial Agents; Biofilms; Cystic Fibrosis; Drug Repositioning; Fluorouracil; High-Throughput | 2023 |
Repurposing the antimycotic drug flucytosine for suppression of Pseudomonas aeruginosa pathogenicity.
Topics: Animals; Antifungal Agents; Bacterial Proteins; Down-Regulation; Flucytosine; Fluorouracil; Gene Exp | 2013 |
Resistance to the quorum-quenching compounds brominated furanone C-30 and 5-fluorouracil in Pseudomonas aeruginosa clinical isolates.
Topics: Anti-Bacterial Agents; Bacterial Proteins; Child; Drug Resistance, Bacterial; Endopeptidases; Fluoro | 2013 |
Protective activity of thymosin against opportunistic infections in animal models.
Topics: Animals; Candida albicans; Candidiasis; Drug Administration Schedule; Enterobacteriaceae Infections; | 1983 |
Influence of various immunosuppressive agents on the occurrence of endogenous bacteraemia in mice.
Topics: Animals; Bacteremia; Cisplatin; Cyclophosphamide; Enterobacteriaceae Infections; Fluorouracil; Immun | 1995 |
Experimental endogenous septicaemia caused by Klebsiella pneumoniae and Escherichia coli in mice.
Topics: Ampicillin; Animals; Bacteremia; Ceftazidime; Cephalosporins; Cyclophosphamide; Disease Models, Anim | 1996 |
Late-onset bleb-related panophthalmitis with orbital abscess caused by Pseudomonas stutzeri.
Topics: Abscess; Aged; Eye Enucleation; Eye Infections, Bacterial; Fluorouracil; Humans; Male; Orbital Disea | 2001 |
Protective effect of ren-shen-yang-rong-tang (Ninjin-youei-to) in mice with drug-induced leukopenia against Pseudomonas aeruginosa infection.
Topics: Animals; Colony-Forming Units Assay; Cyclophosphamide; Drugs, Chinese Herbal; Female; Fluorouracil; | 1992 |
Pseudomonas blepharoconjunctivitis: a complication of combination chemotherapy.
Topics: Antineoplastic Agents; Bacitracin; Blepharitis; Bone Marrow; Breast Neoplasms; Carbenicillin; Cephal | 1974 |