Page last updated: 2024-10-27

fluorouracil and Infections, Pseudomonas

fluorouracil has been researched along with Infections, Pseudomonas in 12 studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Research Excerpts

ExcerptRelevanceReference
"A 61-year-old woman with metastatic breast cancer who was undergoing treatment with capecitabine developed erythema, fissuring, and erosions over both hands and feet, consistent with HFS."8.87Capecitabine-induced hand-foot syndrome complicated by pseudomonal superinfection resulting in bacterial sepsis and death: case report and review of the literature. ( Baker, SG; Cotliar, JA; Gunawardane, ND; Hoesly, FJ, 2011)
"A 61-year-old woman with metastatic breast cancer who was undergoing treatment with capecitabine developed erythema, fissuring, and erosions over both hands and feet, consistent with HFS."4.87Capecitabine-induced hand-foot syndrome complicated by pseudomonal superinfection resulting in bacterial sepsis and death: case report and review of the literature. ( Baker, SG; Cotliar, JA; Gunawardane, ND; Hoesly, FJ, 2011)
" Flucytosine administration at clinically meaningful dosing regimens suppressed P."1.39Repurposing the antimycotic drug flucytosine for suppression of Pseudomonas aeruginosa pathogenicity. ( Bragonzi, A; Facchini, M; Frangipani, E; Imperi, F; Leoni, L; Massai, F; Visaggio, D; Visca, P, 2013)
" Subsequent dosing with 5-FU induced lethal septicaemia caused by the inoculated strains in most of these mice, whereas CY did not regularly induce septicaemia."1.29Experimental endogenous septicaemia caused by Klebsiella pneumoniae and Escherichia coli in mice. ( Furuya, N; Hirakata, Y; Matsumoto, T; Tateda, K; Yamaguchi, K, 1996)

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19902 (16.67)18.7374
1990's3 (25.00)18.2507
2000's1 (8.33)29.6817
2010's3 (25.00)24.3611
2020's3 (25.00)2.80

Authors

AuthorsStudies
Di Bonaventura, G2
Lupetti, V2
De Fabritiis, S1
Piccirilli, A2
Porreca, A1
Di Nicola, M1
Pompilio, A2
Santana, AB1
Souto, BS1
Santos, NCM1
Pereira, JA1
Tagliati, CA1
Novaes, RD1
Corsetti, PP1
de Almeida, LA1
Di Giulio, A1
Muzzi, M1
Cariani, L1
Imperi, F1
Massai, F1
Facchini, M1
Frangipani, E1
Visaggio, D1
Leoni, L1
Bragonzi, A1
Visca, P1
García-Contreras, R1
Martínez-Vázquez, M1
Velázquez Guadarrama, N1
Villegas Pañeda, AG1
Hashimoto, T1
Maeda, T1
Quezada, H1
Wood, TK1
Hoesly, FJ1
Baker, SG1
Gunawardane, ND1
Cotliar, JA1
Ishitsuka, H1
Umeda, Y1
Nakamura, J1
Yagi, Y1
Hirakata, Y2
Furuya, N2
Matsumoto, T2
Tateda, K2
Yamaguchi, K2
Lebowitz, D1
Gürses-Ozden, R1
Rothman, RF1
Liebmann, JM1
Tello, C1
Ritch, R1
Miura, S1
Takimoto, H1
Yoshikai, Y1
Kumazawa, Y1
Yamada, A1
Nomoto, K1
Rosenoff, SH1
Wolf, ML1
Chabner, BA1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Phase II, Randomised Controlled Trial to Evaluate the Efficacy and Safety of Moisturising Creams With or Without Palm-oil-derived Vitamin E Concentrate in Addition to Urea-based Cream or Urea-based Cream Alone in Capecitabine-associated Palmar-Plantar E[NCT05939726]90 participants (Anticipated)Interventional2023-05-16Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for fluorouracil and Infections, Pseudomonas

ArticleYear
Capecitabine-induced hand-foot syndrome complicated by pseudomonal superinfection resulting in bacterial sepsis and death: case report and review of the literature.
    Archives of dermatology, 2011, Volume: 147, Issue:12

    Topics: Antimetabolites, Antineoplastic; Bacteremia; Breast Neoplasms; Capecitabine; Deoxycytidine; Fatal Ou

2011

Other Studies

11 other studies available for fluorouracil and Infections, Pseudomonas

ArticleYear
Giving Drugs a Second Chance: Antibacterial and Antibiofilm Effects of Ciclopirox and Ribavirin against Cystic Fibrosis
    International journal of molecular sciences, 2022, Apr-30, Volume: 23, Issue:9

    Topics: Anti-Bacterial Agents; Biofilms; Ciclopirox; Cystic Fibrosis; Dactinomycin; Drug Repositioning; Extr

2022
Murine response to the opportunistic bacterium Pseudomonas aeruginosa infection in gut dysbiosis caused by 5-fluorouracil chemotherapy-induced mucositis.
    Life sciences, 2022, Oct-15, Volume: 307

    Topics: Animals; Antineoplastic Agents; Bacteria; Dysbiosis; Fluorouracil; Intestinal Mucosa; Mice; Mice, In

2022
Repurposing High-Throughput Screening Identifies Unconventional Drugs with Antibacterial and Antibiofilm Activities against Pseudomonas aeruginosa under Experimental Conditions Relevant to Cystic Fibrosis.
    Microbiology spectrum, 2023, 08-17, Volume: 11, Issue:4

    Topics: Anti-Bacterial Agents; Biofilms; Cystic Fibrosis; Drug Repositioning; Fluorouracil; High-Throughput

2023
Repurposing the antimycotic drug flucytosine for suppression of Pseudomonas aeruginosa pathogenicity.
    Proceedings of the National Academy of Sciences of the United States of America, 2013, Apr-30, Volume: 110, Issue:18

    Topics: Animals; Antifungal Agents; Bacterial Proteins; Down-Regulation; Flucytosine; Fluorouracil; Gene Exp

2013
Resistance to the quorum-quenching compounds brominated furanone C-30 and 5-fluorouracil in Pseudomonas aeruginosa clinical isolates.
    Pathogens and disease, 2013, Volume: 68, Issue:1

    Topics: Anti-Bacterial Agents; Bacterial Proteins; Child; Drug Resistance, Bacterial; Endopeptidases; Fluoro

2013
Protective activity of thymosin against opportunistic infections in animal models.
    Cancer immunology, immunotherapy : CII, 1983, Volume: 14, Issue:3

    Topics: Animals; Candida albicans; Candidiasis; Drug Administration Schedule; Enterobacteriaceae Infections;

1983
Influence of various immunosuppressive agents on the occurrence of endogenous bacteraemia in mice.
    Journal of medical microbiology, 1995, Volume: 42, Issue:3

    Topics: Animals; Bacteremia; Cisplatin; Cyclophosphamide; Enterobacteriaceae Infections; Fluorouracil; Immun

1995
Experimental endogenous septicaemia caused by Klebsiella pneumoniae and Escherichia coli in mice.
    Journal of medical microbiology, 1996, Volume: 44, Issue:3

    Topics: Ampicillin; Animals; Bacteremia; Ceftazidime; Cephalosporins; Cyclophosphamide; Disease Models, Anim

1996
Late-onset bleb-related panophthalmitis with orbital abscess caused by Pseudomonas stutzeri.
    Archives of ophthalmology (Chicago, Ill. : 1960), 2001, Volume: 119, Issue:11

    Topics: Abscess; Aged; Eye Enucleation; Eye Infections, Bacterial; Fluorouracil; Humans; Male; Orbital Disea

2001
Protective effect of ren-shen-yang-rong-tang (Ninjin-youei-to) in mice with drug-induced leukopenia against Pseudomonas aeruginosa infection.
    International journal of immunopharmacology, 1992, Volume: 14, Issue:7

    Topics: Animals; Colony-Forming Units Assay; Cyclophosphamide; Drugs, Chinese Herbal; Female; Fluorouracil;

1992
Pseudomonas blepharoconjunctivitis: a complication of combination chemotherapy.
    Archives of ophthalmology (Chicago, Ill. : 1960), 1974, Volume: 91, Issue:6

    Topics: Antineoplastic Agents; Bacitracin; Blepharitis; Bone Marrow; Breast Neoplasms; Carbenicillin; Cephal

1974
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