fluorouracil has been researched along with Infarction, Middle Cerebral Artery in 6 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Infarction, Middle Cerebral Artery: NECROSIS occurring in the MIDDLE CEREBRAL ARTERY distribution system which brings blood to the entire lateral aspects of each CEREBRAL HEMISPHERE. Clinical signs include impaired cognition; APHASIA; AGRAPHIA; weak and numbness in the face and arms, contralaterally or bilaterally depending on the infarction.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of this study was to evaluate the effect of 5-fluorouracil mobilized bone marrow regenerative cells (BMRCs) transplantation on brain injury following focal cerebral ischemia and to explore the mechanisms." | 7.81 | Effect of 5-fluorouracil mobilized bone marrow regenerative cells transplantation on brain injury following focal cerebral ischemia in rats. ( Li, M; Liao, H; Liu, XL; Xiao, LH; Xu, FF; Xu, ZP; Yang, B, 2015) |
| "The aim of this study was to evaluate the effect of 5-fluorouracil mobilized bone marrow regenerative cells (BMRCs) transplantation on brain injury following focal cerebral ischemia and to explore the mechanisms." | 3.81 | Effect of 5-fluorouracil mobilized bone marrow regenerative cells transplantation on brain injury following focal cerebral ischemia in rats. ( Li, M; Liao, H; Liu, XL; Xiao, LH; Xu, FF; Xu, ZP; Yang, B, 2015) |
| "In a transient 90-min middle cerebral artery occlusion (MCAO) model of rats, a large ischemic lesion is formed where macrophage-like cells massively accumulate, many of which express a macrophage marker, Iba1, and an oligodendrocyte progenitor cell marker, NG2 chondroitin sulfate proteoglycan (NG2); therefore, the cells were termed BINCs (Brain Iba1(+)/NG2(+) Cells)." | 1.36 | Iba1(+)/NG2(+) macrophage-like cells expressing a variety of neuroprotective factors ameliorate ischemic damage of the brain. ( Inoue, A; Kumon, Y; Matsumoto, H; Ohnishi, T; Ohue, S; Smirkin, A; Tagawa, M; Takahashi, H; Tanaka, J; Watanabe, H; Yano, H, 2010) |
| "At 24 h after middle cerebral artery occlusion (MCAO), many round-shaped EGFP-positive cells migrated to the ischemic core and peri-infarct area." | 1.32 | Migration of enhanced green fluorescent protein expressing bone marrow-derived microglia/macrophage into the mouse brain following permanent focal ischemia. ( Furuya, T; Komine-Kobayashi, M; Migita, M; Mizuno, Y; Mochizuki, H; Shimada, T; Tanaka, R; Urabe, T; Yamada, M, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 4 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Xu, FF | 1 |
| Liu, XL | 1 |
| Li, M | 1 |
| Yang, B | 1 |
| Liao, H | 1 |
| Xiao, LH | 1 |
| Xu, ZP | 1 |
| Li, Y | 2 |
| Mao, WW | 2 |
| Zhang, CG | 1 |
| Wan, L | 1 |
| Jing, CH | 1 |
| Hua, XM | 2 |
| Li, ST | 1 |
| Cheng, J | 2 |
| Chen, CH | 1 |
| Yin, Y | 1 |
| Smirkin, A | 1 |
| Matsumoto, H | 1 |
| Takahashi, H | 1 |
| Inoue, A | 1 |
| Tagawa, M | 1 |
| Ohue, S | 1 |
| Watanabe, H | 1 |
| Yano, H | 1 |
| Kumon, Y | 1 |
| Ohnishi, T | 1 |
| Tanaka, J | 1 |
| Tanaka, R | 1 |
| Komine-Kobayashi, M | 1 |
| Mochizuki, H | 1 |
| Yamada, M | 1 |
| Furuya, T | 1 |
| Migita, M | 1 |
| Shimada, T | 1 |
| Mizuno, Y | 1 |
| Urabe, T | 1 |
| Serrano-Castro, PJ | 1 |
| Guardado-Santervás, P | 1 |
| Olivares-Romero, J | 1 |
6 other studies available for fluorouracil and Infarction, Middle Cerebral Artery
| Article | Year |
|---|---|
Effect of 5-fluorouracil mobilized bone marrow regenerative cells transplantation on brain injury following focal cerebral ischemia in rats.
Topics: Administration, Intravenous; Animals; Bone Marrow Cells; Bone Marrow Transplantation; Brain Injuries | 2015 |
Neuroprotective effects of intravenous transplantation of bone marrow mononuclear cells from 5-fluorouracil pre-treated rats on ischemic stroke.
Topics: Animals; Bone Marrow Cells; Bone Marrow Transplantation; Brain; Brain Ischemia; Cell Survival; Disea | 2016 |
Neuroprotection by intravenous transplantation of bone marrow mononuclear cells from 5-fluorouracil pre-treated rats in a model of ischemic stroke.
Topics: Analysis of Variance; Animals; Antigens, CD; Brain Ischemia; Chemokine CXCL12; Cytokines; Disease Mo | 2016 |
Iba1(+)/NG2(+) macrophage-like cells expressing a variety of neuroprotective factors ameliorate ischemic damage of the brain.
Topics: Animals; Antigens; Bone Marrow Transplantation; Brain; Brain Ischemia; Bromodeoxyuridine; Calcium-Bi | 2010 |
Migration of enhanced green fluorescent protein expressing bone marrow-derived microglia/macrophage into the mouse brain following permanent focal ischemia.
Topics: Animals; Bone Marrow; Brain Ischemia; Calcium-Binding Proteins; Cell Count; Cell Movement; Central N | 2003 |
Ischemic stroke following cisplatin and 5-fluorouracil therapy: a transcranial Doppler study.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Fluorour | 2000 |