fluorouracil has been researched along with Incompetence, Pulmonary Valve in 1 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| "5-fluorouracil (5-FU) is an antimetabolite that acts during the S phase of the cell cycle." | 1.35 | Cardiotoxicity of 5-fluorouracil and capecitabine in a pancreatic cancer patient with a novel mutation in the dihydropyrimidine dehydrogenase gene. ( Harold, L; Rajebi, MR; Saif, MW; Shahrokni, A, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Shahrokni, A | 1 |
| Rajebi, MR | 1 |
| Harold, L | 1 |
| Saif, MW | 1 |
1 other study available for fluorouracil and Incompetence, Pulmonary Valve
| Article | Year |
|---|---|
Cardiotoxicity of 5-fluorouracil and capecitabine in a pancreatic cancer patient with a novel mutation in the dihydropyrimidine dehydrogenase gene.
Topics: Antimetabolites, Antineoplastic; Capecitabine; Cardiomyopathy, Dilated; Deoxycytidine; Dihydrouracil | 2009 |