fluorouracil has been researched along with Inborn Errors of Metabolism in 4 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (25.00) | 18.7374 |
| 1990's | 2 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kato, K | 1 |
| Nakayoshi, T | 1 |
| Nagura, A | 1 |
| Hishinuma, E | 1 |
| Hiratsuka, M | 1 |
| Kurimoto, E | 1 |
| Oda, A | 1 |
| Yokota, H | 1 |
| Fernandez-Salguero, P | 1 |
| Furuya, H | 1 |
| Lin, K | 1 |
| McBride, OW | 1 |
| Podschun, B | 1 |
| Schnackerz, KD | 1 |
| Gonzalez, FJ | 1 |
| Sumi, S | 1 |
| Imaeda, M | 1 |
| Kidouchi, K | 1 |
| Ohba, S | 1 |
| Hamajima, N | 1 |
| Kodama, K | 1 |
| Togari, H | 1 |
| Wada, Y | 1 |
| Vesell, ES | 1 |
4 other studies available for fluorouracil and Inborn Errors of Metabolism
| Article | Year |
|---|---|
Structural investigation of pathogenic variants in dihydropyrimidinase using molecular dynamics simulations.
Topics: Amidohydrolases; Fluorouracil; Metabolism, Inborn Errors; Molecular Dynamics Simulation | 2022 |
cDNA cloning and chromosome mapping of human dihydropyrimidine dehydrogenase, an enzyme associated with 5-fluorouracil toxicity and congenital thymine uraciluria.
Topics: Amino Acid Sequence; Animals; Base Sequence; Chromosome Mapping; Chromosomes, Human, Pair 1; Criceti | 1994 |
Population and family studies of dihydropyrimidinuria: prevalence, inheritance mode, and risk of fluorouracil toxicity.
Topics: Adult; Amidohydrolases; Child; Child, Preschool; Female; Fluorouracil; Genes, Recessive; Homozygote; | 1998 |
Genetic host factors: determinants of drug response.
Topics: Drug-Related Side Effects and Adverse Reactions; Fluorouracil; Humans; Metabolism, Inborn Errors; Ph | 1985 |