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fluorouracil and Inappropriate ADH Syndrome

fluorouracil has been researched along with Inappropriate ADH Syndrome in 8 studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Inappropriate ADH Syndrome: A condition of HYPONATREMIA and renal salt loss attributed to overexpansion of BODY FLUIDS resulting from sustained release of ANTIDIURETIC HORMONES which stimulates renal resorption of water. It is characterized by normal KIDNEY function, high urine OSMOLALITY, low serum osmolality, and neurological dysfunction. Etiologies include ADH-producing neoplasms, injuries or diseases involving the HYPOTHALAMUS, the PITUITARY GLAND, and the LUNG. This syndrome can also be drug-induced.

Research Excerpts

ExcerptRelevanceReference
"In patients with esophageal cancer, oxaliplatin appears to have a lower risk of SIADH than cisplatin, suggesting that oxaliplatin can be a therapeutic option for patients with esophageal cancer who are at high risk of SIADH."1.72Folinic Acid, Fluorouracil, and Oxaliplatin Therapy for Recurrent Esophageal Cancer with Syndrome of Inadequate Antidiuretic Hormone Secretion (SIADH) After Preoperative Cisplatin/5-Fluorouracil Therapy. ( Abe, T; Futai, R; Hayashi, H; Iemoto, T; Inoue, Y; Morikawa, T; Ose, T; Sanuki, T; Sasaki, A; Yoshie, T, 2022)
"A 77-year-old male with thoracic esophageal cancer (cT3N3M0, Stage III) received nedaplatin at 80mg/m2 for 1 day and 5-fluorouracil at 800mg/m2 for 5 days as neoadjuvant treatment."1.36[A case of SIADH developed during neoadjuvant chemotherapy using nedaplatin and 5-fluorouracil in a patient with esophageal cancer]. ( Gyobu, K; Hashiba, R; Isohata, N; Iwasaki, H; Kishida, S; Lee, S; Matsuda, Y; Mori, K; Osugi, H, 2010)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (12.50)18.2507
2000's0 (0.00)29.6817
2010's6 (75.00)24.3611
2020's1 (12.50)2.80

Authors

AuthorsStudies
Futai, R1
Yoshie, T1
Sanuki, T1
Inoue, Y1
Abe, T1
Sasaki, A1
Iemoto, T1
Hayashi, H1
Ose, T1
Morikawa, T1
Tamura, T1
Taniguchi, N1
Otsuki, K1
Narai, T1
Kawasaki, M1
Fujii, N1
Doi, R1
Kodani, I1
Endo, C1
Takagawa, R1
Chiba, T1
Kawamoto, M1
Konishi, T1
Honma, Y1
Minami, Y1
Watanabe, J1
Morita, T1
Mogaki, M1
Masui, H1
Sawano, T1
Kawasaki, H1
Wajima, N1
Miyamoto, K1
Ishizawa, Y1
Nakai, M1
Hakamada, K1
Suzuki, S1
Goto, M1
Okamoto, T1
Tomita, I1
Murayama, A1
Sawa, M1
Noguchi, Y1
Hoshikawa, Y1
Shimizu, A1
Matsuda, Y1
Lee, S1
Kishida, S1
Mori, K1
Isohata, N1
Iwasaki, H1
Hashiba, R1
Gyobu, K1
Osugi, H1
Horio, T1
Tsujimoto, H1
Akase, T1
Sakamoto, N1
Yaguchi, Y1
Hiraki, S1
Aiko, S1
Takechi, H1
Hase, K1
Maehara, T1
Tweedy, CR1
Silverberg, DA1
Scott, L1

Reviews

3 reviews available for fluorouracil and Inappropriate ADH Syndrome

ArticleYear
[A Case of Consciousness Disorder Induced by the Syndrome of Inappropriate Antidiuretic Hormone Secretion Following Cisplatin and 5-Fluorouracil Chemotherapy in a Patient with Tongue Cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2018, Volume: 45, Issue:5

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Conscious

2018
[A case of consciousness disorder induced by the syndrome of inappropriate secretion of antidiuretic hormone following cisplatin and 5-fluorouracil chemotherapy in a patient with esophageal cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2013, Volume: 40, Issue:12

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Consciousness Disorders; Esophageal

2013
[A case of syndrome of inappropriate antidiuretic hormone secretion in a patient with esophageal carcinoma possibly induced by cisplatin in neoadjuvant chemotherapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2014, Volume: 41, Issue:8

    Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Esophageal Neoplasms; Fluorouracil; Human

2014

Other Studies

5 other studies available for fluorouracil and Inappropriate ADH Syndrome

ArticleYear
Folinic Acid, Fluorouracil, and Oxaliplatin Therapy for Recurrent Esophageal Cancer with Syndrome of Inadequate Antidiuretic Hormone Secretion (SIADH) After Preoperative Cisplatin/5-Fluorouracil Therapy.
    The American journal of case reports, 2022, Feb-15, Volume: 23

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Esophageal Neoplasms; Fluorouracil;

2022
[A case of small cell carcinoma of the esophagus with SIADH].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2010, Volume: 37, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Small Cell; Cisplatin; Esophageal Neoplas

2010
[A case of SIADH developed during neoadjuvant chemotherapy using nedaplatin and 5-fluorouracil in a patient with esophageal cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2010, Volume: 37, Issue:9

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Biopsy; Esophageal Neoplasms; Fluorouracil; Hu

2010
[Syndrome of inappropriate antidiuretic hormone secretion following adjuvant CDDP and 5-FU administration in a patient with esophageal carcinoma].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2010, Volume: 37, Issue:10

    Topics: Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Cisplatin; Esophageal Neopla

2010
Levamisole-induced syndrome of inappropriate antidiuretic hormone.
    The New England journal of medicine, 1992, Apr-23, Volume: 326, Issue:17

    Topics: Drug Therapy, Combination; Fluorouracil; Humans; Inappropriate ADH Syndrome; Levamisole; Male; Middl

1992