fluorouracil has been researched along with Inappropriate ADH Syndrome in 8 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Inappropriate ADH Syndrome: A condition of HYPONATREMIA and renal salt loss attributed to overexpansion of BODY FLUIDS resulting from sustained release of ANTIDIURETIC HORMONES which stimulates renal resorption of water. It is characterized by normal KIDNEY function, high urine OSMOLALITY, low serum osmolality, and neurological dysfunction. Etiologies include ADH-producing neoplasms, injuries or diseases involving the HYPOTHALAMUS, the PITUITARY GLAND, and the LUNG. This syndrome can also be drug-induced.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In patients with esophageal cancer, oxaliplatin appears to have a lower risk of SIADH than cisplatin, suggesting that oxaliplatin can be a therapeutic option for patients with esophageal cancer who are at high risk of SIADH." | 1.72 | Folinic Acid, Fluorouracil, and Oxaliplatin Therapy for Recurrent Esophageal Cancer with Syndrome of Inadequate Antidiuretic Hormone Secretion (SIADH) After Preoperative Cisplatin/5-Fluorouracil Therapy. ( Abe, T; Futai, R; Hayashi, H; Iemoto, T; Inoue, Y; Morikawa, T; Ose, T; Sanuki, T; Sasaki, A; Yoshie, T, 2022) |
| "A 77-year-old male with thoracic esophageal cancer (cT3N3M0, Stage III) received nedaplatin at 80mg/m2 for 1 day and 5-fluorouracil at 800mg/m2 for 5 days as neoadjuvant treatment." | 1.36 | [A case of SIADH developed during neoadjuvant chemotherapy using nedaplatin and 5-fluorouracil in a patient with esophageal cancer]. ( Gyobu, K; Hashiba, R; Isohata, N; Iwasaki, H; Kishida, S; Lee, S; Matsuda, Y; Mori, K; Osugi, H, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 6 (75.00) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Futai, R | 1 |
| Yoshie, T | 1 |
| Sanuki, T | 1 |
| Inoue, Y | 1 |
| Abe, T | 1 |
| Sasaki, A | 1 |
| Iemoto, T | 1 |
| Hayashi, H | 1 |
| Ose, T | 1 |
| Morikawa, T | 1 |
| Tamura, T | 1 |
| Taniguchi, N | 1 |
| Otsuki, K | 1 |
| Narai, T | 1 |
| Kawasaki, M | 1 |
| Fujii, N | 1 |
| Doi, R | 1 |
| Kodani, I | 1 |
| Endo, C | 1 |
| Takagawa, R | 1 |
| Chiba, T | 1 |
| Kawamoto, M | 1 |
| Konishi, T | 1 |
| Honma, Y | 1 |
| Minami, Y | 1 |
| Watanabe, J | 1 |
| Morita, T | 1 |
| Mogaki, M | 1 |
| Masui, H | 1 |
| Sawano, T | 1 |
| Kawasaki, H | 1 |
| Wajima, N | 1 |
| Miyamoto, K | 1 |
| Ishizawa, Y | 1 |
| Nakai, M | 1 |
| Hakamada, K | 1 |
| Suzuki, S | 1 |
| Goto, M | 1 |
| Okamoto, T | 1 |
| Tomita, I | 1 |
| Murayama, A | 1 |
| Sawa, M | 1 |
| Noguchi, Y | 1 |
| Hoshikawa, Y | 1 |
| Shimizu, A | 1 |
| Matsuda, Y | 1 |
| Lee, S | 1 |
| Kishida, S | 1 |
| Mori, K | 1 |
| Isohata, N | 1 |
| Iwasaki, H | 1 |
| Hashiba, R | 1 |
| Gyobu, K | 1 |
| Osugi, H | 1 |
| Horio, T | 1 |
| Tsujimoto, H | 1 |
| Akase, T | 1 |
| Sakamoto, N | 1 |
| Yaguchi, Y | 1 |
| Hiraki, S | 1 |
| Aiko, S | 1 |
| Takechi, H | 1 |
| Hase, K | 1 |
| Maehara, T | 1 |
| Tweedy, CR | 1 |
| Silverberg, DA | 1 |
| Scott, L | 1 |
3 reviews available for fluorouracil and Inappropriate ADH Syndrome
| Article | Year |
|---|---|
[A Case of Consciousness Disorder Induced by the Syndrome of Inappropriate Antidiuretic Hormone Secretion Following Cisplatin and 5-Fluorouracil Chemotherapy in a Patient with Tongue Cancer].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Conscious | 2018 |
[A case of consciousness disorder induced by the syndrome of inappropriate secretion of antidiuretic hormone following cisplatin and 5-fluorouracil chemotherapy in a patient with esophageal cancer].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Consciousness Disorders; Esophageal | 2013 |
[A case of syndrome of inappropriate antidiuretic hormone secretion in a patient with esophageal carcinoma possibly induced by cisplatin in neoadjuvant chemotherapy].
Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Esophageal Neoplasms; Fluorouracil; Human | 2014 |
5 other studies available for fluorouracil and Inappropriate ADH Syndrome
| Article | Year |
|---|---|
Folinic Acid, Fluorouracil, and Oxaliplatin Therapy for Recurrent Esophageal Cancer with Syndrome of Inadequate Antidiuretic Hormone Secretion (SIADH) After Preoperative Cisplatin/5-Fluorouracil Therapy.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Esophageal Neoplasms; Fluorouracil; | 2022 |
[A case of small cell carcinoma of the esophagus with SIADH].
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Small Cell; Cisplatin; Esophageal Neoplas | 2010 |
[A case of SIADH developed during neoadjuvant chemotherapy using nedaplatin and 5-fluorouracil in a patient with esophageal cancer].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Biopsy; Esophageal Neoplasms; Fluorouracil; Hu | 2010 |
[Syndrome of inappropriate antidiuretic hormone secretion following adjuvant CDDP and 5-FU administration in a patient with esophageal carcinoma].
Topics: Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Cisplatin; Esophageal Neopla | 2010 |
Levamisole-induced syndrome of inappropriate antidiuretic hormone.
Topics: Drug Therapy, Combination; Fluorouracil; Humans; Inappropriate ADH Syndrome; Levamisole; Male; Middl | 1992 |