fluorouracil has been researched along with Hypothyroidism in 11 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Hypothyroidism: A syndrome that results from abnormally low secretion of THYROID HORMONES from the THYROID GLAND, leading to a decrease in BASAL METABOLIC RATE. In its most severe form, there is accumulation of MUCOPOLYSACCHARIDES in the SKIN and EDEMA, known as MYXEDEMA. It may be primary or secondary due to other pituitary disease, or hypothalamic dysfunction.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In two separate experiments, treatment of C3H/He mice bearing transplantable mammary adenocarcinomas (C3HBA) with a regimen of 6-propylthiouracil (PTUra) and 5-fluorouracil (FUra) plus chloroquine phosphate (CP) resulted in complete remissions of 77 and 65%, respectively." | 7.66 | Remissions of mammary adenocarcinoma in hypothyroid mice given 5-fluorouracil and chloroquine phosphate. ( Dagher, RK; Shoemaker, JP, 1979) |
| "In two separate experiments, treatment of C3H/He mice bearing transplantable mammary adenocarcinomas (C3HBA) with a regimen of 6-propylthiouracil (PTUra) and 5-fluorouracil (FUra) plus chloroquine phosphate (CP) resulted in complete remissions of 77 and 65%, respectively." | 3.66 | Remissions of mammary adenocarcinoma in hypothyroid mice given 5-fluorouracil and chloroquine phosphate. ( Dagher, RK; Shoemaker, JP, 1979) |
| "Thyroid function in colorectal cancer patients receiving fluoropyrimidine-based chemotherapy with or without bevacizumab was evaluated at baseline and monthly." | 1.39 | Hypothyroidism in patients with colorectal carcinoma treated with fluoropyrimidines. ( Chayahara, N; Fujiwara, Y; Funakoshi, Y; Kiyota, N; Minami, H; Mukohara, T; Tomioka, H, 2013) |
| "Grade 3 dysphagia-esophageal related to radiation was observed in 3 patients (9." | 1.33 | [Hyperfractionated radiotherapy with concurrent chemotherapy for advanced esophageal cancer]. ( Asakura, H; Hosokawa, N; Kiuchi, T; Mitani, M; Ohkawa, M; Seo, H; Takashima, H; Togami, T; Yokoe, K, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (27.27) | 18.7374 |
| 1990's | 1 (9.09) | 18.2507 |
| 2000's | 3 (27.27) | 29.6817 |
| 2010's | 3 (27.27) | 24.3611 |
| 2020's | 1 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Alotayk, LI | 1 |
| Aldubayan, MA | 1 |
| Alenezi, SK | 1 |
| Anwar, MJ | 1 |
| Alhowail, AH | 1 |
| Fujiwara, Y | 1 |
| Chayahara, N | 1 |
| Mukohara, T | 1 |
| Kiyota, N | 1 |
| Tomioka, H | 1 |
| Funakoshi, Y | 1 |
| Minami, H | 1 |
| O'Neil, BH | 1 |
| Cainap, C | 1 |
| Van Cutsem, E | 1 |
| Gorbunova, V | 1 |
| Karapetis, CS | 1 |
| Berlin, J | 1 |
| Goldberg, RM | 1 |
| Qin, Q | 1 |
| Qian, J | 1 |
| Ricker, JL | 1 |
| Fischer, J | 1 |
| McKee, MD | 1 |
| Carlson, DM | 1 |
| Kim, TW | 1 |
| Nishimura, Y | 1 |
| Hiraoka, M | 1 |
| Koike, R | 1 |
| Nakamatsu, K | 1 |
| Itasaka, S | 1 |
| Kawamura, M | 1 |
| Negoro, Y | 1 |
| Araki, N | 1 |
| Ishikawa, H | 1 |
| Fujii, T | 1 |
| Mitsuhashi, N | 1 |
| Kumar, N | 1 |
| Allen, KA | 1 |
| Riccardi, D | 1 |
| Bercu, BB | 1 |
| Cantor, A | 1 |
| Minton, S | 1 |
| Balducci, L | 1 |
| Jacobsen, PB | 1 |
| Elmiger, R | 1 |
| Gerster, JC | 1 |
| Asakura, H | 1 |
| Takashima, H | 1 |
| Yokoe, K | 1 |
| Togami, T | 1 |
| Mitani, M | 1 |
| Kiuchi, T | 1 |
| Hosokawa, N | 1 |
| Seo, H | 1 |
| Ohkawa, M | 1 |
| Wickramasinghe, SN | 1 |
| Foster, MP | 1 |
| Montecino-Rodriguez, E | 1 |
| Dorshkind, K | 1 |
| Shoemaker, JP | 1 |
| Dagher, RK | 1 |
| Bruckner, HW | 1 |
| Creasey, WA | 1 |
1 review available for fluorouracil and Hypothyroidism
| Article | Year |
|---|---|
The deoxyuridine suppression test: a review of its clinical and research applications.
Topics: Alcoholism; Anemia, Hemolytic; Anticonvulsants; Bone Marrow Cells; Bone Marrow Diseases; Cells; Deox | 1981 |
2 trials available for fluorouracil and Hypothyroidism
| Article | Year |
|---|---|
Randomized phase II open-label study of mFOLFOX6 in combination with linifanib or bevacizumab for metastatic colorectal cancer.
Topics: Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemother | 2014 |
Long-term follow-up of a randomized Phase II study of cisplatin/5-FU concurrent chemoradiotherapy for esophageal cancer (KROSG0101/JROSG021).
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemoradiotherapy; Cisplatin; Esophagea | 2012 |
8 other studies available for fluorouracil and Hypothyroidism
| Article | Year |
|---|---|
Comparative evaluation of doxorubicin, cyclophosphamide, 5-fluorouracil, and cisplatin on cognitive dysfunction in rats: Delineating the role of inflammation of hippocampal neurons and hypothyroidism.
Topics: Animals; Cisplatin; Cognitive Dysfunction; Cyclophosphamide; Doxorubicin; Female; Fluorouracil; Hipp | 2023 |
Hypothyroidism in patients with colorectal carcinoma treated with fluoropyrimidines.
Topics: Adult; Aged; Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Che | 2013 |
Fatigue, weight gain, lethargy and amenorrhea in breast cancer patients on chemotherapy: is subclinical hypothyroidism the culprit?
Topics: Adult; Aged; Amenorrhea; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophos | 2004 |
[Bilateral shoulder-hand syndrome revealing hypothyroidism and colon carcinoma].
Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Chemotherapy, Adjuvant; Colonic Neoplasms; Diagnosi | 2004 |
[Hyperfractionated radiotherapy with concurrent chemotherapy for advanced esophageal cancer].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Combined Modality Therapy; Deglutit | 2005 |
Proliferation of bone marrow pro-B cells is dependent on stimulation by the pituitary/thyroid axis.
Topics: Animals; Apoptosis; B-Lymphocytes; Bone Marrow; Cell Division; Cell Lineage; Cells, Cultured; Fluoro | 1999 |
Remissions of mammary adenocarcinoma in hypothyroid mice given 5-fluorouracil and chloroquine phosphate.
Topics: Adenocarcinoma; Animals; Chloroquine; Drug Therapy, Combination; Female; Fluorouracil; Hypothyroidis | 1979 |
The administration of 5-fluorouracil by mouth.
Topics: Adenocarcinoma; Administration, Oral; Aged; Female; Fluorouracil; Gastrointestinal Neoplasms; Heart | 1974 |