fluorouracil has been researched along with Hypomelanosis in 8 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We report the case of a 74-years old patient with jejunum adenocarcinoma treated by capecitabine." | 8.12 | A case of palmar hypopigmentation induced by capecitabine in a gastrointestinal cancer patient. ( Botsen, D; Bouche, O; Gossery, C; Gratiaux, J; Rezzag-Mahcene, C; Slimano, F; Visseaux, L, 2022) |
| " Outcomes were the number of achromic lesions 30 days after treatment compared with baseline, patient satisfaction, and local or systemic adverse events." | 7.30 | Efficacy and Safety of 5-Fluorouracil Tattooing to Repigment Idiopathic Guttate Hypomelanosis: A Split-Body Randomized Trial. ( Arbache, S; Hirata, SH, 2023) |
| "Vitiligo is one of the most challenging dermatological diseases with little improvement promises." | 5.91 | Efficacy and safety of micro-needling combined with topical 5-fluorouracil and excimer light vs. excimer light alone in treatment of non-segmental vitiligo: A comparative study. ( Abdelaleem, HL; Saad, MA; Tawfik, KM, 2023) |
| "We report the case of a 74-years old patient with jejunum adenocarcinoma treated by capecitabine." | 4.12 | A case of palmar hypopigmentation induced by capecitabine in a gastrointestinal cancer patient. ( Botsen, D; Bouche, O; Gossery, C; Gratiaux, J; Rezzag-Mahcene, C; Slimano, F; Visseaux, L, 2022) |
| " Outcomes were the number of achromic lesions 30 days after treatment compared with baseline, patient satisfaction, and local or systemic adverse events." | 3.30 | Efficacy and Safety of 5-Fluorouracil Tattooing to Repigment Idiopathic Guttate Hypomelanosis: A Split-Body Randomized Trial. ( Arbache, S; Hirata, SH, 2023) |
| "Different approaches are used aiming to improve these scars, including intralesional corticosteroids, surgery and more recently, laser therapy." | 2.82 | Laser therapy for treating hypertrophic and keloid scars. ( da Silva, CA; da Silva, EM; Kuczynski, U; Leszczynski, R; Pinto, ACPN, 2022) |
| "Vitiligo is one of the most challenging dermatological diseases with little improvement promises." | 1.91 | Efficacy and safety of micro-needling combined with topical 5-fluorouracil and excimer light vs. excimer light alone in treatment of non-segmental vitiligo: A comparative study. ( Abdelaleem, HL; Saad, MA; Tawfik, KM, 2023) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (50.00) | 24.3611 |
| 2020's | 4 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Leszczynski, R | 1 |
| da Silva, CA | 1 |
| Pinto, ACPN | 1 |
| Kuczynski, U | 1 |
| da Silva, EM | 1 |
| Saad, MA | 1 |
| Tawfik, KM | 1 |
| Abdelaleem, HL | 1 |
| Arbache, S | 3 |
| Hirata, SH | 3 |
| Gratiaux, J | 1 |
| Gossery, C | 1 |
| Rezzag-Mahcene, C | 1 |
| Botsen, D | 1 |
| Visseaux, L | 1 |
| Slimano, F | 1 |
| Bouche, O | 1 |
| Wambier, CG | 2 |
| Perillo de Farias Wambier, S | 1 |
| Pereira Soares, MT | 1 |
| Breunig, J | 2 |
| Cappel, MA | 1 |
| Landau, M | 1 |
| Roth, D | 1 |
| Steiner, D | 1 |
| Michalany, NS | 2 |
| Arbache, ST | 1 |
| de Souza, LG | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Triamcinolone Acetonide Injections Compared With Micro Injections (MMP Technique) of Triamcinolone Acetonide for the Treatment of Female Genital Lichen Sclerosus and Atrophic[NCT06079645] | Phase 4 | 20 participants (Anticipated) | Interventional | 2023-10-20 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for fluorouracil and Hypomelanosis
| Article | Year |
|---|---|
Laser therapy for treating hypertrophic and keloid scars.
Topics: Adrenal Cortex Hormones; Adult; Aluminum; Atrophy; Carbon Dioxide; Child; Cicatrix, Hypertrophic; Di | 2022 |
2 trials available for fluorouracil and Hypomelanosis
| Article | Year |
|---|---|
Efficacy and Safety of 5-Fluorouracil Tattooing to Repigment Idiopathic Guttate Hypomelanosis: A Split-Body Randomized Trial.
Topics: Adult; Female; Fluorouracil; Humans; Hypopigmentation; Patient Satisfaction; Tattooing | 2023 |
Activation of melanocytes in idiopathic guttate hypomelanosis after 5-fluorouracil infusion using a tattoo machine: Preliminary analysis of a randomized, split-body, single blinded, placebo controlled clinical trial.
Topics: Equipment Design; Fluorouracil; Humans; Hypopigmentation; Infusions, Subcutaneous; Melanocytes; Need | 2018 |
5 other studies available for fluorouracil and Hypomelanosis
| Article | Year |
|---|---|
Efficacy and safety of micro-needling combined with topical 5-fluorouracil and excimer light vs. excimer light alone in treatment of non-segmental vitiligo: A comparative study.
Topics: Combined Modality Therapy; Fluorouracil; Humans; Hypopigmentation; Pigmentation Disorders; Treatment | 2023 |
A case of palmar hypopigmentation induced by capecitabine in a gastrointestinal cancer patient.
Topics: Adenocarcinoma; Aged; Antimetabolites, Antineoplastic; Capecitabine; Fluorouracil; Gastrointestinal | 2022 |
5-Fluorouracil tattooing for idiopathic guttate hypomelanosis.
Topics: Fluorouracil; Humans; Hypopigmentation; Tattooing | 2018 |
Reply to: "Comment on 'Activation of melanocytes in idiopathic guttate hypomelanosis after 5-fluorouracil infusion using a tattoo machine: Preliminary analysis of a randomized, split-body, single blinded, placebo controlled clinical trial'".
Topics: Fluorouracil; Humans; Hypopigmentation; Melanocytes; Tattooing | 2018 |
Comment on "Activation of melanocytes in idiopathic guttate hypomelanosis after 5-fluorouracil infusion using a tattoo machine: Preliminary analysis of a randomized, split-body, single blinded, placebo controlled clinical trial".
Topics: Fluorouracil; Humans; Hypopigmentation; Melanocytes; Tattooing | 2018 |