fluorouracil has been researched along with Hypogonadism in 3 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Hypogonadism: Condition resulting from deficient gonadal functions, such as GAMETOGENESIS and the production of GONADAL STEROID HORMONES. It is characterized by delay in GROWTH, germ cell maturation, and development of secondary sex characteristics. Hypogonadism can be due to a deficiency of GONADOTROPINS (hypogonadotropic hypogonadism) or due to primary gonadal failure (hypergonadotropic hypogonadism).
| Excerpt | Relevance | Reference |
|---|---|---|
| "The incidence of colorectal cancer (CRC) in individuals of fertile age is increasing." | 1.72 | Sex hormones and sperm parameters after adjuvant oxaliplatin-based treatment for colorectal cancer. ( Berglund, Å; Eberhard, J; Falk, P; Guren, MG; Hofsli, E; Österlund, P; Severin, M; Sorbye, H; Tandberg, A, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Falk, P | 1 |
| Severin, M | 1 |
| Berglund, Å | 1 |
| Guren, MG | 1 |
| Hofsli, E | 1 |
| Österlund, P | 1 |
| Tandberg, A | 1 |
| Eberhard, J | 1 |
| Sorbye, H | 1 |
| Yau, I | 1 |
| Vuong, T | 1 |
| Garant, A | 1 |
| Ducruet, T | 1 |
| Doran, P | 1 |
| Faria, S | 1 |
| Liberman, S | 1 |
| Richard, C | 1 |
| Letellier, F | 1 |
| Charlebois, P | 1 |
| Loungnarath, R | 1 |
| Stein, B | 1 |
| Devic, S | 1 |
| Chlebowski, RT | 1 |
| Heber, D | 1 |
3 other studies available for fluorouracil and Hypogonadism
| Article | Year |
|---|---|
Sex hormones and sperm parameters after adjuvant oxaliplatin-based treatment for colorectal cancer.
Topics: Colorectal Neoplasms; Female; Fluorouracil; Follicle Stimulating Hormone; Gonadal Steroid Hormones; | 2022 |
Risk of hypogonadism from scatter radiation during pelvic radiation in male patients with rectal cancer.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Brachytherapy; Fluorouracil; Follic | 2009 |
Hypogonadism in male patients with metastatic cancer prior to chemotherapy.
Topics: Body Weight; Fluorouracil; Follow-Up Studies; Humans; Hypogonadism; Luteinizing Hormone; Male; Middl | 1982 |