fluorouracil has been researched along with Hypocalcemia in 5 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Hypocalcemia: Reduction of the blood calcium below normal. Manifestations include hyperactive deep tendon reflexes, Chvostek's sign, muscle and abdominal cramps, and carpopedal spasm. (Dorland, 27th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "He was diagnosed as gastric cancer, lymph node metastases, brain metastases, bone marrow carcinomas, and disseminated intravascular coagulation(DIC)." | 5.35 | [A case of bone marrow carcinosis from gastric cancer that presented hypocalcemia caused by zoledronic acid during the treatment of methotrexate/5-fluorouracil sequential therapy]. ( Ariyama, H; Baba, E; Esaki, T; Fujimoto, C; Hiranuma, S; Murakawa, M; Syoji, T; Tsukasa, K, 2009) |
| "A patient with resected adenocarcinoma of the pancreas was treated with adjuvant radio-chemo-immunotherapy using a combination of low-dose Cisplatin, 5-Fluorouracil and Interferon alpha together with external beam radiation." | 4.83 | Major combined electrolyte deficiency during therapy with low-dose cisplatin, 5-fluorouracil and interferon alpha: report on several cases and review of the literature [ISRCTN62866759]. ( Buchler, MW; Fritz, S; Hoffmann, K; Jager, D; Lindel, K; Marten, A; Schmidt, J, 2006) |
| "He was diagnosed as gastric cancer, lymph node metastases, brain metastases, bone marrow carcinomas, and disseminated intravascular coagulation(DIC)." | 1.35 | [A case of bone marrow carcinosis from gastric cancer that presented hypocalcemia caused by zoledronic acid during the treatment of methotrexate/5-fluorouracil sequential therapy]. ( Ariyama, H; Baba, E; Esaki, T; Fujimoto, C; Hiranuma, S; Murakawa, M; Syoji, T; Tsukasa, K, 2009) |
| "Transient hypotension was the most common side effect occurring in association with amifostine." | 1.31 | Tolerability of the cytoprotective agent amifostine in elderly patients receiving chemotherapy: a comparative study. ( Genvresse, I; Harder, H; Lange, C; Possinger, K; Schanz, J; Schweigert, M; Späth-Schwalbe, E, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 4 (80.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tsukasa, K | 1 |
| Fujimoto, C | 1 |
| Ariyama, H | 1 |
| Esaki, T | 1 |
| Murakawa, M | 1 |
| Syoji, T | 1 |
| Baba, E | 1 |
| Hiranuma, S | 1 |
| Hoffmann, K | 1 |
| Marten, A | 1 |
| Lindel, K | 1 |
| Fritz, S | 1 |
| Jager, D | 1 |
| Buchler, MW | 1 |
| Schmidt, J | 1 |
| Kido, Y | 1 |
| Okamura, T | 1 |
| Tomikawa, M | 1 |
| Yamamoto, M | 1 |
| Shiraishi, M | 1 |
| Okada, Y | 1 |
| Kimura, T | 1 |
| Sugimachi, K | 1 |
| Posner, MR | 1 |
| Glisson, B | 1 |
| Frenette, G | 1 |
| Al-Sarraf, M | 1 |
| Colevas, AD | 1 |
| Norris, CM | 1 |
| Seroskie, JD | 1 |
| Shin, DM | 1 |
| Olivares, R | 1 |
| Garay, CA | 1 |
| Genvresse, I | 1 |
| Lange, C | 1 |
| Schanz, J | 1 |
| Schweigert, M | 1 |
| Harder, H | 1 |
| Possinger, K | 1 |
| Späth-Schwalbe, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase I/II Pilot Study of Induction Chemotherapy With Docetaxel in Combination With Cisplatin and 5-Fluorouracil (5-FU) in Locally Advanced Squamous Cell Carcinoma of the Head and Neck (SCCHN)[NCT00139269] | Phase 1/Phase 2 | 38 participants | Interventional | 1998-02-28 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for fluorouracil and Hypocalcemia
| Article | Year |
|---|---|
Major combined electrolyte deficiency during therapy with low-dose cisplatin, 5-fluorouracil and interferon alpha: report on several cases and review of the literature [ISRCTN62866759].
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Calcium; Cisplatin; Combined Modalit | 2006 |
2 trials available for fluorouracil and Hypocalcemia
| Article | Year |
|---|---|
Hypocalcemia associated with 5-fluorouracil and low dose leucovorin in patients with advanced colorectal or gastric carcinomas.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Calcitriol; Calcium; Colorectal Neoplasms; Fem | 1996 |
Multicenter phase I-II trial of docetaxel, cisplatin, and fluorouracil induction chemotherapy for patients with locally advanced squamous cell cancer of the head and neck.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Di | 2001 |
2 other studies available for fluorouracil and Hypocalcemia
| Article | Year |
|---|---|
[A case of bone marrow carcinosis from gastric cancer that presented hypocalcemia caused by zoledronic acid during the treatment of methotrexate/5-fluorouracil sequential therapy].
Topics: Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Bone Marrow; Calcinosis; Diphosph | 2009 |
Tolerability of the cytoprotective agent amifostine in elderly patients receiving chemotherapy: a comparative study.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Amifostine; Antihypertensive Agents; Antineoplastic Com | 2001 |