fluorouracil has been researched along with Hypertrophy in 11 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Hypertrophy: General increase in bulk of a part or organ due to CELL ENLARGEMENT and accumulation of FLUIDS AND SECRETIONS, not due to tumor formation, nor to an increase in the number of cells (HYPERPLASIA).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Intralesional treatments for keloid and hypertrophic scars may be the most reliable treatment option to improve pathologic scars, while laser treatment may have specific benefits for Fitzpatrick skin types I-III over types IV-VI." | 3.01 | Treatment of traumatic hypertrophic scars and keloids: a systematic review of randomized control trials. ( Alam, M; Anvery, N; Asadbeigi, SN; Christensen, RE; Dirr, MA; Hisham, FI; Ibrahim, SA; Jain-Poster, K; Kang, BY; Kim, K; Merkel, EA; Poon, E; Reynolds, KA; Worley, B, 2023) |
| "Different approaches are used aiming to improve these scars, including intralesional corticosteroids, surgery and more recently, laser therapy." | 2.82 | Laser therapy for treating hypertrophic and keloid scars. ( da Silva, CA; da Silva, EM; Kuczynski, U; Leszczynski, R; Pinto, ACPN, 2022) |
| "Hypertrophic scars and keloids may complicate wound healing secondary to trauma or surgery." | 2.69 | Treatment of inflamed hypertrophic scars using intralesional 5-FU. ( Fitzpatrick, RE, 1999) |
| "Though both forms of pathologic scarring are distinct entities at the macro and microscopic level, their etiologies and treatment are often similar." | 2.46 | The emerging role of antineoplastic agents in the treatment of keloids and hypertrophic scars: a review. ( Basdag, B; Magarakis, M; Manson, PN; Rosson, GD; Shridharani, SM; Singh, NK, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (27.27) | 18.7374 |
| 1990's | 2 (18.18) | 18.2507 |
| 2000's | 2 (18.18) | 29.6817 |
| 2010's | 2 (18.18) | 24.3611 |
| 2020's | 2 (18.18) | 2.80 |
| Authors | Studies |
|---|---|
| Leszczynski, R | 1 |
| da Silva, CA | 1 |
| Pinto, ACPN | 1 |
| Kuczynski, U | 1 |
| da Silva, EM | 1 |
| Worley, B | 1 |
| Kim, K | 1 |
| Jain-Poster, K | 1 |
| Reynolds, KA | 1 |
| Merkel, EA | 1 |
| Kang, BY | 1 |
| Dirr, MA | 1 |
| Anvery, N | 1 |
| Christensen, RE | 1 |
| Hisham, FI | 1 |
| Ibrahim, SA | 1 |
| Asadbeigi, SN | 1 |
| Poon, E | 1 |
| Alam, M | 1 |
| Xiao, N | 1 |
| Yu, K | 1 |
| Yu, S | 1 |
| Wu, J | 1 |
| Wang, J | 2 |
| Shan, S | 1 |
| Zheng, S | 1 |
| Wang, L | 1 |
| Peng, S | 1 |
| Aussilhou, B | 1 |
| Dokmak, S | 1 |
| Faivre, S | 1 |
| Paradis, V | 1 |
| Vilgrain, V | 1 |
| Belghiti, J | 1 |
| Shridharani, SM | 1 |
| Magarakis, M | 1 |
| Manson, PN | 1 |
| Singh, NK | 1 |
| Basdag, B | 1 |
| Rosson, GD | 1 |
| Tsuji, T | 1 |
| Nakagawa, K | 1 |
| Hamada, T | 1 |
| Maruyama, Y | 1 |
| Grider, C | 1 |
| Williams, A | 1 |
| Pekarske, SL | 1 |
| Shin, SS | 1 |
| Fitzpatrick, RE | 1 |
| Nagy, P | 1 |
| Teramoto, T | 1 |
| Factor, VM | 1 |
| Sanchez, A | 1 |
| Schnur, J | 1 |
| Paku, S | 1 |
| Thorgeirsson, SS | 1 |
| Kaplan, LA | 1 |
| Walter, JF | 1 |
| Macknet, KD | 1 |
4 reviews available for fluorouracil and Hypertrophy
| Article | Year |
|---|---|
Laser therapy for treating hypertrophic and keloid scars.
Topics: Adrenal Cortex Hormones; Adult; Aluminum; Atrophy; Carbon Dioxide; Child; Cicatrix, Hypertrophic; Di | 2022 |
Treatment of traumatic hypertrophic scars and keloids: a systematic review of randomized control trials.
Topics: Cicatrix, Hypertrophic; Fluorouracil; Humans; Hypertrophy; Injections, Intralesional; Keloid; Qualit | 2023 |
The paradigm of tumor shrinkage and rapid liver remnant hypertrophy for conversion of initially unresectable colorectal liver metastasis: a case report and literature review.
Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Carcinoembryonic Antigen; Carcinoma; C | 2017 |
The emerging role of antineoplastic agents in the treatment of keloids and hypertrophic scars: a review.
Topics: Antineoplastic Agents; Bleomycin; Cicatrix; Fluorouracil; Humans; Hypertrophy; Interferon-alpha; Kel | 2010 |
1 trial available for fluorouracil and Hypertrophy
| Article | Year |
|---|---|
Treatment of inflamed hypertrophic scars using intralesional 5-FU.
Topics: Acne Vulgaris; Adult; Aged; Anti-Inflammatory Agents; Antimetabolites; Cicatrix; Female; Fluorouraci | 1999 |
6 other studies available for fluorouracil and Hypertrophy
| Article | Year |
|---|---|
Preoperative liver hypertrophy induced by portal flow occlusion before major hepatic resection for colorectal metastases can be impaired by bevacizumab.
Topics: Adult; Aged; Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Ant | 2009 |
Different effects of topically applied 5-fluorouracil on hairy and hairless mice.
Topics: Animals; Dihydroxyphenylalanine; Fluorouracil; Hyperplasia; Hypertrophy; Melanocytes; Mice; Mice, Ha | 1984 |
Combined chemotherapy--radiotherapy on spleen hypertrophy after C. parvum: combined treatment with 5-FU cyclophosphamide and radiation.
Topics: Adjuvants, Immunologic; Animals; Cyclophosphamide; Drug Therapy, Combination; Fluorouracil; Hypertro | 1981 |
Bone marrow changes induced by recombinant granulocyte colony-stimulating factor resembling metastatic carcinoma: distinction with cytochemical and immunohistochemical studies.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Biomarkers; Biomarkers, Tumor; Bone Marrow; B | 1996 |
Reconstitution of liver mass via cellular hypertrophy in the rat.
Topics: Animals; Bromodeoxyuridine; Cell Division; Dexamethasone; DNA; Fluorouracil; Glucocorticoids; Hepate | 2001 |
Hypertrophic scarring as a complication of fluorouracil therapy.
Topics: Adult; Carcinoma, Basal Cell; Cicatrix; Fluocinonide; Fluorouracil; Humans; Hypertrophy; Male; Skin | 1979 |