fluorouracil has been researched along with Hypertriglyceridemia in 18 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Hypertriglyceridemia: A condition of elevated levels of TRIGLYCERIDES in the blood.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Capecitabine is a tumor-activated oral fluoropyrimidine used in breast and colorectal cancer." | 8.91 | Hypertriglyceridemia and hyperglycemia induced by capecitabine: a report of two cases and review of the literature. ( Han, GH; Huang, JX, 2015) |
| "Several reports have described hypertriglyceridemia (HTG) in cancer patients, including breast cancer patients treated with capecitabine (CAP)." | 7.79 | Hypertriglyceridemia in patients with metastatic breast cancer and treatment with capecitabine. ( Ariad, S; Geffen, DB; Geva, S; Lazarev, I, 2013) |
| "Capecitabine, a prodrug of 5-fluorouracil (5-FU), is rarely associated with severe hypertriglyceridemia." | 7.75 | Uncontrolled hypertriglyceridemia induced by capecitabine: case report and review of the literature. ( Bar-Sela, G; Haim, N, 2009) |
| "To report 2 cases of severe hypertriglyceridemia associated with the use of oral capecitabine." | 7.73 | Capecitabine-induced severe hypertriglyceridemia: report of two cases. ( Babaoglu, MO; Guler, N; Kurt, M; Shorbagi, A; Yasar, U, 2006) |
| "Capecitabine was discountinued and antilipemic treatments were given and both cases are in follow-up with normal lipid levels." | 6.48 | Capecitabine-induced hypertriglyceridemia and hyperglycemia: two cases. ( Afsar, CU; Dilli, MŞ; Duman, BB; Erçolak, V; Gunaldı, M; Haksöyler, V; Paydas, S; Tetiker, T, 2012) |
| "Capecitabine is an oral fluoropyrimidine which is transformed to 5-Fluorouracil inside tumor cells, where it achieves high drug concentrations." | 5.36 | Cancer chemotherapy and cardiovascular risks: is capecitabine-induced hypertriglyceridemia a rare adverse effect? ( Emiliani, A; Losanno, T; Manna, G; Seminara, P, 2010) |
| "Capecitabine is a tumor-activated oral fluoropyrimidine used in breast and colorectal cancer." | 4.91 | Hypertriglyceridemia and hyperglycemia induced by capecitabine: a report of two cases and review of the literature. ( Han, GH; Huang, JX, 2015) |
| "Background The association between fluoropyrimidines except for capecitabine and the risk of hypertriglyceridemia is unclear." | 4.12 | Fluoropyridmidine use and hypertriglyceridemia among Japanese patients: analysis of adverse event database. ( Ishizawa, K; Mitsuboshi, S; Niimura, T; Sakamoto, Y; Yoshino, M; Zamami, Y, 2022) |
| "According to registry studies of capecitabine, grade 3-4 hypertriglyceridemia can occur in 0." | 3.80 | Increase in triglyceride blood level in patients treated with capecitabine: a retrospective survey. ( Bar-Sela, G; Cohensius-Kent, D; Haim, N; Vornikova, O, 2014) |
| "Several reports have described hypertriglyceridemia (HTG) in cancer patients, including breast cancer patients treated with capecitabine (CAP)." | 3.79 | Hypertriglyceridemia in patients with metastatic breast cancer and treatment with capecitabine. ( Ariad, S; Geffen, DB; Geva, S; Lazarev, I, 2013) |
| "Capecitabine, a prodrug of 5-fluorouracil (5-FU), is rarely associated with severe hypertriglyceridemia." | 3.75 | Uncontrolled hypertriglyceridemia induced by capecitabine: case report and review of the literature. ( Bar-Sela, G; Haim, N, 2009) |
| "To report 2 cases of severe hypertriglyceridemia associated with the use of oral capecitabine." | 3.73 | Capecitabine-induced severe hypertriglyceridemia: report of two cases. ( Babaoglu, MO; Guler, N; Kurt, M; Shorbagi, A; Yasar, U, 2006) |
| "Capecitabine was discountinued and antilipemic treatments were given and both cases are in follow-up with normal lipid levels." | 2.48 | Capecitabine-induced hypertriglyceridemia and hyperglycemia: two cases. ( Afsar, CU; Dilli, MŞ; Duman, BB; Erçolak, V; Gunaldı, M; Haksöyler, V; Paydas, S; Tetiker, T, 2012) |
| "Capecitabine is an orally administered pro-drug of 5-fluorouracil that confers superior disease-free survival and presumably has a more favourable side-effect profile." | 1.38 | Hypertriglyceridaemia-induced pancreatitis: a contributory role of capecitabine? ( Chan, AO; Chan, HY; Ng, CM; Shek, CC; Tiu, SC, 2012) |
| "Capecitabine is an oral fluoropyrimidine which is transformed to 5-Fluorouracil inside tumor cells, where it achieves high drug concentrations." | 1.36 | Cancer chemotherapy and cardiovascular risks: is capecitabine-induced hypertriglyceridemia a rare adverse effect? ( Emiliani, A; Losanno, T; Manna, G; Seminara, P, 2010) |
| "Hypertriglyceridemia was maintained within acceptable levels, without adjusting the treatment plan, by an appropriate diet and gemfibrosil administration." | 1.28 | Hypertriglyceridemia during long-term interferon-alpha therapy: efficacy of diet and gemfibrosil treatment. A case report. ( Berruti, A; Dogliotti, L; Gorzegno, G; Tampellini, M; Vitetta, G, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (5.56) | 18.2507 |
| 2000's | 4 (22.22) | 29.6817 |
| 2010's | 11 (61.11) | 24.3611 |
| 2020's | 2 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Mitsuboshi, S | 1 |
| Niimura, T | 1 |
| Yoshino, M | 1 |
| Sakamoto, Y | 1 |
| Zamami, Y | 1 |
| Ishizawa, K | 1 |
| Zhou, W | 1 |
| Ni, L | 1 |
| Luo, M | 1 |
| Shu, X | 1 |
| Cao, P | 1 |
| Qiu, M | 1 |
| Geva, S | 1 |
| Lazarev, I | 1 |
| Geffen, DB | 1 |
| Ariad, S | 1 |
| Bar-Sela, G | 2 |
| Cohensius-Kent, D | 1 |
| Vornikova, O | 1 |
| Haim, N | 2 |
| Han, GH | 1 |
| Huang, JX | 1 |
| Noguchi, Y | 1 |
| Tsurushima, M | 1 |
| Kawara, H | 1 |
| Mitani, T | 1 |
| Tokuyama, Y | 1 |
| Uchiyama, K | 1 |
| Shimizu, Y | 1 |
| Garg, R | 1 |
| Angus, E | 1 |
| Fincher, S | 1 |
| Orphanos, GS | 1 |
| Stavrou, NG | 1 |
| Picolos, MK | 1 |
| Seminara, P | 1 |
| Losanno, T | 1 |
| Emiliani, A | 1 |
| Manna, G | 1 |
| Michie, CO | 1 |
| Sakala, M | 1 |
| Rivans, I | 1 |
| Strachan, MW | 1 |
| Clive, S | 1 |
| Javot, L | 1 |
| Spaëth, D | 1 |
| Scala-Bertola, J | 1 |
| Gambier, N | 1 |
| Petitpain, N | 1 |
| Gillet, P | 1 |
| Polinder-Bos, HA | 1 |
| Kok, EE | 1 |
| van de Wiel, A | 1 |
| Spiering, W | 1 |
| Wielders, JP | 1 |
| Bloemendal, HJ | 1 |
| Duman, BB | 1 |
| Paydas, S | 1 |
| Tetiker, T | 1 |
| Gunaldı, M | 1 |
| Afsar, CU | 1 |
| Erçolak, V | 1 |
| Haksöyler, V | 1 |
| Dilli, MŞ | 1 |
| Chan, HY | 1 |
| Ng, CM | 1 |
| Tiu, SC | 1 |
| Chan, AO | 1 |
| Shek, CC | 1 |
| Kurt, M | 1 |
| Babaoglu, MO | 1 |
| Yasar, U | 1 |
| Shorbagi, A | 1 |
| Guler, N | 1 |
| Elisaf, MS | 1 |
| Nakou, K | 1 |
| Liamis, G | 1 |
| Pavlidis, NA | 1 |
| Berruti, A | 1 |
| Gorzegno, G | 1 |
| Vitetta, G | 1 |
| Tampellini, M | 1 |
| Dogliotti, L | 1 |
4 reviews available for fluorouracil and Hypertriglyceridemia
| Article | Year |
|---|---|
Rare capecitabine-induced acute hypertriglyceridemia with angina: a case report and review of the literature.
Topics: Antimetabolites, Antineoplastic; Capecitabine; Deoxycytidine; Fluorouracil; Humans; Hypertriglycerid | 2022 |
Hypertriglyceridemia and hyperglycemia induced by capecitabine: a report of two cases and review of the literature.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Blood Glucose; Capecitabine; Colorectal Neopl | 2015 |
Capecitabine-induced severe hypertriglyceridaemia and diabetes: a case report and review of the literature.
Topics: Antimetabolites, Antineoplastic; Blood Glucose; Capecitabine; Colonic Neoplasms; Deoxycytidine; Feno | 2009 |
Capecitabine-induced hypertriglyceridemia and hyperglycemia: two cases.
Topics: Antimetabolites, Antineoplastic; Capecitabine; Deoxycytidine; Female; Fluorouracil; Humans; Hypergly | 2012 |
14 other studies available for fluorouracil and Hypertriglyceridemia
| Article | Year |
|---|---|
Fluoropyridmidine use and hypertriglyceridemia among Japanese patients: analysis of adverse event database.
Topics: Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Fluorouracil; Humans; Hypertriglycerid | 2022 |
Hypertriglyceridemia in patients with metastatic breast cancer and treatment with capecitabine.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Breast | 2013 |
Increase in triglyceride blood level in patients treated with capecitabine: a retrospective survey.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Capecitabine; Deoxycytidine; Female; Fluorouracil; Hum | 2014 |
[Survey of the current status of capecitabine-induced hypertriglyceridemia].
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Breast Neoplasms; Capecitabine; Colonic Neoplasms; Deo | 2014 |
Uncontrolled hypertriglyceridemia induced by capecitabine: case report and review of the literature.
Topics: Antimetabolites, Antineoplastic; Breast Neoplasms; Capecitabine; Cholesterol; Deoxycytidine; Female; | 2009 |
Hypertriglyceridemia: An underdiagnosed side effect of Capecitabine chemotherapy.
Topics: Adenocarcinoma; Antineoplastic Agents; Bezafibrate; Capecitabine; Cecum; Deoxycytidine; Fluorouracil | 2010 |
Cancer chemotherapy and cardiovascular risks: is capecitabine-induced hypertriglyceridemia a rare adverse effect?
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Breast Neoplasms; Capecitabine; Col | 2010 |
The frequency and severity of capecitabine-induced hypertriglyceridaemia in routine clinical practice: a prospective study.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Capecitabine; Deoxycytidine; Diabetes Mellitus; Dyslip | 2010 |
Severe hypertriglyceridaemia during treatment with capecitabine.
Topics: Antimetabolites, Antineoplastic; Capecitabine; Deoxycytidine; Female; Fluorouracil; Humans; Hypertri | 2011 |
Severe hypertriglyceridaemia associated with the use of capecitabine.
Topics: Antimetabolites, Antineoplastic; Capecitabine; Deoxycytidine; Fluorouracil; Humans; Hypertriglycerid | 2012 |
Hypertriglyceridaemia-induced pancreatitis: a contributory role of capecitabine?
Topics: Administration, Oral; Adult; Antimetabolites, Antineoplastic; Capecitabine; Colonic Neoplasms; Deoxy | 2012 |
Capecitabine-induced severe hypertriglyceridemia: report of two cases.
Topics: Aged; Antimetabolites, Antineoplastic; Breast Neoplasms; Capecitabine; Colorectal Neoplasms; Deoxycy | 2006 |
Tamoxifen-induced severe hypertriglyceridemia and pancreatitis.
Topics: Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; C | 2000 |
Hypertriglyceridemia during long-term interferon-alpha therapy: efficacy of diet and gemfibrosil treatment. A case report.
Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Combined Mo | 1992 |