fluorouracil has been researched along with Hyperthermia in 6 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Hyperthermia: An abnormal elevation of body temperature, usually as a result of inability to regulate core body temperature due to non-pathologic factors.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Hyperthermia was defined as feasible if 70% of patients received at least eight treatments." | 3.01 | Deep regional hyperthermia with preoperative radiochemotherapy in locally advanced rectal cancer, a prospective phase II trial. ( Bitzer, M; Fend, F; Gani, C; Gellermann, J; Heinrich, V; Königsrainer, A; Lamprecht, U; Moll, M; Wenz, S; Ziegler, A; Zips, D, 2021) |
| "A prospective open-label phase II trial was conducted to evaluate the efficacy of hyperthermia combined with induction chemotherapy in patients with locally advanced resectable oral squamous cell carcinoma (OSCC)." | 3.01 | A multicenter randomized phase II trial of hyperthermia combined with TPF induction chemotherapy compared with TPF induction chemotherapy in locally advanced resectable oral squamous cell carcinoma. ( Chen, Y; Ge, M; Guo, W; He, Y; Ju, H; Ma, X; Meng, J; Qiu, W; Ren, G; Song, H; Wu, Y; Zhuang, Q, 2021) |
| "The overall mEHT group had a comparable response and survival using less radiation dosing compared with standard care; the subgroup with large tumors showed improved efficacy for tumor regression after mEHT." | 1.62 | Beneficial effects of modulated electro-hyperthermia during neoadjuvant treatment for locally advanced rectal cancer. ( Cha, J; Kim, S; Lee, JH; You, SH, 2021) |
| " In the current study, we intended to induce selective radiosensitization in HT29 cancer cells by developing folic acid modified magnetic triblock copolymer nanoparticles as carrier of 5-Flourouracil (5-FU) which was further used in combination with hyperthermia." | 1.62 | Radio-sensitivity enhancement in HT29 cells through magnetic hyperthermia in combination with targeted nano-carrier of 5-Flourouracil. ( Khoee, S; Khoei, S; Mahdavi, SR; Mirzaghavami, PS; Pirhajati Mahabadi, V; Shirvalilou, S, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 6 (100.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mulens-Arias, V | 1 |
| Nicolás-Boluda, A | 1 |
| Pinto, A | 1 |
| Balfourier, A | 1 |
| Carn, F | 1 |
| Silva, AKA | 1 |
| Pocard, M | 1 |
| Gazeau, F | 1 |
| Kim, S | 1 |
| Lee, JH | 1 |
| Cha, J | 1 |
| You, SH | 1 |
| Ergözen, S | 1 |
| Gümüş, T | 1 |
| Gani, C | 1 |
| Lamprecht, U | 1 |
| Ziegler, A | 1 |
| Moll, M | 1 |
| Gellermann, J | 1 |
| Heinrich, V | 1 |
| Wenz, S | 1 |
| Fend, F | 1 |
| Königsrainer, A | 1 |
| Bitzer, M | 1 |
| Zips, D | 1 |
| Mirzaghavami, PS | 1 |
| Khoei, S | 1 |
| Khoee, S | 1 |
| Shirvalilou, S | 1 |
| Mahdavi, SR | 1 |
| Pirhajati Mahabadi, V | 1 |
| Ren, G | 1 |
| Ju, H | 1 |
| Wu, Y | 1 |
| Song, H | 1 |
| Ma, X | 1 |
| Ge, M | 1 |
| Qiu, W | 1 |
| Chen, Y | 1 |
| He, Y | 1 |
| Zhuang, Q | 1 |
| Meng, J | 1 |
| Guo, W | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Preoperative Radiochemotherapy With Concurrent Deep Regional Hyperthermia for Locally Advanced Rectal Cancer. A Prospective Phase II Trial[NCT02353858] | Phase 2 | 78 participants (Actual) | Interventional | 2012-08-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for fluorouracil and Hyperthermia
| Article | Year |
|---|---|
Deep regional hyperthermia with preoperative radiochemotherapy in locally advanced rectal cancer, a prospective phase II trial.
Topics: Adenocarcinoma; Chemoradiotherapy; Fluorouracil; Humans; Hyperthermia; Neoadjuvant Therapy; Neoplasm | 2021 |
A multicenter randomized phase II trial of hyperthermia combined with TPF induction chemotherapy compared with TPF induction chemotherapy in locally advanced resectable oral squamous cell carcinoma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Combined Modali | 2021 |
4 other studies available for fluorouracil and Hyperthermia
| Article | Year |
|---|---|
Tumor-Selective Immune-Active Mild Hyperthermia Associated with Chemotherapy in Colon Peritoneal Metastasis by Photoactivation of Fluorouracil-Gold Nanoparticle Complexes.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Combined Modality Therap | 2021 |
Beneficial effects of modulated electro-hyperthermia during neoadjuvant treatment for locally advanced rectal cancer.
Topics: Fluorouracil; Humans; Hyperthermia; Hyperthermia, Induced; Middle Aged; Neoadjuvant Therapy; Neoplas | 2021 |
Long-Term Survival Outcomes of Metabolically Supported Chemotherapy with Gemcitabine-Based or FOLFIRINOX Regimen Combined with Ketogenic Diet, Hyperthermia, and Hyperbaric Oxygen Therapy in Metastatic Pancreatic Cancer: A Letter to the Editor.
Topics: Antineoplastic Combined Chemotherapy Protocols; Deoxycytidine; Diet, Ketogenic; Fluorouracil; Gemcit | 2021 |
Radio-sensitivity enhancement in HT29 cells through magnetic hyperthermia in combination with targeted nano-carrier of 5-Flourouracil.
Topics: Cell Line, Tumor; Fluorouracil; HT29 Cells; Humans; Hyperthermia; Magnetic Phenomena; Nanoparticles; | 2021 |