fluorouracil has been researched along with Hyperoxia in 1 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Hyperoxia: An abnormal increase in the amount of oxygen in the tissues and organs.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The aim of this study was to elucidate whether hyperoxia also enhances any actual uptake of 5FU (5-fluorouracil) into the tumor tissue and if this can be explained by changes in the interstitium and extracellular matrix." | 7.75 | Hyperoxia increases the uptake of 5-fluorouracil in mammary tumors independently of changes in interstitial fluid pressure and tumor stroma. ( Kolmannskog, O; Moen, I; Reed, RK; Salvesen, GS; Stuhr, LE; Tronstad, KJ, 2009) |
| " The aim of this study was to elucidate whether hyperoxia also enhances any actual uptake of 5FU (5-fluorouracil) into the tumor tissue and if this can be explained by changes in the interstitium and extracellular matrix." | 3.75 | Hyperoxia increases the uptake of 5-fluorouracil in mammary tumors independently of changes in interstitial fluid pressure and tumor stroma. ( Kolmannskog, O; Moen, I; Reed, RK; Salvesen, GS; Stuhr, LE; Tronstad, KJ, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Moen, I | 1 |
| Tronstad, KJ | 1 |
| Kolmannskog, O | 1 |
| Salvesen, GS | 1 |
| Reed, RK | 1 |
| Stuhr, LE | 1 |
1 other study available for fluorouracil and Hyperoxia
| Article | Year |
|---|---|
Hyperoxia increases the uptake of 5-fluorouracil in mammary tumors independently of changes in interstitial fluid pressure and tumor stroma.
Topics: Adenocarcinoma; Animals; Antimetabolites, Antineoplastic; Blood Volume; Dose-Response Relationship, | 2009 |