fluorouracil has been researched along with Hypermelanosis in 26 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Twenty-five patients with vitiligo were subjected to microneedling of 2 patches of vitiligo with dermapen, then application of 5-fluorouracil to 1 patch and tacrolimus on the other patch." | 7.88 | Comparison between the efficacy of microneedling combined with 5-fluorouracil vs microneedling with tacrolimus in the treatment of vitiligo. ( Al-Saeid, H; Elgarhy, L; Ibrahim, Z; Mina, M, 2018) |
| "A 42-year-old woman being treated with 5-fluorouracil for carcinoma of the sigmoid colon developed persistent serpentine supravenous hyperpigmented eruption (PSSHE), bilateral mottling of the palms and diffuse hyperpigmentation of the soles." | 7.80 | 5-Fluorouracil-induced bilateral persistent serpentine supravenous hyperpigmented eruption, bilateral mottling of palms and diffuse hyperpigmentation of soles. ( Agrawal, A; Parihar, A; Suvirya, S, 2014) |
| "Hyperpigmentation of the hands and feet is a rare side effect with capecitabine chemotherapy and appeared to predict impending grade 2 HFS in our patients." | 7.74 | Palmar-plantar hyperpigmentation with capecitabine in adjuvant colon cancer. ( Easaw, JC; Vickers, MM, 2008) |
| "We report an unusual case of cutaneous and mucosal hyperpigmentation in a thirty-six year old African American woman who was receiving capecitabine chemotherapy for Stage IV breast carcinoma." | 7.71 | Capecitabine induced cutaneous hyperpigmentation: report of a case. ( Meehan, S; Moskovits, T; Pui, JC, 2002) |
| "Psoriasis is a papulosquamous disorder that causes significant social and psychological trauma to the patient." | 5.72 | Comparative efficacy of intralesional 5 flurouracil and intralesional triamcinolone acetonide in localized plaque psoriasis. ( Attwa, E; Essam, R; Khater, MH; Selim, HM, 2022) |
| "Capecitabine is an antineoplastic agent used for the treatment of patients with metastatic solid tumors (breast and colon)." | 5.34 | [Capecitabine-induced hyperpigmentation]. ( Galán-Gutiérrez, M; Jiménez-Puya, R; Moreno-Giménez, JC; Rodríguez-Bujaldón, AL; Vázquez-Bayo, C, 2007) |
| "A 45-year-old woman with breast cancer who developed serpentine supravenous hyperpigmentation after intravenous 5-fluorouracil is described." | 4.86 | Antineoplastic agent-associated serpentine supravenous hyperpigmentation: superficial venous system hyperpigmentation following intravenous chemotherapy. ( Cohen, PR; Geddes, ER, 2010) |
| "Twenty-five patients with vitiligo were subjected to microneedling of 2 patches of vitiligo with dermapen, then application of 5-fluorouracil to 1 patch and tacrolimus on the other patch." | 3.88 | Comparison between the efficacy of microneedling combined with 5-fluorouracil vs microneedling with tacrolimus in the treatment of vitiligo. ( Al-Saeid, H; Elgarhy, L; Ibrahim, Z; Mina, M, 2018) |
| "A 42-year-old woman being treated with 5-fluorouracil for carcinoma of the sigmoid colon developed persistent serpentine supravenous hyperpigmented eruption (PSSHE), bilateral mottling of the palms and diffuse hyperpigmentation of the soles." | 3.80 | 5-Fluorouracil-induced bilateral persistent serpentine supravenous hyperpigmented eruption, bilateral mottling of palms and diffuse hyperpigmentation of soles. ( Agrawal, A; Parihar, A; Suvirya, S, 2014) |
| "A 60-year-old Ghanese woman was treated with radiotherapy and capecitabine for metastatic breast cancer." | 3.77 | [A woman with palmar and plantar hyperpigmentation]. ( van Tienhoven, G; Wilmink, JW, 2011) |
| "Hyperpigmentation of the hands and feet is a rare side effect with capecitabine chemotherapy and appeared to predict impending grade 2 HFS in our patients." | 3.74 | Palmar-plantar hyperpigmentation with capecitabine in adjuvant colon cancer. ( Easaw, JC; Vickers, MM, 2008) |
| "Capecitabine is an antineoplastic agent that is currently the only effective treatment for patients with advanced or metastatic breast cancer in whom anthracycline or taxoid treatment has failed." | 3.72 | Onycholysis with the appearance of a "sunset" secondary to capecitabine. ( Maino, KL; Norwood, C; Stashower, ME, 2003) |
| "We report an unusual case of cutaneous and mucosal hyperpigmentation in a thirty-six year old African American woman who was receiving capecitabine chemotherapy for Stage IV breast carcinoma." | 3.71 | Capecitabine induced cutaneous hyperpigmentation: report of a case. ( Meehan, S; Moskovits, T; Pui, JC, 2002) |
| "Hyperpigmentation is a rare side effect occurring with 5-FU infusions; it has been reported in 2-5% of patients." | 2.82 | Serpentine Supra-venous Hyperpigmentation "Badge of Courage" in Fight Against Cancer: An Brief Review. ( Basu, D; Chaudhary, K; Goel, V; Jain, A; Narayan, S; Redhu, P; Soni, S; Talwar, V, 2022) |
| "Psoriasis is a papulosquamous disorder that causes significant social and psychological trauma to the patient." | 1.72 | Comparative efficacy of intralesional 5 flurouracil and intralesional triamcinolone acetonide in localized plaque psoriasis. ( Attwa, E; Essam, R; Khater, MH; Selim, HM, 2022) |
| "Capecitabine is an antineoplastic agent used for the treatment of patients with metastatic solid tumors (breast and colon)." | 1.34 | [Capecitabine-induced hyperpigmentation]. ( Galán-Gutiérrez, M; Jiménez-Puya, R; Moreno-Giménez, JC; Rodríguez-Bujaldón, AL; Vázquez-Bayo, C, 2007) |
| "Acanthosis nigricans is an uncommon skin condition characterized by hyperkeratosis and skin hyperpigmentation." | 1.30 | Malignant acanthosis nigricans: potential role of chemotherapy. ( Anderson, SH; Hudson-Peacock, M; Muller, AF, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (11.54) | 18.2507 |
| 2000's | 9 (34.62) | 29.6817 |
| 2010's | 9 (34.62) | 24.3611 |
| 2020's | 5 (19.23) | 2.80 |
| Authors | Studies |
|---|---|
| Attwa, E | 1 |
| Khater, MH | 1 |
| Selim, HM | 1 |
| Essam, R | 1 |
| Narayan, S | 3 |
| Talwar, V | 3 |
| Redhu, P | 3 |
| Goel, V | 3 |
| Jain, A | 3 |
| Soni, S | 3 |
| Chaudhary, K | 3 |
| Basu, D | 3 |
| Schaefer, JK | 1 |
| Ramnath, N | 1 |
| Holzgreve, H | 1 |
| Ismail, SA | 1 |
| Mohammed, NHK | 1 |
| Sotohy, M | 1 |
| Abou-Taleb, DAE | 1 |
| Co, ML | 1 |
| Esteban, MJ | 1 |
| Dalenc, F | 1 |
| Ribet, V | 1 |
| Rossi, AB | 1 |
| Guyonnaud, J | 1 |
| Bernard-Marty, C | 1 |
| de Lafontan, B | 1 |
| Salas, S | 1 |
| Ranc Royo, AL | 1 |
| Sarda, C | 1 |
| Levasseur, N | 1 |
| Massabeau, C | 1 |
| Levecq, JM | 1 |
| Dulguerova, P | 1 |
| Guerrero, D | 1 |
| Sibaud, V | 1 |
| Hernández-Aragüés, I | 1 |
| Baniandrés-Rodríguez, O | 1 |
| Vilas-Boas, PT | 1 |
| Conde-Montero, E | 1 |
| Suárez-Fernández, R | 1 |
| Mina, M | 1 |
| Elgarhy, L | 1 |
| Al-Saeid, H | 1 |
| Ibrahim, Z | 1 |
| Suvirya, S | 1 |
| Agrawal, A | 1 |
| Parihar, A | 1 |
| Ghosal, N | 1 |
| Misra, V | 1 |
| Vickers, MM | 1 |
| Easaw, JC | 1 |
| Geddes, ER | 1 |
| Cohen, PR | 1 |
| Chan, CC | 1 |
| Lin, SJ | 1 |
| van Tienhoven, G | 1 |
| Wilmink, JW | 1 |
| Agharbi, FZ | 1 |
| Meziane, M | 1 |
| Benhemmne, H | 1 |
| Daoudi, K | 1 |
| Elmesbahi, O | 1 |
| Mikou, O | 1 |
| Mernissi, FZ | 1 |
| Pui, JC | 1 |
| Meehan, S | 1 |
| Moskovits, T | 1 |
| Maino, KL | 1 |
| Norwood, C | 1 |
| Stashower, ME | 1 |
| Fukushima, S | 1 |
| Hatta, N | 1 |
| Chen, GY | 1 |
| Lee, JY | 1 |
| Chen, WC | 1 |
| Jain, V | 1 |
| Bhandary, S | 1 |
| Prasad, GN | 1 |
| Shenoi, SD | 1 |
| Vázquez-Bayo, C | 1 |
| Rodríguez-Bujaldón, AL | 1 |
| Jiménez-Puya, R | 1 |
| Galán-Gutiérrez, M | 1 |
| Moreno-Giménez, JC | 1 |
| Tavares-Bello, R | 1 |
| Allen, BJ | 1 |
| Parker, D | 1 |
| Wright, AL | 1 |
| Chen, JS | 1 |
| Jan, YY | 1 |
| Lin, YC | 1 |
| Wang, HM | 1 |
| Chang, WC | 1 |
| Liau, CT | 1 |
| Anderson, SH | 1 |
| Hudson-Peacock, M | 1 |
| Muller, AF | 1 |
4 reviews available for fluorouracil and Hypermelanosis
| Article | Year |
|---|---|
Serpentine Supra-venous Hyperpigmentation "Badge of Courage" in Fight Against Cancer: An Brief Review.
Topics: Adult; Courage; Fluorouracil; Humans; Hyperpigmentation; Male; Stomach Neoplasms; Syndrome | 2022 |
Serpentine Supra-venous Hyperpigmentation "Badge of Courage" in Fight Against Cancer: An Brief Review.
Topics: Adult; Courage; Fluorouracil; Humans; Hyperpigmentation; Male; Stomach Neoplasms; Syndrome | 2022 |
Serpentine Supra-venous Hyperpigmentation "Badge of Courage" in Fight Against Cancer: An Brief Review.
Topics: Adult; Courage; Fluorouracil; Humans; Hyperpigmentation; Male; Stomach Neoplasms; Syndrome | 2022 |
Serpentine Supra-venous Hyperpigmentation "Badge of Courage" in Fight Against Cancer: An Brief Review.
Topics: Adult; Courage; Fluorouracil; Humans; Hyperpigmentation; Male; Stomach Neoplasms; Syndrome | 2022 |
Topics: Ethnicity; Fluorouracil; Humans; Hyperpigmentation; White People | 2020 |
Antineoplastic agent-associated serpentine supravenous hyperpigmentation: superficial venous system hyperpigmentation following intravenous chemotherapy.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; C | 2010 |
Sclerotic and retracted supravenous hyperpigmentation associated with combination chemotherapy for metastatic breast carcinoma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Blood Vessels; Breast Neoplasms; Cyclophosphamide; E | 2005 |
3 trials available for fluorouracil and Hypermelanosis
| Article | Year |
|---|---|
Botulinum toxin type A versus 5-Fluorouracil in treatment of keloid.
Topics: Adolescent; Adult; Botulinum Toxins, Type A; Female; Fluorouracil; Follow-Up Studies; Humans; Hyperp | 2021 |
Efficacy of a global supportive skin care programme with hydrotherapy after non-metastatic breast cancer treatment: A randomised, controlled study.
Topics: Adult; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; | 2018 |
Weekly 24 h infusion of high-dose 5-fluorouracil and leucovorin in patients with biliary tract carcinomas.
Topics: Aged; Anorexia; Antidotes; Antimetabolites, Antineoplastic; Biliary Tract Neoplasms; Bone Marrow; Di | 1998 |
19 other studies available for fluorouracil and Hypermelanosis
| Article | Year |
|---|---|
Comparative efficacy of intralesional 5 flurouracil and intralesional triamcinolone acetonide in localized plaque psoriasis.
Topics: Drug Therapy, Combination; Fluorouracil; Humans; Hyperpigmentation; Injections, Intralesional; Keloi | 2022 |
Fluorouracil-Induced Hyperpigmentation.
Topics: Chemotherapy, Adjuvant; Colonic Neoplasms; Fluorouracil; Hand; Humans; Hyperpigmentation; Male; Midd | 2020 |
Lingual hyperpigmentation after 5-fluorouracil chemotherapy.
Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Female; Fluor | 2017 |
Cutaneous drug Reactions: Chemotherapy-induced hyperpigmentation.
Topics: Adenocarcinoma; Adult; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy | 2017 |
Comparison between the efficacy of microneedling combined with 5-fluorouracil vs microneedling with tacrolimus in the treatment of vitiligo.
Topics: Administration, Cutaneous; Cosmetic Techniques; Dermatologic Agents; Female; Fluorouracil; Humans; H | 2018 |
5-Fluorouracil-induced bilateral persistent serpentine supravenous hyperpigmented eruption, bilateral mottling of palms and diffuse hyperpigmentation of soles.
Topics: Adult; Antimetabolites, Antineoplastic; Antioxidants; Biopsy; Clobetasol; Diagnosis, Differential; D | 2014 |
A case of capecitabine-induced hyperpigmentation and radiation recall phenomenon.
Topics: Adult; Antimetabolites, Antineoplastic; Breast Neoplasms; Capecitabine; Carcinoma, Ductal, Breast; D | 2009 |
Palmar-plantar hyperpigmentation with capecitabine in adjuvant colon cancer.
Topics: Antimetabolites, Antineoplastic; Capecitabine; Colonic Neoplasms; Deoxycytidine; Female; Fluorouraci | 2008 |
Images in clinical medicine. Serpentine supravenous hyperpigmentation.
Topics: Antimetabolites, Antineoplastic; Fluorouracil; Humans; Hyperpigmentation; Infusions, Intravenous; Ma | 2010 |
[A woman with palmar and plantar hyperpigmentation].
Topics: Antimetabolites, Antineoplastic; Breast Neoplasms; Capecitabine; Deoxycytidine; Female; Fluorouracil | 2011 |
[Capecitabine-induced hyperpigmentation followed by hand-foot syndrome: a new case report].
Topics: Antimetabolites, Antineoplastic; Capecitabine; Colonic Neoplasms; Deoxycytidine; Fluorouracil; Follo | 2012 |
Capecitabine induced cutaneous hyperpigmentation: report of a case.
Topics: Adult; Antimetabolites, Antineoplastic; Capecitabine; Deoxycytidine; Female; Fluorouracil; Humans; H | 2002 |
Onycholysis with the appearance of a "sunset" secondary to capecitabine.
Topics: Adult; Antimetabolites, Antineoplastic; Breast Neoplasms; Capecitabine; Deoxycytidine; Erythema; Fem | 2003 |
Atypical moles in a patient undergoing chemotherapy with oral 5-fluorouracil prodrug.
Topics: Aged; Antimetabolites, Antineoplastic; Diagnosis, Differential; Drug Eruptions; Fluorouracil; Humans | 2004 |
Serpentine supravenous streaks induced by 5-fluorouracil.
Topics: Adenocarcinoma; Adult; Antimetabolites, Antineoplastic; Fluorouracil; Humans; Hyperpigmentation; Inf | 2005 |
[Capecitabine-induced hyperpigmentation].
Topics: Antimetabolites, Antineoplastic; Breast Neoplasms; Capecitabine; Carcinoma; Deoxycytidine; Female; F | 2007 |
Capecitabine-induced hand-foot syndrome and cutaneous hyperpigmentation in an elderly vitiligo patient.
Topics: Adenocarcinoma; Aged, 80 and over; Antimetabolites, Antineoplastic; Capecitabine; Colonic Neoplasms; | 2007 |
Reticulate pigmentation due to 5-fluorouracil.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Carcinoma; Erythema; Fluorouracil; Humans | 1995 |
Malignant acanthosis nigricans: potential role of chemotherapy.
Topics: Acanthosis Nigricans; Aged; Anal Canal; Antibiotics, Antineoplastic; Antimetabolites; Antineoplastic | 1999 |