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fluorouracil and Hyperglycemia, Postprandial

fluorouracil has been researched along with Hyperglycemia, Postprandial in 16 studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Hyperglycemia, Postprandial: Abnormally high BLOOD GLUCOSE level after a meal.

Research Excerpts

ExcerptRelevanceReference
"Capecitabine is a tumor-activated oral fluoropyrimidine used in breast and colorectal cancer."8.91Hypertriglyceridemia and hyperglycemia induced by capecitabine: a report of two cases and review of the literature. ( Han, GH; Huang, JX, 2015)
"The aim of the study was to analyse the prevalence and characteristics of secondary diabetes induced by 5-fluorouracil (5-FU) based chemotherapy in non-diabetic patients with colorectal cancer (CRC)."7.79Secondary diabetes associated with 5-fluorouracil-based chemotherapy regimens in non-diabetic patients with colorectal cancer: results from a single-centre cohort study. ( Fang, J; Feng, JP; Li, M; Lin, M; Luo, M; Xie, T; Ye, DW; Yuan, XL; Zhou, Y; Zhu, YM, 2013)
" In the present study we investigated effect of hyperglycemia on cytotoxic efficacy of carboplatin and 5-fluorouracil in MCF-7 cells."7.77Hyperglycemia regulates MDR-1, drug accumulation and ROS levels causing increased toxicity of carboplatin and 5-fluorouracil in MCF-7 cells. ( Bhat, MK; Chaube, B; Pandey, V, 2011)
"Capecitabine was discountinued and antilipemic treatments were given and both cases are in follow-up with normal lipid levels."6.48Capecitabine-induced hypertriglyceridemia and hyperglycemia: two cases. ( Afsar, CU; Dilli, MŞ; Duman, BB; Erçolak, V; Gunaldı, M; Haksöyler, V; Paydas, S; Tetiker, T, 2012)
"Many adjuvant chemotherapy regimens used for breast cancer include prednisone, which has the potential to cause hyperglycemia."5.06Hyperglycemic complications associated with adjuvant chemotherapy of breast cancer. A cancer and leukemia group B (CALGB) study. ( Ellis, ME; Korzun, AH; Lesnick, GJ; Norton, L; Perloff, M; Rice, MA; Weiss, RB; Wood, WC, 1986)
"Capecitabine is a tumor-activated oral fluoropyrimidine used in breast and colorectal cancer."4.91Hypertriglyceridemia and hyperglycemia induced by capecitabine: a report of two cases and review of the literature. ( Han, GH; Huang, JX, 2015)
" Transplantation of bone marrow hematopoietic stem and progenitor cells from diabetic C57Bl/6 donor mice to recipient CBA mice with 5-fluorouracilinduced leukopenia accelerated regeneration of granulocytopoiesis in recipient mice."3.83Role of Hematopoietic Stem Cells in Inflammation of the Pancreas during Diabetes Mellitus. ( Choinzonov, EL; Dygai, AM; Ellinidi, VN; Ermakova, NN; Ermolaeva, LA; Goldberg, VE; Kravtsov, VY; Krupin, VA; Pershina, OV; Reikhart, DV; Skurikhin, EG; Stakheeva, MN, 2016)
"The aim of the study was to analyse the prevalence and characteristics of secondary diabetes induced by 5-fluorouracil (5-FU) based chemotherapy in non-diabetic patients with colorectal cancer (CRC)."3.79Secondary diabetes associated with 5-fluorouracil-based chemotherapy regimens in non-diabetic patients with colorectal cancer: results from a single-centre cohort study. ( Fang, J; Feng, JP; Li, M; Lin, M; Luo, M; Xie, T; Ye, DW; Yuan, XL; Zhou, Y; Zhu, YM, 2013)
" In the present study we investigated effect of hyperglycemia on cytotoxic efficacy of carboplatin and 5-fluorouracil in MCF-7 cells."3.77Hyperglycemia regulates MDR-1, drug accumulation and ROS levels causing increased toxicity of carboplatin and 5-fluorouracil in MCF-7 cells. ( Bhat, MK; Chaube, B; Pandey, V, 2011)
"Capecitabine was discountinued and antilipemic treatments were given and both cases are in follow-up with normal lipid levels."2.48Capecitabine-induced hypertriglyceridemia and hyperglycemia: two cases. ( Afsar, CU; Dilli, MŞ; Duman, BB; Erçolak, V; Gunaldı, M; Haksöyler, V; Paydas, S; Tetiker, T, 2012)
"Chemoradiation for head and neck cancer may produce severe glucose metabolism alteration during treatment."1.35Altered glucose metabolism during chemoradiation for head and neck cancer. ( Borok, TL; Dutta, S; Jo, BH; Karlsson, U; Lee, H; Martinez, T; Nguyen, LM; Nguyen, N; Nguyen, NP; Sallah, S; Vinh-Hung, V; Vos, P, 2009)

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19903 (18.75)18.7374
1990's2 (12.50)18.2507
2000's2 (12.50)29.6817
2010's9 (56.25)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Westerweel, PE1
Teraa, M1
Rafii, S1
Jaspers, JE1
White, IA1
Hooper, AT1
Doevendans, PA1
Verhaar, MC1
Meyerhardt, JA1
Ma, YS1
Yang, IP1
Tsai, HL1
Huang, CW1
Juo, SH1
Wang, JY1
Han, GH1
Huang, JX1
Dygai, AM1
Skurikhin, EG1
Pershina, OV1
Ermakova, NN1
Krupin, VA1
Ermolaeva, LA1
Stakheeva, MN1
Choinzonov, EL1
Goldberg, VE1
Reikhart, DV1
Ellinidi, VN1
Kravtsov, VY1
Hickish, T1
Astras, G1
Thomas, P1
Penfold, S1
Purandare, L1
Hickish, TF1
Kerr, D1
Nguyen, NP1
Vos, P1
Vinh-Hung, V1
Borok, TL1
Dutta, S1
Karlsson, U1
Lee, H1
Martinez, T1
Jo, BH1
Nguyen, LM1
Nguyen, N1
Sallah, S1
Pandey, V1
Chaube, B1
Bhat, MK1
Feng, JP1
Yuan, XL1
Li, M1
Fang, J1
Xie, T1
Zhou, Y1
Zhu, YM1
Luo, M1
Lin, M1
Ye, DW1
Flaherty, AM1
Duman, BB1
Paydas, S1
Tetiker, T1
Gunaldı, M1
Afsar, CU1
Erçolak, V1
Haksöyler, V1
Dilli, MŞ1
Gade, PV1
Andrades, JA1
Nimni, ME1
Becerra, J1
Longoria, J1
Asemanfar, N1
Sorgente, N1
Sadoff, L1
Cubilla, AL1
Hajdu, SI1
Ellis, ME1
Weiss, RB1
Korzun, AH1
Rice, MA1
Norton, L1
Perloff, M1
Lesnick, GJ1
Wood, WC1
Kulemin, VV1
Al'bitskiĭ, VB1
Kotomin, SV1
Varigin, IuA1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Allogeneic Mesenchymal Stromal Cells for Angiogenesis and Neovascularization in No-option Ischemic Limbs; A Double-blind, Randomized, Placebo-controlled Trial[NCT03042572]Phase 2/Phase 360 participants (Anticipated)Interventional2018-12-31Not yet recruiting
Surveillance of Metabolic Parameters in Patients Who Will Receive Chemotherapy After Surgical Resection of Colorectal Cancer: KBSMC Colon Cancer Cohort[NCT02700555]23 participants (Actual)Observational [Patient Registry]2016-02-29Terminated (stopped due to The patient's study enrollment was too low.)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

3 reviews available for fluorouracil and Hyperglycemia, Postprandial

ArticleYear
Hypertriglyceridemia and hyperglycemia induced by capecitabine: a report of two cases and review of the literature.
    Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners, 2015, Volume: 21, Issue:5

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Blood Glucose; Capecitabine; Colorectal Neopl

2015
Management of diabetes and pancreatic cancer.
    Oncology nursing forum, 2012, Volume: 39, Issue:5

    Topics: Adenocarcinoma; Antiemetics; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Thera

2012
Capecitabine-induced hypertriglyceridemia and hyperglycemia: two cases.
    Pharmacology, 2012, Volume: 90, Issue:3-4

    Topics: Antimetabolites, Antineoplastic; Capecitabine; Deoxycytidine; Female; Fluorouracil; Humans; Hypergly

2012

Trials

1 trial available for fluorouracil and Hyperglycemia, Postprandial

ArticleYear
Hyperglycemic complications associated with adjuvant chemotherapy of breast cancer. A cancer and leukemia group B (CALGB) study.
    American journal of clinical oncology, 1986, Volume: 9, Issue:6

    Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cisplatin; Clinical Trials as Topi

1986

Other Studies

12 other studies available for fluorouracil and Hyperglycemia, Postprandial

ArticleYear
Impaired endothelial progenitor cell mobilization and dysfunctional bone marrow stroma in diabetes mellitus.
    PloS one, 2013, Volume: 8, Issue:3

    Topics: Animals; Antigens, CD34; Bone Marrow; Cell Count; Cell Movement; Cell Survival; Cells, Cultured; Coc

2013
The impact of glycemic levels in patients with colon cancer.
    Clinical advances in hematology & oncology : H&O, 2013, Volume: 11, Issue:2

    Topics: Antineoplastic Agents; Blood Glucose; Chemotherapy, Adjuvant; Colorectal Neoplasms; Diet; Fluorourac

2013
High glucose modulates antiproliferative effect and cytotoxicity of 5-fluorouracil in human colon cancer cells.
    DNA and cell biology, 2014, Volume: 33, Issue:2

    Topics: Apoptosis; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Deoxyuracil Nucleotides; DNA Rep

2014
Role of Hematopoietic Stem Cells in Inflammation of the Pancreas during Diabetes Mellitus.
    Bulletin of experimental biology and medicine, 2016, Volume: 160, Issue:4

    Topics: Animals; Bone Marrow Cells; Cell Differentiation; Cell- and Tissue-Based Therapy; Diabetes Mellitus,

2016
Glucose intolerance during adjuvant chemotherapy for breast cancer.
    Journal of the National Cancer Institute, 2009, Apr-01, Volume: 101, Issue:7

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Blood Glucose; Breast Neoplasms; Chemot

2009
Altered glucose metabolism during chemoradiation for head and neck cancer.
    Anticancer research, 2009, Volume: 29, Issue:11

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Blood Glucose; Cispl

2009
Hyperglycemia regulates MDR-1, drug accumulation and ROS levels causing increased toxicity of carboplatin and 5-fluorouracil in MCF-7 cells.
    Journal of cellular biochemistry, 2011, Volume: 112, Issue:10

    Topics: Acetylcysteine; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Carboplat

2011
Secondary diabetes associated with 5-fluorouracil-based chemotherapy regimens in non-diabetic patients with colorectal cancer: results from a single-centre cohort study.
    Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland, 2013, Volume: 15, Issue:1

    Topics: Aged; Analysis of Variance; Antimetabolites, Antineoplastic; C-Peptide; Colorectal Neoplasms; Diabet

2013
Nitric oxide mediates hyperglycemia-induced defective migration in cultured endothelial cells.
    Journal of vascular surgery, 1997, Volume: 26, Issue:2

    Topics: Animals; Antimetabolites; Aorta; Cattle; Cell Movement; Cells, Cultured; Endothelium, Vascular; Fluo

1997
Overwhelming 5-fluorouracil toxicity in patients whose diabetes is poorly controlled.
    American journal of clinical oncology, 1998, Volume: 21, Issue:6

    Topics: Aged; Antimetabolites, Antineoplastic; Diabetes Complications; Female; Fluorouracil; Humans; Hypergl

1998
Islet cell carcinoma of the pancreas.
    Archives of pathology, 1975, Volume: 99, Issue:4

    Topics: Adenoma, Islet Cell; Adolescent; Adult; Aged; Child; Cyclophosphamide; Dactinomycin; Female; Fluorou

1975
[Whole-body hyperthermia and hyperglycemia in the combined treatment of rectal cancer].
    Meditsinskaia radiologiia, 1987, Volume: 32, Issue:1

    Topics: Combined Modality Therapy; Fluorouracil; Follow-Up Studies; Glucose; Humans; Hyperglycemia; Hyperthe

1987