fluorouracil has been researched along with Hyperglycemia, Postprandial in 16 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Hyperglycemia, Postprandial: Abnormally high BLOOD GLUCOSE level after a meal.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Capecitabine is a tumor-activated oral fluoropyrimidine used in breast and colorectal cancer." | 8.91 | Hypertriglyceridemia and hyperglycemia induced by capecitabine: a report of two cases and review of the literature. ( Han, GH; Huang, JX, 2015) |
| "The aim of the study was to analyse the prevalence and characteristics of secondary diabetes induced by 5-fluorouracil (5-FU) based chemotherapy in non-diabetic patients with colorectal cancer (CRC)." | 7.79 | Secondary diabetes associated with 5-fluorouracil-based chemotherapy regimens in non-diabetic patients with colorectal cancer: results from a single-centre cohort study. ( Fang, J; Feng, JP; Li, M; Lin, M; Luo, M; Xie, T; Ye, DW; Yuan, XL; Zhou, Y; Zhu, YM, 2013) |
| " In the present study we investigated effect of hyperglycemia on cytotoxic efficacy of carboplatin and 5-fluorouracil in MCF-7 cells." | 7.77 | Hyperglycemia regulates MDR-1, drug accumulation and ROS levels causing increased toxicity of carboplatin and 5-fluorouracil in MCF-7 cells. ( Bhat, MK; Chaube, B; Pandey, V, 2011) |
| "Capecitabine was discountinued and antilipemic treatments were given and both cases are in follow-up with normal lipid levels." | 6.48 | Capecitabine-induced hypertriglyceridemia and hyperglycemia: two cases. ( Afsar, CU; Dilli, MŞ; Duman, BB; Erçolak, V; Gunaldı, M; Haksöyler, V; Paydas, S; Tetiker, T, 2012) |
| "Many adjuvant chemotherapy regimens used for breast cancer include prednisone, which has the potential to cause hyperglycemia." | 5.06 | Hyperglycemic complications associated with adjuvant chemotherapy of breast cancer. A cancer and leukemia group B (CALGB) study. ( Ellis, ME; Korzun, AH; Lesnick, GJ; Norton, L; Perloff, M; Rice, MA; Weiss, RB; Wood, WC, 1986) |
| "Capecitabine is a tumor-activated oral fluoropyrimidine used in breast and colorectal cancer." | 4.91 | Hypertriglyceridemia and hyperglycemia induced by capecitabine: a report of two cases and review of the literature. ( Han, GH; Huang, JX, 2015) |
| " Transplantation of bone marrow hematopoietic stem and progenitor cells from diabetic C57Bl/6 donor mice to recipient CBA mice with 5-fluorouracilinduced leukopenia accelerated regeneration of granulocytopoiesis in recipient mice." | 3.83 | Role of Hematopoietic Stem Cells in Inflammation of the Pancreas during Diabetes Mellitus. ( Choinzonov, EL; Dygai, AM; Ellinidi, VN; Ermakova, NN; Ermolaeva, LA; Goldberg, VE; Kravtsov, VY; Krupin, VA; Pershina, OV; Reikhart, DV; Skurikhin, EG; Stakheeva, MN, 2016) |
| "The aim of the study was to analyse the prevalence and characteristics of secondary diabetes induced by 5-fluorouracil (5-FU) based chemotherapy in non-diabetic patients with colorectal cancer (CRC)." | 3.79 | Secondary diabetes associated with 5-fluorouracil-based chemotherapy regimens in non-diabetic patients with colorectal cancer: results from a single-centre cohort study. ( Fang, J; Feng, JP; Li, M; Lin, M; Luo, M; Xie, T; Ye, DW; Yuan, XL; Zhou, Y; Zhu, YM, 2013) |
| " In the present study we investigated effect of hyperglycemia on cytotoxic efficacy of carboplatin and 5-fluorouracil in MCF-7 cells." | 3.77 | Hyperglycemia regulates MDR-1, drug accumulation and ROS levels causing increased toxicity of carboplatin and 5-fluorouracil in MCF-7 cells. ( Bhat, MK; Chaube, B; Pandey, V, 2011) |
| "Capecitabine was discountinued and antilipemic treatments were given and both cases are in follow-up with normal lipid levels." | 2.48 | Capecitabine-induced hypertriglyceridemia and hyperglycemia: two cases. ( Afsar, CU; Dilli, MŞ; Duman, BB; Erçolak, V; Gunaldı, M; Haksöyler, V; Paydas, S; Tetiker, T, 2012) |
| "Chemoradiation for head and neck cancer may produce severe glucose metabolism alteration during treatment." | 1.35 | Altered glucose metabolism during chemoradiation for head and neck cancer. ( Borok, TL; Dutta, S; Jo, BH; Karlsson, U; Lee, H; Martinez, T; Nguyen, LM; Nguyen, N; Nguyen, NP; Sallah, S; Vinh-Hung, V; Vos, P, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (18.75) | 18.7374 |
| 1990's | 2 (12.50) | 18.2507 |
| 2000's | 2 (12.50) | 29.6817 |
| 2010's | 9 (56.25) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Westerweel, PE | 1 |
| Teraa, M | 1 |
| Rafii, S | 1 |
| Jaspers, JE | 1 |
| White, IA | 1 |
| Hooper, AT | 1 |
| Doevendans, PA | 1 |
| Verhaar, MC | 1 |
| Meyerhardt, JA | 1 |
| Ma, YS | 1 |
| Yang, IP | 1 |
| Tsai, HL | 1 |
| Huang, CW | 1 |
| Juo, SH | 1 |
| Wang, JY | 1 |
| Han, GH | 1 |
| Huang, JX | 1 |
| Dygai, AM | 1 |
| Skurikhin, EG | 1 |
| Pershina, OV | 1 |
| Ermakova, NN | 1 |
| Krupin, VA | 1 |
| Ermolaeva, LA | 1 |
| Stakheeva, MN | 1 |
| Choinzonov, EL | 1 |
| Goldberg, VE | 1 |
| Reikhart, DV | 1 |
| Ellinidi, VN | 1 |
| Kravtsov, VY | 1 |
| Hickish, T | 1 |
| Astras, G | 1 |
| Thomas, P | 1 |
| Penfold, S | 1 |
| Purandare, L | 1 |
| Hickish, TF | 1 |
| Kerr, D | 1 |
| Nguyen, NP | 1 |
| Vos, P | 1 |
| Vinh-Hung, V | 1 |
| Borok, TL | 1 |
| Dutta, S | 1 |
| Karlsson, U | 1 |
| Lee, H | 1 |
| Martinez, T | 1 |
| Jo, BH | 1 |
| Nguyen, LM | 1 |
| Nguyen, N | 1 |
| Sallah, S | 1 |
| Pandey, V | 1 |
| Chaube, B | 1 |
| Bhat, MK | 1 |
| Feng, JP | 1 |
| Yuan, XL | 1 |
| Li, M | 1 |
| Fang, J | 1 |
| Xie, T | 1 |
| Zhou, Y | 1 |
| Zhu, YM | 1 |
| Luo, M | 1 |
| Lin, M | 1 |
| Ye, DW | 1 |
| Flaherty, AM | 1 |
| Duman, BB | 1 |
| Paydas, S | 1 |
| Tetiker, T | 1 |
| Gunaldı, M | 1 |
| Afsar, CU | 1 |
| Erçolak, V | 1 |
| Haksöyler, V | 1 |
| Dilli, MŞ | 1 |
| Gade, PV | 1 |
| Andrades, JA | 1 |
| Nimni, ME | 1 |
| Becerra, J | 1 |
| Longoria, J | 1 |
| Asemanfar, N | 1 |
| Sorgente, N | 1 |
| Sadoff, L | 1 |
| Cubilla, AL | 1 |
| Hajdu, SI | 1 |
| Ellis, ME | 1 |
| Weiss, RB | 1 |
| Korzun, AH | 1 |
| Rice, MA | 1 |
| Norton, L | 1 |
| Perloff, M | 1 |
| Lesnick, GJ | 1 |
| Wood, WC | 1 |
| Kulemin, VV | 1 |
| Al'bitskiĭ, VB | 1 |
| Kotomin, SV | 1 |
| Varigin, IuA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Allogeneic Mesenchymal Stromal Cells for Angiogenesis and Neovascularization in No-option Ischemic Limbs; A Double-blind, Randomized, Placebo-controlled Trial[NCT03042572] | Phase 2/Phase 3 | 60 participants (Anticipated) | Interventional | 2018-12-31 | Not yet recruiting | ||
| Surveillance of Metabolic Parameters in Patients Who Will Receive Chemotherapy After Surgical Resection of Colorectal Cancer: KBSMC Colon Cancer Cohort[NCT02700555] | 23 participants (Actual) | Observational [Patient Registry] | 2016-02-29 | Terminated (stopped due to The patient's study enrollment was too low.) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for fluorouracil and Hyperglycemia, Postprandial
| Article | Year |
|---|---|
Hypertriglyceridemia and hyperglycemia induced by capecitabine: a report of two cases and review of the literature.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Blood Glucose; Capecitabine; Colorectal Neopl | 2015 |
Management of diabetes and pancreatic cancer.
Topics: Adenocarcinoma; Antiemetics; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Thera | 2012 |
Capecitabine-induced hypertriglyceridemia and hyperglycemia: two cases.
Topics: Antimetabolites, Antineoplastic; Capecitabine; Deoxycytidine; Female; Fluorouracil; Humans; Hypergly | 2012 |
1 trial available for fluorouracil and Hyperglycemia, Postprandial
| Article | Year |
|---|---|
Hyperglycemic complications associated with adjuvant chemotherapy of breast cancer. A cancer and leukemia group B (CALGB) study.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cisplatin; Clinical Trials as Topi | 1986 |
12 other studies available for fluorouracil and Hyperglycemia, Postprandial
| Article | Year |
|---|---|
Impaired endothelial progenitor cell mobilization and dysfunctional bone marrow stroma in diabetes mellitus.
Topics: Animals; Antigens, CD34; Bone Marrow; Cell Count; Cell Movement; Cell Survival; Cells, Cultured; Coc | 2013 |
The impact of glycemic levels in patients with colon cancer.
Topics: Antineoplastic Agents; Blood Glucose; Chemotherapy, Adjuvant; Colorectal Neoplasms; Diet; Fluorourac | 2013 |
High glucose modulates antiproliferative effect and cytotoxicity of 5-fluorouracil in human colon cancer cells.
Topics: Apoptosis; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Deoxyuracil Nucleotides; DNA Rep | 2014 |
Role of Hematopoietic Stem Cells in Inflammation of the Pancreas during Diabetes Mellitus.
Topics: Animals; Bone Marrow Cells; Cell Differentiation; Cell- and Tissue-Based Therapy; Diabetes Mellitus, | 2016 |
Glucose intolerance during adjuvant chemotherapy for breast cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Blood Glucose; Breast Neoplasms; Chemot | 2009 |
Altered glucose metabolism during chemoradiation for head and neck cancer.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Blood Glucose; Cispl | 2009 |
Hyperglycemia regulates MDR-1, drug accumulation and ROS levels causing increased toxicity of carboplatin and 5-fluorouracil in MCF-7 cells.
Topics: Acetylcysteine; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Carboplat | 2011 |
Secondary diabetes associated with 5-fluorouracil-based chemotherapy regimens in non-diabetic patients with colorectal cancer: results from a single-centre cohort study.
Topics: Aged; Analysis of Variance; Antimetabolites, Antineoplastic; C-Peptide; Colorectal Neoplasms; Diabet | 2013 |
Nitric oxide mediates hyperglycemia-induced defective migration in cultured endothelial cells.
Topics: Animals; Antimetabolites; Aorta; Cattle; Cell Movement; Cells, Cultured; Endothelium, Vascular; Fluo | 1997 |
Overwhelming 5-fluorouracil toxicity in patients whose diabetes is poorly controlled.
Topics: Aged; Antimetabolites, Antineoplastic; Diabetes Complications; Female; Fluorouracil; Humans; Hypergl | 1998 |
Islet cell carcinoma of the pancreas.
Topics: Adenoma, Islet Cell; Adolescent; Adult; Aged; Child; Cyclophosphamide; Dactinomycin; Female; Fluorou | 1975 |
[Whole-body hyperthermia and hyperglycemia in the combined treatment of rectal cancer].
Topics: Combined Modality Therapy; Fluorouracil; Follow-Up Studies; Glucose; Humans; Hyperglycemia; Hyperthe | 1987 |